RFIP3_HUMAN
Evidence for PS localization
Functions
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RFIP3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.8889 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 38.8889 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.8889 | 4 | no |
| GO:0003924 | GTPase activity | 33.3333 | 7 | no |
| GO:0005525 | GTP binding | 33.3333 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 33.3333 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 33.3333 | 5 | no |
| GO:0031267 | small GTPase binding | 27.7778 | 5 | yes |
| GO:0051020 | GTPase binding | 27.7778 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 22.2222 | 4 | yes |
| GO:0046872 | metal ion binding | 22.2222 | 4 | yes |
| GO:0005509 | calcium ion binding | 11.1111 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RFIP3_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 77.7778 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 66.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 66.6667 | 4 | no |
| GO:0071705 | nitrogen compound transport | 66.6667 | 4 | no |
| GO:0015031 | protein transport | 61.1111 | 4 | no |
| GO:0033365 | protein localization to organelle | 50.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | yes |
| GO:0022607 | cellular component assembly | 44.4444 | 4 | no |
| GO:0046903 | secretion | 44.4444 | 4 | no |
| GO:0032880 | regulation of protein localization | 38.8889 | 5 | yes |
| GO:0051046 | regulation of secretion | 38.8889 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 38.8889 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | no |
| GO:0006996 | organelle organization | 38.8889 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 38.8889 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | yes |
| GO:0016197 | endosomal transport | 33.3333 | 4 | yes |
| GO:0032456 | endocytic recycling | 33.3333 | 5 | yes |
| GO:0051223 | regulation of protein transport | 33.3333 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 33.3333 | 6 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 33.3333 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 33.3333 | 4 | yes |
| GO:0006886 | intracellular protein transport | 33.3333 | 4 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0070925 | organelle assembly | 33.3333 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0006887 | exocytosis | 33.3333 | 4 | no |
| GO:0061512 | protein localization to cilium | 27.7778 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.7778 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 27.7778 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.7778 | 4 | no |
| GO:0030031 | cell projection assembly | 27.7778 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 27.7778 | 4 | no |
| GO:0120031 | plasma membrane bounded cell projection assembly | 27.7778 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.7778 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 22.2222 | 5 | yes |
| GO:0051051 | negative regulation of transport | 22.2222 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 22.2222 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 22.2222 | 4 | yes |
| GO:1903828 | negative regulation of protein localization | 22.2222 | 5 | yes |
| GO:0010468 | regulation of gene expression | 22.2222 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.2222 | 5 | no |
| GO:0009306 | protein secretion | 22.2222 | 4 | no |
| GO:0035592 | establishment of protein localization to extracellular region | 22.2222 | 4 | no |
| GO:0044782 | cilium organization | 22.2222 | 5 | no |
| GO:0060271 | cilium assembly | 22.2222 | 6 | no |
| GO:0071692 | protein localization to extracellular region | 22.2222 | 5 | no |
| GO:0072657 | protein localization to membrane | 22.2222 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 22.2222 | 5 | no |
| GO:0002790 | peptide secretion | 22.2222 | 5 | no |
| GO:0015833 | peptide transport | 22.2222 | 5 | no |
| GO:0042886 | amide transport | 22.2222 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 16.6667 | 5 | yes |
| GO:0032465 | regulation of cytokinesis | 16.6667 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 16.6667 | 4 | yes |
| GO:0046888 | negative regulation of hormone secretion | 16.6667 | 5 | yes |
| GO:0050709 | negative regulation of protein secretion | 16.6667 | 6 | yes |
| GO:0051048 | negative regulation of secretion | 16.6667 | 5 | yes |
| GO:0051224 | negative regulation of protein transport | 16.6667 | 5 | yes |
| GO:0051302 | regulation of cell division | 16.6667 | 4 | yes |
| GO:0070163 | regulation of adiponectin secretion | 16.6667 | 5 | yes |
| GO:0070164 | negative regulation of adiponectin secretion | 16.6667 | 5 | yes |
| GO:1903531 | negative regulation of secretion by cell | 16.6667 | 5 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 16.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGAP1_HUMAN | [view interactions] | Low throughput | no | no |
| KIF23_HUMAN | [view interactions] | Low throughput | no | yes |
| TBC14_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RFIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ASAP2_HUMAN | [view interactions] | Low throughput | no | yes |
| ASAP3_HUMAN | [view interactions] | Low throughput | no | yes |
| ACAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACAP2_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB3I_HUMAN | [view interactions] | Low throughput | no | no |
| PI4KB_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EXOC7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RFIP1_HUMAN | [view interactions] | Computational | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |