Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAGE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAGE_HUMAN
GO:0017076 purine nucleotide binding 38.8889 4 no
GO:0019900 kinase binding 38.8889 4 no
GO:0019901 protein kinase binding 38.8889 5 no
GO:0032555 purine ribonucleotide binding 38.8889 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.8889 4 no
GO:0046872 metal ion binding 38.8889 4 no
GO:0070851 growth factor receptor binding 27.7778 4 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0005525 GTP binding 22.2222 5 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0019001 guanyl nucleotide binding 22.2222 5 no
GO:0019003 GDP binding 22.2222 4 no
GO:0032561 guanyl ribonucleotide binding 22.2222 5 no
GO:0016301 kinase activity 22.2222 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.2222 4 no
GO:0001540 amyloid-beta binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAGE_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0009966 regulation of signal transduction 94.4444 4 yes
GO:0010646 regulation of cell communication 94.4444 4 yes
GO:1902531 regulation of intracellular signal transduction 94.4444 5 yes
GO:0009967 positive regulation of signal transduction 88.8889 5 yes
GO:0010647 positive regulation of cell communication 88.8889 5 yes
GO:0023056 positive regulation of signaling 88.8889 4 yes
GO:0042127 regulation of cell population proliferation 88.8889 4 yes
GO:0048584 positive regulation of response to stimulus 88.8889 4 yes
GO:1902533 positive regulation of intracellular signal transduction 88.8889 6 yes
GO:0008284 positive regulation of cell population proliferation 77.7778 5 yes
GO:0009893 positive regulation of metabolic process 77.7778 4 yes
GO:0031323 regulation of cellular metabolic process 77.7778 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 72.2222 5 yes
GO:0031325 positive regulation of cellular metabolic process 72.2222 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 72.2222 4 yes
GO:0060255 regulation of macromolecule metabolic process 72.2222 4 yes
GO:0080090 regulation of primary metabolic process 72.2222 4 yes
GO:0010468 regulation of gene expression 66.6667 5 yes
GO:0010628 positive regulation of gene expression 66.6667 6 yes
GO:0031399 regulation of protein modification process 66.6667 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 66.6667 5 yes
GO:0051240 positive regulation of multicellular organismal process 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 66.6667 6 yes
GO:0006355 regulation of DNA-templated transcription 61.1111 6 yes
GO:0009889 regulation of biosynthetic process 61.1111 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 61.1111 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 61.1111 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 61.1111 5 yes
GO:0019220 regulation of phosphate metabolic process 61.1111 6 yes
GO:0030334 regulation of cell migration 61.1111 5 yes
GO:0031326 regulation of cellular biosynthetic process 61.1111 5 yes
GO:0031401 positive regulation of protein modification process 61.1111 7 yes
GO:0042325 regulation of phosphorylation 61.1111 7 yes
GO:0042327 positive regulation of phosphorylation 61.1111 8 yes
GO:0043408 regulation of MAPK cascade 61.1111 6 yes
GO:0045937 positive regulation of phosphate metabolic process 61.1111 7 yes
GO:0051174 regulation of phosphorus metabolic process 61.1111 5 yes
GO:0051252 regulation of RNA metabolic process 61.1111 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 61.1111 7 yes
GO:2000145 regulation of cell motility 61.1111 4 yes
GO:2001141 regulation of RNA biosynthetic process 61.1111 6 yes
GO:0048523 negative regulation of cellular process 61.1111 4 no
GO:0001932 regulation of protein phosphorylation 61.1111 7 yes
GO:0001934 positive regulation of protein phosphorylation 61.1111 8 yes
GO:0060548 negative regulation of cell death 55.5556 5 no
GO:0010243 response to organonitrogen compound 55.5556 4 yes
GO:0030335 positive regulation of cell migration 55.5556 6 yes
GO:0040017 positive regulation of locomotion 55.5556 4 yes
GO:0043085 positive regulation of catalytic activity 55.5556 4 yes
GO:0043410 positive regulation of MAPK cascade 55.5556 7 yes
GO:0045595 regulation of cell differentiation 55.5556 4 yes
GO:0071310 cellular response to organic substance 55.5556 4 yes
GO:0080134 regulation of response to stress 55.5556 4 yes
GO:2000147 positive regulation of cell motility 55.5556 5 yes
GO:0010941 regulation of cell death 55.5556 4 no
GO:0043067 regulation of programmed cell death 55.5556 5 no
GO:0002684 positive regulation of immune system process 55.5556 4 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0032101 regulation of response to external stimulus 50.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0051336 regulation of hydrolase activity 50.0000 4 yes
GO:0051338 regulation of transferase activity 50.0000 4 yes
GO:0051345 positive regulation of hydrolase activity 50.0000 5 yes
GO:0051347 positive regulation of transferase activity 50.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 50.0000 4 yes
GO:0042981 regulation of apoptotic process 50.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 yes
GO:0016192 vesicle-mediated transport 44.4444 4 yes
GO:0030030 cell projection organization 44.4444 4 yes
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0033674 positive regulation of kinase activity 44.4444 6 yes
GO:0043549 regulation of kinase activity 44.4444 5 yes
GO:0045597 positive regulation of cell differentiation 44.4444 5 yes
GO:0045859 regulation of protein kinase activity 44.4444 6 yes
GO:0045860 positive regulation of protein kinase activity 44.4444 7 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 44.4444 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 44.4444 8 yes
GO:0043066 negative regulation of apoptotic process 44.4444 7 no
GO:0043069 negative regulation of programmed cell death 44.4444 6 no
GO:0001817 regulation of cytokine production 44.4444 4 yes
GO:0001819 positive regulation of cytokine production 44.4444 5 yes
GO:0051049 regulation of transport 44.4444 4 no
GO:0009968 negative regulation of signal transduction 38.8889 5 no
GO:0010648 negative regulation of cell communication 38.8889 5 no
GO:0023057 negative regulation of signaling 38.8889 4 no
GO:0048585 negative regulation of response to stimulus 38.8889 4 no
GO:0030155 regulation of cell adhesion 38.8889 4 yes
GO:0044087 regulation of cellular component biogenesis 38.8889 4 no
GO:0051130 positive regulation of cellular component organization 38.8889 5 no
GO:0031347 regulation of defense response 38.8889 5 yes
GO:0032103 positive regulation of response to external stimulus 38.8889 5 yes
GO:0045785 positive regulation of cell adhesion 38.8889 5 yes
GO:0050776 regulation of immune response 38.8889 4 yes
GO:0050865 regulation of cell activation 38.8889 4 yes
GO:0050867 positive regulation of cell activation 38.8889 5 yes
GO:0050890 cognition 38.8889 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 38.8889 4 yes
GO:0051241 negative regulation of multicellular organismal process 38.8889 4 yes
GO:2000026 regulation of multicellular organismal development 38.8889 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 38.8889 7 no
GO:0009891 positive regulation of biosynthetic process 38.8889 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 38.8889 6 no
GO:0031328 positive regulation of cellular biosynthetic process 38.8889 6 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0002694 regulation of leukocyte activation 33.3333 4 yes
GO:0002696 positive regulation of leukocyte activation 33.3333 5 yes
GO:1901214 regulation of neuron death 33.3333 5 no
GO:1901215 negative regulation of neuron death 33.3333 6 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 33.3333 8 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0007264 small GTPase mediated signal transduction 33.3333 4 no
GO:0007265 Ras protein signal transduction 33.3333 5 no
GO:0022407 regulation of cell-cell adhesion 33.3333 5 yes
GO:0022409 positive regulation of cell-cell adhesion 33.3333 6 yes
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0032872 regulation of stress-activated MAPK cascade 33.3333 6 yes
GO:0044057 regulation of system process 33.3333 4 yes
GO:0050727 regulation of inflammatory response 33.3333 5 yes
GO:0050920 regulation of chemotaxis 33.3333 4 yes
GO:0050921 positive regulation of chemotaxis 33.3333 5 yes
GO:0051092 positive regulation of NF-kappaB transcription factor activity 33.3333 5 yes
GO:0051249 regulation of lymphocyte activation 33.3333 5 yes
GO:0051251 positive regulation of lymphocyte activation 33.3333 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 33.3333 5 yes
GO:0071417 cellular response to organonitrogen compound 33.3333 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 33.3333 8 yes
GO:0080135 regulation of cellular response to stress 33.3333 4 yes
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 yes
GO:1901699 cellular response to nitrogen compound 33.3333 4 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 33.3333 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 33.3333 7 yes
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0034097 response to cytokine 33.3333 4 no
GO:0043523 regulation of neuron apoptotic process 33.3333 6 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 33.3333 8 no
GO:0002685 regulation of leukocyte migration 33.3333 4 yes
GO:0002687 positive regulation of leukocyte migration 27.7778 5 yes
GO:1903829 positive regulation of protein localization 27.7778 5 no
GO:0006954 inflammatory response 27.7778 4 yes
GO:0006897 endocytosis 27.7778 5 no
GO:0009894 regulation of catabolic process 27.7778 4 no
GO:0032990 cell part morphogenesis 27.7778 4 no
GO:0045596 negative regulation of cell differentiation 27.7778 5 no
GO:0048812 neuron projection morphogenesis 27.7778 7 no
GO:0048858 cell projection morphogenesis 27.7778 5 no
GO:0051093 negative regulation of developmental process 27.7778 4 no
GO:0010629 negative regulation of gene expression 27.7778 6 yes
GO:0051726 regulation of cell cycle 27.7778 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.7778 6 no
GO:0002009 morphogenesis of an epithelium 27.7778 4 no
GO:0010950 positive regulation of endopeptidase activity 27.7778 7 yes
GO:0010952 positive regulation of peptidase activity 27.7778 6 yes
GO:0000165 MAPK cascade 27.7778 4 no
GO:0010638 positive regulation of organelle organization 27.7778 6 no
GO:0030162 regulation of proteolysis 27.7778 6 yes
GO:0031175 neuron projection development 27.7778 6 yes
GO:0044089 positive regulation of cellular component biogenesis 27.7778 5 no
GO:0051493 regulation of cytoskeleton organization 27.7778 6 no
GO:0031324 negative regulation of cellular metabolic process 27.7778 5 no
GO:0032651 regulation of interleukin-1 beta production 27.7778 6 yes
GO:0032652 regulation of interleukin-1 production 27.7778 5 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 27.7778 6 no
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 27.7778 7 no
GO:0032680 regulation of tumor necrosis factor production 27.7778 6 yes
GO:0032731 positive regulation of interleukin-1 beta production 27.7778 7 yes
GO:0032732 positive regulation of interleukin-1 production 27.7778 6 yes
GO:0032760 positive regulation of tumor necrosis factor production 27.7778 7 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 27.7778 7 yes
GO:0043405 regulation of MAP kinase activity 27.7778 8 yes
GO:0043406 positive regulation of MAP kinase activity 27.7778 8 yes
GO:0045862 positive regulation of proteolysis 27.7778 7 yes
GO:0046328 regulation of JNK cascade 27.7778 7 yes
GO:0046330 positive regulation of JNK cascade 27.7778 8 yes
GO:0046634 regulation of alpha-beta T cell activation 27.7778 7 yes
GO:0050863 regulation of T cell activation 27.7778 6 yes
GO:0050870 positive regulation of T cell activation 27.7778 7 yes
GO:0052547 regulation of peptidase activity 27.7778 5 yes
GO:0052548 regulation of endopeptidase activity 27.7778 6 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 27.7778 6 yes
GO:0070663 regulation of leukocyte proliferation 27.7778 5 yes
GO:0070665 positive regulation of leukocyte proliferation 27.7778 6 yes
GO:0071675 regulation of mononuclear cell migration 27.7778 5 yes
GO:1901222 regulation of NIK/NF-kappaB signaling 27.7778 6 yes
GO:1901224 positive regulation of NIK/NF-kappaB signaling 27.7778 7 yes
GO:1901652 response to peptide 27.7778 4 yes
GO:1901653 cellular response to peptide 27.7778 5 yes
GO:1903522 regulation of blood circulation 27.7778 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 27.7778 5 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 27.7778 6 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 27.7778 4 no
GO:0008285 negative regulation of cell population proliferation 27.7778 5 no
GO:0022607 cellular component assembly 27.7778 4 no
GO:0032880 regulation of protein localization 27.7778 5 no
GO:0043524 negative regulation of neuron apoptotic process 27.7778 7 no
GO:0051050 positive regulation of transport 27.7778 4 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0071219 cellular response to molecule of bacterial origin 22.2222 4 no
GO:0071222 cellular response to lipopolysaccharide 22.2222 5 no
GO:0071345 cellular response to cytokine stimulus 22.2222 5 no
GO:0071396 cellular response to lipid 22.2222 5 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0008104 protein localization 22.2222 4 yes
GO:0001667 ameboidal-type cell migration 22.2222 4 no
GO:0009416 response to light stimulus 22.2222 4 no
GO:0010631 epithelial cell migration 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0043542 endothelial cell migration 22.2222 6 no
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 no
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 no
GO:0060191 regulation of lipase activity 22.2222 5 no
GO:0060193 positive regulation of lipase activity 22.2222 6 no
GO:2000628 regulation of miRNA metabolic process 22.2222 6 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0051495 positive regulation of cytoskeleton organization 22.2222 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0032642 regulation of chemokine production 22.2222 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0070848 response to growth factor 22.2222 4 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:1902905 positive regulation of supramolecular fiber organization 22.2222 6 no
GO:0032675 regulation of interleukin-6 production 22.2222 5 yes
GO:0043254 regulation of protein-containing complex assembly 22.2222 5 no
GO:0032722 positive regulation of chemokine production 22.2222 6 yes
GO:0032755 positive regulation of interleukin-6 production 22.2222 6 yes
GO:0032944 regulation of mononuclear cell proliferation 22.2222 6 yes
GO:0032946 positive regulation of mononuclear cell proliferation 22.2222 7 yes
GO:0042116 macrophage activation 22.2222 4 yes
GO:0050670 regulation of lymphocyte proliferation 22.2222 6 yes
GO:0050671 positive regulation of lymphocyte proliferation 22.2222 7 yes
GO:0050806 positive regulation of synaptic transmission 22.2222 5 yes
GO:0071677 positive regulation of mononuclear cell migration 22.2222 6 yes
GO:0150003 regulation of spontaneous synaptic transmission 22.2222 6 yes
GO:1902105 regulation of leukocyte differentiation 22.2222 5 yes
GO:1902107 positive regulation of leukocyte differentiation 22.2222 6 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 22.2222 6 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 22.2222 7 yes
GO:1903523 negative regulation of blood circulation 22.2222 5 yes
GO:1903706 regulation of hemopoiesis 22.2222 4 yes
GO:1903708 positive regulation of hemopoiesis 22.2222 5 yes
GO:0002237 response to molecule of bacterial origin 22.2222 4 no
GO:0006468 protein phosphorylation 22.2222 5 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0010942 positive regulation of cell death 22.2222 5 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0016310 phosphorylation 22.2222 5 no
GO:0019221 cytokine-mediated signaling pathway 22.2222 4 no
GO:0032496 response to lipopolysaccharide 22.2222 4 no
GO:0033993 response to lipid 22.2222 4 no
GO:0036211 protein modification process 22.2222 4 no
GO:0043065 positive regulation of apoptotic process 22.2222 7 no
GO:0043068 positive regulation of programmed cell death 22.2222 6 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0001774 microglial cell activation 22.2222 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 22.2222 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0002697 regulation of immune effector process 16.6667 4 yes
GO:0002703 regulation of leukocyte mediated immunity 16.6667 5 yes
GO:0002706 regulation of lymphocyte mediated immunity 16.6667 6 yes
GO:0002709 regulation of T cell mediated immunity 16.6667 7 yes
GO:0002819 regulation of adaptive immune response 16.6667 5 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 16.6667 6 yes
GO:0003018 vascular process in circulatory system 16.6667 4 yes
GO:0032653 regulation of interleukin-10 production 16.6667 5 yes
GO:0032655 regulation of interleukin-12 production 16.6667 5 yes
GO:0032735 positive regulation of interleukin-12 production 16.6667 6 yes
GO:0036293 response to decreased oxygen levels 16.6667 4 yes
GO:0042102 positive regulation of T cell proliferation 16.6667 8 yes
GO:0042129 regulation of T cell proliferation 16.6667 7 yes
GO:0048143 astrocyte activation 16.6667 4 yes
GO:0051101 regulation of DNA binding 16.6667 4 yes
GO:0072657 protein localization to membrane 16.6667 4 yes
GO:1900271 regulation of long-term synaptic potentiation 16.6667 4 yes
GO:1900272 negative regulation of long-term synaptic potentiation 16.6667 4 yes
GO:1900452 regulation of long-term synaptic depression 16.6667 4 yes
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 16.6667 7 yes
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 16.6667 8 yes
GO:1904470 regulation of endothelin production 16.6667 5 yes
GO:1904472 positive regulation of endothelin production 16.6667 6 yes
GO:1904645 response to amyloid-beta 16.6667 5 yes
GO:1904646 cellular response to amyloid-beta 16.6667 6 yes
GO:1905245 regulation of aspartic-type peptidase activity 16.6667 6 yes
GO:1905247 positive regulation of aspartic-type peptidase activity 16.6667 7 yes
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 16.6667 8 yes
GO:0002691 regulation of cellular extravasation 11.1111 5 yes
GO:0002693 positive regulation of cellular extravasation 11.1111 6 yes
GO:0009757 hexose mediated signaling 11.1111 5 yes
GO:0010182 sugar mediated signaling pathway 11.1111 4 yes
GO:0010232 vascular transport 11.1111 4 yes
GO:0010255 glucose mediated signaling pathway 11.1111 6 yes
GO:0031341 regulation of cell killing 11.1111 4 yes
GO:0032693 negative regulation of interleukin-10 production 11.1111 6 yes
GO:0034114 regulation of heterotypic cell-cell adhesion 11.1111 6 yes
GO:0034116 positive regulation of heterotypic cell-cell adhesion 11.1111 7 yes
GO:0042104 positive regulation of activated T cell proliferation 11.1111 9 yes
GO:0043506 regulation of JUN kinase activity 11.1111 9 yes
GO:0043507 positive regulation of JUN kinase activity 11.1111 9 yes
GO:0046006 regulation of activated T cell proliferation 11.1111 8 yes
GO:0050926 regulation of positive chemotaxis 11.1111 5 yes
GO:0050927 positive regulation of positive chemotaxis 11.1111 6 yes
GO:0050930 induction of positive chemotaxis 11.1111 7 yes
GO:0071637 regulation of monocyte chemotactic protein-1 production 11.1111 6 yes
GO:0071639 positive regulation of monocyte chemotactic protein-1 production 11.1111 7 yes
GO:0150104 transport across blood-brain barrier 11.1111 5 yes
GO:1900453 negative regulation of long-term synaptic depression 11.1111 4 yes
GO:1900744 regulation of p38MAPK cascade 11.1111 7 yes
GO:1900745 positive regulation of p38MAPK cascade 11.1111 8 yes
GO:2000437 regulation of monocyte extravasation 11.1111 6 yes
GO:2000439 positive regulation of monocyte extravasation 11.1111 7 yes
GO:2001198 regulation of dendritic cell differentiation 11.1111 6 yes
GO:2001200 positive regulation of dendritic cell differentiation 11.1111 7 yes
GO:0001818 negative regulation of cytokine production 11.1111 5 yes
GO:0001910 regulation of leukocyte mediated cytotoxicity 11.1111 5 yes
GO:0001914 regulation of T cell mediated cytotoxicity 11.1111 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in RAGE_HUMAN
DOID:0050686 organ system cancer 11.1111 3 no
DOID:2531 hematologic cancer 11.1111 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DIAP1_HUMAN [view interactions] Low throughput no yes
MAPK5_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
HMGB1_HUMAN [view interactions] Low throughput no yes
S10A1_HUMAN [view interactions] Low throughput no yes
S10AC_HUMAN [view interactions] Low throughput no no
S100P_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
RAGE_HUMAN [view entry] [view interactions] Low throughput yes no
TTHY_HUMAN [view interactions] Low throughput no no
SC61B_HUMAN [view interactions] Low throughput no yes
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
FPR2_HUMAN [view interactions] Low throughput no yes
FPR1_HUMAN [view interactions] Low throughput no no
S10A6_HUMAN [view interactions] Low throughput no yes
S10AD_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
TIRAP_HUMAN [view interactions] High throughput no no
MYD88_HUMAN [view entry] [view interactions] High throughput yes yes
IRAK4_HUMAN [view interactions] High throughput no yes
TCAM2_HUMAN [view interactions] High throughput no no
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
CKLF7_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
CB015_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CREB3_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSTF2_HUMAN [view interactions] High throughput no yes
FGF2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
JAK2_HUMAN [view entry] [view interactions] Computational yes yes
APEX1_HUMAN [view interactions] Computational no yes
NFKB2_HUMAN [view interactions] Computational no yes
NFKB1_HUMAN [view interactions] Computational no yes
TF65_HUMAN [view entry] [view interactions] Computational yes yes
TLR4_HUMAN [view interactions] Computational no yes
NOX4_HUMAN [view interactions] Computational no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
CY24B_HUMAN [view interactions] Computational no no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
S10AB_HUMAN [view interactions] Computational no no
TLR2_HUMAN [view interactions] Computational no no
ITB2_HUMAN [view interactions] Computational no no
RASN_HUMAN [view entry] [view interactions] Computational yes no
NOX1_HUMAN [view interactions] Computational no no
ITAM_HUMAN [view interactions] Computational no no