Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IF4G2_HUMAN

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in IF4G2_HUMAN
GO:0003723 RNA binding 55.1020 4 yes
GO:0017076 purine nucleotide binding 34.6939 4 no
GO:0032555 purine ribonucleotide binding 32.6531 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.6531 4 no
GO:0030554 adenyl nucleotide binding 30.6122 5 no
GO:0005524 ATP binding 28.5714 5 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0003743 translation initiation factor activity 22.4490 4 yes
GO:0045296 cadherin binding 22.4490 4 yes
GO:0016462 pyrophosphatase activity 20.4082 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.4082 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.4082 6 no
GO:0003729 mRNA binding 12.2449 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IF4G2_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 67.3469 4 yes
GO:0060255 regulation of macromolecule metabolic process 67.3469 4 yes
GO:0080090 regulation of primary metabolic process 67.3469 4 yes
GO:0031323 regulation of cellular metabolic process 65.3061 4 yes
GO:0048523 negative regulation of cellular process 65.3061 4 yes
GO:0048522 positive regulation of cellular process 63.2653 4 yes
GO:0051246 regulation of protein metabolic process 61.2245 5 yes
GO:0010468 regulation of gene expression 55.1020 5 yes
GO:0009889 regulation of biosynthetic process 51.0204 4 yes
GO:0031326 regulation of cellular biosynthetic process 51.0204 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 48.9796 5 yes
GO:0010646 regulation of cell communication 46.9388 4 no
GO:0009893 positive regulation of metabolic process 46.9388 4 yes
GO:0009892 negative regulation of metabolic process 44.8980 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.8980 5 yes
GO:0022607 cellular component assembly 42.8571 4 no
GO:0009966 regulation of signal transduction 40.8163 4 no
GO:0051128 regulation of cellular component organization 40.8163 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 40.8163 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 40.8163 5 no
GO:0031324 negative regulation of cellular metabolic process 38.7755 5 yes
GO:0031325 positive regulation of cellular metabolic process 38.7755 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 38.7755 5 no
GO:0009894 regulation of catabolic process 36.7347 4 yes
GO:0051247 positive regulation of protein metabolic process 36.7347 6 yes
GO:0010941 regulation of cell death 34.6939 4 no
GO:0043067 regulation of programmed cell death 32.6531 5 no
GO:0043933 protein-containing complex organization 32.6531 4 no
GO:0042981 regulation of apoptotic process 30.6122 6 no
GO:0051248 negative regulation of protein metabolic process 30.6122 6 no
GO:0006996 organelle organization 30.6122 4 no
GO:0006417 regulation of translation 30.6122 6 yes
GO:0010608 post-transcriptional regulation of gene expression 30.6122 6 yes
GO:0010628 positive regulation of gene expression 30.6122 6 yes
GO:0034248 regulation of cellular amide metabolic process 30.6122 5 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 30.6122 6 yes
GO:0008104 protein localization 30.6122 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.6122 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 yes
GO:0051726 regulation of cell cycle 28.5714 4 yes
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:1903506 regulation of nucleic acid-templated transcription 26.5306 7 no
GO:2001141 regulation of RNA biosynthetic process 26.5306 6 no
GO:1902531 regulation of intracellular signal transduction 26.5306 5 no
GO:0009968 negative regulation of signal transduction 24.4898 5 no
GO:0010648 negative regulation of cell communication 24.4898 5 no
GO:0023057 negative regulation of signaling 24.4898 4 no
GO:0048585 negative regulation of response to stimulus 24.4898 4 no
GO:0060548 negative regulation of cell death 24.4898 5 no
GO:0048584 positive regulation of response to stimulus 24.4898 4 no
GO:0009891 positive regulation of biosynthetic process 24.4898 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 24.4898 6 yes
GO:0006355 regulation of DNA-templated transcription 24.4898 6 no
GO:0044087 regulation of cellular component biogenesis 24.4898 4 no
GO:0051129 negative regulation of cellular component organization 24.4898 5 no
GO:0043066 negative regulation of apoptotic process 22.4490 7 no
GO:0043069 negative regulation of programmed cell death 22.4490 6 no
GO:0010647 positive regulation of cell communication 22.4490 5 no
GO:0023056 positive regulation of signaling 22.4490 4 no
GO:0006446 regulation of translational initiation 22.4490 7 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 22.4490 6 yes
GO:0051049 regulation of transport 22.4490 4 no
GO:0090304 nucleic acid metabolic process 22.4490 4 no
GO:0030162 regulation of proteolysis 20.4082 6 no
GO:0009967 positive regulation of signal transduction 20.4082 5 no
GO:0009059 macromolecule biosynthetic process 20.4082 4 yes
GO:0051130 positive regulation of cellular component organization 20.4082 5 yes
GO:0009057 macromolecule catabolic process 20.4082 4 no
GO:0032880 regulation of protein localization 20.4082 5 no
GO:0060341 regulation of cellular localization 20.4082 4 no
GO:0034645 cellular macromolecule biosynthetic process 18.3673 4 yes
GO:0045595 regulation of cell differentiation 18.3673 4 yes
GO:0034250 positive regulation of cellular amide metabolic process 16.3265 6 yes
GO:0045727 positive regulation of translation 16.3265 7 yes
GO:0051094 positive regulation of developmental process 16.3265 4 yes
GO:0051240 positive regulation of multicellular organismal process 16.3265 4 yes
GO:0009895 negative regulation of catabolic process 14.2857 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 14.2857 4 yes
GO:0031330 negative regulation of cellular catabolic process 14.2857 6 yes
GO:2000026 regulation of multicellular organismal development 14.2857 4 yes
GO:0001558 regulation of cell growth 12.2449 4 yes
GO:0010506 regulation of autophagy 12.2449 6 yes
GO:0031344 regulation of cell projection organization 12.2449 5 yes
GO:0045597 positive regulation of cell differentiation 10.2041 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 10.2041 6 yes
GO:0010975 regulation of neuron projection development 8.1633 7 yes
GO:0030307 positive regulation of cell growth 8.1633 5 yes
GO:0031346 positive regulation of cell projection organization 8.1633 6 yes
GO:0045927 positive regulation of growth 8.1633 4 yes
GO:0007507 heart development 6.1224 4 yes
GO:0010507 negative regulation of autophagy 6.1224 7 yes
GO:0060998 regulation of dendritic spine development 6.1224 4 yes
GO:0010720 positive regulation of cell development 4.0816 6 yes
GO:0030516 regulation of axon extension 4.0816 5 yes
GO:0045773 positive regulation of axon extension 4.0816 6 yes
GO:0048638 regulation of developmental growth 4.0816 4 yes
GO:0048639 positive regulation of developmental growth 4.0816 5 yes
GO:0050767 regulation of neurogenesis 4.0816 6 yes
GO:0050769 positive regulation of neurogenesis 4.0816 6 yes
GO:0050770 regulation of axonogenesis 4.0816 5 yes
GO:0050772 positive regulation of axonogenesis 4.0816 6 yes
GO:0051960 regulation of nervous system development 4.0816 5 yes
GO:0051962 positive regulation of nervous system development 4.0816 5 yes
GO:0060284 regulation of cell development 4.0816 5 yes
GO:0060999 positive regulation of dendritic spine development 4.0816 5 yes
GO:0061387 regulation of extent of cell growth 4.0816 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in IF4G2_HUMAN
DOID:0050539 Charcot-Marie-Tooth disease type 2 4.0816 7 no
DOID:10595 Charcot-Marie-Tooth disease 4.0816 6 no
DOID:440 neuromuscular disease 4.0816 5 no
DOID:574 peripheral nervous system disease 4.0816 3 no
DOID:870 neuropathy 4.0816 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IF2B_HUMAN [view interactions] Low throughput no yes
EIF3J_HUMAN [view interactions] Low throughput no yes
IF4A1_HUMAN [view interactions] Low throughput no no
EIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
PDCD4_HUMAN [view interactions] Low throughput no yes
IF2A_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4A2_HUMAN [view entry] [view interactions] Low throughput yes yes
MKNK1_HUMAN [view interactions] Low throughput no yes
ZBT7A_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SKIL_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3I_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
RRP1B_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
DDX60_HUMAN [view interactions] High throughput no no
HTRA4_HUMAN [view interactions] High throughput no no
MAGA6_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
GSTK1_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
