Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

2A5D_HUMAN

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in 2A5D_HUMAN
GO:0017076 purine nucleotide binding 44.9275 4 no
GO:0032555 purine ribonucleotide binding 42.0290 4 no
GO:0030554 adenyl nucleotide binding 39.1304 5 no
GO:0032559 adenyl ribonucleotide binding 36.2319 5 no
GO:0035639 purine ribonucleoside triphosphate binding 36.2319 4 no
GO:0016301 kinase activity 30.4348 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.4348 4 no
GO:0005524 ATP binding 30.4348 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 28.9855 4 no
GO:0019900 kinase binding 24.6377 4 no
GO:0019901 protein kinase binding 24.6377 5 no
GO:0004674 protein serine/threonine kinase activity 23.1884 4 no
GO:0046872 metal ion binding 21.7391 4 no
GO:0106310 protein serine kinase activity 21.7391 4 no
GO:0016791 phosphatase activity 10.1449 5 yes
GO:0042578 phosphoric ester hydrolase activity 10.1449 4 yes
GO:0019888 protein phosphatase regulator activity 4.3478 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 2A5D_HUMAN
GO:0060255 regulation of macromolecule metabolic process 76.8116 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 75.3623 4 yes
GO:0080090 regulation of primary metabolic process 75.3623 4 yes
GO:0051246 regulation of protein metabolic process 72.4638 5 yes
GO:0048522 positive regulation of cellular process 71.0145 4 yes
GO:0031323 regulation of cellular metabolic process 69.5652 4 yes
GO:0048523 negative regulation of cellular process 69.5652 4 no
GO:0010646 regulation of cell communication 65.2174 4 no
GO:0031399 regulation of protein modification process 59.4203 6 yes
GO:0019220 regulation of phosphate metabolic process 56.5217 6 yes
GO:0051174 regulation of phosphorus metabolic process 56.5217 5 yes
GO:0009966 regulation of signal transduction 56.5217 4 no
GO:0010468 regulation of gene expression 55.0725 5 no
GO:0009893 positive regulation of metabolic process 53.6232 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 52.1739 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 52.1739 5 yes
GO:0051247 positive regulation of protein metabolic process 52.1739 6 yes
GO:0001932 regulation of protein phosphorylation 50.7246 7 no
GO:0042325 regulation of phosphorylation 50.7246 7 no
GO:0051128 regulation of cellular component organization 50.7246 4 no
GO:0031325 positive regulation of cellular metabolic process 47.8261 5 yes
GO:0036211 protein modification process 46.3768 4 yes
GO:0043412 macromolecule modification 46.3768 4 yes
GO:0009889 regulation of biosynthetic process 44.9275 4 no
GO:0009892 negative regulation of metabolic process 44.9275 4 no
GO:0031326 regulation of cellular biosynthetic process 44.9275 5 no
GO:0010556 regulation of macromolecule biosynthetic process 43.4783 5 no
GO:0010605 negative regulation of macromolecule metabolic process 43.4783 5 no
GO:0031401 positive regulation of protein modification process 40.5797 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 40.5797 5 no
GO:0051248 negative regulation of protein metabolic process 40.5797 6 no
GO:0006796 phosphate-containing compound metabolic process 39.1304 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 39.1304 6 yes
GO:0045937 positive regulation of phosphate metabolic process 39.1304 7 yes
GO:0001934 positive regulation of protein phosphorylation 37.6812 8 no
GO:0042327 positive regulation of phosphorylation 37.6812 8 no
GO:0010647 positive regulation of cell communication 37.6812 5 no
GO:0023056 positive regulation of signaling 37.6812 4 no
GO:0048584 positive regulation of response to stimulus 37.6812 4 no
GO:0051049 regulation of transport 37.6812 4 no
GO:0010941 regulation of cell death 36.2319 4 no
GO:0051130 positive regulation of cellular component organization 36.2319 5 no
GO:0031324 negative regulation of cellular metabolic process 34.7826 5 no
GO:0048585 negative regulation of response to stimulus 34.7826 4 no
GO:1902531 regulation of intracellular signal transduction 34.7826 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0006355 regulation of DNA-templated transcription 31.8841 6 no
GO:0031400 negative regulation of protein modification process 31.8841 7 no
GO:0043085 positive regulation of catalytic activity 31.8841 4 no
GO:0051252 regulation of RNA metabolic process 31.8841 5 no
GO:1903506 regulation of nucleic acid-templated transcription 31.8841 7 no
GO:2001141 regulation of RNA biosynthetic process 31.8841 6 no
GO:0009967 positive regulation of signal transduction 31.8841 5 no
GO:0060341 regulation of cellular localization 31.8841 4 no
GO:0042981 regulation of apoptotic process 31.8841 6 no
GO:0043067 regulation of programmed cell death 31.8841 5 no
GO:0071310 cellular response to organic substance 31.8841 4 no
