Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ZN451_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed, PubMed). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation . Has no activity with SUMO1 (PubMed). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site Lys-11 (PubMed). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at Lys-9 (PubMed). Plays a role in regulating the transcription of AR targets (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002813 LIG_SUMO_SIM_anti_2 LIG 44 55 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ZN451_HUMAN
GO:0046872 metal ion binding 38.0952 4 yes
GO:0003723 RNA binding 33.3333 4 no
GO:0019900 kinase binding 23.8095 4 no
GO:0019789 SUMO transferase activity 9.5238 4 yes
GO:0061659 ubiquitin-like protein ligase activity 9.5238 4 yes
GO:0061665 SUMO ligase activity 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ZN451_HUMAN
GO:0048523 negative regulation of cellular process 85.7143 4 yes
GO:0031323 regulation of cellular metabolic process 80.9524 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 80.9524 4 yes
GO:0060255 regulation of macromolecule metabolic process 80.9524 4 yes
GO:0080090 regulation of primary metabolic process 80.9524 4 yes
GO:0009892 negative regulation of metabolic process 76.1905 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 76.1905 5 yes
GO:0031324 negative regulation of cellular metabolic process 76.1905 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 76.1905 5 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0009893 positive regulation of metabolic process 61.9048 4 yes
GO:0010646 regulation of cell communication 61.9048 4 yes
GO:0031325 positive regulation of cellular metabolic process 61.9048 5 yes
GO:0051248 negative regulation of protein metabolic process 61.9048 6 yes
GO:0009966 regulation of signal transduction 57.1429 4 yes
GO:0010468 regulation of gene expression 57.1429 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 57.1429 5 yes
GO:0009889 regulation of biosynthetic process 52.3810 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 52.3810 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 52.3810 5 yes
GO:0031326 regulation of cellular biosynthetic process 52.3810 5 yes
GO:0031399 regulation of protein modification process 52.3810 6 yes
GO:0051252 regulation of RNA metabolic process 52.3810 5 yes
GO:0019220 regulation of phosphate metabolic process 47.6190 6 no
GO:0051049 regulation of transport 47.6190 4 no
GO:0051174 regulation of phosphorus metabolic process 47.6190 5 no
GO:0051128 regulation of cellular component organization 47.6190 4 no
GO:0009890 negative regulation of biosynthetic process 42.8571 5 yes
GO:0009891 positive regulation of biosynthetic process 42.8571 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 yes
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0044087 regulation of cellular component biogenesis 42.8571 4 no
GO:0006355 regulation of DNA-templated transcription 38.0952 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 38.0952 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 38.0952 6 yes
GO:0010648 negative regulation of cell communication 38.0952 5 yes
GO:0023057 negative regulation of signaling 38.0952 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 38.0952 6 yes
GO:0048585 negative regulation of response to stimulus 38.0952 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 38.0952 7 yes
GO:2001141 regulation of RNA biosynthetic process 38.0952 6 yes
GO:0043085 positive regulation of catalytic activity 38.0952 4 no
GO:0044057 regulation of system process 38.0952 4 no
GO:0051050 positive regulation of transport 38.0952 4 no
GO:0051051 negative regulation of transport 38.0952 4 no
GO:0051247 positive regulation of protein metabolic process 38.0952 6 no
GO:1902531 regulation of intracellular signal transduction 38.0952 5 no
GO:0006996 organelle organization 38.0952 4 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0031400 negative regulation of protein modification process 33.3333 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 33.3333 6 yes
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 7 yes
GO:0036211 protein modification process 28.5714 4 yes
GO:0043412 macromolecule modification 28.5714 4 yes
GO:0051253 negative regulation of RNA metabolic process 28.5714 6 yes
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0010959 regulation of metal ion transport 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0034765 regulation of ion transmembrane transport 28.5714 5 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043269 regulation of ion transport 28.5714 5 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051099 positive regulation of binding 28.5714 4 no
GO:0051345 positive regulation of hydrolase activity 28.5714 5 no
GO:0051924 regulation of calcium ion transport 28.5714 7 no
GO:1903169 regulation of calcium ion transmembrane transport 28.5714 7 no
GO:1904062 regulation of cation transmembrane transport 28.5714 6 no
GO:0080135 regulation of cellular response to stress 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0010942 positive regulation of cell death 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0034248 regulation of cellular amide metabolic process 28.5714 5 no
GO:0034249 negative regulation of cellular amide metabolic process 28.5714 6 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 23.8095 8 yes
GO:0045892 negative regulation of DNA-templated transcription 23.8095 7 yes
GO:0045893 positive regulation of DNA-templated transcription 23.8095 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.8095 6 yes
GO:0051254 positive regulation of RNA metabolic process 23.8095 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 23.8095 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 23.8095 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 23.8095 8 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 23.8095 8 yes
GO:0001933 negative regulation of protein phosphorylation 23.8095 8 no
GO:0010564 regulation of cell cycle process 23.8095 5 no
GO:0022898 regulation of transmembrane transporter activity 23.8095 4 no
GO:0032412 regulation of ion transmembrane transporter activity 23.8095 5 no
GO:0034763 negative regulation of transmembrane transport 23.8095 5 no
GO:0034766 negative regulation of ion transmembrane transport 23.8095 6 no
GO:0042326 negative regulation of phosphorylation 23.8095 8 no
GO:0043271 negative regulation of ion transport 23.8095 5 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0051926 negative regulation of calcium ion transport 23.8095 6 no
GO:0071900 regulation of protein serine/threonine kinase activity 23.8095 7 no
GO:0090257 regulation of muscle system process 23.8095 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 23.8095 6 no
GO:1903170 negative regulation of calcium ion transmembrane transport 23.8095 7 no
GO:1904063 negative regulation of cation transmembrane transport 23.8095 7 no
GO:2001257 regulation of cation channel activity 23.8095 6 no
GO:0051129 negative regulation of cellular component organization 23.8095 5 no
GO:0007010 cytoskeleton organization 23.8095 5 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010629 negative regulation of gene expression 23.8095 6 no
GO:0030100 regulation of endocytosis 23.8095 5 no
GO:0034250 positive regulation of cellular amide metabolic process 23.8095 6 no
GO:0044089 positive regulation of cellular component biogenesis 23.8095 5 no
GO:0050804 modulation of chemical synaptic transmission 23.8095 5 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 no
GO:0060627 regulation of vesicle-mediated transport 23.8095 4 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:0099177 regulation of trans-synaptic signaling 23.8095 4 no
GO:0010628 positive regulation of gene expression 23.8095 6 no
GO:2001020 regulation of response to DNA damage stimulus 23.8095 5 no
GO:0018193 peptidyl-amino acid modification 19.0476 5 yes
GO:0032446 protein modification by small protein conjugation 19.0476 6 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 19.0476 8 yes
GO:0070647 protein modification by small protein conjugation or removal 19.0476 5 yes
GO:0016925 protein sumoylation 14.2857 7 yes
GO:0018205 peptidyl-lysine modification 14.2857 6 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 14.2857 5 yes
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 9.5238 6 yes
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 9.5238 7 yes
GO:0031056 regulation of histone modification 9.5238 7 yes
GO:0031057 negative regulation of histone modification 9.5238 8 yes
GO:0035065 regulation of histone acetylation 9.5238 8 yes
GO:0035067 negative regulation of histone acetylation 9.5238 9 yes
GO:0060260 regulation of transcription initiation by RNA polymerase II 9.5238 8 yes
GO:0060633 negative regulation of transcription initiation by RNA polymerase II 9.5238 9 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 9.5238 6 yes
GO:0090287 regulation of cellular response to growth factor stimulus 9.5238 4 yes
GO:1901983 regulation of protein acetylation 9.5238 7 yes
GO:1901984 negative regulation of protein acetylation 9.5238 8 yes
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 9.5238 5 yes
GO:2000142 regulation of DNA-templated transcription initiation 9.5238 7 yes
GO:2000143 negative regulation of DNA-templated transcription initiation 9.5238 8 yes
GO:2000615 regulation of histone H3-K9 acetylation 9.5238 9 yes
GO:2000616 negative regulation of histone H3-K9 acetylation 9.5238 10 yes
GO:2000756 regulation of peptidyl-lysine acetylation 9.5238 8 yes
GO:2000757 negative regulation of peptidyl-lysine acetylation 9.5238 9 yes

Disease

Term Name % Distance from top the of the tree Annotated in ZN451_HUMAN
DOID:0050700 cardiomyopathy 9.5238 4 no
DOID:0060036 intrinsic cardiomyopathy 9.5238 5 no
DOID:114 heart disease 9.5238 3 no
DOID:2843 long QT syndrome 9.5238 6 no
DOID:0080000 muscular disease 9.5238 3 no
DOID:423 myopathy 9.5238 5 no
DOID:66 muscle tissue disease 9.5238 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBC9_HUMAN [view interactions] Low throughput no yes
MCM4_HUMAN [view interactions] Low throughput no yes
ZN451_HUMAN [view entry] [view interactions] Low throughput yes no
ANDR_HUMAN [view interactions] Low throughput no no
PIAS1_HUMAN [view interactions] Low throughput no yes
PIAS2_HUMAN [view interactions] Low throughput no yes
ZBED1_HUMAN [view interactions] Low throughput no yes
SUMO2_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO1_HUMAN [view interactions] Low throughput no yes
PML_HUMAN [view interactions] Low throughput no yes
RAGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] High throughput no yes
SNIP1_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
CDCA4_HUMAN [view interactions] High throughput no no
F118A_HUMAN [view interactions] High throughput no yes
SUV91_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
ANM8_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
CPTP_HUMAN [view interactions] High throughput no yes
P55G_HUMAN [view interactions] High throughput no yes
LZTR1_HUMAN [view interactions] High throughput no no
PHS_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
BRE1B_HUMAN [view interactions] High throughput no yes
CREB1_HUMAN [view interactions] High throughput no yes
TOP2B_HUMAN [view interactions] High throughput no yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR1_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
HNF4A_HUMAN [view interactions] High throughput no no
CBP_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
KLH40_HUMAN [view interactions] High throughput no no
OPLA_HUMAN [view interactions] High throughput no no
ZN467_HUMAN [view interactions] High throughput no no
PALS1_HUMAN [view interactions] High throughput no no
BATF3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
TOP2A_HUMAN [view interactions] High throughput no no
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
NEUL4_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
MUCL1_HUMAN [view interactions] High throughput no no
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
SENP3_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
CBX3_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
DHX8_HUMAN [view interactions] High throughput no yes
NUP50_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes