FCHO1_HUMAN
Evidence for PS localization
Functions
Functions in an early step of clathrin-mediated endocytosis (PubMed). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed, PubMed). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 34 | Ala | Pro | Immunodeficiency76(IMD76) | - |
| 679 | Arg | Pro | Immunodeficiency76(IMD76) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FCHO1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | no |
| GO:0046872 | metal ion binding | 33.3333 | 5 | no |
| GO:0043168 | anion binding | 27.7778 | 4 | no |
| GO:0019900 | kinase binding | 27.7778 | 4 | no |
| GO:0019901 | protein kinase binding | 27.7778 | 5 | no |
| GO:0045296 | cadherin binding | 27.7778 | 4 | no |
| GO:0000166 | nucleotide binding | 22.2222 | 4 | no |
| GO:0005524 | ATP binding | 22.2222 | 5 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.2222 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0005509 | calcium ion binding | 22.2222 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FCHO1_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.4444 | 4 | yes |
| GO:0098657 | import into cell | 44.4444 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.8889 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.8889 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.8889 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
| GO:0006996 | organelle organization | 38.8889 | 4 | no |
| GO:0008104 | protein localization | 38.8889 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.7778 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 27.7778 | 5 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 27.7778 | 5 | yes |
| GO:0036211 | protein modification process | 27.7778 | 4 | no |
| GO:0043412 | macromolecule modification | 27.7778 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.7778 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.7778 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0015031 | protein transport | 27.7778 | 4 | no |
| GO:0071702 | organic substance transport | 27.7778 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.7778 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 22.2222 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0051726 | regulation of cell cycle | 22.2222 | 4 | no |
| GO:0070925 | organelle assembly | 22.2222 | 5 | no |
| GO:0031623 | receptor internalization | 22.2222 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.2222 | 5 | no |
| GO:0048268 | clathrin coat assembly | 16.6667 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 16.6667 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 11.1111 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 11.1111 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NECP1_HUMAN | [view interactions] | Low throughput | no | no |
| FCHO2_HUMAN | [view interactions] | Low throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGFG1_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A_HUMAN | [view interactions] | Low throughput | no | no |
| PTK6_HUMAN | [view interactions] | High throughput | no | yes |
| PPL13_HUMAN | [view interactions] | High throughput | no | no |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN688_HUMAN | [view interactions] | High throughput | no | yes |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYTL4_HUMAN | [view interactions] | High throughput | no | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT24_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| PLS4_HUMAN | [view interactions] | High throughput | no | no |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GUCD1_HUMAN | [view interactions] | High throughput | no | no |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| PLAC8_HUMAN | [view interactions] | High throughput | no | no |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI42_HUMAN | [view interactions] | High throughput | no | no |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| MB213_HUMAN | [view interactions] | High throughput | no | no |
| TEANC_HUMAN | [view interactions] | High throughput | no | no |
| PHLA2_HUMAN | [view interactions] | High throughput | no | no |
| KR132_HUMAN | [view interactions] | High throughput | no | no |
| FBXL7_HUMAN | [view interactions] | High throughput | no | no |
| KRA61_HUMAN | [view interactions] | High throughput | no | no |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| KR134_HUMAN | [view interactions] | High throughput | no | no |
| SESQ1_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| TSN4_HUMAN | [view interactions] | High throughput | no | no |
| KR101_HUMAN | [view interactions] | High throughput | no | no |
| CCD13_HUMAN | [view interactions] | High throughput | no | no |
| ACVR1_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIWL4_HUMAN | [view interactions] | High throughput | no | yes |
| ERC6L_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| POTEF_HUMAN | [view interactions] | High throughput | no | no |
| C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNBP1_HUMAN | [view interactions] | High throughput | no | yes |