Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BRSK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in BRSK1_HUMAN
GO:0000166 nucleotide binding 52.3810 4 yes
GO:0017076 purine nucleotide binding 52.3810 5 yes
GO:0030554 adenyl nucleotide binding 52.3810 6 yes
GO:0032555 purine ribonucleotide binding 52.3810 4 yes
GO:0032559 adenyl ribonucleotide binding 52.3810 5 yes
GO:0043168 anion binding 52.3810 4 yes
GO:0005524 ATP binding 42.8571 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 42.8571 4 yes
GO:0015631 tubulin binding 33.3333 4 yes
GO:0004674 protein serine/threonine kinase activity 28.5714 4 yes
GO:0016301 kinase activity 28.5714 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 yes
GO:0019900 kinase binding 28.5714 4 yes
GO:0019901 protein kinase binding 28.5714 5 yes
GO:0106310 protein serine kinase activity 28.5714 4 yes
GO:0003723 RNA binding 28.5714 4 no
GO:0043169 cation binding 23.8095 4 yes
GO:0046872 metal ion binding 23.8095 5 yes
GO:0048156 tau protein binding 19.0476 4 yes
GO:0000287 magnesium ion binding 14.2857 6 yes
GO:0043015 gamma-tubulin binding 14.2857 5 yes
GO:0050321 tau-protein kinase activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BRSK1_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0006996 organelle organization 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 61.9048 4 no
GO:0031326 regulation of cellular biosynthetic process 57.1429 5 no
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 no
GO:0009889 regulation of biosynthetic process 57.1429 4 no
GO:0010556 regulation of macromolecule biosynthetic process 57.1429 5 no
GO:0031325 positive regulation of cellular metabolic process 52.3810 5 no
GO:0051246 regulation of protein metabolic process 52.3810 5 no
GO:0009892 negative regulation of metabolic process 52.3810 4 no
GO:0010468 regulation of gene expression 52.3810 6 no
GO:0010605 negative regulation of macromolecule metabolic process 52.3810 5 no
GO:0031324 negative regulation of cellular metabolic process 52.3810 5 no
GO:0051248 negative regulation of protein metabolic process 47.6190 6 no
GO:0006796 phosphate-containing compound metabolic process 47.6190 4 yes
GO:0050804 modulation of chemical synaptic transmission 47.6190 5 yes
GO:0099177 regulation of trans-synaptic signaling 47.6190 4 yes
GO:0023056 positive regulation of signaling 47.6190 4 no
GO:0031399 regulation of protein modification process 47.6190 6 no
GO:0048584 positive regulation of response to stimulus 47.6190 4 no
GO:0031327 negative regulation of cellular biosynthetic process 42.8571 6 no
GO:0051252 regulation of RNA metabolic process 42.8571 5 no
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0042981 regulation of apoptotic process 42.8571 5 no
GO:0043067 regulation of programmed cell death 42.8571 4 no
GO:0036211 protein modification process 42.8571 4 yes
GO:0043412 macromolecule modification 42.8571 4 yes
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0009890 negative regulation of biosynthetic process 42.8571 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 no
GO:2001141 regulation of RNA biosynthetic process 38.0952 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 38.0952 6 no
GO:0031400 negative regulation of protein modification process 38.0952 7 no
GO:0043066 negative regulation of apoptotic process 38.0952 6 no
GO:0043069 negative regulation of programmed cell death 38.0952 5 no
GO:0051049 regulation of transport 38.0952 4 no
GO:0051129 negative regulation of cellular component organization 38.0952 5 no
GO:0071310 cellular response to organic substance 38.0952 4 no
GO:0022603 regulation of anatomical structure morphogenesis 38.0952 4 yes
GO:0031344 regulation of cell projection organization 38.0952 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.0952 6 yes
GO:0019220 regulation of phosphate metabolic process 38.0952 6 no
GO:0044087 regulation of cellular component biogenesis 38.0952 4 no
GO:0051130 positive regulation of cellular component organization 38.0952 5 no
GO:0051174 regulation of phosphorus metabolic process 38.0952 5 no
GO:0051247 positive regulation of protein metabolic process 38.0952 6 no
GO:1902531 regulation of intracellular signal transduction 38.0952 5 no
GO:0006355 regulation of DNA-templated transcription 38.0952 7 no
GO:0009894 regulation of catabolic process 38.0952 4 no
GO:0030162 regulation of proteolysis 38.0952 6 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045862 positive regulation of proteolysis 33.3333 7 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0010975 regulation of neuron projection development 33.3333 7 yes
GO:0030030 cell projection organization 33.3333 4 yes
GO:0050770 regulation of axonogenesis 33.3333 5 yes
GO:0002684 positive regulation of immune system process 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0043254 regulation of protein-containing complex assembly 33.3333 5 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0051253 negative regulation of RNA metabolic process 28.5714 6 no
GO:0061136 regulation of proteasomal protein catabolic process 28.5714 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 28.5714 7 no
GO:0009896 positive regulation of catabolic process 28.5714 5 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0010628 positive regulation of gene expression 28.5714 7 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0006468 protein phosphorylation 28.5714 5 yes
GO:0006974 DNA damage response 28.5714 4 yes
GO:0016310 phosphorylation 28.5714 5 yes
GO:0050890 cognition 28.5714 4 yes
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0031334 positive regulation of protein-containing complex assembly 28.5714 6 no
GO:0032886 regulation of microtubule-based process 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0050776 regulation of immune response 28.5714 4 no
GO:0050778 positive regulation of immune response 28.5714 5 no
GO:0051493 regulation of cytoskeleton organization 28.5714 6 no
GO:0070507 regulation of microtubule cytoskeleton organization 28.5714 5 no
GO:1902903 regulation of supramolecular fiber organization 28.5714 5 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 23.8095 6 no
GO:0045892 negative regulation of DNA-templated transcription 23.8095 8 no
GO:1902679 negative regulation of RNA biosynthetic process 23.8095 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 23.8095 5 no
GO:0007005 mitochondrion organization 23.8095 5 no
GO:0010243 response to organonitrogen compound 23.8095 4 no
GO:0033993 response to lipid 23.8095 4 no
GO:0045597 positive regulation of cell differentiation 23.8095 5 no
GO:0045732 positive regulation of protein catabolic process 23.8095 6 no
GO:0051093 negative regulation of developmental process 23.8095 4 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:0070201 regulation of establishment of protein localization 23.8095 6 no
GO:1901800 positive regulation of proteasomal protein catabolic process 23.8095 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 23.8095 8 no
GO:0018105 peptidyl-serine phosphorylation 23.8095 6 yes
GO:0018193 peptidyl-amino acid modification 23.8095 5 yes
GO:0018209 peptidyl-serine modification 23.8095 6 yes
GO:0051726 regulation of cell cycle 23.8095 4 yes
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0031110 regulation of microtubule polymerization or depolymerization 23.8095 6 no
GO:0031113 regulation of microtubule polymerization 23.8095 6 no
GO:0031347 regulation of defense response 23.8095 5 no
GO:0031349 positive regulation of defense response 23.8095 5 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0032101 regulation of response to external stimulus 23.8095 4 no
GO:0032103 positive regulation of response to external stimulus 23.8095 5 no
GO:0032271 regulation of protein polymerization 23.8095 6 no
GO:0042127 regulation of cell population proliferation 23.8095 4 no
GO:0042327 positive regulation of phosphorylation 23.8095 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:1902905 positive regulation of supramolecular fiber organization 23.8095 6 no
GO:0010564 regulation of cell cycle process 19.0476 5 yes
GO:0046903 secretion 19.0476 4 yes
GO:0048812 neuron projection morphogenesis 19.0476 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 19.0476 4 yes
GO:0006836 neurotransmitter transport 14.2857 4 yes
GO:0007346 regulation of mitotic cell cycle 14.2857 5 yes
GO:0007409 axonogenesis 14.2857 6 yes
GO:0007612 learning 14.2857 4 yes
GO:0008306 associative learning 14.2857 5 yes
GO:0009416 response to light stimulus 14.2857 4 yes
GO:0023061 signal release 14.2857 4 yes
GO:0030182 neuron differentiation 14.2857 4 yes
GO:0044772 mitotic cell cycle phase transition 14.2857 4 yes
GO:0099643 signal release from synapse 14.2857 5 yes
GO:0000075 cell cycle checkpoint signaling 9.5238 4 yes
GO:0000077 DNA damage checkpoint signaling 9.5238 5 yes
GO:0000086 G2/M transition of mitotic cell cycle 9.5238 5 yes
GO:0007093 mitotic cell cycle checkpoint signaling 9.5238 4 yes
GO:0007095 mitotic G2 DNA damage checkpoint signaling 9.5238 6 yes
GO:0007269 neurotransmitter secretion 9.5238 4 yes
GO:0009411 response to UV 9.5238 5 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 9.5238 7 yes
GO:0010948 negative regulation of cell cycle process 9.5238 6 yes
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 9.5238 8 yes
GO:0031570 DNA integrity checkpoint signaling 9.5238 5 yes
GO:0042770 signal transduction in response to DNA damage 9.5238 4 yes
GO:0044773 mitotic DNA damage checkpoint signaling 9.5238 6 yes
GO:0044774 mitotic DNA integrity checkpoint signaling 9.5238 5 yes
GO:0044818 mitotic G2/M transition checkpoint 9.5238 5 yes
GO:0044839 cell cycle G2/M phase transition 9.5238 4 yes
GO:0045786 negative regulation of cell cycle 9.5238 5 yes
GO:0045930 negative regulation of mitotic cell cycle 9.5238 6 yes
GO:0090176 microtubule cytoskeleton organization involved in establishment of planar polarity 9.5238 4 yes
GO:0099504 synaptic vesicle cycle 9.5238 4 yes
GO:1901987 regulation of cell cycle phase transition 9.5238 6 yes
GO:1901988 negative regulation of cell cycle phase transition 9.5238 7 yes
GO:1901990 regulation of mitotic cell cycle phase transition 9.5238 6 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 9.5238 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 9.5238 7 yes
GO:1902750 negative regulation of cell cycle G2/M phase transition 9.5238 8 yes
GO:2000807 regulation of synaptic vesicle clustering 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
STK11_HUMAN [view interactions] Low throughput no yes
MPIP3_HUMAN [view interactions] Low throughput no yes
BRSK1_HUMAN [view entry] [view interactions] Low throughput yes no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
H2B2C_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANR28_HUMAN [view interactions] High throughput no no
IMDH2_HUMAN [view interactions] High throughput no yes
IDE_HUMAN [view interactions] High throughput no yes
ACOHC_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
OBSCN_HUMAN [view interactions] High throughput no yes
BRSK2_HUMAN [view interactions] High throughput no no
ANR52_HUMAN [view interactions] High throughput no yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
EXOS8_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
NT5D2_HUMAN [view interactions] High throughput no yes
PNMA2_HUMAN [view interactions] High throughput no yes
PP6R1_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
DHB7_HUMAN [view interactions] High throughput no yes
AKA10_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
AAPK1_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
TISD_HUMAN [view interactions] High throughput no no
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
S10A2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R3_HUMAN [view interactions] High throughput no yes
HSF1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes