Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IF4G2_HUMAN

Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in IF4G2_HUMAN
GO:0003723 RNA binding 55.1724 4 yes
GO:0000166 nucleotide binding 31.0345 4 no
GO:0017076 purine nucleotide binding 31.0345 5 no
GO:0043168 anion binding 31.0345 4 no
GO:0032555 purine ribonucleotide binding 29.3103 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.3103 4 no
GO:0030554 adenyl nucleotide binding 25.8621 6 no
GO:0005524 ATP binding 24.1379 5 no
GO:0032559 adenyl ribonucleotide binding 24.1379 5 no
GO:0045296 cadherin binding 22.4138 4 yes
GO:0019900 kinase binding 20.6897 4 no
GO:0003743 translation initiation factor activity 17.2414 4 yes
GO:0003729 mRNA binding 12.0690 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IF4G2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 70.6897 4 yes
GO:0080090 regulation of primary metabolic process 68.9655 4 yes
GO:0031323 regulation of cellular metabolic process 67.2414 4 yes
GO:0048522 positive regulation of cellular process 65.5172 4 yes
GO:0048523 negative regulation of cellular process 62.0690 4 yes
GO:0051246 regulation of protein metabolic process 60.3448 5 yes
GO:0009889 regulation of biosynthetic process 60.3448 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 58.6207 5 yes
GO:0031326 regulation of cellular biosynthetic process 58.6207 5 yes
GO:0010468 regulation of gene expression 58.6207 6 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.2759 5 yes
GO:0010646 regulation of cell communication 48.2759 4 no
GO:0051128 regulation of cellular component organization 46.5517 4 yes
GO:0009892 negative regulation of metabolic process 46.5517 4 yes
GO:0009966 regulation of signal transduction 44.8276 4 no
GO:0031325 positive regulation of cellular metabolic process 43.1034 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 43.1034 5 no
GO:0031324 negative regulation of cellular metabolic process 41.3793 5 yes
GO:0043067 regulation of programmed cell death 41.3793 4 no
GO:0022607 cellular component assembly 41.3793 4 no
GO:0051247 positive regulation of protein metabolic process 39.6552 6 yes
GO:0042981 regulation of apoptotic process 39.6552 5 no
GO:0009891 positive regulation of biosynthetic process 37.9310 5 yes
GO:0009894 regulation of catabolic process 37.9310 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 36.2069 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 36.2069 6 yes
GO:0009890 negative regulation of biosynthetic process 34.4828 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 34.4828 6 no
GO:0031327 negative regulation of cellular biosynthetic process 34.4828 6 no
GO:0051248 negative regulation of protein metabolic process 32.7586 6 no
GO:0008104 protein localization 32.7586 4 no
GO:0043933 protein-containing complex organization 32.7586 4 no
GO:0006996 organelle organization 32.7586 4 no
GO:0051726 regulation of cell cycle 31.0345 4 yes
GO:0009968 negative regulation of signal transduction 31.0345 5 no
GO:0010648 negative regulation of cell communication 31.0345 5 no
GO:0023057 negative regulation of signaling 31.0345 4 no
GO:0048585 negative regulation of response to stimulus 31.0345 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.0345 5 no
GO:1902531 regulation of intracellular signal transduction 31.0345 5 no
GO:0010628 positive regulation of gene expression 29.3103 7 yes
GO:0048584 positive regulation of response to stimulus 29.3103 4 no
GO:0006355 regulation of DNA-templated transcription 29.3103 7 no
GO:0051129 negative regulation of cellular component organization 29.3103 5 no
GO:0051252 regulation of RNA metabolic process 29.3103 5 no
GO:0071310 cellular response to organic substance 29.3103 4 no
GO:2001141 regulation of RNA biosynthetic process 29.3103 6 no
GO:0031399 regulation of protein modification process 29.3103 6 no
GO:0009967 positive regulation of signal transduction 27.5862 5 no
GO:0010647 positive regulation of cell communication 27.5862 5 no
GO:0023056 positive regulation of signaling 27.5862 4 no
GO:0043066 negative regulation of apoptotic process 27.5862 6 no
GO:0043069 negative regulation of programmed cell death 27.5862 5 no
GO:0090304 nucleic acid metabolic process 27.5862 4 no
GO:0032880 regulation of protein localization 27.5862 5 no
GO:0060341 regulation of cellular localization 27.5862 4 no
GO:0065003 protein-containing complex assembly 27.5862 5 no
GO:0010608 post-transcriptional regulation of gene expression 25.8621 7 yes
GO:0051094 positive regulation of developmental process 25.8621 4 yes
GO:0010629 negative regulation of gene expression 25.8621 7 no
GO:0030162 regulation of proteolysis 25.8621 6 no
GO:0006417 regulation of translation 25.8621 6 yes
GO:0044087 regulation of cellular component biogenesis 24.1379 4 no
GO:0009059 macromolecule biosynthetic process 24.1379 4 yes
GO:0045595 regulation of cell differentiation 22.4138 4 yes
GO:0042176 regulation of protein catabolic process 22.4138 5 no
GO:0019220 regulation of phosphate metabolic process 22.4138 6 no
GO:0051174 regulation of phosphorus metabolic process 22.4138 5 no
GO:0051240 positive regulation of multicellular organismal process 20.6897 4 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 20.6897 7 no
GO:0051049 regulation of transport 20.6897 4 no
GO:0080134 regulation of response to stress 20.6897 4 no
GO:2000026 regulation of multicellular organismal development 18.9655 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 17.2414 4 yes
GO:0045597 positive regulation of cell differentiation 17.2414 5 yes
GO:0051130 positive regulation of cellular component organization 17.2414 5 yes
GO:0001558 regulation of cell growth 17.2414 4 yes
GO:0006446 regulation of translational initiation 17.2414 7 yes
GO:0010506 regulation of autophagy 13.7931 6 yes
GO:0031329 regulation of cellular catabolic process 13.7931 5 yes
GO:0031344 regulation of cell projection organization 13.7931 5 yes
GO:0045727 positive regulation of translation 13.7931 7 yes
GO:0060284 regulation of cell development 13.7931 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 12.0690 6 yes
GO:0009895 negative regulation of catabolic process 12.0690 5 yes
GO:0030307 positive regulation of cell growth 10.3448 5 yes
GO:0045927 positive regulation of growth 10.3448 4 yes
GO:0010720 positive regulation of cell development 8.6207 6 yes
GO:0010975 regulation of neuron projection development 8.6207 7 yes
GO:0050767 regulation of neurogenesis 8.6207 6 yes
GO:0051960 regulation of nervous system development 8.6207 5 yes
GO:0048638 regulation of developmental growth 6.8966 4 yes
GO:0050769 positive regulation of neurogenesis 6.8966 6 yes
GO:0051962 positive regulation of nervous system development 6.8966 5 yes
GO:0010507 negative regulation of autophagy 5.1724 7 yes
GO:0030516 regulation of axon extension 5.1724 5 yes
GO:0031330 negative regulation of cellular catabolic process 5.1724 6 yes
GO:0031346 positive regulation of cell projection organization 5.1724 6 yes
GO:0048639 positive regulation of developmental growth 5.1724 5 yes
GO:0050770 regulation of axonogenesis 5.1724 5 yes
GO:0060998 regulation of dendritic spine development 5.1724 4 yes
GO:0061387 regulation of extent of cell growth 5.1724 5 yes
GO:0007507 heart development 5.1724 4 yes
GO:0045773 positive regulation of axon extension 3.4483 6 yes
GO:0050772 positive regulation of axonogenesis 3.4483 6 yes
GO:0060999 positive regulation of dendritic spine development 3.4483 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IF2B_HUMAN [view interactions] Low throughput no yes
EIF3J_HUMAN [view interactions] Low throughput no yes
IF4A1_HUMAN [view interactions] Low throughput no no
EIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
PDCD4_HUMAN [view interactions] Low throughput no yes
IF2A_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4A2_HUMAN [view entry] [view interactions] Low throughput yes yes
MKNK1_HUMAN [view interactions] Low throughput no yes
ZBT7A_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
IF4E_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G3_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
IF4H_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SLIRP_HUMAN [view interactions] High throughput no yes
PDIP3_HUMAN [view interactions] High throughput no no
OAT_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
IF5_HUMAN [view interactions] High throughput no yes
CASP3_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD2_HUMAN [view interactions] High throughput no yes
YTHD3_HUMAN [view interactions] High throughput no no
ZCCHV_HUMAN [view interactions] High throughput no yes
EST1A_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
PHLP1_HUMAN [view interactions] High throughput no yes
NUP43_HUMAN [view interactions] High throughput no yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SKIL_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3I_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
RRP1B_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
RMC1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
DDX60_HUMAN [view interactions] High throughput no no
HTRA4_HUMAN [view interactions] High throughput no no
MAGA6_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
GSTK1_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
BCAR1_HUMAN [view interactions] High throughput no yes
DCNL1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
C1T9A_HUMAN [view interactions] High throughput no no
LCOR_HUMAN [view interactions] High throughput no yes
TTC3_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
TRAF2_HUMAN [view interactions] High throughput no yes
TANK_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
NADC_HUMAN [view interactions] High throughput no yes
MAGA1_HUMAN [view interactions] High throughput no no
CP1A1_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
RN126_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
U5S1_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL2_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
WWP2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF23_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
TGM1_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
MD2L1_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
FA24B_HUMAN [view interactions] High throughput no no
P5CR2_HUMAN [view interactions] High throughput no yes
D2HDH_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
EFMT3_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
EIF3B_HUMAN [view interactions] High throughput no yes
MAP2_HUMAN [view interactions] High throughput no yes
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG24_HUMAN [view interactions] High throughput no yes
MOB3C_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SMC5_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
ACL6A_HUMAN [view interactions] High throughput no yes
ARL2_HUMAN [view interactions] High throughput no yes
CI114_HUMAN [view interactions] High throughput no yes
PRP17_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
CENPP_HUMAN [view interactions] High throughput no yes
DUT_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G2_HUMAN [view entry] [view interactions] High throughput yes yes
NEP1_HUMAN [view interactions] High throughput no yes
EXOS2_HUMAN [view interactions] High throughput no yes
FA50A_HUMAN [view interactions] High throughput no yes
GEMI2_HUMAN [view interactions] High throughput no yes
NOG2_HUMAN [view interactions] High throughput no yes
GTPB4_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
SYMC_HUMAN [view interactions] High throughput no yes
MFAP1_HUMAN [view interactions] High throughput no yes
NAMPT_HUMAN [view interactions] High throughput no no
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
NFYC_HUMAN [view interactions] High throughput no no
OGFD1_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
PMF1_HUMAN [view interactions] High throughput no no
DPOLA_HUMAN [view interactions] High throughput no yes
DPOLN_HUMAN [view interactions] High throughput no no
2ABA_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
SPF45_HUMAN [view interactions] High throughput no yes
RINT1_HUMAN [view interactions] High throughput no yes
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
SPDLY_HUMAN [view interactions] High throughput no yes
TAF2_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes