NUMBL_HUMAN
Evidence for PS localization
Functions
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002842 | DEG_MDM2_SWIB_1 | DEG | 577 | 584 | - |
| ELMI001135 | LIG_EH_1 | LIG | 594 | 598 | - |
| ELMI002842 | DEG_MDM2_SWIB_1 | DEG | 577 | 584 | - |
| ELMI001135 | LIG_EH_1 | LIG | 594 | 598 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NUMBL_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.5385 | 4 | no |
| GO:0000166 | nucleotide binding | 32.6923 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.6923 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.6923 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6923 | 4 | no |
| GO:0019900 | kinase binding | 23.0769 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
| GO:0045296 | cadherin binding | 23.0769 | 4 | no |
| GO:0043169 | cation binding | 21.1538 | 4 | no |
| GO:0046872 | metal ion binding | 21.1538 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NUMBL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.3077 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 61.5385 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.7692 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 55.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.7692 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.8462 | 4 | no |
| GO:0008104 | protein localization | 51.9231 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.9231 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 44.2308 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 42.3077 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.3077 | 5 | no |
| GO:0009966 | regulation of signal transduction | 40.3846 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.3846 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.3846 | 5 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0022607 | cellular component assembly | 38.4615 | 4 | no |
| GO:0071702 | organic substance transport | 38.4615 | 4 | no |
| GO:0071705 | nitrogen compound transport | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 38.4615 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.5385 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.5385 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 34.6154 | 5 | no |
| GO:0031399 | regulation of protein modification process | 34.6154 | 6 | no |
| GO:0030030 | cell projection organization | 32.6923 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 32.6923 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 32.6923 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.6923 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.6923 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 32.6923 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 32.6923 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.6923 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.6923 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.6923 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.7692 | 4 | yes |
| GO:0015031 | protein transport | 30.7692 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.7692 | 5 | no |
| GO:0032880 | regulation of protein localization | 30.7692 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 28.8462 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 28.8462 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.8462 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.8462 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.8462 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.9231 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 26.9231 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.9231 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.9231 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0060284 | regulation of cell development | 23.0769 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 23.0769 | 7 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0034330 | cell junction organization | 21.1538 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 21.1538 | 5 | yes |
| GO:0006886 | intracellular protein transport | 21.1538 | 4 | no |
| GO:0098657 | import into cell | 21.1538 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.1538 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 21.1538 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.1538 | 7 | no |
| GO:0036211 | protein modification process | 21.1538 | 4 | no |
| GO:0043412 | macromolecule modification | 21.1538 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.1538 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.1538 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 21.1538 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.1538 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.1538 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.1538 | 6 | no |
| GO:0050767 | regulation of neurogenesis | 17.3077 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 17.3077 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 15.3846 | 6 | yes |
| GO:0007409 | axonogenesis | 11.5385 | 6 | yes |
| GO:0048812 | neuron projection morphogenesis | 11.5385 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 11.5385 | 4 | yes |
| GO:0045216 | cell-cell junction organization | 9.6154 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 9.6154 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 9.6154 | 5 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 7.6923 | 4 | yes |
| GO:0034332 | adherens junction organization | 7.6923 | 6 | yes |
| GO:0007399 | nervous system development | 5.7692 | 4 | yes |
| GO:0021849 | neuroblast division in subventricular zone | 3.8462 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRAF5_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AUP1_HUMAN | [view interactions] | Low throughput | no | yes |
| LNX2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| TPO_HUMAN | [view interactions] | High throughput | no | no |
| BHE40_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
| TMC5_HUMAN | [view interactions] | High throughput | no | no |
| ESRP2_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| BTBD8_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN5CL_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| SPSB3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |