Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TBG2_HUMAN
GO:0017076 purine nucleotide binding 76.1905 4 yes
GO:0032555 purine ribonucleotide binding 76.1905 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 76.1905 4 yes
GO:0005524 ATP binding 66.6667 5 no
GO:0030554 adenyl nucleotide binding 66.6667 5 no
GO:0032559 adenyl ribonucleotide binding 66.6667 5 no
GO:0016462 pyrophosphatase activity 57.1429 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 57.1429 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 57.1429 6 yes
GO:0016887 ATP hydrolysis activity 47.6190 7 no
GO:0003723 RNA binding 33.3333 4 no
GO:0003924 GTPase activity 9.5238 7 yes
GO:0005525 GTP binding 9.5238 5 yes
GO:0019001 guanyl nucleotide binding 9.5238 5 yes
GO:0032561 guanyl ribonucleotide binding 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TBG2_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0051128 regulation of cellular component organization 61.9048 4 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 no
GO:0051130 positive regulation of cellular component organization 57.1429 5 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 57.1429 5 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0009889 regulation of biosynthetic process 52.3810 4 no
GO:0009891 positive regulation of biosynthetic process 52.3810 5 no
GO:0010556 regulation of macromolecule biosynthetic process 52.3810 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 52.3810 6 no
GO:0010638 positive regulation of organelle organization 52.3810 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 52.3810 5 no
GO:0031326 regulation of cellular biosynthetic process 52.3810 5 no
GO:0031328 positive regulation of cellular biosynthetic process 52.3810 6 no
GO:0033043 regulation of organelle organization 52.3810 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 52.3810 6 no
GO:0060341 regulation of cellular localization 52.3810 4 no
GO:0032204 regulation of telomere maintenance 47.6190 6 no
GO:0032206 positive regulation of telomere maintenance 47.6190 7 no
GO:0032210 regulation of telomere maintenance via telomerase 47.6190 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 47.6190 8 no
GO:0033044 regulation of chromosome organization 47.6190 6 no
GO:0051052 regulation of DNA metabolic process 47.6190 5 no
GO:0051054 positive regulation of DNA metabolic process 47.6190 6 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 47.6190 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 47.6190 8 no
GO:2000278 regulation of DNA biosynthetic process 47.6190 6 no
GO:2000573 positive regulation of DNA biosynthetic process 47.6190 7 no
GO:2001252 positive regulation of chromosome organization 47.6190 7 no
GO:0032880 regulation of protein localization 42.8571 5 no
GO:1903829 positive regulation of protein localization 42.8571 5 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0050821 protein stabilization 38.0952 4 no
GO:0070201 regulation of establishment of protein localization 38.0952 6 no
GO:0070202 regulation of establishment of protein localization to chromosome 38.0952 7 no
GO:0070203 regulation of establishment of protein localization to telomere 38.0952 7 no
GO:1900180 regulation of protein localization to nucleus 38.0952 6 no
GO:1900182 positive regulation of protein localization to nucleus 38.0952 6 no
GO:1901998 toxin transport 38.0952 4 no
GO:1904814 regulation of protein localization to chromosome, telomeric region 38.0952 6 no
GO:1904816 positive regulation of protein localization to chromosome, telomeric region 38.0952 6 no
GO:1904851 positive regulation of establishment of protein localization to telomere 38.0952 7 no
GO:1904869 regulation of protein localization to Cajal body 38.0952 7 no
GO:1904871 positive regulation of protein localization to Cajal body 38.0952 7 no
GO:1904872 regulation of telomerase RNA localization to Cajal body 38.0952 4 no
GO:1904874 positive regulation of telomerase RNA localization to Cajal body 38.0952 4 no
GO:1904951 positive regulation of establishment of protein localization 38.0952 6 no
GO:0006996 organelle organization 28.5714 4 yes
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0051338 regulation of transferase activity 23.8095 4 no
GO:0051347 positive regulation of transferase activity 23.8095 5 no
GO:0051972 regulation of telomerase activity 23.8095 5 no
GO:0051973 positive regulation of telomerase activity 23.8095 6 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0009966 regulation of signal transduction 23.8095 4 no
GO:0010646 regulation of cell communication 23.8095 4 no
GO:0010647 positive regulation of cell communication 23.8095 5 no
GO:0023056 positive regulation of signaling 23.8095 4 no
GO:0048584 positive regulation of response to stimulus 23.8095 4 no
GO:0007010 cytoskeleton organization 19.0476 5 yes
GO:0000070 mitotic sister chromatid segregation 9.5238 4 yes
GO:0000819 sister chromatid segregation 9.5238 4 yes
GO:0007020 microtubule nucleation 9.5238 4 yes
GO:0007052 mitotic spindle organization 9.5238 4 yes
GO:0031122 cytoplasmic microtubule organization 9.5238 4 yes
GO:0051276 chromosome organization 9.5238 5 yes
GO:0097435 supramolecular fiber organization 9.5238 4 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GCP5_HUMAN [view interactions] Low throughput no yes
GCP4_HUMAN [view interactions] Low throughput no yes
GCP3_HUMAN [view interactions] Low throughput no yes
GCP2_HUMAN [view interactions] Low throughput no yes
PHLP_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
MZT2A_HUMAN [view interactions] High throughput no yes
MZT2B_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
TXND9_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
TP4A3_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC5_HUMAN [view interactions] High throughput no yes
HAUS6_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
FHI2B_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
GCP6_HUMAN [view interactions] High throughput no yes
NDK7_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
RBCC1_HUMAN [view interactions] High throughput no no
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
CENPJ_HUMAN [view interactions] Computational no no
MZT1_HUMAN [view interactions] Computational no yes
NEDD1_HUMAN [view interactions] Computational no yes