GO:0080134 regulation of response to stress 31.8841 4 no
GO:1901701 cellular response to oxygen-containing compound 31.8841 4 no
GO:0009968 negative regulation of signal transduction 28.9855 5 no
GO:0010648 negative regulation of cell communication 28.9855 5 no
GO:0023057 negative regulation of signaling 28.9855 4 no
GO:0006468 protein phosphorylation 28.9855 5 no
GO:0016310 phosphorylation 28.9855 5 no
GO:0010243 response to organonitrogen compound 28.9855 4 no
GO:0009891 positive regulation of biosynthetic process 28.9855 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.9855 6 no
GO:0042127 regulation of cell population proliferation 27.5362 4 no
GO:0051094 positive regulation of developmental process 27.5362 4 no
GO:0050804 modulation of chemical synaptic transmission 27.5362 5 no
GO:0099177 regulation of trans-synaptic signaling 27.5362 4 no
GO:0006996 organelle organization 27.5362 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.5362 6 no
GO:0043549 regulation of kinase activity 26.0870 5 no
GO:0045859 regulation of protein kinase activity 26.0870 6 no
GO:0022607 cellular component assembly 26.0870 4 no
GO:0051336 regulation of hydrolase activity 26.0870 4 no
GO:0043086 negative regulation of catalytic activity 26.0870 4 no
GO:0032880 regulation of protein localization 26.0870 5 no
GO:0060548 negative regulation of cell death 26.0870 5 no
GO:0010563 negative regulation of phosphorus metabolic process 24.6377 6 no
GO:0045936 negative regulation of phosphate metabolic process 24.6377 7 no
GO:0018193 peptidyl-amino acid modification 24.6377 5 no
GO:2000145 regulation of cell motility 24.6377 4 no
GO:0008104 protein localization 24.6377 4 no
GO:0009894 regulation of catabolic process 24.6377 4 no
GO:0030162 regulation of proteolysis 24.6377 6 no
GO:0051726 regulation of cell cycle 23.1884 4 no
GO:0010628 positive regulation of gene expression 23.1884 6 no
GO:0031344 regulation of cell projection organization 23.1884 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.1884 6 no
GO:0051129 negative regulation of cellular component organization 23.1884 5 no
GO:0071417 cellular response to organonitrogen compound 23.1884 4 no
GO:0080135 regulation of cellular response to stress 23.1884 4 no
GO:1901699 cellular response to nitrogen compound 23.1884 4 no
GO:0010638 positive regulation of organelle organization 23.1884 6 no
GO:0051493 regulation of cytoskeleton organization 23.1884 6 no
GO:0044087 regulation of cellular component biogenesis 23.1884 4 no
GO:0030334 regulation of cell migration 21.7391 5 no
GO:0045597 positive regulation of cell differentiation 21.7391 5 no
GO:0006357 regulation of transcription by RNA polymerase II 21.7391 7 no
GO:0043066 negative regulation of apoptotic process 21.7391 7 no
GO:0043069 negative regulation of programmed cell death 21.7391 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.7391 6 no
GO:0043408 regulation of MAPK cascade 21.7391 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.7391 6 no
GO:0001933 negative regulation of protein phosphorylation 20.2899 8 no
GO:0030155 regulation of cell adhesion 20.2899 4 no
GO:0042326 negative regulation of phosphorylation 20.2899 8 no
GO:0051240 positive regulation of multicellular organismal process 20.2899 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 20.2899 4 no
GO:0030335 positive regulation of cell migration 20.2899 6 no
GO:0040017 positive regulation of locomotion 20.2899 4 no
GO:0045862 positive regulation of proteolysis 20.2899 7 no
GO:0045893 positive regulation of DNA-templated transcription 20.2899 7 no
GO:0051254 positive regulation of RNA metabolic process 20.2899 6 no
GO:1902680 positive regulation of RNA biosynthetic process 20.2899 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 20.2899 8 no
GO:2000147 positive regulation of cell motility 20.2899 5 no
GO:0060627 regulation of vesicle-mediated transport 20.2899 4 no
GO:0010942 positive regulation of cell death 20.2899 5 no
GO:0035303 regulation of dephosphorylation 10.1449 7 yes
GO:0006470 protein dephosphorylation 8.6957 5 yes
GO:0016311 dephosphorylation 8.6957 5 yes
GO:0035304 regulation of protein dephosphorylation 8.6957 7 yes
GO:0007399 nervous system development 4.3478 4 yes
GO:0035306 positive regulation of dephosphorylation 4.3478 8 yes
GO:0035307 positive regulation of protein dephosphorylation 2.8986 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in 2A5D_HUMAN
DOID:0050686 organ system cancer 2.8986 3 no
DOID:0050700 cardiomyopathy 2.8986 4 no
DOID:0060036 intrinsic cardiomyopathy 2.8986 5 no
DOID:114 heart disease 2.8986 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLK1_HUMAN [view interactions] Low throughput no yes
ARL2_HUMAN [view interactions] Low throughput no yes
2A5A_HUMAN [view interactions] Low throughput no yes
SGO1_HUMAN [view interactions] Low throughput no no
CHK2_HUMAN [view interactions] Low throughput no yes
SGO2_HUMAN [view interactions] Low throughput no no
DZIP1_HUMAN [view interactions] Low throughput no yes
2AAB_HUMAN [view interactions] Low throughput no yes
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
MPIP3_HUMAN [view interactions] Low throughput no yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K3_HUMAN [view interactions] Low throughput no no
HAND2_HUMAN [view interactions] Low throughput no yes
HAND1_HUMAN [view interactions] Low throughput no yes
BUB1B_HUMAN [view interactions] Low throughput no no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
TEBP_HUMAN [view interactions] High throughput no yes
TTC27_HUMAN [view interactions] High throughput no yes
RDH8_HUMAN [view interactions] High throughput no no
TGM2_HUMAN [view interactions] High throughput no no
LURA1_HUMAN [view interactions] High throughput no yes
DRA_HUMAN [view interactions] High throughput no no
PAIRB_HUMAN [view interactions] High throughput no yes
PTN18_HUMAN [view interactions] High throughput no yes
VWA2_HUMAN [view interactions] High throughput no no
KLH14_HUMAN [view interactions] High throughput no yes
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
NTNG1_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
FKBP5_HUMAN [view interactions] High throughput no yes
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
NIF3L_HUMAN [view interactions] High throughput no yes
ARC1B_HUMAN [view interactions] High throughput no no
DHYS_HUMAN [view interactions] High throughput no no
FEN1_HUMAN [view interactions] High throughput no yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
HECD1_HUMAN [view interactions] High throughput no yes
LPP_HUMAN [view interactions] High throughput no yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
TPD54_HUMAN [view interactions] High throughput no yes
DAAF5_HUMAN [view interactions] High throughput no no
SYLC_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
2ABA_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
RIR2_HUMAN [view interactions] High throughput no no
XPO6_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A2_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
DPPA3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
DJC12_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
NEK1_HUMAN [view interactions] High throughput no yes
CLOCK_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
BHE40_HUMAN [view interactions] High throughput no yes
RORG_HUMAN [view interactions] High throughput no no
CRY2_HUMAN [view interactions] High throughput no yes
CRY1_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AB_HUMAN [view interactions] High throughput no yes
PP4C_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD61_HUMAN [view interactions] High throughput no yes
PXDC1_HUMAN [view interactions] High throughput no no
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
DUS19_HUMAN [view interactions] High throughput no yes
MD2L1_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
FSD2_HUMAN [view interactions] High throughput no no
USBP1_HUMAN [view interactions] High throughput no no
DYDC1_HUMAN [view interactions] High throughput no no
TANK_HUMAN [view interactions] High throughput no yes
DEC1_HUMAN [view interactions] High throughput no no
BCAT1_HUMAN [view interactions] High throughput no no
DNS2B_HUMAN [view interactions] High throughput no no
PPME1_HUMAN [view interactions] High throughput no yes
FA43A_HUMAN [view interactions] High throughput no no
WNT3A_HUMAN [view entry] [view interactions] High throughput yes no
PON2_HUMAN [view interactions] High throughput no yes
CCNG1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
CTR9_HUMAN [view interactions] High throughput no yes
CCHCR_HUMAN [view interactions] High throughput no no
PRR14_HUMAN [view interactions] High throughput no no
CCNG2_HUMAN [view entry] [view interactions] High throughput yes yes
CEL3A_HUMAN [view interactions] High throughput no no
RPGF5_HUMAN [view interactions] High throughput no yes
UBP47_HUMAN [view interactions] High throughput no yes
FBXL3_HUMAN [view interactions] High throughput no no
YBEY_HUMAN [view interactions] High throughput no yes
BTBD6_HUMAN [view interactions] High throughput no yes
RS27_HUMAN [view entry] [view interactions] High throughput yes no
GPR37_HUMAN [view interactions] High throughput no no
GALD1_HUMAN [view interactions] High throughput no yes
BMP7_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] High throughput yes yes
IDD_HUMAN [view interactions] High throughput no no
SPRY7_HUMAN [view interactions] High throughput no yes
LHPL2_HUMAN [view interactions] High throughput no no
FOXF1_HUMAN [view interactions] High throughput no no
DNJB7_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
RAD9B_HUMAN [view interactions] High throughput no no
S39A7_HUMAN [view interactions] High throughput no yes
GPR17_HUMAN [view interactions] High throughput no no
TPGS1_HUMAN [view interactions] High throughput no no
CDK1_HUMAN [view interactions] Computational no no
KS6B1_HUMAN [view entry] [view interactions] Computational yes yes
DVL2_HUMAN [view interactions] Computational no yes
WNT8B_HUMAN [view interactions] Computational no no
P2R3A_HUMAN [view interactions] Computational no yes
2ABB_HUMAN [view interactions] Computational no yes
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
TGFB2_HUMAN [view interactions] Computational no no
PTPA_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
ARRB1_HUMAN [view entry] [view interactions] Computational yes yes
F261_HUMAN [view interactions] Computational no no
CND1_HUMAN [view interactions] Computational no yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
KAP0_HUMAN [view entry] [view interactions] Computational yes yes
TERT_HUMAN [view interactions] Computational no no
PKN1_HUMAN [view entry] [view interactions] Computational yes yes
KPCE_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
TGFB3_HUMAN [view interactions] Computational no no
P2R3C_HUMAN [view interactions] Computational no yes
AAKG1_HUMAN [view interactions] Computational no no
KAP3_HUMAN [view entry] [view interactions] Computational yes yes
FRAT2_HUMAN [view interactions] Computational no no
AKAP9_HUMAN [view entry] [view interactions] Computational yes yes
IF4G1_HUMAN [view entry] [view interactions] Computational yes yes
INSR_HUMAN [view interactions] Computational no yes
INS_HUMAN [view interactions] Computational no no
DVL3_HUMAN [view interactions] Computational no yes
SYUA_HUMAN [view entry] [view interactions] Computational yes no
LCK_HUMAN [view entry] [view interactions] Computational yes no
AURKB_HUMAN [view interactions] Computational no yes
MARK3_HUMAN [view interactions] Computational no yes
MLXPL_HUMAN [view interactions] Computational no no
IF4E_HUMAN [view entry] [view interactions] Computational yes yes
FRAT1_HUMAN [view interactions] Computational no yes
LRP6_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
4EBP1_HUMAN [view entry] [view interactions] Computational yes yes
TY3H_HUMAN [view interactions] Computational no no
YES_HUMAN [view entry] [view interactions] Computational yes yes
P2R3B_HUMAN [view interactions] Computational no no
TEP1_HUMAN [view interactions] Computational no no
RASN_HUMAN [view entry] [view interactions] Computational yes no
AKAP8_HUMAN [view interactions] Computational no yes
TGFR1_HUMAN [view interactions] Computational no no
AKT3_HUMAN [view interactions] Computational no yes
LYN_HUMAN [view entry] [view interactions] Computational yes no
KSR1_HUMAN [view interactions] Computational no yes
2ABG_HUMAN [view interactions] Computational no yes
MK07_HUMAN [view interactions] Computational no yes
MEA1_HUMAN [view interactions] Computational no no
AXIN1_HUMAN [view interactions] Computational no yes
TGFR2_HUMAN [view interactions] Computational no no
PP1G_HUMAN [view entry] [view interactions] Computational yes yes
EGFR_HUMAN [view interactions] Computational no no
RAF1_HUMAN [view entry] [view interactions] Computational yes no
NKD1_HUMAN [view interactions] Computational no no
KAP2_HUMAN [view entry] [view interactions] Computational yes yes
CACB4_HUMAN [view entry] [view interactions] Computational yes yes
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
LRP5_HUMAN [view interactions] Computational no yes
FZD2_HUMAN [view interactions] Computational no no
PPR1B_HUMAN [view entry] [view interactions] Computational yes yes
APC_HUMAN [view entry] [view interactions] Computational yes no
MP2K7_HUMAN [view entry] [view interactions] Computational yes yes
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
MTOR_HUMAN [view entry] [view interactions] Computational yes yes
AURKA_HUMAN [view entry] [view interactions] Computational yes no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
FZD1_HUMAN [view interactions] Computational no yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
KLDC3_HUMAN [view interactions] Computational no yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
KAP1_HUMAN [view entry] [view interactions] Computational yes yes
MP2K4_HUMAN [view interactions] Computational no yes
PROC_HUMAN [view interactions] Computational no no
EGF_HUMAN [view interactions] Computational no no
IF4A1_HUMAN [view interactions] Computational no no
REC8_HUMAN [view interactions] Computational no yes
MAP1B_HUMAN [view entry] [view interactions] Computational yes yes
WNT1_HUMAN [view interactions] Computational no no