Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PACN1_HUMAN

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission . Binds to membranes via its F-BAR domain and mediates membrane tubulation. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PACN1_HUMAN
GO:0046872 metal ion binding 24.5283 4 no
GO:0003723 RNA binding 24.5283 4 no
GO:0019900 kinase binding 24.5283 4 no
GO:0003779 actin binding 20.7547 4 no
GO:0019901 protein kinase binding 20.7547 5 no
GO:0017076 purine nucleotide binding 20.7547 4 no
GO:0032555 purine ribonucleotide binding 20.7547 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.7547 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PACN1_HUMAN
GO:0048522 positive regulation of cellular process 56.6038 4 yes
GO:0048523 negative regulation of cellular process 54.7170 4 yes
GO:0051128 regulation of cellular component organization 54.7170 4 yes
GO:0010646 regulation of cell communication 47.1698 4 no
GO:0060255 regulation of macromolecule metabolic process 47.1698 4 no
GO:0006996 organelle organization 43.3962 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 43.3962 4 no
GO:0080090 regulation of primary metabolic process 43.3962 4 no
GO:0051049 regulation of transport 41.5094 4 yes
GO:0009966 regulation of signal transduction 39.6226 4 no
GO:0022607 cellular component assembly 39.6226 4 no
GO:0031323 regulation of cellular metabolic process 39.6226 4 no
GO:0030030 cell projection organization 37.7358 4 yes
GO:0016192 vesicle-mediated transport 33.9623 4 yes
GO:0051130 positive regulation of cellular component organization 32.0755 5 yes
GO:0009893 positive regulation of metabolic process 32.0755 4 no
GO:0010468 regulation of gene expression 32.0755 5 no
GO:0051246 regulation of protein metabolic process 32.0755 5 no
GO:0009892 negative regulation of metabolic process 32.0755 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.0755 5 no
GO:0010604 positive regulation of macromolecule metabolic process 30.1887 5 no
GO:0043933 protein-containing complex organization 30.1887 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.1887 5 no
GO:0008104 protein localization 28.3019 4 yes
GO:0031325 positive regulation of cellular metabolic process 28.3019 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.3019 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.3019 5 no
GO:0051129 negative regulation of cellular component organization 26.4151 5 yes
GO:0051050 positive regulation of transport 26.4151 4 no
GO:0031324 negative regulation of cellular metabolic process 26.4151 5 no
GO:0033043 regulation of organelle organization 26.4151 5 no
GO:0007010 cytoskeleton organization 24.5283 5 yes
GO:0060627 regulation of vesicle-mediated transport 24.5283 4 yes
GO:0065003 protein-containing complex assembly 24.5283 5 no
GO:0031399 regulation of protein modification process 24.5283 6 no
GO:0044087 regulation of cellular component biogenesis 24.5283 4 no
GO:1902531 regulation of intracellular signal transduction 24.5283 5 no
GO:0030100 regulation of endocytosis 22.6415 5 yes
GO:0061024 membrane organization 22.6415 4 yes
GO:0006355 regulation of DNA-templated transcription 22.6415 6 no
GO:0009889 regulation of biosynthetic process 22.6415 4 no
GO:0010556 regulation of macromolecule biosynthetic process 22.6415 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.6415 5 no
GO:0031326 regulation of cellular biosynthetic process 22.6415 5 no
GO:0051252 regulation of RNA metabolic process 22.6415 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.6415 7 no
GO:2001141 regulation of RNA biosynthetic process 22.6415 6 no
GO:0051248 negative regulation of protein metabolic process 22.6415 6 no
GO:0006897 endocytosis 20.7547 5 yes
GO:0031344 regulation of cell projection organization 20.7547 5 yes
GO:0097435 supramolecular fiber organization 20.7547 4 yes
GO:0048584 positive regulation of response to stimulus 20.7547 4 no
GO:0050804 modulation of chemical synaptic transmission 20.7547 5 no
GO:0051336 regulation of hydrolase activity 20.7547 4 no
GO:0099177 regulation of trans-synaptic signaling 20.7547 4 no
GO:0019220 regulation of phosphate metabolic process 20.7547 6 no
GO:0042325 regulation of phosphorylation 20.7547 7 no
GO:0051174 regulation of phosphorus metabolic process 20.7547 5 no
GO:0006796 phosphate-containing compound metabolic process 20.7547 4 no
GO:0031346 positive regulation of cell projection organization 18.8679 6 yes
GO:0051094 positive regulation of developmental process 18.8679 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 18.8679 6 yes
GO:0007015 actin filament organization 15.0943 5 yes
GO:0032990 cell part morphogenesis 15.0943 4 yes
GO:0048858 cell projection morphogenesis 15.0943 5 yes
GO:0051051 negative regulation of transport 15.0943 4 yes
GO:0072657 protein localization to membrane 15.0943 4 yes
GO:0010975 regulation of neuron projection development 13.2075 7 yes
GO:0048488 synaptic vesicle endocytosis 13.2075 5 yes
GO:0048812 neuron projection morphogenesis 13.2075 7 yes
GO:0099003 vesicle-mediated transport in synapse 13.2075 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 13.2075 6 yes
GO:0140238 presynaptic endocytosis 13.2075 4 yes
GO:1990778 protein localization to cell periphery 11.3208 5 yes
GO:0007009 plasma membrane organization 7.5472 5 yes
GO:0010976 positive regulation of neuron projection development 7.5472 7 yes
GO:0045806 negative regulation of endocytosis 7.5472 5 yes
GO:0072659 protein localization to plasma membrane 7.5472 5 yes
GO:0050773 regulation of dendrite development 5.6604 4 yes
GO:0097320 plasma membrane tubulation 5.6604 6 yes
GO:1900006 positive regulation of dendrite development 5.6604 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PACN1_HUMAN
DOID:0050700 cardiomyopathy 3.7736 4 no
DOID:0060036 intrinsic cardiomyopathy 3.7736 5 no
DOID:114 heart disease 3.7736 3 no
DOID:2843 long QT syndrome 3.7736 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SYNJ1_HUMAN [view entry] [view interactions] Low throughput yes yes
COBL_HUMAN [view interactions] Low throughput no yes
SPN90_HUMAN [view entry] [view interactions] Low throughput yes no
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TNFL6_HUMAN [view interactions] Low throughput no yes
PACN3_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
PACN1_HUMAN [view entry] [view interactions] Low throughput yes yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN3_HUMAN [view entry] [view interactions] Low throughput yes no
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
PACN2_HUMAN [view entry] [view interactions] Low throughput yes no
EHD3_HUMAN [view entry] [view interactions] Low throughput yes no
SYNEM_HUMAN [view entry] [view interactions] Low throughput yes no
ITCH_HUMAN [view interactions] Low throughput no yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
TBG1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCAM1_HUMAN [view entry] [view interactions] Low throughput yes no
WASL_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3A_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CYTN_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
ADA17_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
PKHF2_HUMAN [view interactions] High throughput no yes
CCD26_HUMAN [view interactions] High throughput no no
SLN12_HUMAN [view interactions] High throughput no no
SNX12_HUMAN [view entry] [view interactions] High throughput yes yes
NDKM_HUMAN [view interactions] High throughput no yes
KAT7_HUMAN [view interactions] High throughput no yes
RHG17_HUMAN [view interactions] High throughput no no
ATP8_HUMAN [view interactions] High throughput no no
GAS7_HUMAN [view entry] [view interactions] High throughput yes yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
RTKN2_HUMAN [view interactions] High throughput no no
JADE2_HUMAN [view interactions] High throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
ANR24_HUMAN [view entry] [view interactions] High throughput yes no
COBL1_HUMAN [view interactions] High throughput no yes
EHBP1_HUMAN [view interactions] High throughput no yes
FCHO2_HUMAN [view interactions] High throughput no yes
DIP2A_HUMAN [view interactions] High throughput no no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
FRYL_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
RU17_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
S66A2_HUMAN [view interactions] High throughput no yes
PHIPL_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
NELFB_HUMAN [view interactions] High throughput no no
SYCC_HUMAN [view interactions] High throughput no yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR1_HUMAN [view interactions] High throughput no yes
MILK1_HUMAN [view interactions] High throughput no yes
AB1IP_HUMAN [view interactions] High throughput no no
WASP_HUMAN [view interactions] High throughput no yes
WIPF1_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
SETD3_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
SETD2_HUMAN [view interactions] High throughput no yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
RAI14_HUMAN [view interactions] High throughput no yes
TARA_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
RWDD4_HUMAN [view interactions] High throughput no yes
CMS1_HUMAN [view interactions] High throughput no yes