Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DCC_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
793 Val Gly Mirrormovements1(MRMV1) -
805 Gly Glu Mirrormovements1(MRMV1) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI001102 DEG_SIAH_1 DEG 1331 1339 -
ELMI003302 DOC_MAPK_DCC_7 DOC 1146 1155 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DCC_HUMAN
GO:0003723 RNA binding 40.4255 4 no
GO:0017076 purine nucleotide binding 34.0426 4 no
GO:0032555 purine ribonucleotide binding 34.0426 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.9149 4 no
GO:0030554 adenyl nucleotide binding 27.6596 5 no
GO:0032559 adenyl ribonucleotide binding 27.6596 5 no
GO:0019900 kinase binding 25.5319 4 no
GO:0019901 protein kinase binding 25.5319 5 no
GO:0005524 ATP binding 25.5319 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.2766 4 no
GO:0016301 kinase activity 21.2766 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.2766 4 no
GO:0005042 netrin receptor activity 4.2553 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DCC_HUMAN
GO:0048522 positive regulation of cellular process 61.7021 4 no
GO:0060255 regulation of macromolecule metabolic process 59.5745 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.4468 4 no
GO:0080090 regulation of primary metabolic process 57.4468 4 no
GO:0048523 negative regulation of cellular process 55.3191 4 yes
GO:0031323 regulation of cellular metabolic process 55.3191 4 no
GO:0051246 regulation of protein metabolic process 53.1915 5 no
GO:0009893 positive regulation of metabolic process 48.9362 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.9362 5 no
GO:0010646 regulation of cell communication 48.9362 4 yes
GO:0010468 regulation of gene expression 46.8085 5 no
GO:0051128 regulation of cellular component organization 44.6809 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 44.6809 5 no
GO:0051247 positive regulation of protein metabolic process 42.5532 6 no
GO:0009889 regulation of biosynthetic process 40.4255 4 no
GO:0009966 regulation of signal transduction 40.4255 4 no
GO:0031326 regulation of cellular biosynthetic process 40.4255 5 no
GO:0031325 positive regulation of cellular metabolic process 38.2979 5 no
GO:0022603 regulation of anatomical structure morphogenesis 36.1702 4 yes
GO:0051049 regulation of transport 34.0426 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.0426 5 no
GO:1902531 regulation of intracellular signal transduction 34.0426 5 no
GO:0033043 regulation of organelle organization 34.0426 5 no
GO:0071310 cellular response to organic substance 31.9149 4 no
GO:0031399 regulation of protein modification process 31.9149 6 no
GO:0048584 positive regulation of response to stimulus 31.9149 4 no
GO:0022607 cellular component assembly 31.9149 4 no
GO:0031344 regulation of cell projection organization 29.7872 5 yes
GO:0045595 regulation of cell differentiation 29.7872 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.7872 6 yes
GO:0010628 positive regulation of gene expression 29.7872 6 no
GO:0051130 positive regulation of cellular component organization 29.7872 5 no
GO:0009059 macromolecule biosynthetic process 29.7872 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 29.7872 4 no
GO:0019220 regulation of phosphate metabolic process 29.7872 6 no
GO:0042325 regulation of phosphorylation 29.7872 7 no
GO:0051174 regulation of phosphorus metabolic process 29.7872 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 27.6596 4 no
GO:0030334 regulation of cell migration 27.6596 5 no
GO:0060341 regulation of cellular localization 27.6596 4 no
GO:0080134 regulation of response to stress 27.6596 4 no
GO:2000145 regulation of cell motility 27.6596 4 no
GO:0006412 translation 27.6596 4 no
GO:0006518 peptide metabolic process 27.6596 4 no
GO:0009892 negative regulation of metabolic process 27.6596 4 no
GO:0034645 cellular macromolecule biosynthetic process 27.6596 4 no
GO:0042127 regulation of cell population proliferation 27.6596 4 no
GO:0043043 peptide biosynthetic process 27.6596 5 no
GO:0043603 cellular amide metabolic process 27.6596 4 no
GO:0043604 amide biosynthetic process 27.6596 5 no
GO:0051338 regulation of transferase activity 27.6596 4 no
GO:1901566 organonitrogen compound biosynthetic process 27.6596 4 no
GO:0001932 regulation of protein phosphorylation 27.6596 7 no
GO:0010562 positive regulation of phosphorus metabolic process 27.6596 6 no
GO:0042327 positive regulation of phosphorylation 27.6596 8 no
GO:0045937 positive regulation of phosphate metabolic process 27.6596 7 no
GO:0010941 regulation of cell death 25.5319 4 yes
GO:0030030 cell projection organization 25.5319 4 yes
GO:0002181 cytoplasmic translation 25.5319 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.5319 5 no
GO:0010647 positive regulation of cell communication 25.5319 5 no
GO:0023056 positive regulation of signaling 25.5319 4 no
GO:0006796 phosphate-containing compound metabolic process 25.5319 4 no
GO:0044087 regulation of cellular component biogenesis 25.5319 4 no
GO:0001934 positive regulation of protein phosphorylation 25.5319 8 no
GO:0006996 organelle organization 25.5319 4 no
GO:0031401 positive regulation of protein modification process 25.5319 7 no
GO:0051129 negative regulation of cellular component organization 23.4043 5 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 23.4043 5 no
GO:0009891 positive regulation of biosynthetic process 23.4043 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.4043 6 no
GO:0032101 regulation of response to external stimulus 23.4043 4 no
GO:0060627 regulation of vesicle-mediated transport 23.4043 4 no
GO:0009894 regulation of catabolic process 23.4043 4 no
GO:0009967 positive regulation of signal transduction 23.4043 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.4043 5 no
GO:0031324 negative regulation of cellular metabolic process 23.4043 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.4043 5 no
GO:1901701 cellular response to oxygen-containing compound 23.4043 4 no
GO:0002684 positive regulation of immune system process 23.4043 4 no
GO:0030335 positive regulation of cell migration 23.4043 6 no
GO:0040017 positive regulation of locomotion 23.4043 4 no
GO:2000147 positive regulation of cell motility 23.4043 5 no
GO:0032386 regulation of intracellular transport 23.4043 5 no
GO:0051493 regulation of cytoskeleton organization 23.4043 6 no
GO:0043085 positive regulation of catalytic activity 23.4043 4 no
GO:0036211 protein modification process 23.4043 4 no
GO:0043412 macromolecule modification 23.4043 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.2766 5 yes
GO:0050776 regulation of immune response 21.2766 4 no
GO:0008284 positive regulation of cell population proliferation 21.2766 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.2766 6 no
GO:0051094 positive regulation of developmental process 21.2766 4 no
GO:0022604 regulation of cell morphogenesis 21.2766 5 no
GO:0030155 regulation of cell adhesion 21.2766 4 no
GO:0007010 cytoskeleton organization 21.2766 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.2766 6 no
GO:0051347 positive regulation of transferase activity 21.2766 5 no
GO:0006468 protein phosphorylation 21.2766 5 no
GO:0016310 phosphorylation 21.2766 5 no
GO:0010975 regulation of neuron projection development 17.0213 7 yes
GO:0031175 neuron projection development 17.0213 6 yes
GO:0032990 cell part morphogenesis 17.0213 4 yes
GO:0048812 neuron projection morphogenesis 17.0213 7 yes
GO:0048858 cell projection morphogenesis 17.0213 5 yes
GO:0050804 modulation of chemical synaptic transmission 17.0213 5 yes
GO:0060284 regulation of cell development 17.0213 5 yes
GO:0099177 regulation of trans-synaptic signaling 17.0213 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 17.0213 6 yes
GO:1901214 regulation of neuron death 14.8936 5 yes
GO:2000026 regulation of multicellular organismal development 14.8936 4 yes
GO:0006915 apoptotic process 14.8936 4 yes
GO:0045596 negative regulation of cell differentiation 12.7660 5 yes
GO:0050770 regulation of axonogenesis 12.7660 5 yes
GO:0051093 negative regulation of developmental process 12.7660 4 yes
GO:0097485 neuron projection guidance 12.7660 7 yes
GO:0001558 regulation of cell growth 12.7660 4 yes
GO:0001764 neuron migration 12.7660 4 yes
GO:0007411 axon guidance 12.7660 8 yes
GO:0048638 regulation of developmental growth 10.6383 4 yes
GO:0050767 regulation of neurogenesis 10.6383 6 yes
GO:0051241 negative regulation of multicellular organismal process 10.6383 4 yes
GO:0051960 regulation of nervous system development 10.6383 5 yes
GO:0031345 negative regulation of cell projection organization 8.5106 6 yes
GO:0061387 regulation of extent of cell growth 8.5106 5 yes
GO:0010977 negative regulation of neuron projection development 6.3830 7 yes
GO:0050773 regulation of dendrite development 6.3830 4 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 6.3830 6 yes
GO:0007409 axonogenesis 6.3830 8 yes
GO:0021952 central nervous system projection neuron axonogenesis 4.2553 10 yes
GO:0021955 central nervous system neuron axonogenesis 4.2553 9 yes
GO:0021965 spinal cord ventral commissure morphogenesis 4.2553 11 yes
GO:0030308 negative regulation of cell growth 4.2553 5 yes
GO:0033563 dorsal/ventral axon guidance 4.2553 9 yes
GO:0033564 anterior/posterior axon guidance 4.2553 9 yes
GO:0045926 negative regulation of growth 4.2553 4 yes
GO:0048640 negative regulation of developmental growth 4.2553 5 yes
GO:0048670 regulation of collateral sprouting 4.2553 5 yes
GO:0048671 negative regulation of collateral sprouting 4.2553 6 yes
GO:0050768 negative regulation of neurogenesis 4.2553 6 yes
GO:0050771 negative regulation of axonogenesis 4.2553 6 yes
GO:0051961 negative regulation of nervous system development 4.2553 5 yes
GO:2000171 negative regulation of dendrite development 4.2553 5 yes
GO:0010721 negative regulation of cell development 4.2553 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in DCC_HUMAN
DOID:0060038 specific developmental disorder 4.2553 3 no
DOID:0060307 autosomal dominant intellectual developmental disorder 4.2553 5 no
DOID:1059 intellectual disability 4.2553 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SIAH1_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] Low throughput no no
CASP3_HUMAN [view interactions] Low throughput no yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
DP13A_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH2_HUMAN [view interactions] Low throughput no no
NCK1_HUMAN [view interactions] Low throughput no yes
IF4E_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] Low throughput yes no
TRI67_HUMAN [view interactions] Low throughput no no
DRAXI_HUMAN [view interactions] Low throughput no no
MAZ_HUMAN [view interactions] Low throughput no yes
DSCAM_HUMAN [view interactions] Low throughput no yes
DCC_HUMAN [view entry] [view interactions] Low throughput yes yes
ROBO1_HUMAN [view interactions] Low throughput no yes
MYO10_HUMAN [view interactions] Low throughput no no
AGAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
UNC5B_HUMAN [view interactions] Low throughput no yes
CASP9_HUMAN [view interactions] Low throughput no yes
RL5_HUMAN [view entry] [view interactions] Low throughput yes yes
NET4_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
MOES_HUMAN [view entry] [view interactions] Low throughput yes no
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
NET1_HUMAN [view interactions] Low throughput no no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
RL28_HUMAN [view entry] [view interactions] Low throughput yes yes
EIF2A_HUMAN [view interactions] Low throughput no yes
ITB5_HUMAN [view interactions] Low throughput no yes
RS6_HUMAN [view entry] [view interactions] Low throughput yes yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
BARD1_HUMAN [view interactions] High throughput no yes
IF1AX_HUMAN [view interactions] High throughput no yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
REEP6_HUMAN [view interactions] High throughput no no
ADA17_HUMAN [view interactions] High throughput no yes
CNO6L_HUMAN [view interactions] High throughput no no
PHOS_HUMAN [view interactions] High throughput no no
LHX3_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
APC_HUMAN [view entry] [view interactions] High throughput yes no
IFNL3_HUMAN [view interactions] High throughput no no
I10R1_HUMAN [view interactions] High throughput no no
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E3_HUMAN [view interactions] High throughput no no
IF2B_HUMAN [view interactions] High throughput no yes
IF5A2_HUMAN [view interactions] High throughput no yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BA_HUMAN [view interactions] High throughput no yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
IF2G_HUMAN [view interactions] High throughput no yes
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
RL10A_HUMAN [view entry] [view interactions] High throughput yes yes
EI2BD_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOB_HUMAN [view interactions] High throughput no no
AN32B_HUMAN [view interactions] High throughput no yes
TRMO_HUMAN [view interactions] High throughput no no
TSTD2_HUMAN [view interactions] High throughput no yes
CATL2_HUMAN [view interactions] High throughput no yes
COR2A_HUMAN [view entry] [view interactions] High throughput yes no
F16P1_HUMAN [view interactions] High throughput no no
HEMGN_HUMAN [view interactions] High throughput no no
MAPK3_HUMAN [view interactions] High throughput no no
RASA1_HUMAN [view interactions] High throughput no yes
TBD2A_HUMAN [view interactions] High throughput no yes
SFRP2_HUMAN [view interactions] High throughput no no
TDRD7_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
IF2A_HUMAN [view entry] [view interactions] High throughput yes yes
SLIT2_HUMAN [view interactions] Computational no no
YES_HUMAN [view entry] [view interactions] Computational yes yes
SLIT3_HUMAN [view interactions] Computational no yes
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
MP2K2_HUMAN [view entry] [view interactions] Computational yes yes
PIPNA_HUMAN [view entry] [view interactions] Computational yes no
UNC5D_HUMAN [view interactions] Computational no no
RAC1_HUMAN [view entry] [view interactions] Computational yes no
BCAR1_HUMAN [view interactions] Computational no yes
PLCG2_HUMAN [view interactions] Computational no yes
UNC5C_HUMAN [view interactions] Computational no no
DOCK1_HUMAN [view entry] [view interactions] Computational yes yes
PAK1_HUMAN [view entry] [view interactions] Computational yes yes
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
UNC5A_HUMAN [view interactions] Computational no no
SLIT1_HUMAN [view interactions] Computational no no
MAP1B_HUMAN [view entry] [view interactions] Computational yes yes
ELMO1_HUMAN [view interactions] Computational no no
ROBO3_HUMAN [view interactions] Computational no no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
TRIO_HUMAN [view entry] [view interactions] Computational yes yes
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes