Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SRR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SRR_HUMAN
GO:0000166 nucleotide binding 45.4545 4 yes
GO:0017076 purine nucleotide binding 45.4545 5 yes
GO:0030554 adenyl nucleotide binding 45.4545 6 yes
GO:0032555 purine ribonucleotide binding 45.4545 4 yes
GO:0032559 adenyl ribonucleotide binding 45.4545 5 yes
GO:0043168 anion binding 45.4545 4 yes
GO:0005524 ATP binding 36.3636 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.3636 4 yes
GO:0042803 protein homodimerization activity 27.2727 4 yes
GO:0043169 cation binding 27.2727 4 yes
GO:0046872 metal ion binding 27.2727 5 yes
GO:0003677 DNA binding 27.2727 4 no
GO:0019900 kinase binding 27.2727 4 no
GO:0019901 protein kinase binding 27.2727 5 no
GO:0000287 magnesium ion binding 18.1818 6 yes
GO:0003941 L-serine ammonia-lyase activity 18.1818 5 yes
GO:0005509 calcium ion binding 18.1818 6 yes
GO:0008721 D-serine ammonia-lyase activity 18.1818 5 yes
GO:0016841 ammonia-lyase activity 18.1818 4 yes
GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives 18.1818 4 yes
GO:0018114 threonine racemase activity 18.1818 7 yes
GO:0030165 PDZ domain binding 18.1818 4 yes
GO:0030170 pyridoxal phosphate binding 18.1818 4 yes
GO:0030378 serine racemase activity 18.1818 7 yes
GO:0031406 carboxylic acid binding 18.1818 4 yes
GO:0036361 racemase activity, acting on amino acids and derivatives 18.1818 5 yes
GO:0047661 amino-acid racemase activity 18.1818 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SRR_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 no
GO:0009893 positive regulation of metabolic process 63.6364 4 no
GO:0010646 regulation of cell communication 63.6364 4 no
GO:0051240 positive regulation of multicellular organismal process 63.6364 4 no
GO:0051246 regulation of protein metabolic process 63.6364 5 no
GO:0060255 regulation of macromolecule metabolic process 63.6364 4 no
GO:0080090 regulation of primary metabolic process 63.6364 4 no
GO:0010647 positive regulation of cell communication 54.5455 5 no
GO:0023056 positive regulation of signaling 54.5455 4 no
GO:0042127 regulation of cell population proliferation 54.5455 4 no
GO:0048584 positive regulation of response to stimulus 54.5455 4 no
GO:0009889 regulation of biosynthetic process 54.5455 4 no
GO:0009966 regulation of signal transduction 54.5455 4 no
GO:0010556 regulation of macromolecule biosynthetic process 54.5455 5 no
GO:0010604 positive regulation of macromolecule metabolic process 54.5455 5 no
GO:0019220 regulation of phosphate metabolic process 54.5455 6 no
GO:0031323 regulation of cellular metabolic process 54.5455 4 no
GO:0031326 regulation of cellular biosynthetic process 54.5455 5 no
GO:0031399 regulation of protein modification process 54.5455 6 no
GO:0042325 regulation of phosphorylation 54.5455 7 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0051128 regulation of cellular component organization 54.5455 4 no
GO:0051174 regulation of phosphorus metabolic process 54.5455 5 no
GO:0051247 positive regulation of protein metabolic process 54.5455 6 no
GO:0051338 regulation of transferase activity 54.5455 4 no
GO:1901701 cellular response to oxygen-containing compound 45.4545 4 no
GO:1902531 regulation of intracellular signal transduction 45.4545 5 no
GO:0001932 regulation of protein phosphorylation 45.4545 7 no
GO:0002684 positive regulation of immune system process 45.4545 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 45.4545 5 no
GO:0071310 cellular response to organic substance 45.4545 4 no
GO:0006996 organelle organization 45.4545 4 no
GO:0009890 negative regulation of biosynthetic process 45.4545 5 no
GO:0009892 negative regulation of metabolic process 45.4545 4 no
GO:0009894 regulation of catabolic process 45.4545 4 no
GO:0010468 regulation of gene expression 45.4545 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 45.4545 6 no
GO:0010562 positive regulation of phosphorus metabolic process 45.4545 6 no
GO:0010605 negative regulation of macromolecule metabolic process 45.4545 5 no
GO:0031324 negative regulation of cellular metabolic process 45.4545 5 no
GO:0031325 positive regulation of cellular metabolic process 45.4545 5 no
GO:0031327 negative regulation of cellular biosynthetic process 45.4545 6 no
GO:0042327 positive regulation of phosphorylation 45.4545 8 no
GO:0043549 regulation of kinase activity 45.4545 5 no
GO:0045595 regulation of cell differentiation 45.4545 4 no
GO:0045937 positive regulation of phosphate metabolic process 45.4545 7 no
GO:0080134 regulation of response to stress 45.4545 4 no
GO:0099177 regulation of trans-synaptic signaling 36.3636 4 no
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 no
GO:0006355 regulation of DNA-templated transcription 36.3636 7 no
GO:0006357 regulation of transcription by RNA polymerase II 36.3636 8 no
GO:0008284 positive regulation of cell population proliferation 36.3636 5 no
GO:0009891 positive regulation of biosynthetic process 36.3636 5 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 36.3636 6 no
GO:0031328 positive regulation of cellular biosynthetic process 36.3636 6 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0032101 regulation of response to external stimulus 36.3636 4 no
GO:0034097 response to cytokine 36.3636 4 no
GO:0045859 regulation of protein kinase activity 36.3636 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 36.3636 5 no
GO:0050776 regulation of immune response 36.3636 4 no
GO:0051252 regulation of RNA metabolic process 36.3636 5 no
GO:2001141 regulation of RNA biosynthetic process 36.3636 6 no
GO:0030155 regulation of cell adhesion 36.3636 4 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0001558 regulation of cell growth 36.3636 4 no
GO:0010629 negative regulation of gene expression 36.3636 7 no
GO:0022607 cellular component assembly 36.3636 4 no
GO:0036211 protein modification process 36.3636 4 no
GO:0043085 positive regulation of catalytic activity 36.3636 4 no
GO:0043412 macromolecule modification 36.3636 4 no
GO:0048638 regulation of developmental growth 36.3636 4 no
GO:0050804 modulation of chemical synaptic transmission 36.3636 5 no
GO:0051130 positive regulation of cellular component organization 36.3636 5 no
GO:0051248 negative regulation of protein metabolic process 36.3636 6 no
GO:0051347 positive regulation of transferase activity 36.3636 5 no
GO:0060341 regulation of cellular localization 36.3636 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:0120036 plasma membrane bounded cell projection organization 27.2727 5 no
GO:1903829 positive regulation of protein localization 27.2727 5 no
GO:2000026 regulation of multicellular organismal development 27.2727 4 no
GO:0008285 negative regulation of cell population proliferation 27.2727 5 no
GO:0010628 positive regulation of gene expression 27.2727 7 no
GO:0031347 regulation of defense response 27.2727 5 no
GO:0032103 positive regulation of response to external stimulus 27.2727 5 no
GO:0043408 regulation of MAPK cascade 27.2727 6 no
GO:0045893 positive regulation of DNA-templated transcription 27.2727 8 no
GO:0050778 positive regulation of immune response 27.2727 5 no
GO:0051254 positive regulation of RNA metabolic process 27.2727 6 no
GO:0071345 cellular response to cytokine stimulus 27.2727 5 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:1902680 positive regulation of RNA biosynthetic process 27.2727 7 no
GO:0002685 regulation of leukocyte migration 27.2727 4 no
GO:0002694 regulation of leukocyte activation 27.2727 4 no
GO:0006468 protein phosphorylation 27.2727 5 no
GO:0006796 phosphate-containing compound metabolic process 27.2727 4 no
GO:0006915 apoptotic process 27.2727 4 no
GO:0009896 positive regulation of catabolic process 27.2727 5 no
GO:0010243 response to organonitrogen compound 27.2727 4 no
GO:0016310 phosphorylation 27.2727 5 no
GO:0022407 regulation of cell-cell adhesion 27.2727 5 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:0030335 positive regulation of cell migration 27.2727 6 no
GO:0040017 positive regulation of locomotion 27.2727 4 no
GO:0043393 regulation of protein binding 27.2727 4 no
GO:0045785 positive regulation of cell adhesion 27.2727 5 no
GO:0050807 regulation of synapse organization 27.2727 5 no
GO:0050863 regulation of T cell activation 27.2727 6 no
GO:0050865 regulation of cell activation 27.2727 4 no
GO:0051249 regulation of lymphocyte activation 27.2727 5 no
GO:0071417 cellular response to organonitrogen compound 27.2727 4 no
GO:0071675 regulation of mononuclear cell migration 27.2727 5 no
GO:1901699 cellular response to nitrogen compound 27.2727 4 no
GO:1903037 regulation of leukocyte cell-cell adhesion 27.2727 6 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:2000147 positive regulation of cell motility 27.2727 5 no
GO:0006873 intracellular monoatomic ion homeostasis 27.2727 4 no
GO:0030003 intracellular monoatomic cation homeostasis 27.2727 5 no
GO:0055080 monoatomic cation homeostasis 27.2727 4 no
GO:0098657 import into cell 27.2727 4 no
GO:0014070 response to organic cyclic compound 27.2727 4 yes
GO:0019752 carboxylic acid metabolic process 27.2727 5 yes
GO:0032787 monocarboxylic acid metabolic process 27.2727 6 yes
GO:0033993 response to lipid 27.2727 4 yes
GO:0043436 oxoacid metabolic process 27.2727 4 yes
GO:0000302 response to reactive oxygen species 27.2727 4 no
GO:0007005 mitochondrion organization 27.2727 5 no
GO:0007010 cytoskeleton organization 27.2727 5 no
GO:0010038 response to metal ion 27.2727 4 no
GO:0010563 negative regulation of phosphorus metabolic process 27.2727 6 no
GO:0010975 regulation of neuron projection development 27.2727 7 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0030162 regulation of proteolysis 27.2727 6 no
GO:0030307 positive regulation of cell growth 27.2727 5 no
GO:0031329 regulation of cellular catabolic process 27.2727 5 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0031400 negative regulation of protein modification process 27.2727 7 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0033673 negative regulation of kinase activity 27.2727 6 no
GO:0033674 positive regulation of kinase activity 27.2727 6 no
GO:0034599 cellular response to oxidative stress 27.2727 4 no
GO:0034614 cellular response to reactive oxygen species 27.2727 5 no
GO:0042326 negative regulation of phosphorylation 27.2727 8 no
GO:0043086 negative regulation of catalytic activity 27.2727 4 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0045597 positive regulation of cell differentiation 27.2727 5 no
GO:0045862 positive regulation of proteolysis 27.2727 7 no
GO:0045927 positive regulation of growth 27.2727 4 no
GO:0045936 negative regulation of phosphate metabolic process 27.2727 7 no
GO:0048639 positive regulation of developmental growth 27.2727 5 no
GO:0050890 cognition 27.2727 4 no
GO:0051093 negative regulation of developmental process 27.2727 4 no
GO:0051094 positive regulation of developmental process 27.2727 4 no
GO:0051336 regulation of hydrolase activity 27.2727 4 no
GO:0051345 positive regulation of hydrolase activity 27.2727 5 no
GO:0051348 negative regulation of transferase activity 27.2727 5 no
GO:0051960 regulation of nervous system development 27.2727 5 no
GO:0060284 regulation of cell development 27.2727 5 no
GO:0062197 cellular response to chemical stress 27.2727 4 no
GO:0090304 nucleic acid metabolic process 27.2727 4 no
GO:0002237 response to molecule of bacterial origin 18.1818 4 yes
GO:0006090 pyruvate metabolic process 18.1818 7 yes
GO:0006563 L-serine metabolic process 18.1818 6 yes
GO:0008652 amino acid biosynthetic process 18.1818 4 yes
GO:0009069 serine family amino acid metabolic process 18.1818 5 yes
GO:0016053 organic acid biosynthetic process 18.1818 4 yes
GO:0032496 response to lipopolysaccharide 18.1818 4 yes
GO:0042866 pyruvate biosynthetic process 18.1818 7 yes
GO:0046394 carboxylic acid biosynthetic process 18.1818 5 yes
GO:0046416 D-amino acid metabolic process 18.1818 5 yes
GO:0046437 D-amino acid biosynthetic process 18.1818 6 yes
GO:0070178 D-serine metabolic process 18.1818 6 yes
GO:0070179 D-serine biosynthetic process 18.1818 7 yes
GO:0072330 monocarboxylic acid biosynthetic process 18.1818 6 yes
GO:0170033 L-amino acid metabolic process 18.1818 5 yes
GO:0170039 proteinogenic amino acid metabolic process 18.1818 4 yes
GO:0170041 non-proteinogenic amino acid metabolic process 18.1818 4 yes
GO:0170043 non-proteinogenic amino acid biosynthetic process 18.1818 5 yes
GO:1901566 organonitrogen compound biosynthetic process 18.1818 4 yes
GO:1901605 alpha-amino acid metabolic process 18.1818 4 yes
GO:1901607 alpha-amino acid biosynthetic process 18.1818 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRR_HUMAN [view entry] [view interactions] Low throughput yes yes
GOGA3_HUMAN [view interactions] Low throughput no yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
FBX22_HUMAN [view interactions] Low throughput no no
SACA1_HUMAN [view interactions] High throughput no no
OXND1_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF41_HUMAN [view interactions] High throughput no yes
LNX2_HUMAN [view interactions] High throughput no yes
FCHO1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
S22A4_HUMAN [view interactions] High throughput no yes
FNDC8_HUMAN [view interactions] High throughput no no
TNFL8_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes