MTMRD_HUMAN
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed, PubMed). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed, PubMed). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Acts as an adapter for the phosphatase MTMR2 . Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate . [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MTMRD_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 28.5714 | 4 | no |
GO:0030695 | GTPase regulator activity | 23.8095 | 4 | yes |
GO:0031267 | small GTPase binding | 23.8095 | 5 | no |
GO:0051020 | GTPase binding | 23.8095 | 4 | no |
GO:0005085 | guanyl-nucleotide exchange factor activity | 14.2857 | 5 | yes |
GO:0035091 | phosphatidylinositol binding | 9.5238 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MTMRD_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 52.3810 | 4 | no |
GO:0048523 | negative regulation of cellular process | 52.3810 | 4 | no |
GO:0051128 | regulation of cellular component organization | 52.3810 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 52.3810 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | no |
GO:0048522 | positive regulation of cellular process | 52.3810 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 47.6190 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 47.6190 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 42.8571 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 42.8571 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 38.0952 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 38.0952 | 6 | no |
GO:0051049 | regulation of transport | 38.0952 | 4 | no |
GO:0008104 | protein localization | 38.0952 | 4 | no |
GO:0009894 | regulation of catabolic process | 33.3333 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 33.3333 | 5 | no |
GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 28.5714 | 4 | yes |
GO:0006996 | organelle organization | 28.5714 | 4 | no |
GO:0010038 | response to metal ion | 28.5714 | 4 | no |
GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 28.5714 | 4 | no |
GO:0036211 | protein modification process | 28.5714 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0015031 | protein transport | 28.5714 | 4 | no |
GO:0071702 | organic substance transport | 28.5714 | 4 | no |
GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
GO:0009895 | negative regulation of catabolic process | 23.8095 | 5 | no |
GO:0031330 | negative regulation of cellular catabolic process | 23.8095 | 6 | no |
GO:0031344 | regulation of cell projection organization | 23.8095 | 5 | no |
GO:0031399 | regulation of protein modification process | 23.8095 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 23.8095 | 7 | no |
GO:0051338 | regulation of transferase activity | 23.8095 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.8095 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | no |
GO:0044057 | regulation of system process | 23.8095 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
GO:0051051 | negative regulation of transport | 23.8095 | 4 | no |
GO:0051592 | response to calcium ion | 23.8095 | 5 | no |
GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
GO:0033365 | protein localization to organelle | 23.8095 | 5 | no |
GO:0043087 | regulation of GTPase activity | 14.2857 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in MTMRD_HUMAN |
---|---|---|---|---|
DOID:10595 | Charcot-Marie-Tooth disease | 14.2857 | 6 | no |
DOID:440 | neuromuscular disease | 14.2857 | 5 | no |
DOID:574 | peripheral nervous system disease | 14.2857 | 3 | no |
DOID:870 | neuropathy | 14.2857 | 4 | no |
DOID:0050541 | Charcot-Marie-Tooth disease type 4 | 9.5238 | 7 | no |
DOID:0050700 | cardiomyopathy | 9.5238 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 9.5238 | 5 | no |
DOID:114 | heart disease | 9.5238 | 3 | no |
DOID:2843 | long QT syndrome | 9.5238 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SORT_HUMAN | [view interactions] | High throughput | no | yes |
MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
MTMR5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBPMS_HUMAN | [view interactions] | High throughput | no | no |
FHL3_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FOS_HUMAN | [view interactions] | High throughput | no | yes |
DCTP1_HUMAN | [view interactions] | High throughput | no | no |
TXD12_HUMAN | [view interactions] | High throughput | no | no |
MPPB_HUMAN | [view interactions] | High throughput | no | yes |
KAD2_HUMAN | [view interactions] | High throughput | no | no |
G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FTO_HUMAN | [view interactions] | High throughput | no | yes |
UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H2AW_HUMAN | [view interactions] | High throughput | no | yes |
PMS1_HUMAN | [view interactions] | High throughput | no | no |
FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
SMD2_HUMAN | [view interactions] | High throughput | no | yes |
SQOR_HUMAN | [view interactions] | High throughput | no | yes |
PPM1G_HUMAN | [view interactions] | High throughput | no | no |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
LSM7_HUMAN | [view interactions] | High throughput | no | yes |
DYR_HUMAN | [view interactions] | High throughput | no | yes |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAB21_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAE2_HUMAN | [view interactions] | Computational | no | yes |
S3TC2_HUMAN | [view interactions] | Computational | no | yes |
FIG4_HUMAN | [view interactions] | Computational | no | yes |
RAE1_HUMAN | [view interactions] | Computational | no | yes |
FGD4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |