Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAGE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAGE_HUMAN
GO:0043169 cation binding 46.1538 4 no
GO:0046872 metal ion binding 46.1538 5 no
GO:0019900 kinase binding 38.4615 4 no
GO:0019901 protein kinase binding 38.4615 5 no
GO:0000166 nucleotide binding 30.7692 4 no
GO:0017076 purine nucleotide binding 30.7692 5 no
GO:0032555 purine ribonucleotide binding 30.7692 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 no
GO:0043168 anion binding 30.7692 4 no
GO:0098631 cell adhesion mediator activity 23.0769 4 yes
GO:0016301 kinase activity 23.0769 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.0769 4 no
GO:0048018 receptor ligand activity 23.0769 4 no
GO:0005509 calcium ion binding 23.0769 6 no
GO:0046914 transition metal ion binding 23.0769 6 no
GO:0005055 laminin receptor activity 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAGE_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0048584 positive regulation of response to stimulus 100.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 100.0000 5 yes
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 92.3077 6 yes
GO:0009967 positive regulation of signal transduction 92.3077 5 yes
GO:0010647 positive regulation of cell communication 92.3077 5 yes
GO:0023056 positive regulation of signaling 92.3077 4 yes
GO:0042127 regulation of cell population proliferation 84.6154 4 yes
GO:0045595 regulation of cell differentiation 84.6154 4 yes
GO:0045597 positive regulation of cell differentiation 76.9231 5 yes
GO:0048523 negative regulation of cellular process 76.9231 4 yes
GO:0051094 positive regulation of developmental process 76.9231 4 yes
GO:0051240 positive regulation of multicellular organismal process 76.9231 4 yes
GO:0009893 positive regulation of metabolic process 76.9231 4 yes
GO:0031323 regulation of cellular metabolic process 76.9231 4 yes
GO:0031325 positive regulation of cellular metabolic process 76.9231 5 yes
GO:0042325 regulation of phosphorylation 69.2308 7 yes
GO:0051174 regulation of phosphorus metabolic process 69.2308 5 yes
GO:0051246 regulation of protein metabolic process 69.2308 5 yes
GO:0060255 regulation of macromolecule metabolic process 69.2308 4 yes
GO:0080090 regulation of primary metabolic process 69.2308 4 yes
GO:2000026 regulation of multicellular organismal development 69.2308 4 yes
GO:0001932 regulation of protein phosphorylation 69.2308 7 yes
GO:0008284 positive regulation of cell population proliferation 69.2308 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 69.2308 5 yes
GO:0019220 regulation of phosphate metabolic process 69.2308 6 yes
GO:0031399 regulation of protein modification process 69.2308 6 yes
GO:0040017 positive regulation of locomotion 61.5385 4 yes
GO:0042327 positive regulation of phosphorylation 61.5385 8 yes
GO:0043408 regulation of MAPK cascade 61.5385 6 yes
GO:0045937 positive regulation of phosphate metabolic process 61.5385 7 yes
GO:0051247 positive regulation of protein metabolic process 61.5385 6 yes
GO:0060284 regulation of cell development 61.5385 5 yes
GO:2000145 regulation of cell motility 61.5385 4 yes
GO:2000147 positive regulation of cell motility 61.5385 5 yes
GO:0001934 positive regulation of protein phosphorylation 61.5385 8 yes
GO:0009889 regulation of biosynthetic process 61.5385 4 yes
GO:0010468 regulation of gene expression 61.5385 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 61.5385 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 61.5385 6 yes
GO:0010720 positive regulation of cell development 61.5385 6 yes
GO:0030334 regulation of cell migration 61.5385 5 yes
GO:0030335 positive regulation of cell migration 61.5385 6 yes
GO:0031326 regulation of cellular biosynthetic process 61.5385 5 yes
GO:0031401 positive regulation of protein modification process 61.5385 7 yes
GO:0043410 positive regulation of MAPK cascade 53.8462 7 yes
GO:0044057 regulation of system process 53.8462 4 yes
GO:0050804 modulation of chemical synaptic transmission 53.8462 5 yes
GO:0050890 cognition 53.8462 4 yes
GO:0051241 negative regulation of multicellular organismal process 53.8462 4 yes
GO:0051252 regulation of RNA metabolic process 53.8462 5 yes
GO:0099177 regulation of trans-synaptic signaling 53.8462 4 yes
GO:2001141 regulation of RNA biosynthetic process 53.8462 6 yes
GO:0043067 regulation of programmed cell death 53.8462 4 no
GO:0051128 regulation of cellular component organization 53.8462 4 no
GO:0006355 regulation of DNA-templated transcription 53.8462 7 yes
GO:0009892 negative regulation of metabolic process 53.8462 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 53.8462 5 yes
GO:0030030 cell projection organization 53.8462 4 yes
GO:0031324 negative regulation of cellular metabolic process 53.8462 5 yes
GO:0043085 positive regulation of catalytic activity 46.1538 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 46.1538 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 46.1538 8 yes
GO:0120036 plasma membrane bounded cell projection organization 46.1538 5 yes
GO:0002009 morphogenesis of an epithelium 46.1538 4 no
GO:0042981 regulation of apoptotic process 46.1538 5 no
GO:0002684 positive regulation of immune system process 46.1538 4 yes
GO:0009890 negative regulation of biosynthetic process 46.1538 5 yes
GO:0009891 positive regulation of biosynthetic process 46.1538 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 46.1538 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 yes
GO:0010628 positive regulation of gene expression 46.1538 7 yes
GO:0045664 regulation of neuron differentiation 46.1538 5 no
GO:0031328 positive regulation of cellular biosynthetic process 46.1538 6 yes
GO:0032101 regulation of response to external stimulus 46.1538 4 yes
GO:0032103 positive regulation of response to external stimulus 46.1538 5 yes
GO:0045785 positive regulation of cell adhesion 38.4615 5 yes
GO:0050920 regulation of chemotaxis 38.4615 4 yes
GO:0050921 positive regulation of chemotaxis 38.4615 5 yes
GO:0051336 regulation of hydrolase activity 38.4615 4 yes
GO:0051345 positive regulation of hydrolase activity 38.4615 5 yes
GO:0071310 cellular response to organic substance 38.4615 4 yes
GO:0080134 regulation of response to stress 38.4615 4 yes
GO:1901701 cellular response to oxygen-containing compound 38.4615 4 yes
GO:0009968 negative regulation of signal transduction 38.4615 5 no
GO:0010648 negative regulation of cell communication 38.4615 5 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0023057 negative regulation of signaling 38.4615 4 no
GO:0043066 negative regulation of apoptotic process 38.4615 6 no
GO:0043069 negative regulation of programmed cell death 38.4615 5 no
GO:0044087 regulation of cellular component biogenesis 38.4615 4 no
GO:0048585 negative regulation of response to stimulus 38.4615 4 no
GO:0001817 regulation of cytokine production 38.4615 4 yes
GO:0051049 regulation of transport 38.4615 4 no
GO:0051130 positive regulation of cellular component organization 38.4615 5 no
GO:0006996 organelle organization 38.4615 4 no
GO:0007010 cytoskeleton organization 38.4615 5 no
GO:0010243 response to organonitrogen compound 38.4615 4 yes
GO:0141124 intracellular signaling cassette 38.4615 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 38.4615 6 yes
GO:0010629 negative regulation of gene expression 38.4615 7 yes
GO:0030155 regulation of cell adhesion 38.4615 4 yes
GO:0051726 regulation of cell cycle 38.4615 4 no
GO:0031175 neuron projection development 38.4615 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 38.4615 6 yes
GO:0046634 regulation of alpha-beta T cell activation 30.7692 7 yes
GO:0050776 regulation of immune response 30.7692 4 yes
GO:0050806 positive regulation of synaptic transmission 30.7692 5 yes
GO:0050863 regulation of T cell activation 30.7692 6 yes
GO:0050865 regulation of cell activation 30.7692 4 yes
GO:0050867 positive regulation of cell activation 30.7692 5 yes
GO:0050870 positive regulation of T cell activation 30.7692 7 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 30.7692 4 yes
GO:0051249 regulation of lymphocyte activation 30.7692 5 yes
GO:0051251 positive regulation of lymphocyte activation 30.7692 6 yes
GO:0071417 cellular response to organonitrogen compound 30.7692 4 yes
GO:0071675 regulation of mononuclear cell migration 30.7692 5 yes
GO:0071677 positive regulation of mononuclear cell migration 30.7692 6 yes
GO:0150003 regulation of spontaneous synaptic transmission 30.7692 6 yes
GO:1901222 regulation of non-canonical NF-kappaB signal transduction 30.7692 6 yes
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction 30.7692 7 yes
GO:1901699 cellular response to nitrogen compound 30.7692 4 yes
GO:1902105 regulation of leukocyte differentiation 30.7692 5 yes
GO:1902107 positive regulation of leukocyte differentiation 30.7692 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 30.7692 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 30.7692 7 yes
GO:1903522 regulation of blood circulation 30.7692 5 yes
GO:1903706 regulation of hemopoiesis 30.7692 4 yes
GO:1903708 positive regulation of hemopoiesis 30.7692 5 yes
GO:0001667 ameboidal-type cell migration 30.7692 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 30.7692 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 30.7692 5 no
GO:0010594 regulation of endothelial cell migration 30.7692 5 no
GO:0010631 epithelial cell migration 30.7692 5 no
GO:0010632 regulation of epithelial cell migration 30.7692 4 no
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 no
GO:0043535 regulation of blood vessel endothelial cell migration 30.7692 6 no
GO:0043542 endothelial cell migration 30.7692 6 no
GO:0045596 negative regulation of cell differentiation 30.7692 5 no
GO:0048638 regulation of developmental growth 30.7692 4 no
GO:0001819 positive regulation of cytokine production 30.7692 5 yes
GO:0048812 neuron projection morphogenesis 30.7692 5 no
GO:0050767 regulation of neurogenesis 30.7692 6 no
GO:0050769 positive regulation of neurogenesis 30.7692 6 no
GO:0002685 regulation of leukocyte migration 30.7692 4 yes
GO:0002687 positive regulation of leukocyte migration 30.7692 5 yes
GO:0051093 negative regulation of developmental process 30.7692 4 no
GO:0002694 regulation of leukocyte activation 30.7692 4 yes
GO:0002696 positive regulation of leukocyte activation 30.7692 5 yes
GO:0051960 regulation of nervous system development 30.7692 5 no
GO:0051962 positive regulation of nervous system development 30.7692 5 no
GO:0090287 regulation of cellular response to growth factor stimulus 30.7692 4 no
GO:0003018 vascular process in circulatory system 30.7692 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 30.7692 4 no
GO:0006954 inflammatory response 30.7692 4 yes
GO:0008104 protein localization 30.7692 4 yes
GO:1902903 regulation of supramolecular fiber organization 30.7692 5 no
GO:1902905 positive regulation of supramolecular fiber organization 30.7692 6 no
GO:1990138 neuron projection extension 30.7692 4 no
GO:0007264 small GTPase-mediated signal transduction 30.7692 5 no
GO:0006357 regulation of transcription by RNA polymerase II 30.7692 8 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045666 positive regulation of neuron differentiation 30.7692 6 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0022407 regulation of cell-cell adhesion 30.7692 5 yes
GO:0022409 positive regulation of cell-cell adhesion 30.7692 6 yes
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0032722 positive regulation of chemokine production 23.0769 6 yes
GO:0032731 positive regulation of interleukin-1 beta production 23.0769 7 yes
GO:0032732 positive regulation of interleukin-1 production 23.0769 6 yes
GO:0032755 positive regulation of interleukin-6 production 23.0769 6 yes
GO:0032760 positive regulation of tumor necrosis factor production 23.0769 7 yes
GO:0042116 macrophage activation 23.0769 4 yes
GO:0046328 regulation of JNK cascade 23.0769 7 yes
GO:0046330 positive regulation of JNK cascade 23.0769 8 yes
GO:0048143 astrocyte activation 23.0769 4 yes
GO:0050727 regulation of inflammatory response 23.0769 5 yes
GO:0051092 positive regulation of NF-kappaB transcription factor activity 23.0769 5 yes
GO:0072657 protein localization to membrane 23.0769 4 yes
GO:1900271 regulation of long-term synaptic potentiation 23.0769 4 yes
GO:1900272 negative regulation of long-term synaptic potentiation 23.0769 4 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 23.0769 5 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 23.0769 6 yes
GO:1904645 response to amyloid-beta 23.0769 4 yes
GO:1904646 cellular response to amyloid-beta 23.0769 5 yes
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 23.0769 8 yes
GO:0001764 neuron migration 23.0769 4 no
GO:0001936 regulation of endothelial cell proliferation 23.0769 6 no
GO:0001938 positive regulation of endothelial cell proliferation 23.0769 7 no
GO:0001952 regulation of cell-matrix adhesion 23.0769 6 no
GO:0002042 cell migration involved in sprouting angiogenesis 23.0769 8 no
GO:0007409 axonogenesis 23.0769 6 no
GO:0010595 positive regulation of endothelial cell migration 23.0769 6 no
GO:0010634 positive regulation of epithelial cell migration 23.0769 5 no
GO:0010638 positive regulation of organelle organization 23.0769 6 no
GO:0010810 regulation of cell-substrate adhesion 23.0769 5 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0030031 cell projection assembly 23.0769 5 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0032956 regulation of actin cytoskeleton organization 23.0769 5 no
GO:0032970 regulation of actin filament-based process 23.0769 4 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0040013 negative regulation of locomotion 23.0769 4 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0043524 negative regulation of neuron apoptotic process 23.0769 7 no
GO:0043534 blood vessel endothelial cell migration 23.0769 7 no
GO:0043536 positive regulation of blood vessel endothelial cell migration 23.0769 7 no
GO:0044089 positive regulation of cellular component biogenesis 23.0769 5 no
GO:0045765 regulation of angiogenesis 23.0769 5 no
GO:0045766 positive regulation of angiogenesis 23.0769 6 no
GO:0045927 positive regulation of growth 23.0769 4 no
GO:0001774 microglial cell activation 23.0769 4 yes
GO:0048639 positive regulation of developmental growth 23.0769 5 no
GO:0001818 negative regulation of cytokine production 23.0769 5 yes
GO:0048754 branching morphogenesis of an epithelial tube 23.0769 4 no
GO:0050678 regulation of epithelial cell proliferation 23.0769 5 no
GO:0050679 positive regulation of epithelial cell proliferation 23.0769 6 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 23.0769 8 no
GO:0051056 regulation of small GTPase mediated signal transduction 23.0769 6 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0002697 regulation of immune effector process 23.0769 4 yes
GO:0051495 positive regulation of cytoskeleton organization 23.0769 7 no
GO:0002703 regulation of leukocyte mediated immunity 23.0769 5 yes
GO:0002706 regulation of lymphocyte mediated immunity 23.0769 6 yes
GO:0002709 regulation of T cell mediated immunity 23.0769 7 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 23.0769 7 no
GO:0002819 regulation of adaptive immune response 23.0769 5 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 23.0769 6 yes
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:1901342 regulation of vasculature development 23.0769 5 no
GO:1901888 regulation of cell junction assembly 23.0769 5 no
GO:1904018 positive regulation of vasculature development 23.0769 5 no
GO:0007265 Ras protein signal transduction 23.0769 6 no
GO:0008543 fibroblast growth factor receptor signaling pathway 23.0769 6 no
GO:0021782 glial cell development 23.0769 4 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0098657 import into cell 23.0769 4 no
GO:0000165 MAPK cascade 23.0769 5 no
GO:0006468 protein phosphorylation 23.0769 5 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0009059 macromolecule biosynthetic process 23.0769 4 no
GO:0009792 embryo development ending in birth or egg hatching 23.0769 4 no
GO:0010564 regulation of cell cycle process 23.0769 5 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0045787 positive regulation of cell cycle 23.0769 5 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 23.0769 6 no
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 23.0769 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 23.0769 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 23.0769 8 no
GO:0090068 positive regulation of cell cycle process 23.0769 6 no
GO:0030855 epithelial cell differentiation 23.0769 4 no
GO:2000177 regulation of neural precursor cell proliferation 23.0769 5 no
GO:0006915 apoptotic process 23.0769 4 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 23.0769 6 no
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 23.0769 7 no
GO:0031347 regulation of defense response 23.0769 5 yes
GO:0050807 regulation of synapse organization 23.0769 5 no
GO:0051402 neuron apoptotic process 23.0769 5 no
GO:0048168 regulation of neuronal synaptic plasticity 23.0769 4 no
GO:0007612 learning 23.0769 4 no
GO:0008306 associative learning 23.0769 5 no
GO:0032642 regulation of chemokine production 23.0769 5 yes
GO:0008542 visual learning 23.0769 4 no
GO:0032651 regulation of interleukin-1 beta production 23.0769 6 yes
GO:0009416 response to light stimulus 23.0769 4 no
GO:0032652 regulation of interleukin-1 production 23.0769 5 yes
GO:0032653 regulation of interleukin-10 production 23.0769 5 yes
GO:0032675 regulation of interleukin-6 production 23.0769 5 yes
GO:0032680 regulation of tumor necrosis factor production 23.0769 6 yes
GO:0032735 positive regulation of interleukin-12 production 15.3846 6 yes
GO:0032944 regulation of mononuclear cell proliferation 15.3846 6 yes
GO:0032946 positive regulation of mononuclear cell proliferation 15.3846 7 yes
GO:0034114 regulation of heterotypic cell-cell adhesion 15.3846 6 yes
GO:0034116 positive regulation of heterotypic cell-cell adhesion 15.3846 7 yes
GO:0036293 response to decreased oxygen levels 15.3846 4 yes
GO:0042102 positive regulation of T cell proliferation 15.3846 8 yes
GO:0042104 positive regulation of activated T cell proliferation 15.3846 9 yes
GO:0042129 regulation of T cell proliferation 15.3846 7 yes
GO:0045862 positive regulation of proteolysis 15.3846 7 yes
GO:0046006 regulation of activated T cell proliferation 15.3846 8 yes
GO:0050670 regulation of lymphocyte proliferation 15.3846 6 yes
GO:0050671 positive regulation of lymphocyte proliferation 15.3846 7 yes
GO:0050926 regulation of positive chemotaxis 15.3846 5 yes
GO:0050927 positive regulation of positive chemotaxis 15.3846 6 yes
GO:0050930 induction of positive chemotaxis 15.3846 7 yes
GO:0052547 regulation of peptidase activity 15.3846 5 yes
GO:0052548 regulation of endopeptidase activity 15.3846 6 yes
GO:0070663 regulation of leukocyte proliferation 15.3846 5 yes
GO:0070665 positive regulation of leukocyte proliferation 15.3846 6 yes
GO:0071637 regulation of monocyte chemotactic protein-1 production 15.3846 6 yes
GO:0071639 positive regulation of monocyte chemotactic protein-1 production 15.3846 7 yes
GO:0150104 transport across blood-brain barrier 15.3846 5 yes
GO:1900452 regulation of long-term synaptic depression 15.3846 4 yes
GO:1900453 negative regulation of long-term synaptic depression 15.3846 4 yes
GO:1900744 regulation of p38MAPK cascade 15.3846 7 yes
GO:1900745 positive regulation of p38MAPK cascade 15.3846 8 yes
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 15.3846 7 yes
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 15.3846 8 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 15.3846 6 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 15.3846 7 yes
GO:1903523 negative regulation of blood circulation 15.3846 5 yes
GO:1904470 regulation of endothelin production 15.3846 5 yes
GO:1904472 positive regulation of endothelin production 15.3846 6 yes
GO:1905245 regulation of aspartic-type peptidase activity 15.3846 6 yes
GO:1905247 positive regulation of aspartic-type peptidase activity 15.3846 7 yes
GO:2000437 regulation of monocyte extravasation 15.3846 6 yes
GO:2000439 positive regulation of monocyte extravasation 15.3846 7 yes
GO:2001198 regulation of dendritic cell differentiation 15.3846 6 yes
GO:2001200 positive regulation of dendritic cell differentiation 15.3846 7 yes
GO:0001910 regulation of leukocyte mediated cytotoxicity 15.3846 5 yes
GO:0001914 regulation of T cell mediated cytotoxicity 15.3846 6 yes
GO:0002691 regulation of cellular extravasation 15.3846 5 yes
GO:0002693 positive regulation of cellular extravasation 15.3846 6 yes
GO:0009757 hexose mediated signaling 15.3846 5 yes
GO:0010182 sugar mediated signaling pathway 15.3846 4 yes
GO:0010232 vascular transport 15.3846 4 yes
GO:0010255 glucose mediated signaling pathway 15.3846 6 yes
GO:0010950 positive regulation of endopeptidase activity 15.3846 7 yes
GO:0010952 positive regulation of peptidase activity 15.3846 6 yes
GO:0030162 regulation of proteolysis 15.3846 6 yes
GO:0031341 regulation of cell killing 15.3846 4 yes
GO:0032655 regulation of interleukin-12 production 15.3846 5 yes
GO:0032693 negative regulation of interleukin-10 production 15.3846 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DIAP1_HUMAN [view interactions] Low throughput no yes
MAPK5_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
HMGB1_HUMAN [view interactions] Low throughput no yes
S10A1_HUMAN [view interactions] Low throughput no yes
S10AC_HUMAN [view interactions] Low throughput no no
S100P_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
FBX10_HUMAN [view interactions] Low throughput no no
RAGE_HUMAN [view entry] [view interactions] Low throughput yes no
TTHY_HUMAN [view interactions] Low throughput no no
SC61B_HUMAN [view interactions] Low throughput no yes
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
FPR2_HUMAN [view interactions] Low throughput no yes
FPR1_HUMAN [view interactions] Low throughput no no
S10AD_HUMAN [view interactions] Low throughput no yes
S10A6_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MYD88_HUMAN [view interactions] High throughput no yes
TIRAP_HUMAN [view interactions] High throughput no no
IRAK4_HUMAN [view interactions] High throughput no yes
TCAM2_HUMAN [view interactions] High throughput no no
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
CKLF7_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
CB015_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CREB3_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSTF2_HUMAN [view interactions] High throughput no yes
FGF2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes