ADDG_HUMAN
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed). Binds to calmodulin. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ADDG_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 43.4783 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 43.4783 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 43.4783 | 4 | no |
GO:0019900 | kinase binding | 41.3043 | 4 | no |
GO:0019901 | protein kinase binding | 39.1304 | 5 | no |
GO:0003924 | GTPase activity | 34.7826 | 7 | no |
GO:0005525 | GTP binding | 34.7826 | 5 | no |
GO:0016462 | pyrophosphatase activity | 34.7826 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 34.7826 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 34.7826 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 34.7826 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 34.7826 | 5 | no |
GO:0003779 | actin binding | 23.9130 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ADDG_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 76.0870 | 4 | no |
GO:0051128 | regulation of cellular component organization | 67.3913 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 60.8696 | 4 | yes |
GO:0006996 | organelle organization | 60.8696 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 56.5217 | 4 | no |
GO:0022607 | cellular component assembly | 52.1739 | 4 | no |
GO:0007010 | cytoskeleton organization | 52.1739 | 5 | no |
GO:0051049 | regulation of transport | 52.1739 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 47.8261 | 5 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 47.8261 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 47.8261 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 45.6522 | 4 | no |
GO:0010646 | regulation of cell communication | 45.6522 | 4 | no |
GO:0008104 | protein localization | 45.6522 | 4 | no |
GO:0030030 | cell projection organization | 43.4783 | 4 | no |
GO:0032970 | regulation of actin filament-based process | 41.3043 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 41.3043 | 6 | yes |
GO:0009966 | regulation of signal transduction | 41.3043 | 4 | no |
GO:0010468 | regulation of gene expression | 41.3043 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 41.3043 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 39.1304 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 39.1304 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | no |
GO:0071702 | organic substance transport | 39.1304 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 36.9565 | 4 | no |
GO:0071310 | cellular response to organic substance | 36.9565 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 36.9565 | 5 | no |
GO:0016192 | vesicle-mediated transport | 36.9565 | 4 | no |
GO:0097435 | supramolecular fiber organization | 34.7826 | 4 | no |
GO:0030334 | regulation of cell migration | 34.7826 | 5 | no |
GO:0051094 | positive regulation of developmental process | 34.7826 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.7826 | 5 | no |
GO:2000145 | regulation of cell motility | 34.7826 | 4 | no |
GO:0071705 | nitrogen compound transport | 34.7826 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 34.7826 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 32.6087 | 4 | no |
GO:0007015 | actin filament organization | 30.4348 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.4348 | 5 | no |
GO:0031344 | regulation of cell projection organization | 30.4348 | 5 | no |
GO:0045595 | regulation of cell differentiation | 30.4348 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 30.4348 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.4348 | 6 | no |
GO:1902903 | regulation of supramolecular fiber organization | 28.2609 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 28.2609 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.2609 | 4 | no |
GO:0010647 | positive regulation of cell communication | 28.2609 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 28.2609 | 6 | no |
GO:0023056 | positive regulation of signaling | 28.2609 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 28.2609 | 5 | no |
GO:0031399 | regulation of protein modification process | 28.2609 | 6 | no |
GO:0042325 | regulation of phosphorylation | 28.2609 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 28.2609 | 5 | no |
GO:0032880 | regulation of protein localization | 28.2609 | 5 | no |
GO:0060341 | regulation of cellular localization | 28.2609 | 4 | no |
GO:0110053 | regulation of actin filament organization | 26.0870 | 6 | yes |
GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | no |
GO:0030335 | positive regulation of cell migration | 26.0870 | 6 | no |
GO:0040017 | positive regulation of locomotion | 26.0870 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 26.0870 | 4 | no |
GO:0045597 | positive regulation of cell differentiation | 26.0870 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 26.0870 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 26.0870 | 4 | no |
GO:2000147 | positive regulation of cell motility | 26.0870 | 5 | no |
GO:0015031 | protein transport | 26.0870 | 4 | no |
GO:0032535 | regulation of cellular component size | 23.9130 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 23.9130 | 5 | yes |
GO:0007264 | small GTPase mediated signal transduction | 23.9130 | 4 | no |
GO:0010243 | response to organonitrogen compound | 23.9130 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.9130 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.9130 | 5 | no |
GO:0022604 | regulation of cell morphogenesis | 23.9130 | 5 | no |
GO:0030155 | regulation of cell adhesion | 23.9130 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.9130 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.9130 | 5 | no |
GO:0051050 | positive regulation of transport | 23.9130 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 21.7391 | 5 | yes |
GO:0007265 | Ras protein signal transduction | 21.7391 | 5 | no |
GO:0008360 | regulation of cell shape | 21.7391 | 6 | no |
GO:0010628 | positive regulation of gene expression | 21.7391 | 6 | no |
GO:0010648 | negative regulation of cell communication | 21.7391 | 5 | no |
GO:0023057 | negative regulation of signaling | 21.7391 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.7391 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 21.7391 | 5 | no |
GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
GO:0031175 | neuron projection development | 21.7391 | 6 | no |
GO:0010720 | positive regulation of cell development | 21.7391 | 6 | no |
GO:0051223 | regulation of protein transport | 21.7391 | 5 | no |
GO:0060284 | regulation of cell development | 21.7391 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 21.7391 | 6 | no |
GO:0032271 | regulation of protein polymerization | 19.5652 | 6 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 17.3913 | 6 | yes |
GO:0030832 | regulation of actin filament length | 17.3913 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 15.2174 | 6 | yes |
GO:0030833 | regulation of actin filament polymerization | 15.2174 | 7 | yes |
GO:0031333 | negative regulation of protein-containing complex assembly | 15.2174 | 6 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 15.2174 | 7 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 15.2174 | 6 | yes |
GO:0030834 | regulation of actin filament depolymerization | 13.0435 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 13.0435 | 7 | yes |
GO:0032272 | negative regulation of protein polymerization | 13.0435 | 7 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 13.0435 | 6 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 13.0435 | 5 | yes |
GO:1901879 | regulation of protein depolymerization | 13.0435 | 6 | yes |
GO:1901880 | negative regulation of protein depolymerization | 13.0435 | 7 | yes |
GO:0030837 | negative regulation of actin filament polymerization | 10.8696 | 7 | yes |
GO:0051693 | actin filament capping | 10.8696 | 8 | yes |
GO:0051016 | barbed-end actin filament capping | 8.6957 | 9 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
JUN_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGTR1_HUMAN | [view interactions] | High throughput | no | no |
OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCD61_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
DRC5_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FOXP3_HUMAN | [view interactions] | High throughput | no | no |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
S2541_HUMAN | [view interactions] | High throughput | no | no |
FA78A_HUMAN | [view interactions] | High throughput | no | yes |
ANR29_HUMAN | [view interactions] | High throughput | no | no |
ELL3_HUMAN | [view interactions] | High throughput | no | yes |
CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBP2_HUMAN | [view interactions] | High throughput | no | yes |
ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VMA5A_HUMAN | [view interactions] | High throughput | no | no |
HDA11_HUMAN | [view interactions] | High throughput | no | no |
KLF15_HUMAN | [view interactions] | High throughput | no | yes |
RN111_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
GIP_HUMAN | [view interactions] | High throughput | no | no |
MELPH_HUMAN | [view interactions] | High throughput | no | yes |
GPSM3_HUMAN | [view interactions] | High throughput | no | no |
CRIS3_HUMAN | [view interactions] | High throughput | no | no |
NOG2_HUMAN | [view interactions] | High throughput | no | yes |
FEM1A_HUMAN | [view interactions] | High throughput | no | no |
TGM7_HUMAN | [view interactions] | High throughput | no | no |
NGN3_HUMAN | [view interactions] | High throughput | no | no |
BORC8_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC9_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
CPNE3_HUMAN | [view interactions] | High throughput | no | yes |
DYLT1_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
MK14_HUMAN | [view interactions] | High throughput | no | yes |
DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
PML_HUMAN | [view interactions] | High throughput | no | yes |
CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
STA5A_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCK_HUMAN | [view interactions] | High throughput | no | yes |
MCM7_HUMAN | [view interactions] | High throughput | no | no |
DEMA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
XPP1_HUMAN | [view interactions] | Computational | no | yes |