2A5D_HUMAN
Evidence for PS localization
Functions
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 2A5D_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 26.3158 | 4 | no |
| GO:0046872 | metal ion binding | 26.3158 | 5 | no |
| GO:0003723 | RNA binding | 23.6842 | 4 | no |
| GO:0016791 | phosphatase activity | 13.1579 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 13.1579 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 7.8947 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 2A5D_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.7895 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.8947 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.2632 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.6316 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 47.3684 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 44.7368 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.4737 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.4737 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 39.4737 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.8421 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.8421 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.8421 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.2105 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 34.2105 | 6 | yes |
| GO:0036211 | protein modification process | 34.2105 | 4 | yes |
| GO:0043412 | macromolecule modification | 34.2105 | 4 | yes |
| GO:0008104 | protein localization | 34.2105 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.5789 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 31.5789 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 31.5789 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.5789 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.9474 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9474 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.9474 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.9474 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.9474 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.3158 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 26.3158 | 7 | yes |
| GO:0022607 | cellular component assembly | 26.3158 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.3158 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 26.3158 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.3158 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.3158 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.3158 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.3158 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.6842 | 7 | yes |
| GO:0042325 | regulation of phosphorylation | 23.6842 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 23.6842 | 6 | yes |
| GO:0051049 | regulation of transport | 23.6842 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 23.6842 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.0526 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 21.0526 | 5 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.0526 | 7 | yes |
| GO:0006996 | organelle organization | 21.0526 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | no |
| GO:0043393 | regulation of protein binding | 21.0526 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.0526 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.0526 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.0526 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 21.0526 | 7 | no |
| GO:0030111 | regulation of Wnt signaling pathway | 21.0526 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.0526 | 6 | no |
| GO:0042176 | regulation of protein catabolic process | 21.0526 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.0526 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.0526 | 5 | no |
| GO:0031400 | negative regulation of protein modification process | 18.4211 | 7 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 15.7895 | 6 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 15.7895 | 7 | yes |
| GO:0006470 | protein dephosphorylation | 13.1579 | 5 | yes |
| GO:0016311 | dephosphorylation | 13.1579 | 5 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 10.5263 | 8 | yes |
| GO:0035303 | regulation of dephosphorylation | 10.5263 | 7 | yes |
| GO:0035304 | regulation of protein dephosphorylation | 10.5263 | 7 | yes |
| GO:0042326 | negative regulation of phosphorylation | 10.5263 | 8 | yes |
| GO:0007399 | nervous system development | 5.2632 | 4 | yes |
| GO:0035306 | positive regulation of dephosphorylation | 5.2632 | 8 | yes |
| GO:0035307 | positive regulation of protein dephosphorylation | 5.2632 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| M3K3_HUMAN | [view interactions] | Low throughput | no | no |
| HAND2_HUMAN | [view interactions] | Low throughput | no | yes |
| HAND1_HUMAN | [view interactions] | Low throughput | no | yes |
| BUB1B_HUMAN | [view interactions] | Low throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL2_HUMAN | [view interactions] | Low throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | Low throughput | no | yes |
| SGO1_HUMAN | [view interactions] | Low throughput | no | no |
| CHK2_HUMAN | [view interactions] | Low throughput | no | yes |
| SGO2_HUMAN | [view interactions] | Low throughput | no | no |
| DZIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 2AAB_HUMAN | [view interactions] | Low throughput | no | yes |
| MPIP3_HUMAN | [view interactions] | Low throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FSD2_HUMAN | [view interactions] | High throughput | no | no |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| DYDC1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| DEC1_HUMAN | [view interactions] | High throughput | no | no |
| BCAT1_HUMAN | [view interactions] | High throughput | no | no |
| DNS2B_HUMAN | [view interactions] | High throughput | no | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| FA43A_HUMAN | [view interactions] | High throughput | no | no |
| WNT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNG1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| PRR14_HUMAN | [view interactions] | High throughput | no | no |
| CCNG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEL3A_HUMAN | [view interactions] | High throughput | no | no |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| FBXL3_HUMAN | [view interactions] | High throughput | no | no |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD6_HUMAN | [view interactions] | High throughput | no | yes |
| RS27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| GALD1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
| LHPL2_HUMAN | [view interactions] | High throughput | no | no |
| FOXF1_HUMAN | [view interactions] | High throughput | no | no |
| DNJB7_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAD9B_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| TTC27_HUMAN | [view interactions] | High throughput | no | yes |
| RDH8_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN18_HUMAN | [view interactions] | High throughput | no | yes |
| VWA2_HUMAN | [view interactions] | High throughput | no | no |
| KLH14_HUMAN | [view interactions] | High throughput | no | yes |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| FEN1_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| XPO6_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| ICAL_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| DCNL5_HUMAN | [view interactions] | High throughput | no | yes |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC12_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BHE40_HUMAN | [view interactions] | High throughput | no | yes |
| RORG_HUMAN | [view interactions] | High throughput | no | no |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD61_HUMAN | [view interactions] | High throughput | no | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDC1_HUMAN | [view interactions] | High throughput | no | no |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |