NFASC_HUMAN
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NFASC_HUMAN |
---|---|---|---|---|
GO:0017124 | SH3 domain binding | 28.0000 | 4 | no |
GO:0019900 | kinase binding | 24.0000 | 4 | no |
GO:0046875 | ephrin receptor binding | 24.0000 | 4 | no |
GO:0098631 | cell adhesion mediator activity | 12.0000 | 4 | yes |
GO:0098632 | cell-cell adhesion mediator activity | 12.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NFASC_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 64.0000 | 4 | no |
GO:0030030 | cell projection organization | 60.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
GO:0008104 | protein localization | 52.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 52.0000 | 4 | no |
GO:0051049 | regulation of transport | 52.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 52.0000 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 48.0000 | 5 | yes |
GO:0022607 | cellular component assembly | 48.0000 | 4 | no |
GO:0043269 | regulation of ion transport | 48.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 48.0000 | 4 | no |
GO:0006996 | organelle organization | 44.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 44.0000 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
GO:0031175 | neuron projection development | 36.0000 | 6 | yes |
GO:0034330 | cell junction organization | 36.0000 | 4 | yes |
GO:0007010 | cytoskeleton organization | 36.0000 | 5 | no |
GO:0031344 | regulation of cell projection organization | 36.0000 | 5 | no |
GO:0033043 | regulation of organelle organization | 36.0000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 36.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 36.0000 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 36.0000 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 36.0000 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 36.0000 | 5 | no |
GO:0051050 | positive regulation of transport | 36.0000 | 4 | no |
GO:0032990 | cell part morphogenesis | 36.0000 | 4 | no |
GO:0048812 | neuron projection morphogenesis | 36.0000 | 7 | no |
GO:0048858 | cell projection morphogenesis | 36.0000 | 5 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 36.0000 | 6 | no |
GO:0009966 | regulation of signal transduction | 36.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 36.0000 | 4 | no |
GO:0072657 | protein localization to membrane | 32.0000 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 32.0000 | 7 | no |
GO:0032970 | regulation of actin filament-based process | 32.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 32.0000 | 4 | no |
GO:0045595 | regulation of cell differentiation | 32.0000 | 4 | no |
GO:0050890 | cognition | 32.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 32.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 32.0000 | 4 | no |
GO:0050808 | synapse organization | 28.0000 | 5 | yes |
GO:0006468 | protein phosphorylation | 28.0000 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 28.0000 | 4 | no |
GO:0016310 | phosphorylation | 28.0000 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 28.0000 | 5 | no |
GO:0036211 | protein modification process | 28.0000 | 4 | no |
GO:0043412 | macromolecule modification | 28.0000 | 4 | no |
GO:0050807 | regulation of synapse organization | 28.0000 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 28.0000 | 6 | no |
GO:1902903 | regulation of supramolecular fiber organization | 28.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 28.0000 | 6 | no |
GO:0010647 | positive regulation of cell communication | 28.0000 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 28.0000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 28.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 28.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 28.0000 | 5 | no |
GO:0072659 | protein localization to plasma membrane | 24.0000 | 5 | yes |
GO:1990778 | protein localization to cell periphery | 24.0000 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 24.0000 | 4 | no |
GO:0034329 | cell junction assembly | 24.0000 | 5 | no |
GO:0110053 | regulation of actin filament organization | 24.0000 | 6 | no |
GO:0001508 | action potential | 24.0000 | 4 | no |
GO:0006811 | ion transport | 24.0000 | 4 | no |
GO:0006812 | cation transport | 24.0000 | 5 | no |
GO:0010959 | regulation of metal ion transport | 24.0000 | 6 | no |
GO:0030001 | metal ion transport | 24.0000 | 6 | no |
GO:0043270 | positive regulation of ion transport | 24.0000 | 5 | no |
GO:0044057 | regulation of system process | 24.0000 | 4 | no |
GO:0061024 | membrane organization | 24.0000 | 4 | no |
GO:0071702 | organic substance transport | 24.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 24.0000 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 24.0000 | 6 | no |
GO:0045597 | positive regulation of cell differentiation | 24.0000 | 5 | no |
GO:0048638 | regulation of developmental growth | 24.0000 | 4 | no |
GO:0007612 | learning | 24.0000 | 4 | no |
GO:0023056 | positive regulation of signaling | 24.0000 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 24.0000 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 24.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 24.0000 | 7 | no |
GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.0000 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 24.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 24.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 24.0000 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 24.0000 | 5 | no |
GO:0080134 | regulation of response to stress | 24.0000 | 4 | no |
GO:0007411 | axon guidance | 20.0000 | 8 | yes |
GO:0097485 | neuron projection guidance | 20.0000 | 7 | yes |
GO:0007420 | brain development | 16.0000 | 4 | yes |
GO:0042552 | myelination | 16.0000 | 4 | yes |
GO:0007422 | peripheral nervous system development | 8.0000 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in NFASC_HUMAN |
---|---|---|---|---|
DOID:0050701 | electroclinical syndrome | 12.0000 | 6 | no |
DOID:0112202 | developmental and epileptic encephalopathy | 12.0000 | 7 | no |
DOID:1826 | epilepsy | 12.0000 | 5 | no |
DOID:331 | central nervous system disease | 12.0000 | 3 | no |
DOID:936 | brain disease | 12.0000 | 4 | no |
DOID:0050703 | infancy electroclinical syndrome | 8.0000 | 7 | no |
DOID:0060169 | benign familial infantile epilepsy | 8.0000 | 8 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MYP0_HUMAN | [view interactions] | Low throughput | no | no |
SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
SCN3B_HUMAN | [view interactions] | Low throughput | no | no |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
NRCAM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCN2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SCN1A_HUMAN | [view interactions] | Computational | no | no |
CNTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SPTB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ANK1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SPTN4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CNTP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GLDN_HUMAN | [view interactions] | Computational | no | no |
SDCB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ANK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ANK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SCN8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNQ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCNQ3_HUMAN | [view interactions] | Computational | no | no |
CNTP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |