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BRSK1_HUMAN

GO
G2C
SynGO

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in BRSK1_HUMAN
GO:0017076 purine nucleotide binding 44.4444 4 yes
GO:0030554 adenyl nucleotide binding 44.4444 5 yes
GO:0032555 purine ribonucleotide binding 44.4444 4 yes
GO:0032559 adenyl ribonucleotide binding 44.4444 5 yes
GO:0005524 ATP binding 38.8889 5 yes
GO:0015631 tubulin binding 38.8889 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.8889 4 yes
GO:0003723 RNA binding 33.3333 4 no
GO:0004674 protein serine/threonine kinase activity 27.7778 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 27.7778 4 yes
GO:0016301 kinase activity 27.7778 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 27.7778 4 yes
GO:0019900 kinase binding 27.7778 4 yes
GO:0019901 protein kinase binding 27.7778 5 yes
GO:0106310 protein serine kinase activity 27.7778 4 yes
GO:0046872 metal ion binding 22.2222 4 yes
GO:0048156 tau protein binding 22.2222 4 yes
GO:0008017 microtubule binding 22.2222 5 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0000287 magnesium ion binding 11.1111 5 yes
GO:0043015 gamma-tubulin binding 11.1111 5 yes
GO:0050321 tau-protein kinase activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BRSK1_HUMAN
GO:0048523 negative regulation of cellular process 77.7778 4 yes
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0031323 regulation of cellular metabolic process 72.2222 4 no
GO:0051171 regulation of nitrogen compound metabolic process 72.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 72.2222 4 no
GO:0080090 regulation of primary metabolic process 72.2222 4 no
GO:0006996 organelle organization 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0010468 regulation of gene expression 61.1111 5 no
GO:0010604 positive regulation of macromolecule metabolic process 61.1111 5 no
GO:0010605 negative regulation of macromolecule metabolic process 61.1111 5 no
GO:0031325 positive regulation of cellular metabolic process 61.1111 5 no
GO:0031399 regulation of protein modification process 61.1111 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 61.1111 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 61.1111 5 no
GO:0051246 regulation of protein metabolic process 61.1111 5 no
GO:0009892 negative regulation of metabolic process 61.1111 4 no
GO:0009893 positive regulation of metabolic process 61.1111 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 no
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 no
GO:0031324 negative regulation of cellular metabolic process 55.5556 5 no
GO:0009889 regulation of biosynthetic process 55.5556 4 no
GO:0010941 regulation of cell death 50.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051248 negative regulation of protein metabolic process 50.0000 6 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0031400 negative regulation of protein modification process 44.4444 7 no
GO:0042981 regulation of apoptotic process 44.4444 6 no
GO:0043067 regulation of programmed cell death 44.4444 5 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0071310 cellular response to organic substance 44.4444 4 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:1903506 regulation of nucleic acid-templated transcription 44.4444 7 no
GO:2001141 regulation of RNA biosynthetic process 44.4444 6 no
GO:0036211 protein modification process 44.4444 4 yes
GO:0043412 macromolecule modification 44.4444 4 yes
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 yes
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 yes
GO:0043254 regulation of protein-containing complex assembly 44.4444 5 no
GO:0045595 regulation of cell differentiation 44.4444 4 no
GO:0051050 positive regulation of transport 44.4444 4 no
GO:0051129 negative regulation of cellular component organization 44.4444 5 no
GO:0006355 regulation of DNA-templated transcription 44.4444 6 no
GO:0009894 regulation of catabolic process 38.8889 4 no
GO:0010648 negative regulation of cell communication 38.8889 5 no
GO:0023057 negative regulation of signaling 38.8889 4 no
GO:0030162 regulation of proteolysis 38.8889 6 no
GO:0031329 regulation of cellular catabolic process 38.8889 5 no
GO:0043066 negative regulation of apoptotic process 38.8889 7 no
GO:0043069 negative regulation of programmed cell death 38.8889 6 no
GO:0044089 positive regulation of cellular component biogenesis 38.8889 5 no
GO:0045862 positive regulation of proteolysis 38.8889 7 no
GO:0051094 positive regulation of developmental process 38.8889 4 no
GO:0060548 negative regulation of cell death 38.8889 5 no
GO:0042325 regulation of phosphorylation 38.8889 7 no
GO:0043085 positive regulation of catalytic activity 38.8889 4 no
GO:0051338 regulation of transferase activity 38.8889 4 no
GO:0009890 negative regulation of biosynthetic process 38.8889 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 38.8889 6 no
GO:0031327 negative regulation of cellular biosynthetic process 38.8889 6 no
GO:0007010 cytoskeleton organization 38.8889 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 38.8889 4 yes
GO:0030030 cell projection organization 38.8889 4 yes
GO:0031344 regulation of cell projection organization 38.8889 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.8889 6 yes
GO:0032886 regulation of microtubule-based process 38.8889 4 no
GO:0033043 regulation of organelle organization 38.8889 5 no
GO:0051493 regulation of cytoskeleton organization 38.8889 6 no
GO:0070507 regulation of microtubule cytoskeleton organization 38.8889 5 no
GO:1902903 regulation of supramolecular fiber organization 38.8889 5 no
GO:2000026 regulation of multicellular organismal development 38.8889 4 no
GO:0009896 positive regulation of catabolic process 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010628 positive regulation of gene expression 33.3333 6 no
GO:0010629 negative regulation of gene expression 33.3333 6 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0031334 positive regulation of protein-containing complex assembly 33.3333 6 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 33.3333 6 no
GO:0051253 negative regulation of RNA metabolic process 33.3333 6 no
GO:0010975 regulation of neuron projection development 33.3333 7 yes
GO:0016192 vesicle-mediated transport 33.3333 4 yes
GO:0050770 regulation of axonogenesis 33.3333 5 yes
GO:0001558 regulation of cell growth 33.3333 4 no
GO:0031110 regulation of microtubule polymerization or depolymerization 33.3333 6 no
GO:0031113 regulation of microtubule polymerization 33.3333 6 no
GO:0032271 regulation of protein polymerization 33.3333 6 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0031331 positive regulation of cellular catabolic process 27.7778 6 no
GO:0042127 regulation of cell population proliferation 27.7778 4 no
GO:0045597 positive regulation of cell differentiation 27.7778 5 no
GO:0045732 positive regulation of protein catabolic process 27.7778 6 no
GO:0050776 regulation of immune response 27.7778 4 no
GO:0051240 positive regulation of multicellular organismal process 27.7778 4 no
GO:0061136 regulation of proteasomal protein catabolic process 27.7778 6 no
GO:1901800 positive regulation of proteasomal protein catabolic process 27.7778 7 no
GO:1902905 positive regulation of supramolecular fiber organization 27.7778 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 27.7778 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 27.7778 8 no
GO:0043269 regulation of ion transport 27.7778 5 no
GO:0070201 regulation of establishment of protein localization 27.7778 6 no
GO:1903829 positive regulation of protein localization 27.7778 5 no
GO:0007005 mitochondrion organization 27.7778 5 no
GO:0010942 positive regulation of cell death 27.7778 5 no
GO:0033674 positive regulation of kinase activity 27.7778 6 no
GO:0051345 positive regulation of hydrolase activity 27.7778 5 no
GO:0051347 positive regulation of transferase activity 27.7778 5 no
GO:1901701 cellular response to oxygen-containing compound 27.7778 4 no
GO:0001934 positive regulation of protein phosphorylation 27.7778 8 no
GO:0031401 positive regulation of protein modification process 27.7778 7 no
GO:1901699 cellular response to nitrogen compound 27.7778 4 no
GO:0045859 regulation of protein kinase activity 27.7778 6 no
GO:0045892 negative regulation of DNA-templated transcription 27.7778 7 no
GO:1902679 negative regulation of RNA biosynthetic process 27.7778 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 27.7778 8 no
GO:0006468 protein phosphorylation 27.7778 5 yes
GO:0016310 phosphorylation 27.7778 5 yes
GO:0010243 response to organonitrogen compound 27.7778 4 no
GO:0051093 negative regulation of developmental process 27.7778 4 no
GO:0120036 plasma membrane bounded cell projection organization 27.7778 5 no
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0031112 positive regulation of microtubule polymerization or depolymerization 22.2222 7 no
GO:0031116 positive regulation of microtubule polymerization 22.2222 7 no
GO:0032273 positive regulation of protein polymerization 22.2222 7 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 22.2222 7 no
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 22.2222 8 no
GO:0033993 response to lipid 22.2222 4 no
GO:0034599 cellular response to oxidative stress 22.2222 4 no
GO:0034605 cellular response to heat 22.2222 4 no
GO:0051091 positive regulation of DNA-binding transcription factor activity 22.2222 4 no
GO:0051092 positive regulation of NF-kappaB transcription factor activity 22.2222 5 no
GO:0051495 positive regulation of cytoskeleton organization 22.2222 7 no
GO:0062197 cellular response to chemical stress 22.2222 4 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 22.2222 6 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 22.2222 7 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 22.2222 6 no
GO:0008104 protein localization 22.2222 4 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051924 regulation of calcium ion transport 22.2222 7 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0051348 negative regulation of transferase activity 22.2222 5 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:1901214 regulation of neuron death 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0046928 regulation of neurotransmitter secretion 22.2222 4 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051588 regulation of neurotransmitter transport 22.2222 5 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0007006 mitochondrial membrane organization 22.2222 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0051346 negative regulation of hydrolase activity 22.2222 5 no
GO:0006974 cellular response to DNA damage stimulus 22.2222 4 yes
GO:0061024 membrane organization 22.2222 4 no
GO:0018105 peptidyl-serine phosphorylation 22.2222 6 yes
GO:0018193 peptidyl-amino acid modification 22.2222 5 yes
GO:0018209 peptidyl-serine modification 22.2222 6 yes
GO:0050890 cognition 22.2222 4 yes
GO:0051726 regulation of cell cycle 22.2222 4 yes
GO:1901652 response to peptide 22.2222 4 no
GO:0010639 negative regulation of organelle organization 22.2222 6 no
GO:0030516 regulation of axon extension 22.2222 5 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031333 negative regulation of protein-containing complex assembly 22.2222 6 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0032388 positive regulation of intracellular transport 22.2222 5 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0060284 regulation of cell development 22.2222 5 no
GO:0061387 regulation of extent of cell growth 22.2222 5 no
GO:0001817 regulation of cytokine production 22.2222 4 no
GO:0001819 positive regulation of cytokine production 22.2222 5 no
GO:0010564 regulation of cell cycle process 16.6667 5 yes
GO:0032990 cell part morphogenesis 16.6667 4 yes
GO:0046903 secretion 16.6667 4 yes
GO:0048812 neuron projection morphogenesis 16.6667 7 yes
GO:0048858 cell projection morphogenesis 16.6667 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 16.6667 6 yes
GO:0006836 neurotransmitter transport 11.1111 4 yes
GO:0007346 regulation of mitotic cell cycle 11.1111 5 yes
GO:0009411 response to UV 11.1111 5 yes
GO:0009416 response to light stimulus 11.1111 4 yes
GO:0023061 signal release 11.1111 4 yes
GO:0030182 neuron differentiation 11.1111 4 yes
GO:0044772 mitotic cell cycle phase transition 11.1111 4 yes
GO:0099003 vesicle-mediated transport in synapse 11.1111 5 yes
GO:0099643 signal release from synapse 11.1111 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
H2B2C_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANR52_HUMAN [view interactions] High throughput no yes
OBSCN_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
PP6R1_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
NT5D2_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
EXOS8_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
BRSK2_HUMAN [view interactions] High throughput no no
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
ACOHC_HUMAN [view interactions] High throughput no yes
IDE_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
DHB7_HUMAN [view interactions] High throughput no yes
AKA10_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
AAPK1_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
TISD_HUMAN [view interactions] High throughput no no
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
S10A2_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
MPIP2_HUMAN [view interactions] Computational no no
STRAB_HUMAN [view interactions] Computational no no
MTAP2_HUMAN [view entry] [view interactions] Computational yes yes
CAB39_HUMAN [view interactions] Computational no yes
PMYT1_HUMAN [view interactions] Computational no no
STRAA_HUMAN [view interactions] Computational no yes
STK11_HUMAN [view interactions] Computational no yes