Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SRR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SRR_HUMAN
GO:0042803 protein homodimerization activity 45.4545 4 yes
GO:0046872 metal ion binding 45.4545 4 yes
GO:0005524 ATP binding 36.3636 5 yes
GO:0017076 purine nucleotide binding 36.3636 4 yes
GO:0030554 adenyl nucleotide binding 36.3636 5 yes
GO:0032555 purine ribonucleotide binding 36.3636 4 yes
GO:0032559 adenyl ribonucleotide binding 36.3636 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.3636 4 yes
GO:0016597 amino acid binding 27.2727 4 yes
GO:0030170 pyridoxal phosphate binding 27.2727 4 yes
GO:0031406 carboxylic acid binding 27.2727 4 yes
GO:0019900 kinase binding 27.2727 4 no
GO:0019901 protein kinase binding 27.2727 5 no
GO:0001664 G protein-coupled receptor binding 27.2727 4 no
GO:0003677 DNA binding 27.2727 4 no
GO:0000287 magnesium ion binding 18.1818 5 yes
GO:0003941 L-serine ammonia-lyase activity 18.1818 5 yes
GO:0005509 calcium ion binding 18.1818 5 yes
GO:0008721 D-serine ammonia-lyase activity 18.1818 5 yes
GO:0016594 glycine binding 18.1818 4 yes
GO:0016841 ammonia-lyase activity 18.1818 4 yes
GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives 18.1818 4 yes
GO:0018114 threonine racemase activity 18.1818 7 yes
GO:0030165 PDZ domain binding 18.1818 4 yes
GO:0030378 serine racemase activity 18.1818 7 yes
GO:0036361 racemase activity, acting on amino acids and derivatives 18.1818 5 yes
GO:0047661 amino-acid racemase activity 18.1818 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SRR_HUMAN
GO:0009893 positive regulation of metabolic process 63.6364 4 no
GO:0010646 regulation of cell communication 63.6364 4 no
GO:0031323 regulation of cellular metabolic process 63.6364 4 no
GO:0036211 protein modification process 63.6364 4 no
GO:0043412 macromolecule modification 63.6364 4 no
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0051128 regulation of cellular component organization 63.6364 4 no
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 no
GO:0051246 regulation of protein metabolic process 63.6364 5 no
GO:0060255 regulation of macromolecule metabolic process 63.6364 4 no
GO:0080090 regulation of primary metabolic process 63.6364 4 no
GO:0009966 regulation of signal transduction 54.5455 4 no
GO:0010468 regulation of gene expression 54.5455 5 no
GO:0010604 positive regulation of macromolecule metabolic process 54.5455 5 no
GO:0031325 positive regulation of cellular metabolic process 54.5455 5 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 54.5455 5 no
GO:0051240 positive regulation of multicellular organismal process 54.5455 4 no
GO:0051247 positive regulation of protein metabolic process 54.5455 6 no
GO:0050804 modulation of chemical synaptic transmission 45.4545 5 no
GO:0051130 positive regulation of cellular component organization 45.4545 5 no
GO:0099177 regulation of trans-synaptic signaling 45.4545 4 no
GO:0010243 response to organonitrogen compound 45.4545 4 yes
GO:0009889 regulation of biosynthetic process 45.4545 4 no
GO:0009894 regulation of catabolic process 45.4545 4 no
GO:0010556 regulation of macromolecule biosynthetic process 45.4545 5 no
GO:0010562 positive regulation of phosphorus metabolic process 45.4545 6 no
GO:0019220 regulation of phosphate metabolic process 45.4545 6 no
GO:0031326 regulation of cellular biosynthetic process 45.4545 5 no
GO:0031399 regulation of protein modification process 45.4545 6 no
GO:0033043 regulation of organelle organization 45.4545 5 no
GO:0034097 response to cytokine 45.4545 4 no
GO:0042127 regulation of cell population proliferation 45.4545 4 no
GO:0042325 regulation of phosphorylation 45.4545 7 no
GO:0042327 positive regulation of phosphorylation 45.4545 8 no
GO:0043085 positive regulation of catalytic activity 45.4545 4 no
GO:0045595 regulation of cell differentiation 45.4545 4 no
GO:0045937 positive regulation of phosphate metabolic process 45.4545 7 no
GO:0051174 regulation of phosphorus metabolic process 45.4545 5 no
GO:0051338 regulation of transferase activity 45.4545 4 no
GO:0051347 positive regulation of transferase activity 45.4545 5 no
GO:0060341 regulation of cellular localization 45.4545 4 no
GO:0071310 cellular response to organic substance 45.4545 4 no
GO:1902531 regulation of intracellular signal transduction 45.4545 5 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0023056 positive regulation of signaling 36.3636 4 no
GO:0048584 positive regulation of response to stimulus 36.3636 4 no
GO:0090304 nucleic acid metabolic process 36.3636 4 no
GO:0022607 cellular component assembly 36.3636 4 no
GO:0030030 cell projection organization 36.3636 4 no
GO:0120036 plasma membrane bounded cell projection organization 36.3636 5 no
GO:0014070 response to organic cyclic compound 36.3636 4 yes
GO:0019752 carboxylic acid metabolic process 36.3636 5 yes
GO:0043436 oxoacid metabolic process 36.3636 4 yes
GO:0001558 regulation of cell growth 36.3636 4 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 no
GO:0002684 positive regulation of immune system process 36.3636 4 no
GO:0006468 protein phosphorylation 36.3636 5 no
GO:0006796 phosphate-containing compound metabolic process 36.3636 4 no
GO:0006996 organelle organization 36.3636 4 no
GO:0008284 positive regulation of cell population proliferation 36.3636 5 no
GO:0009891 positive regulation of biosynthetic process 36.3636 5 no
GO:0009892 negative regulation of metabolic process 36.3636 4 no
GO:0010038 response to metal ion 36.3636 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 36.3636 6 no
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 no
GO:0010628 positive regulation of gene expression 36.3636 6 no
GO:0010639 negative regulation of organelle organization 36.3636 6 no
GO:0010648 negative regulation of cell communication 36.3636 5 no
GO:0010941 regulation of cell death 36.3636 4 no
GO:0016310 phosphorylation 36.3636 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.3636 5 no
GO:0023057 negative regulation of signaling 36.3636 4 no
GO:0030162 regulation of proteolysis 36.3636 6 no
GO:0031324 negative regulation of cellular metabolic process 36.3636 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.3636 6 no
GO:0031329 regulation of cellular catabolic process 36.3636 5 no
GO:0031344 regulation of cell projection organization 36.3636 5 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0032880 regulation of protein localization 36.3636 5 no
GO:0033674 positive regulation of kinase activity 36.3636 6 no
GO:0043549 regulation of kinase activity 36.3636 5 no
GO:0045597 positive regulation of cell differentiation 36.3636 5 no
GO:0045862 positive regulation of proteolysis 36.3636 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 36.3636 6 no
GO:0048638 regulation of developmental growth 36.3636 4 no
GO:0048878 chemical homeostasis 36.3636 4 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0051094 positive regulation of developmental process 36.3636 4 no
GO:0051129 negative regulation of cellular component organization 36.3636 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0051336 regulation of hydrolase activity 36.3636 4 no
GO:0051345 positive regulation of hydrolase activity 36.3636 5 no
GO:0070848 response to growth factor 36.3636 4 no
GO:0080134 regulation of response to stress 36.3636 4 no
GO:0080135 regulation of cellular response to stress 36.3636 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.3636 6 no
GO:1901701 cellular response to oxygen-containing compound 36.3636 4 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 27.2727 6 no
GO:2000116 regulation of cysteine-type endopeptidase activity 27.2727 7 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:2000147 positive regulation of cell motility 27.2727 5 no
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010942 positive regulation of cell death 27.2727 5 no
GO:0043408 regulation of MAPK cascade 27.2727 6 no
GO:0050776 regulation of immune response 27.2727 4 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:0050890 cognition 27.2727 4 no
GO:0051093 negative regulation of developmental process 27.2727 4 no
GO:0051259 protein complex oligomerization 27.2727 6 no
GO:0051260 protein homooligomerization 27.2727 7 no
GO:0051493 regulation of cytoskeleton organization 27.2727 6 no
GO:0065003 protein-containing complex assembly 27.2727 5 no
GO:0070201 regulation of establishment of protein localization 27.2727 6 no
GO:1902903 regulation of supramolecular fiber organization 27.2727 5 no
GO:0006873 cellular ion homeostasis 27.2727 4 no
GO:0016192 vesicle-mediated transport 27.2727 4 no
GO:0030003 cellular cation homeostasis 27.2727 5 no
GO:0050801 ion homeostasis 27.2727 5 no
GO:0055080 cation homeostasis 27.2727 6 no
GO:0060627 regulation of vesicle-mediated transport 27.2727 4 no
GO:0098771 inorganic ion homeostasis 27.2727 6 no
GO:0006563 L-serine metabolic process 27.2727 6 yes
GO:0008652 cellular amino acid biosynthetic process 27.2727 4 yes
GO:0009069 serine family amino acid metabolic process 27.2727 5 yes
GO:0009070 serine family amino acid biosynthetic process 27.2727 6 yes
GO:0016053 organic acid biosynthetic process 27.2727 4 yes
GO:0032787 monocarboxylic acid metabolic process 27.2727 6 yes
GO:0033993 response to lipid 27.2727 4 yes
GO:0046394 carboxylic acid biosynthetic process 27.2727 5 yes
GO:1901566 organonitrogen compound biosynthetic process 27.2727 4 yes
GO:1901605 alpha-amino acid metabolic process 27.2727 4 yes
GO:1901607 alpha-amino acid biosynthetic process 27.2727 5 yes
GO:0000302 response to reactive oxygen species 27.2727 4 no
GO:0002685 regulation of leukocyte migration 27.2727 4 no
GO:0006355 regulation of DNA-templated transcription 27.2727 6 no
GO:0006357 regulation of transcription by RNA polymerase II 27.2727 7 no
GO:0006417 regulation of translation 27.2727 6 no
GO:0006915 apoptotic process 27.2727 4 no
GO:0007005 mitochondrion organization 27.2727 5 no
GO:0008104 protein localization 27.2727 4 no
GO:0009896 positive regulation of catabolic process 27.2727 5 no
GO:0009968 negative regulation of signal transduction 27.2727 5 no
GO:0010608 post-transcriptional regulation of gene expression 27.2727 6 no
GO:0010629 negative regulation of gene expression 27.2727 6 no
GO:0010821 regulation of mitochondrion organization 27.2727 6 no
GO:0010823 negative regulation of mitochondrion organization 27.2727 7 no
GO:0010975 regulation of neuron projection development 27.2727 7 no
GO:0030307 positive regulation of cell growth 27.2727 5 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:0030335 positive regulation of cell migration 27.2727 6 no
GO:0031331 positive regulation of cellular catabolic process 27.2727 6 no
GO:0031667 response to nutrient levels 27.2727 4 no
GO:0034248 regulation of cellular amide metabolic process 27.2727 5 no
GO:0034599 cellular response to oxidative stress 27.2727 4 no
GO:0034614 cellular response to reactive oxygen species 27.2727 5 no
GO:0040017 positive regulation of locomotion 27.2727 4 no
GO:0042176 regulation of protein catabolic process 27.2727 5 no
GO:0042981 regulation of apoptotic process 27.2727 6 no
GO:0043067 regulation of programmed cell death 27.2727 5 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 27.2727 8 no
GO:0043393 regulation of protein binding 27.2727 4 no
GO:0043467 regulation of generation of precursor metabolites and energy 27.2727 5 no
GO:0044271 cellular nitrogen compound biosynthetic process 27.2727 4 no
GO:0045859 regulation of protein kinase activity 27.2727 6 no
GO:0045860 positive regulation of protein kinase activity 27.2727 7 no
GO:0045893 positive regulation of DNA-templated transcription 27.2727 7 no
GO:0045927 positive regulation of growth 27.2727 4 no
GO:0048585 negative regulation of response to stimulus 27.2727 4 no
GO:0048639 positive regulation of developmental growth 27.2727 5 no
GO:0051050 positive regulation of transport 27.2727 4 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0051254 positive regulation of RNA metabolic process 27.2727 6 no
GO:0051960 regulation of nervous system development 27.2727 5 no
GO:0052547 regulation of peptidase activity 27.2727 5 no
GO:0052548 regulation of endopeptidase activity 27.2727 6 no
GO:0060284 regulation of cell development 27.2727 5 no
GO:0062197 cellular response to chemical stress 27.2727 4 no
GO:0071241 cellular response to inorganic substance 27.2727 4 no
GO:0071248 cellular response to metal ion 27.2727 5 no
GO:0071345 cellular response to cytokine stimulus 27.2727 5 no
GO:0071363 cellular response to growth factor stimulus 27.2727 5 no
GO:0071417 cellular response to organonitrogen compound 27.2727 4 no
GO:0071675 regulation of mononuclear cell migration 27.2727 5 no
GO:0071702 organic substance transport 27.2727 4 no
GO:1901214 regulation of neuron death 27.2727 5 no
GO:1901699 cellular response to nitrogen compound 27.2727 4 no
GO:1902680 positive regulation of RNA biosynthetic process 27.2727 7 no
GO:1903506 regulation of nucleic acid-templated transcription 27.2727 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 27.2727 8 no
GO:1903829 positive regulation of protein localization 27.2727 5 no
GO:1990090 cellular response to nerve growth factor stimulus 27.2727 4 no
GO:2000026 regulation of multicellular organismal development 27.2727 4 no
GO:0002237 response to molecule of bacterial origin 18.1818 4 yes
GO:0006090 pyruvate metabolic process 18.1818 7 yes
GO:0007420 brain development 18.1818 4 yes
GO:0014072 response to isoquinoline alkaloid 18.1818 5 yes
GO:0032496 response to lipopolysaccharide 18.1818 4 yes
GO:0042866 pyruvate biosynthetic process 18.1818 7 yes
GO:0043278 response to morphine 18.1818 6 yes
GO:0043279 response to alkaloid 18.1818 5 yes
GO:0046416 D-amino acid metabolic process 18.1818 5 yes
GO:0046437 D-amino acid biosynthetic process 18.1818 6 yes
GO:0070178 D-serine metabolic process 18.1818 6 yes
GO:0070179 D-serine biosynthetic process 18.1818 7 yes
GO:0072330 monocarboxylic acid biosynthetic process 18.1818 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRR_HUMAN [view entry] [view interactions] Low throughput yes yes
GOGA3_HUMAN [view interactions] Low throughput no yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
FBX22_HUMAN [view interactions] Low throughput no no
SACA1_HUMAN [view interactions] High throughput no no
OXND1_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF41_HUMAN [view interactions] High throughput no yes
LNX2_HUMAN [view interactions] High throughput no yes
FCHO1_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
S22A4_HUMAN [view interactions] High throughput no yes
FNDC8_HUMAN [view interactions] High throughput no no
TNFL8_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] Computational yes yes
GLYC_HUMAN [view interactions] Computational no no
SPTC1_HUMAN [view interactions] Computational no yes
SDHL_HUMAN [view interactions] Computational no yes
SDSL_HUMAN [view interactions] Computational no yes
SPTC3_HUMAN [view interactions] Computational no no
SERB_HUMAN [view interactions] Computational no yes
OXDA_HUMAN [view interactions] Computational no no
SPTC2_HUMAN [view interactions] Computational no no
SPYA_HUMAN [view interactions] Computational no no
CBS_HUMAN [view interactions] Computational no yes
PICK1_HUMAN [view entry] [view interactions] Computational yes yes