BCAR1_HUMAN [view interactions] High throughput no yes
DCNL1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
C1T9A_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
TANK_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
NADC_HUMAN [view interactions] High throughput no yes
MAGA1_HUMAN [view interactions] High throughput no no
CP1A1_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
RN126_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
U5S1_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL2_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
WWP2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF23_HUMAN [view interactions] High throughput no yes
RMC1_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
TGM1_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
MD2L1_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
FA24B_HUMAN [view interactions] High throughput no no
P5CR2_HUMAN [view interactions] High throughput no yes
D2HDH_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
EFMT3_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
PAIRB_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
EIF3B_HUMAN [view interactions] High throughput no yes
MAP2_HUMAN [view interactions] High throughput no yes
ACL6A_HUMAN [view interactions] High throughput no yes
ARL2_HUMAN [view interactions] High throughput no yes
CI114_HUMAN [view interactions] High throughput no yes
PRP17_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
CENPP_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G2_HUMAN [view entry] [view interactions] High throughput yes yes
NEP1_HUMAN [view interactions] High throughput no yes
EXOS2_HUMAN [view interactions] High throughput no yes
FA50A_HUMAN [view interactions] High throughput no yes
GEMI2_HUMAN [view interactions] High throughput no yes
NOG2_HUMAN [view interactions] High throughput no yes
GTPB4_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
SYMC_HUMAN [view interactions] High throughput no yes
MFAP1_HUMAN [view interactions] High throughput no yes
NAMPT_HUMAN [view interactions] High throughput no no
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
NFYC_HUMAN [view interactions] High throughput no no
OGFD1_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
PMF1_HUMAN [view interactions] High throughput no no
DPOLA_HUMAN [view interactions] High throughput no yes
DPOLN_HUMAN [view interactions] High throughput no no
2ABA_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
SPF45_HUMAN [view interactions] High throughput no yes
RINT1_HUMAN [view interactions] High throughput no yes
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
SPDLY_HUMAN [view interactions] High throughput no yes
TAF2_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
SUMO2_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G3_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
IF4H_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SLIRP_HUMAN [view interactions] High throughput no yes
PDIP3_HUMAN [view interactions] High throughput no no
OAT_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF5_HUMAN [view interactions] High throughput no yes
CASP3_HUMAN [view interactions] High throughput no yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD2_HUMAN [view interactions] High throughput no yes
YTHD3_HUMAN [view interactions] High throughput no no
ZCCHV_HUMAN [view interactions] High throughput no yes
EST1A_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] Computational yes yes
IF2G_HUMAN [view interactions] Computational no yes
4EBP3_HUMAN [view interactions] Computational no yes
PABP1_HUMAN [view entry] [view interactions] Computational yes yes
CASP1_HUMAN [view interactions] Computational no yes
EIF1_HUMAN [view interactions] Computational no no
CASP9_HUMAN [view interactions] Computational no yes
CASP8_HUMAN [view interactions] Computational no yes
IF4E2_HUMAN [view interactions] Computational no no
CASP2_HUMAN [view interactions] Computational no yes
CASP4_HUMAN [view interactions] Computational no yes
CASP5_HUMAN [view interactions] Computational no no
I4E1B_HUMAN [view interactions] Computational no no
CASPA_HUMAN [view interactions] Computational no yes
CASP6_HUMAN [view interactions] Computational no no
PTBP1_HUMAN [view interactions] Computational no no
IF4E3_HUMAN [view interactions] Computational no no
PTBP2_HUMAN [view interactions] Computational no no