DCC_HUMAN
Evidence for PS localization
Functions
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 793 | Val | Gly | Mirrormovements1(MRMV1) | - |
| 805 | Gly | Glu | Mirrormovements1(MRMV1) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001102 | DEG_SIAH_1 | DEG | 1331 | 1339 | - |
| ELMI003302 | DOC_MAPK_DCC_7 | DOC | 1146 | 1155 | - |
| ELMI004678 | LIG_FERM_MyoX_1 | LIG | 1425 | 1443 | - |
| ELMI001102 | DEG_SIAH_1 | DEG | 1331 | 1339 | - |
| ELMI003302 | DOC_MAPK_DCC_7 | DOC | 1146 | 1155 | - |
| ELMI004678 | LIG_FERM_MyoX_1 | LIG | 1425 | 1443 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DCC_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 52.9412 | 4 | no |
| GO:0019900 | kinase binding | 23.5294 | 4 | no |
| GO:0019901 | protein kinase binding | 20.5882 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DCC_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 58.8235 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.8824 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.8824 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 44.1176 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.1176 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.1176 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.1176 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 44.1176 | 5 | no |
| GO:0009059 | macromolecule biosynthetic process | 41.1765 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.1765 | 6 | no |
| GO:0010646 | regulation of cell communication | 38.2353 | 4 | yes |
| GO:0006412 | translation | 38.2353 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 38.2353 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | yes |
| GO:0002181 | cytoplasmic translation | 35.2941 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.2941 | 6 | no |
| GO:0022607 | cellular component assembly | 32.3529 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0009894 | regulation of catabolic process | 29.4118 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.4706 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.4706 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.4706 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 26.4706 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.5294 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.5882 | 4 | yes |
| GO:0030030 | cell projection organization | 20.5882 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 20.5882 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 20.5882 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 20.5882 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.5882 | 5 | yes |
| GO:0006417 | regulation of translation | 20.5882 | 6 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 20.5882 | 7 | no |
| GO:0010628 | positive regulation of gene expression | 20.5882 | 7 | no |
| GO:0031399 | regulation of protein modification process | 20.5882 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.5882 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.5882 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.5882 | 6 | no |
| GO:0008284 | positive regulation of cell population proliferation | 20.5882 | 5 | no |
| GO:0006996 | organelle organization | 20.5882 | 4 | no |
| GO:0008104 | protein localization | 20.5882 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.5882 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 20.5882 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.5882 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 20.5882 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.5882 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 17.6471 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 17.6471 | 5 | yes |
| GO:0006915 | apoptotic process | 14.7059 | 4 | yes |
| GO:0031175 | neuron projection development | 14.7059 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 14.7059 | 6 | yes |
| GO:0045596 | negative regulation of cell differentiation | 11.7647 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 11.7647 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 11.7647 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 11.7647 | 4 | yes |
| GO:0001558 | regulation of cell growth | 8.8235 | 4 | yes |
| GO:0001764 | neuron migration | 8.8235 | 4 | yes |
| GO:0007411 | axon guidance | 8.8235 | 8 | yes |
| GO:0010975 | regulation of neuron projection development | 8.8235 | 7 | yes |
| GO:0048812 | neuron projection morphogenesis | 8.8235 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 8.8235 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 8.8235 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 8.8235 | 5 | yes |
| GO:0060284 | regulation of cell development | 8.8235 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 8.8235 | 5 | yes |
| GO:0097485 | neuron projection guidance | 8.8235 | 7 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 8.8235 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 8.8235 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 8.8235 | 4 | yes |
| GO:0007409 | axonogenesis | 5.8824 | 6 | yes |
| GO:0010721 | negative regulation of cell development | 5.8824 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 5.8824 | 7 | yes |
| GO:0021952 | central nervous system projection neuron axonogenesis | 5.8824 | 8 | yes |
| GO:0021955 | central nervous system neuron axonogenesis | 5.8824 | 7 | yes |
| GO:0021965 | spinal cord ventral commissure morphogenesis | 5.8824 | 9 | yes |
| GO:0030308 | negative regulation of cell growth | 5.8824 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 5.8824 | 6 | yes |
| GO:0033563 | dorsal/ventral axon guidance | 5.8824 | 9 | yes |
| GO:0033564 | anterior/posterior axon guidance | 5.8824 | 9 | yes |
| GO:0045926 | negative regulation of growth | 5.8824 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 5.8824 | 5 | yes |
| GO:0048670 | regulation of collateral sprouting | 5.8824 | 5 | yes |
| GO:0048671 | negative regulation of collateral sprouting | 5.8824 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 5.8824 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 5.8824 | 6 | yes |
| GO:0050773 | regulation of dendrite development | 5.8824 | 4 | yes |
| GO:0051961 | negative regulation of nervous system development | 5.8824 | 5 | yes |
| GO:2000171 | negative regulation of dendrite development | 5.8824 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAZ_HUMAN | [view interactions] | Low throughput | no | yes |
| DSCAM_HUMAN | [view interactions] | Low throughput | no | yes |
| DCC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ROBO1_HUMAN | [view interactions] | Low throughput | no | yes |
| MYO10_HUMAN | [view interactions] | Low throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UNC5B_HUMAN | [view interactions] | Low throughput | no | yes |
| CASP9_HUMAN | [view interactions] | Low throughput | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NET4_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MOES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NET1_HUMAN | [view interactions] | Low throughput | no | no |
| RL28_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EIF2A_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB5_HUMAN | [view interactions] | Low throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| CASP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIAH2_HUMAN | [view interactions] | Low throughput | no | no |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| IF4E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRI67_HUMAN | [view interactions] | Low throughput | no | no |
| DRAXI_HUMAN | [view interactions] | Low throughput | no | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E3_HUMAN | [view interactions] | High throughput | no | no |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOB_HUMAN | [view interactions] | High throughput | no | no |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| TRMO_HUMAN | [view interactions] | High throughput | no | no |
| TSTD2_HUMAN | [view interactions] | High throughput | no | yes |
| COR2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| HEMGN_HUMAN | [view interactions] | High throughput | no | no |
| MAPK3_HUMAN | [view interactions] | High throughput | no | no |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| SFRP2_HUMAN | [view interactions] | High throughput | no | no |
| TBD2A_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| IF1AX_HUMAN | [view interactions] | High throughput | no | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| CNO6L_HUMAN | [view interactions] | High throughput | no | no |
| PHOS_HUMAN | [view interactions] | High throughput | no | no |
| LHX3_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFNL3_HUMAN | [view interactions] | High throughput | no | no |
| I10R1_HUMAN | [view interactions] | High throughput | no | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |