SPN90_HUMAN
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo . In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 . May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SPN90_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 37.2881 | 4 | no |
GO:0019901 | protein kinase binding | 33.8983 | 5 | no |
GO:0003779 | actin binding | 32.2034 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.7288 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 23.7288 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.7288 | 4 | no |
GO:0046872 | metal ion binding | 20.3390 | 4 | no |
GO:0005524 | ATP binding | 20.3390 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 20.3390 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 20.3390 | 5 | no |
GO:0017124 | SH3 domain binding | 11.8644 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SPN90_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 66.1017 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 64.4068 | 4 | yes |
GO:0010646 | regulation of cell communication | 52.5424 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.8475 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.8475 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 49.1525 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 49.1525 | 4 | no |
GO:0006996 | organelle organization | 47.4576 | 4 | yes |
GO:0022607 | cellular component assembly | 47.4576 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 47.4576 | 4 | no |
GO:0009966 | regulation of signal transduction | 45.7627 | 4 | no |
GO:0033043 | regulation of organelle organization | 44.0678 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 40.6780 | 6 | no |
GO:0030030 | cell projection organization | 37.2881 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 37.2881 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.5932 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 35.5932 | 5 | yes |
GO:0008104 | protein localization | 35.5932 | 4 | no |
GO:0051049 | regulation of transport | 35.5932 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 33.8983 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.8983 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 33.8983 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 33.8983 | 4 | no |
GO:1902903 | regulation of supramolecular fiber organization | 33.8983 | 5 | no |
GO:0071310 | cellular response to organic substance | 33.8983 | 4 | no |
GO:0010468 | regulation of gene expression | 32.2034 | 5 | no |
GO:0016192 | vesicle-mediated transport | 32.2034 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.5085 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 30.5085 | 5 | no |
GO:0097435 | supramolecular fiber organization | 30.5085 | 4 | no |
GO:0110053 | regulation of actin filament organization | 30.5085 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 30.5085 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.8136 | 5 | no |
GO:0006897 | endocytosis | 28.8136 | 5 | yes |
GO:0031344 | regulation of cell projection organization | 28.8136 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 28.8136 | 4 | no |
GO:0007015 | actin filament organization | 28.8136 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 28.8136 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 27.1186 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.1186 | 6 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.1186 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 27.1186 | 6 | no |
GO:0031399 | regulation of protein modification process | 25.4237 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.4237 | 5 | no |
GO:0007010 | cytoskeleton organization | 25.4237 | 5 | yes |
GO:0032880 | regulation of protein localization | 25.4237 | 5 | no |
GO:0043933 | protein-containing complex organization | 25.4237 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.4237 | 5 | no |
GO:0060341 | regulation of cellular localization | 25.4237 | 4 | no |
GO:0065003 | protein-containing complex assembly | 25.4237 | 5 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.4237 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.4237 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.4237 | 5 | no |
GO:0042325 | regulation of phosphorylation | 23.7288 | 7 | no |
GO:0010647 | positive regulation of cell communication | 23.7288 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.7288 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 23.7288 | 4 | no |
GO:0051094 | positive regulation of developmental process | 23.7288 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 22.0339 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 22.0339 | 5 | no |
GO:0032271 | regulation of protein polymerization | 22.0339 | 6 | no |
GO:0043254 | regulation of protein-containing complex assembly | 22.0339 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.0339 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 22.0339 | 4 | no |
GO:0031346 | positive regulation of cell projection organization | 22.0339 | 6 | yes |
GO:0015031 | protein transport | 22.0339 | 4 | no |
GO:0071702 | organic substance transport | 22.0339 | 4 | no |
GO:0071705 | nitrogen compound transport | 22.0339 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 22.0339 | 6 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 22.0339 | 5 | no |
GO:0051495 | positive regulation of cytoskeleton organization | 22.0339 | 7 | no |
GO:1902905 | positive regulation of supramolecular fiber organization | 22.0339 | 6 | no |
GO:2000145 | regulation of cell motility | 22.0339 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 22.0339 | 7 | no |
GO:0051248 | negative regulation of protein metabolic process | 20.3390 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.3390 | 5 | no |
GO:0032535 | regulation of cellular component size | 20.3390 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 20.3390 | 5 | no |
GO:0032990 | cell part morphogenesis | 20.3390 | 4 | no |
GO:0048858 | cell projection morphogenesis | 20.3390 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 20.3390 | 5 | no |
GO:0034330 | cell junction organization | 20.3390 | 4 | no |
GO:0010941 | regulation of cell death | 20.3390 | 4 | no |
GO:0030334 | regulation of cell migration | 20.3390 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 20.3390 | 4 | no |
GO:0080134 | regulation of response to stress | 20.3390 | 4 | no |
GO:0010975 | regulation of neuron projection development | 18.6441 | 7 | yes |
GO:0010976 | positive regulation of neuron projection development | 10.1695 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DIAP3_HUMAN | [view interactions] | Low throughput | no | no |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PALLD_HUMAN | [view interactions] | Low throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STAC_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
GEMI7_HUMAN | [view interactions] | High throughput | no | no |
SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
SMN_HUMAN | [view interactions] | High throughput | no | yes |
GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX20_HUMAN | [view interactions] | High throughput | no | no |
GEMI4_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CLTR2_HUMAN | [view interactions] | High throughput | no | no |
RL3R1_HUMAN | [view interactions] | High throughput | no | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP54_HUMAN | [view interactions] | High throughput | no | yes |
GEMI8_HUMAN | [view interactions] | High throughput | no | yes |
JCAD_HUMAN | [view interactions] | High throughput | no | yes |
DMRTB_HUMAN | [view interactions] | High throughput | no | no |
GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKP2_HUMAN | [view interactions] | High throughput | no | yes |
RBM22_HUMAN | [view interactions] | High throughput | no | yes |
MED25_HUMAN | [view interactions] | High throughput | no | yes |
PRP31_HUMAN | [view interactions] | High throughput | no | yes |
ZBT47_HUMAN | [view interactions] | High throughput | no | yes |
ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
RU1C_HUMAN | [view interactions] | High throughput | no | yes |
PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
RET7_HUMAN | [view interactions] | High throughput | no | yes |
LEG4_HUMAN | [view interactions] | High throughput | no | no |
SEN54_HUMAN | [view interactions] | High throughput | no | yes |
RPC3_HUMAN | [view interactions] | High throughput | no | yes |
PS1C2_HUMAN | [view interactions] | High throughput | no | no |
CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CEP43_HUMAN | [view interactions] | High throughput | no | no |
LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
SMC6_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASF1_HUMAN | [view interactions] | High throughput | no | yes |
NRIP3_HUMAN | [view interactions] | High throughput | no | no |
TBA3C_HUMAN | [view interactions] | High throughput | no | no |
TBA3D_HUMAN | [view interactions] | High throughput | no | no |
FCSD1_HUMAN | [view interactions] | High throughput | no | yes |
ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARHG6_HUMAN | [view interactions] | High throughput | no | no |
GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GIT2_HUMAN | [view interactions] | High throughput | no | yes |
ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX33_HUMAN | [view interactions] | High throughput | no | yes |
RBM15_HUMAN | [view interactions] | High throughput | no | yes |
USP9Y_HUMAN | [view interactions] | High throughput | no | no |
RB15B_HUMAN | [view interactions] | High throughput | no | yes |
DACH1_HUMAN | [view interactions] | High throughput | no | no |
KC1A_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
PDD2L_HUMAN | [view interactions] | High throughput | no | yes |
FBX28_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARPC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARP3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARPC4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
BTK_HUMAN | [view interactions] | Computational | no | no |
ARPC3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARPC5_HUMAN | [view interactions] | Computational | no | yes |
WASP_HUMAN | [view interactions] | Computational | no | yes |