NUMBL_HUMAN
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI002842 | DEG_MDM2_SWIB_1 | DEG | 577 | 584 | - |
ELMI001135 | LIG_EH_1 | LIG | 594 | 598 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NUMBL_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 40.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 37.7778 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 37.7778 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 24.4444 | 5 | no |
GO:0019900 | kinase binding | 22.2222 | 4 | no |
GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
GO:0045296 | cadherin binding | 22.2222 | 4 | no |
GO:0005524 | ATP binding | 22.2222 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NUMBL_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 71.1111 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 62.2222 | 4 | no |
GO:0008104 | protein localization | 60.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 57.7778 | 4 | no |
GO:0048523 | negative regulation of cellular process | 57.7778 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 57.7778 | 4 | no |
GO:0071702 | organic substance transport | 57.7778 | 4 | no |
GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | no |
GO:0010646 | regulation of cell communication | 53.3333 | 4 | no |
GO:0071705 | nitrogen compound transport | 53.3333 | 4 | no |
GO:0051049 | regulation of transport | 46.6667 | 4 | no |
GO:0015031 | protein transport | 44.4444 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 44.4444 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 42.2222 | 4 | no |
GO:0016192 | vesicle-mediated transport | 42.2222 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.2222 | 4 | no |
GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 37.7778 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.7778 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 37.7778 | 5 | no |
GO:0010468 | regulation of gene expression | 37.7778 | 5 | no |
GO:0030030 | cell projection organization | 35.5556 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 35.5556 | 5 | no |
GO:0006996 | organelle organization | 35.5556 | 4 | no |
GO:0031344 | regulation of cell projection organization | 35.5556 | 5 | no |
GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:0006886 | intracellular protein transport | 33.3333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 33.3333 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0045595 | regulation of cell differentiation | 31.1111 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 31.1111 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 31.1111 | 5 | no |
GO:0023056 | positive regulation of signaling | 31.1111 | 4 | no |
GO:0032880 | regulation of protein localization | 31.1111 | 5 | no |
GO:0042981 | regulation of apoptotic process | 31.1111 | 6 | no |
GO:0043067 | regulation of programmed cell death | 31.1111 | 5 | no |
GO:0060341 | regulation of cellular localization | 31.1111 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 31.1111 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.1111 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 28.8889 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 28.8889 | 7 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 28.8889 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 28.8889 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 28.8889 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 28.8889 | 6 | no |
GO:1901699 | cellular response to nitrogen compound | 28.8889 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.8889 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 28.8889 | 5 | no |
GO:0034330 | cell junction organization | 26.6667 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 26.6667 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 26.6667 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 26.6667 | 4 | no |
GO:0030334 | regulation of cell migration | 26.6667 | 5 | no |
GO:2000145 | regulation of cell motility | 26.6667 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 26.6667 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 26.6667 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 26.6667 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 26.6667 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 24.4444 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 24.4444 | 8 | no |
GO:0031401 | positive regulation of protein modification process | 24.4444 | 7 | no |
GO:0043549 | regulation of kinase activity | 24.4444 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 24.4444 | 5 | no |
GO:0051338 | regulation of transferase activity | 24.4444 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 24.4444 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 24.4444 | 4 | no |
GO:0007010 | cytoskeleton organization | 24.4444 | 5 | no |
GO:0031346 | positive regulation of cell projection organization | 24.4444 | 6 | no |
GO:0051050 | positive regulation of transport | 24.4444 | 4 | no |
GO:0010975 | regulation of neuron projection development | 24.4444 | 7 | no |
GO:0036211 | protein modification process | 22.2222 | 4 | no |
GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
GO:0060548 | negative regulation of cell death | 22.2222 | 5 | no |
GO:1905475 | regulation of protein localization to membrane | 22.2222 | 6 | no |
GO:0006897 | endocytosis | 22.2222 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 22.2222 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
GO:0050767 | regulation of neurogenesis | 20.0000 | 6 | yes |
GO:0051960 | regulation of nervous system development | 20.0000 | 5 | yes |
GO:0060284 | regulation of cell development | 20.0000 | 5 | yes |
GO:0045597 | positive regulation of cell differentiation | 17.7778 | 5 | yes |
GO:0007409 | axonogenesis | 13.3333 | 8 | yes |
GO:0010720 | positive regulation of cell development | 13.3333 | 6 | yes |
GO:0032990 | cell part morphogenesis | 13.3333 | 4 | yes |
GO:0045216 | cell-cell junction organization | 13.3333 | 5 | yes |
GO:0048812 | neuron projection morphogenesis | 13.3333 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 13.3333 | 5 | yes |
GO:0050769 | positive regulation of neurogenesis | 13.3333 | 6 | yes |
GO:0051962 | positive regulation of nervous system development | 13.3333 | 5 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 13.3333 | 6 | yes |
GO:0034332 | adherens junction organization | 8.8889 | 6 | yes |
GO:0007399 | nervous system development | 6.6667 | 4 | yes |
GO:0019221 | cytokine-mediated signaling pathway | 4.4444 | 4 | yes |
GO:0021849 | neuroblast division in subventricular zone | 4.4444 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TRAF5_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
TAB2_HUMAN | [view interactions] | Low throughput | no | yes |
GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AUP1_HUMAN | [view interactions] | Low throughput | no | yes |
LNX2_HUMAN | [view interactions] | Low throughput | no | yes |
NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYAG_HUMAN | [view interactions] | High throughput | no | yes |
PSA3_HUMAN | [view interactions] | High throughput | no | no |
SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
TPO_HUMAN | [view interactions] | High throughput | no | no |
BHE40_HUMAN | [view interactions] | High throughput | no | yes |
RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
MAGD1_HUMAN | [view interactions] | High throughput | no | no |
GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
TMC5_HUMAN | [view interactions] | High throughput | no | no |
ESRP2_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GTSE1_HUMAN | [view interactions] | High throughput | no | no |
K1107_HUMAN | [view interactions] | High throughput | no | yes |
KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UN5CL_HUMAN | [view interactions] | High throughput | no | no |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
SPSB3_HUMAN | [view interactions] | High throughput | no | yes |
CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
ROR1_HUMAN | [view interactions] | High throughput | no | no |
ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
RAB3I_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAAT_HUMAN | [view interactions] | High throughput | no | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
RET_HUMAN | [view interactions] | High throughput | no | yes |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VASP_HUMAN | [view interactions] | High throughput | no | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
PML_HUMAN | [view interactions] | High throughput | no | yes |
MDM2_HUMAN | [view interactions] | High throughput | no | yes |
NOTC4_HUMAN | [view interactions] | Computational | no | no |
KPCI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NOTC3_HUMAN | [view interactions] | Computational | no | yes |
NOTC2_HUMAN | [view interactions] | Computational | no | yes |