ZN451_HUMAN
Evidence for PS localization
Functions
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed, PubMed). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation . Has no activity with SUMO1 (PubMed). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site Lys-11 (PubMed). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at Lys-9 (PubMed). Plays a role in regulating the transcription of AR targets (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002813 | LIG_SUMO_SIM_anti_2 | LIG | 44 | 55 | - |
| ELMI002813 | LIG_SUMO_SIM_anti_2 | LIG | 44 | 55 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ZN451_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 38.7097 | 4 | yes |
| GO:0046872 | metal ion binding | 35.4839 | 5 | yes |
| GO:0003723 | RNA binding | 35.4839 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 29.0323 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 25.8065 | 5 | no |
| GO:0016755 | aminoacyltransferase activity | 19.3548 | 4 | yes |
| GO:0003677 | DNA binding | 16.1290 | 4 | yes |
| GO:0019789 | SUMO transferase activity | 16.1290 | 4 | yes |
| GO:0043565 | sequence-specific DNA binding | 12.9032 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 12.9032 | 4 | yes |
| GO:0061665 | SUMO ligase activity | 9.6774 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ZN451_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 74.1935 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 74.1935 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 74.1935 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 74.1935 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 67.7419 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 67.7419 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 64.5161 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 61.2903 | 4 | yes |
| GO:0010468 | regulation of gene expression | 61.2903 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 61.2903 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 61.2903 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 58.0645 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 58.0645 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 58.0645 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 58.0645 | 5 | no |
| GO:0010646 | regulation of cell communication | 54.8387 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 54.8387 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.6129 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.6129 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 48.3871 | 7 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 48.3871 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 48.3871 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 48.3871 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 48.3871 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 48.3871 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 45.1613 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 45.1613 | 4 | no |
| GO:0036211 | protein modification process | 41.9355 | 4 | yes |
| GO:0043412 | macromolecule modification | 41.9355 | 4 | yes |
| GO:0051049 | regulation of transport | 41.9355 | 4 | no |
| GO:0022607 | cellular component assembly | 41.9355 | 4 | no |
| GO:0031399 | regulation of protein modification process | 38.7097 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 38.7097 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 38.7097 | 5 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 35.4839 | 8 | yes |
| GO:0043687 | post-translational protein modification | 35.4839 | 5 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 35.4839 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 35.4839 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 35.4839 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 32.2581 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 32.2581 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 32.2581 | 4 | yes |
| GO:0032446 | protein modification by small protein conjugation | 32.2581 | 7 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 32.2581 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 32.2581 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 32.2581 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 32.2581 | 5 | no |
| GO:0006996 | organelle organization | 32.2581 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 32.2581 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.2581 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.2581 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.2581 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 32.2581 | 5 | no |
| GO:0009894 | regulation of catabolic process | 32.2581 | 4 | no |
| GO:0018193 | peptidyl-amino acid modification | 29.0323 | 5 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 29.0323 | 8 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 29.0323 | 7 | yes |
| GO:0032880 | regulation of protein localization | 29.0323 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.0323 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.0323 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 29.0323 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 29.0323 | 7 | no |
| GO:0051051 | negative regulation of transport | 29.0323 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 29.0323 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.0323 | 4 | no |
| GO:0030162 | regulation of proteolysis | 29.0323 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 25.8065 | 9 | yes |
| GO:0016925 | protein sumoylation | 25.8065 | 7 | yes |
| GO:0018205 | peptidyl-lysine modification | 25.8065 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 25.8065 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 25.8065 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 25.8065 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.8065 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 25.8065 | 5 | no |
| GO:0044057 | regulation of system process | 25.8065 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.8065 | 4 | no |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 25.8065 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.8065 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.8065 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.8065 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.8065 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 25.8065 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.5806 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.5806 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.5806 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.5806 | 7 | no |
| GO:0051336 | regulation of hydrolase activity | 22.5806 | 4 | no |
| GO:0051338 | regulation of transferase activity | 22.5806 | 4 | no |
| GO:0051726 | regulation of cell cycle | 22.5806 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 22.5806 | 7 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 22.5806 | 7 | no |
| GO:0007010 | cytoskeleton organization | 22.5806 | 5 | no |
| GO:0008104 | protein localization | 22.5806 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.5806 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5806 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 22.5806 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 22.5806 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.5806 | 5 | no |
| GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 9.6774 | 5 | yes |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 6.4516 | 6 | yes |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 6.4516 | 7 | yes |
| GO:0060260 | regulation of transcription initiation by RNA polymerase II | 6.4516 | 9 | yes |
| GO:0060633 | negative regulation of transcription initiation by RNA polymerase II | 6.4516 | 10 | yes |
| GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 6.4516 | 6 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 6.4516 | 4 | yes |
| GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 6.4516 | 5 | yes |
| GO:2000142 | regulation of DNA-templated transcription initiation | 6.4516 | 8 | yes |
| GO:2000143 | negative regulation of DNA-templated transcription initiation | 6.4516 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MCM4_HUMAN | [view interactions] | Low throughput | no | yes |
| SIMC1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZN451_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| PIAS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIAS2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZBED1_HUMAN | [view interactions] | Low throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | Low throughput | no | no |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA4_HUMAN | [view interactions] | High throughput | no | no |
| F118A_HUMAN | [view interactions] | High throughput | no | yes |
| SUV91_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPTP_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| PHS_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| CREB1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| KLH40_HUMAN | [view interactions] | High throughput | no | no |
| OPLA_HUMAN | [view interactions] | High throughput | no | no |
| ZN467_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| BATF3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUL4_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUCL1_HUMAN | [view interactions] | High throughput | no | no |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLF2_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| CENPA_HUMAN | [view interactions] | High throughput | no | no |
| DHX8_HUMAN | [view interactions] | High throughput | no | yes |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| SNR40_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |