SPN90_HUMAN
Evidence for PS localization
Functions
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo . In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 . May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SPN90_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 35.2941 | 4 | no |
| GO:0043168 | anion binding | 30.8824 | 4 | no |
| GO:0019901 | protein kinase binding | 30.8824 | 5 | no |
| GO:0000166 | nucleotide binding | 26.4706 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.4706 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.4706 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.4706 | 4 | no |
| GO:0005524 | ATP binding | 23.5294 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.5294 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.5294 | 5 | no |
| GO:0003779 | actin binding | 22.0588 | 4 | no |
| GO:0043169 | cation binding | 22.0588 | 4 | no |
| GO:0046872 | metal ion binding | 22.0588 | 5 | no |
| GO:0003723 | RNA binding | 22.0588 | 4 | no |
| GO:0017124 | SH3 domain binding | 10.2941 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SPN90_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.7059 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.2941 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.8824 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.8824 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.4118 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.9412 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.9412 | 4 | no |
| GO:0006996 | organelle organization | 48.5294 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.6471 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.1765 | 4 | no |
| GO:0022607 | cellular component assembly | 41.1765 | 4 | no |
| GO:0008104 | protein localization | 39.7059 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.7059 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.7059 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 36.7647 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.7647 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 36.7647 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.7647 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.2941 | 5 | no |
| GO:0030030 | cell projection organization | 35.2941 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0051049 | regulation of transport | 33.8235 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.8824 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.8824 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.8824 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.8824 | 5 | no |
| GO:0033043 | regulation of organelle organization | 30.8824 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.8824 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.4118 | 6 | no |
| GO:0031399 | regulation of protein modification process | 29.4118 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.4118 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.4118 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.9412 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.9412 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.9412 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 27.9412 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 27.9412 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.4706 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.5294 | 6 | no |
| GO:0043933 | protein-containing complex organization | 22.0588 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 22.0588 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 22.0588 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.0588 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.0588 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.0588 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.0588 | 4 | no |
| GO:2000145 | regulation of cell motility | 22.0588 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.0588 | 5 | no |
| GO:0080134 | regulation of response to stress | 20.5882 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.5882 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.5882 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 20.5882 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.5882 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.5882 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.5882 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0098657 | import into cell | 20.5882 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.5882 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.5882 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.5882 | 6 | no |
| GO:0010975 | regulation of neuron projection development | 17.6471 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 17.6471 | 6 | yes |
| GO:0010976 | positive regulation of neuron projection development | 7.3529 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DIAP3_HUMAN | [view interactions] | Low throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PALLD_HUMAN | [view interactions] | Low throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| RL3R1_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| JCAD_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI8_HUMAN | [view interactions] | High throughput | no | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| DMRTB_HUMAN | [view interactions] | High throughput | no | no |
| GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| MED25_HUMAN | [view interactions] | High throughput | no | yes |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT47_HUMAN | [view interactions] | High throughput | no | yes |
| ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| RET7_HUMAN | [view interactions] | High throughput | no | yes |
| LEG4_HUMAN | [view interactions] | High throughput | no | no |
| SEN54_HUMAN | [view interactions] | High throughput | no | yes |
| RPC3_HUMAN | [view interactions] | High throughput | no | yes |
| PS1C2_HUMAN | [view interactions] | High throughput | no | no |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP3_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| FCSD1_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFYV9_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX33_HUMAN | [view interactions] | High throughput | no | yes |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| USP9Y_HUMAN | [view interactions] | High throughput | no | no |
| RB15B_HUMAN | [view interactions] | High throughput | no | yes |
| DACH1_HUMAN | [view interactions] | High throughput | no | no |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| PDD2L_HUMAN | [view interactions] | High throughput | no | yes |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSN8_HUMAN | [view interactions] | High throughput | no | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |