PACN1_HUMAN
Evidence for PS localization
Functions
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission . Binds to membranes via its F-BAR domain and mediates membrane tubulation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PACN1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 28.3019 | 4 | no |
| GO:0043169 | cation binding | 26.4151 | 4 | no |
| GO:0046872 | metal ion binding | 24.5283 | 5 | no |
| GO:0003723 | RNA binding | 24.5283 | 4 | no |
| GO:0003779 | actin binding | 22.6415 | 4 | no |
| GO:0019900 | kinase binding | 22.6415 | 4 | no |
| GO:0000166 | nucleotide binding | 20.7547 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.7547 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 20.7547 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.7547 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PACN1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 52.8302 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.8302 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.9434 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 49.0566 | 4 | no |
| GO:0022607 | cellular component assembly | 47.1698 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.2830 | 4 | no |
| GO:0030030 | cell projection organization | 45.2830 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.3962 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.3962 | 4 | no |
| GO:0006996 | organelle organization | 43.3962 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.7358 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.7358 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.7358 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.7358 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.8491 | 4 | no |
| GO:0043933 | protein-containing complex organization | 35.8491 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.9623 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 30.1887 | 4 | no |
| GO:0051049 | regulation of transport | 30.1887 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.1887 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.3019 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.3019 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.3019 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.3019 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 28.3019 | 5 | no |
| GO:0008104 | protein localization | 28.3019 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.3019 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.4151 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.4151 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.5283 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.5283 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.5283 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.5283 | 6 | no |
| GO:0007010 | cytoskeleton organization | 24.5283 | 5 | yes |
| GO:0031175 | neuron projection development | 24.5283 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.5283 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 22.6415 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.6415 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.6415 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.6415 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.6415 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.6415 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.6415 | 6 | no |
| GO:0033043 | regulation of organelle organization | 20.7547 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.7547 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.7547 | 5 | no |
| GO:0061024 | membrane organization | 20.7547 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 18.8679 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 18.8679 | 4 | yes |
| GO:0098657 | import into cell | 18.8679 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 16.9811 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 16.9811 | 6 | yes |
| GO:0048812 | neuron projection morphogenesis | 16.9811 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 16.9811 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.9811 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 16.9811 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 16.9811 | 4 | yes |
| GO:0007015 | actin filament organization | 13.2075 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 13.2075 | 7 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 13.2075 | 5 | yes |
| GO:0072657 | protein localization to membrane | 13.2075 | 4 | yes |
| GO:0140238 | presynaptic endocytosis | 13.2075 | 4 | yes |
| GO:0051051 | negative regulation of transport | 11.3208 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 11.3208 | 5 | yes |
| GO:0007009 | plasma membrane organization | 7.5472 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 7.5472 | 7 | yes |
| GO:0045806 | negative regulation of endocytosis | 7.5472 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 7.5472 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 5.6604 | 4 | yes |
| GO:0097320 | plasma membrane tubulation | 5.6604 | 6 | yes |
| GO:1900006 | positive regulation of dendrite development | 5.6604 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMD3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COBL_HUMAN | [view interactions] | Low throughput | no | yes |
| SPN90_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNFL6_HUMAN | [view interactions] | Low throughput | no | yes |
| PACN3_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNEM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF4_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN12_HUMAN | [view interactions] | High throughput | no | no |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| ATP8_HUMAN | [view interactions] | High throughput | no | no |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JADE2_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN2_HUMAN | [view interactions] | High throughput | no | no |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR24_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COBL1_HUMAN | [view interactions] | High throughput | no | yes |
| EHBP1_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| DIP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S66A2_HUMAN | [view interactions] | High throughput | no | yes |
| PHIPL_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| NELFB_HUMAN | [view interactions] | High throughput | no | yes |
| SYCC_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| MILK1_HUMAN | [view interactions] | High throughput | no | yes |
| AB1IP_HUMAN | [view interactions] | High throughput | no | no |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| SETD3_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| RWDD4_HUMAN | [view interactions] | High throughput | no | yes |
| CMS1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |