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NUMBL_HUMAN

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI002842 DEG_MDM2_SWIB_1 DEG 577 584 -
ELMI001135 LIG_EH_1 LIG 594 598 -

Molecular function

Term Name % Distance from the top of the tree Annotated in NUMBL_HUMAN
GO:0017076 purine nucleotide binding 40.0000 4 no
GO:0032555 purine ribonucleotide binding 37.7778 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.7778 4 no
GO:0030554 adenyl nucleotide binding 24.4444 5 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in NUMBL_HUMAN
GO:0048522 positive regulation of cellular process 71.1111 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.2222 4 no
GO:0008104 protein localization 60.0000 4 no
GO:0080090 regulation of primary metabolic process 60.0000 4 no
GO:0031323 regulation of cellular metabolic process 57.7778 4 no
GO:0048523 negative regulation of cellular process 57.7778 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.7778 4 no
GO:0071702 organic substance transport 57.7778 4 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0010646 regulation of cell communication 53.3333 4 no
GO:0071705 nitrogen compound transport 53.3333 4 no
GO:0051049 regulation of transport 46.6667 4 no
GO:0015031 protein transport 44.4444 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0009893 positive regulation of metabolic process 42.2222 4 no
GO:0016192 vesicle-mediated transport 42.2222 4 no
GO:0009966 regulation of signal transduction 42.2222 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0019220 regulation of phosphate metabolic process 37.7778 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.7778 5 no
GO:0051174 regulation of phosphorus metabolic process 37.7778 5 no
GO:0010468 regulation of gene expression 37.7778 5 no
GO:0030030 cell projection organization 35.5556 4 yes
GO:0031325 positive regulation of cellular metabolic process 35.5556 5 no
GO:0006996 organelle organization 35.5556 4 no
GO:0031344 regulation of cell projection organization 35.5556 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0045595 regulation of cell differentiation 31.1111 4 yes
GO:0051094 positive regulation of developmental process 31.1111 4 yes
GO:0010647 positive regulation of cell communication 31.1111 5 no
GO:0023056 positive regulation of signaling 31.1111 4 no
GO:0032880 regulation of protein localization 31.1111 5 no
GO:0042981 regulation of apoptotic process 31.1111 6 no
GO:0043067 regulation of programmed cell death 31.1111 5 no
GO:0060341 regulation of cellular localization 31.1111 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.1111 5 no
GO:1902531 regulation of intracellular signal transduction 31.1111 5 no
GO:0051240 positive regulation of multicellular organismal process 28.8889 4 yes
GO:0001932 regulation of protein phosphorylation 28.8889 7 no
GO:0010562 positive regulation of phosphorus metabolic process 28.8889 6 no
GO:0042327 positive regulation of phosphorylation 28.8889 8 no
GO:0045937 positive regulation of phosphate metabolic process 28.8889 7 no
GO:0051247 positive regulation of protein metabolic process 28.8889 6 no
GO:1901699 cellular response to nitrogen compound 28.8889 4 no
GO:0009892 negative regulation of metabolic process 28.8889 4 no
GO:0051252 regulation of RNA metabolic process 28.8889 5 no
GO:0034330 cell junction organization 26.6667 4 yes
GO:0010243 response to organonitrogen compound 26.6667 4 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:1901701 cellular response to oxygen-containing compound 26.6667 4 no
GO:0030334 regulation of cell migration 26.6667 5 no
GO:2000145 regulation of cell motility 26.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.6667 5 no
GO:0006355 regulation of DNA-templated transcription 26.6667 6 no
GO:1903506 regulation of nucleic acid-templated transcription 26.6667 7 no
GO:2001141 regulation of RNA biosynthetic process 26.6667 6 no
GO:0120036 plasma membrane bounded cell projection organization 26.6667 5 no
GO:0009967 positive regulation of signal transduction 26.6667 5 no
GO:2000026 regulation of multicellular organismal development 24.4444 4 yes
GO:0001934 positive regulation of protein phosphorylation 24.4444 8 no
GO:0031401 positive regulation of protein modification process 24.4444 7 no
GO:0043549 regulation of kinase activity 24.4444 5 no
GO:0050804 modulation of chemical synaptic transmission 24.4444 5 no
GO:0051338 regulation of transferase activity 24.4444 4 no
GO:0071417 cellular response to organonitrogen compound 24.4444 4 no
GO:0099177 regulation of trans-synaptic signaling 24.4444 4 no
GO:0007010 cytoskeleton organization 24.4444 5 no
GO:0031346 positive regulation of cell projection organization 24.4444 6 no
GO:0051050 positive regulation of transport 24.4444 4 no
GO:0010975 regulation of neuron projection development 24.4444 7 no
GO:0036211 protein modification process 22.2222 4 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:0006897 endocytosis 22.2222 5 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0050767 regulation of neurogenesis 20.0000 6 yes
GO:0051960 regulation of nervous system development 20.0000 5 yes
GO:0060284 regulation of cell development 20.0000 5 yes
GO:0045597 positive regulation of cell differentiation 17.7778 5 yes
GO:0007409 axonogenesis 13.3333 8 yes
GO:0010720 positive regulation of cell development 13.3333 6 yes
GO:0032990 cell part morphogenesis 13.3333 4 yes
GO:0045216 cell-cell junction organization 13.3333 5 yes
GO:0048812 neuron projection morphogenesis 13.3333 7 yes
GO:0048858 cell projection morphogenesis 13.3333 5 yes
GO:0050769 positive regulation of neurogenesis 13.3333 6 yes
GO:0051962 positive regulation of nervous system development 13.3333 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 13.3333 6 yes
GO:0034332 adherens junction organization 8.8889 6 yes
GO:0007399 nervous system development 6.6667 4 yes
GO:0019221 cytokine-mediated signaling pathway 4.4444 4 yes
GO:0021849 neuroblast division in subventricular zone 4.4444 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRAF5_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view interactions] Low throughput no yes
TAB2_HUMAN [view interactions] Low throughput no yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
AUP1_HUMAN [view interactions] Low throughput no yes
LNX2_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LYAG_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
SIAH1_HUMAN [view interactions] High throughput no yes
TPO_HUMAN [view interactions] High throughput no no
BHE40_HUMAN [view interactions] High throughput no yes
RIPK1_HUMAN [view interactions] High throughput no yes
MAGD1_HUMAN [view interactions] High throughput no no
GPTC8_HUMAN [view interactions] High throughput no yes
TMC5_HUMAN [view interactions] High throughput no no
ESRP2_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
GTSE1_HUMAN [view interactions] High throughput no no
K1107_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
UN5CL_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
RFOX1_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
SPSB3_HUMAN [view interactions] High throughput no yes
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
ROR1_HUMAN [view interactions] High throughput no no
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
CBY1_HUMAN [view interactions] High throughput no no
RAB3I_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
PAAT_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBE3A_HUMAN [view interactions] High throughput no yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
SMAP2_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
NOTC4_HUMAN [view interactions] Computational no no
KPCI_HUMAN [view entry] [view interactions] Computational yes yes
NOTC3_HUMAN [view interactions] Computational no yes
NOTC2_HUMAN [view interactions] Computational no yes