TBG2_HUMAN
Evidence for PS localization
Functions
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TBG2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 75.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 75.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 75.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 75.0000 | 4 | yes |
| GO:0043168 | anion binding | 75.0000 | 4 | yes |
| GO:0005524 | ATP binding | 65.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 65.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 65.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 50.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 50.0000 | 4 | no |
| GO:0016887 | ATP hydrolysis activity | 50.0000 | 7 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 50.0000 | 6 | no |
| GO:0003723 | RNA binding | 35.0000 | 4 | no |
| GO:0005525 | GTP binding | 10.0000 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 10.0000 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 10.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TBG2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 55.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 55.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 55.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 50.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 50.0000 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 50.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 50.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 50.0000 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 50.0000 | 4 | no |
| GO:0032204 | regulation of telomere maintenance | 45.0000 | 6 | no |
| GO:0032206 | positive regulation of telomere maintenance | 45.0000 | 7 | no |
| GO:0032210 | regulation of telomere maintenance via telomerase | 45.0000 | 7 | no |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | 45.0000 | 8 | no |
| GO:0032880 | regulation of protein localization | 45.0000 | 5 | no |
| GO:0033044 | regulation of chromosome organization | 45.0000 | 6 | no |
| GO:0051052 | regulation of DNA metabolic process | 45.0000 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 45.0000 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 45.0000 | 5 | no |
| GO:1904356 | regulation of telomere maintenance via telomere lengthening | 45.0000 | 7 | no |
| GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 45.0000 | 8 | no |
| GO:2000278 | regulation of DNA biosynthetic process | 45.0000 | 6 | no |
| GO:2000573 | positive regulation of DNA biosynthetic process | 45.0000 | 7 | no |
| GO:2001252 | positive regulation of chromosome organization | 45.0000 | 7 | no |
| GO:0050821 | protein stabilization | 40.0000 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 40.0000 | 6 | no |
| GO:0070202 | regulation of establishment of protein localization to chromosome | 40.0000 | 7 | no |
| GO:0070203 | regulation of establishment of protein localization to telomere | 40.0000 | 7 | no |
| GO:1900180 | regulation of protein localization to nucleus | 40.0000 | 6 | no |
| GO:1900182 | positive regulation of protein localization to nucleus | 40.0000 | 6 | no |
| GO:1904814 | regulation of protein localization to chromosome, telomeric region | 40.0000 | 6 | no |
| GO:1904816 | positive regulation of protein localization to chromosome, telomeric region | 40.0000 | 6 | no |
| GO:1904851 | positive regulation of establishment of protein localization to telomere | 40.0000 | 7 | no |
| GO:1904869 | regulation of protein localization to Cajal body | 40.0000 | 7 | no |
| GO:1904871 | positive regulation of protein localization to Cajal body | 40.0000 | 7 | no |
| GO:1904872 | regulation of telomerase RNA localization to Cajal body | 40.0000 | 4 | no |
| GO:1904874 | positive regulation of telomerase RNA localization to Cajal body | 40.0000 | 4 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 40.0000 | 6 | no |
| GO:0007339 | binding of sperm to zona pellucida | 35.0000 | 5 | no |
| GO:0035036 | sperm-egg recognition | 35.0000 | 4 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0000070 | mitotic sister chromatid segregation | 10.0000 | 4 | yes |
| GO:0000819 | sister chromatid segregation | 10.0000 | 5 | yes |
| GO:0007020 | microtubule nucleation | 10.0000 | 4 | yes |
| GO:0007052 | mitotic spindle organization | 10.0000 | 4 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 10.0000 | 4 | yes |
| GO:0051276 | chromosome organization | 10.0000 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 10.0000 | 4 | yes |
| GO:0098813 | nuclear chromosome segregation | 10.0000 | 4 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 10.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GCP2_HUMAN | [view interactions] | Low throughput | no | yes |
| GCP3_HUMAN | [view interactions] | Low throughput | no | yes |
| GCP4_HUMAN | [view interactions] | Low throughput | no | yes |
| GCP5_HUMAN | [view interactions] | Low throughput | no | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP_HUMAN | [view interactions] | High throughput | no | yes |
| MZT2B_HUMAN | [view interactions] | High throughput | no | yes |
| MZT2A_HUMAN | [view interactions] | High throughput | no | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| GCP6_HUMAN | [view interactions] | High throughput | no | yes |
| NDK7_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |