Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NFASC_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NFASC_HUMAN
GO:0043169 cation binding 46.6667 4 no
GO:0046872 metal ion binding 46.6667 5 no
GO:0017124 SH3 domain binding 46.6667 4 no
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0045309 protein phosphorylated amino acid binding 26.6667 4 no
GO:0046875 ephrin receptor binding 26.6667 4 no
GO:0098631 cell adhesion mediator activity 13.3333 4 yes
GO:0098632 cell-cell adhesion mediator activity 13.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NFASC_HUMAN
GO:0048522 positive regulation of cellular process 86.6667 4 no
GO:0051128 regulation of cellular component organization 73.3333 4 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0030030 cell projection organization 60.0000 4 yes
GO:0120036 plasma membrane bounded cell projection organization 60.0000 5 yes
GO:0022607 cellular component assembly 60.0000 4 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0050807 regulation of synapse organization 53.3333 5 no
GO:0009966 regulation of signal transduction 53.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 53.3333 4 no
GO:0031175 neuron projection development 46.6667 6 yes
GO:0009889 regulation of biosynthetic process 46.6667 4 no
GO:0010468 regulation of gene expression 46.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 46.6667 5 no
GO:0010975 regulation of neuron projection development 46.6667 7 no
GO:0031326 regulation of cellular biosynthetic process 46.6667 5 no
GO:0031344 regulation of cell projection organization 46.6667 5 no
GO:0048584 positive regulation of response to stimulus 46.6667 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 46.6667 6 no
GO:0034330 cell junction organization 40.0000 4 no
GO:0045595 regulation of cell differentiation 40.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 40.0000 5 no
GO:0050890 cognition 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0006468 protein phosphorylation 40.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 no
GO:0016310 phosphorylation 40.0000 5 no
GO:0036211 protein modification process 40.0000 4 no
GO:0043412 macromolecule modification 40.0000 4 no
GO:0010243 response to organonitrogen compound 40.0000 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0071417 cellular response to organonitrogen compound 40.0000 4 no
GO:1901699 cellular response to nitrogen compound 40.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 40.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0010647 positive regulation of cell communication 40.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 40.0000 4 no
GO:0023056 positive regulation of signaling 40.0000 4 no
GO:0032101 regulation of response to external stimulus 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0080134 regulation of response to stress 40.0000 4 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:0007612 learning 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0048812 neuron projection morphogenesis 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0099175 regulation of postsynapse organization 33.3333 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:1902903 regulation of supramolecular fiber organization 33.3333 5 no
GO:0002684 positive regulation of immune system process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0048638 regulation of developmental growth 33.3333 4 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0001558 regulation of cell growth 33.3333 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 33.3333 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0030155 regulation of cell adhesion 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0032956 regulation of actin cytoskeleton organization 33.3333 5 no
GO:0032970 regulation of actin filament-based process 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0050776 regulation of immune response 33.3333 4 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 26.6667 6 no
GO:0034329 cell junction assembly 26.6667 5 no
GO:0043269 regulation of monoatomic ion transport 26.6667 5 no
GO:0044057 regulation of system process 26.6667 4 no
GO:0050808 synapse organization 26.6667 5 no
GO:0110053 regulation of actin filament organization 26.6667 6 no
GO:2000026 regulation of multicellular organismal development 26.6667 4 no
GO:1902905 positive regulation of supramolecular fiber organization 26.6667 6 no
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 no
GO:0019220 regulation of phosphate metabolic process 26.6667 6 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0031401 positive regulation of protein modification process 26.6667 7 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0042327 positive regulation of phosphorylation 26.6667 8 no
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 26.6667 8 no
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 no
GO:0051246 regulation of protein metabolic process 26.6667 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0097435 supramolecular fiber organization 26.6667 4 no
GO:0009890 negative regulation of biosynthetic process 26.6667 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0031327 negative regulation of cellular biosynthetic process 26.6667 6 no
GO:0007411 axon guidance 26.6667 8 yes
GO:0097485 neuron projection guidance 26.6667 7 yes
GO:0051050 positive regulation of transport 26.6667 4 no
GO:0098657 import into cell 26.6667 4 no
GO:0002685 regulation of leukocyte migration 26.6667 4 no
GO:0006355 regulation of DNA-templated transcription 26.6667 7 no
GO:0006357 regulation of transcription by RNA polymerase II 26.6667 8 no
GO:0007010 cytoskeleton organization 26.6667 5 no
GO:0008104 protein localization 26.6667 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0030335 positive regulation of cell migration 26.6667 6 no
GO:0031347 regulation of defense response 26.6667 5 no
GO:0032102 negative regulation of response to external stimulus 26.6667 5 no
GO:0032880 regulation of protein localization 26.6667 5 no
GO:0040017 positive regulation of locomotion 26.6667 4 no
GO:0051252 regulation of RNA metabolic process 26.6667 5 no
GO:0060341 regulation of cellular localization 26.6667 4 no
GO:0071675 regulation of mononuclear cell migration 26.6667 5 no
GO:1902533 positive regulation of intracellular signal transduction 26.6667 6 no
GO:2000147 positive regulation of cell motility 26.6667 5 no
GO:2000401 regulation of lymphocyte migration 26.6667 6 no
GO:2000404 regulation of T cell migration 26.6667 7 no
GO:0007420 brain development 13.3333 4 yes
GO:0042552 myelination 13.3333 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MYP0_HUMAN [view interactions] Low throughput no no
SCN1B_HUMAN [view interactions] Low throughput no no
SCN3B_HUMAN [view interactions] Low throughput no no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RIGI_HUMAN [view interactions] High throughput no yes
EAA2_HUMAN [view entry] [view interactions] High throughput yes no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
NRCAM_HUMAN [view entry] [view interactions] High throughput yes no
TENR_HUMAN [view entry] [view interactions] High throughput yes no