Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MTMRD_HUMAN

Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed, PubMed). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed, PubMed). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Acts as an adapter for the phosphatase MTMR2 . Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MTMRD_HUMAN
GO:0003723 RNA binding 28.5714 4 no
GO:0030695 GTPase regulator activity 23.8095 4 yes
GO:0031267 small GTPase binding 23.8095 5 no
GO:0051020 GTPase binding 23.8095 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 14.2857 5 yes
GO:0035091 phosphatidylinositol binding 9.5238 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MTMRD_HUMAN
GO:0031323 regulation of cellular metabolic process 52.3810 4 no
GO:0048523 negative regulation of cellular process 52.3810 4 no
GO:0051128 regulation of cellular component organization 52.3810 4 no
GO:0060255 regulation of macromolecule metabolic process 52.3810 4 no
GO:0080090 regulation of primary metabolic process 52.3810 4 no
GO:0048522 positive regulation of cellular process 52.3810 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.6190 4 no
GO:0051246 regulation of protein metabolic process 47.6190 5 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 38.0952 5 no
GO:0051248 negative regulation of protein metabolic process 38.0952 6 no
GO:0051049 regulation of transport 38.0952 4 no
GO:0008104 protein localization 38.0952 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051336 regulation of hydrolase activity 28.5714 4 yes
GO:0006996 organelle organization 28.5714 4 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0036211 protein modification process 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0015031 protein transport 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0009895 negative regulation of catabolic process 23.8095 5 no
GO:0031330 negative regulation of cellular catabolic process 23.8095 6 no
GO:0031344 regulation of cell projection organization 23.8095 5 no
GO:0031399 regulation of protein modification process 23.8095 6 no
GO:0031400 negative regulation of protein modification process 23.8095 7 no
GO:0051338 regulation of transferase activity 23.8095 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.8095 6 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0044057 regulation of system process 23.8095 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0051051 negative regulation of transport 23.8095 4 no
GO:0051592 response to calcium ion 23.8095 5 no
GO:0060341 regulation of cellular localization 23.8095 4 no
GO:0033365 protein localization to organelle 23.8095 5 no
GO:0043087 regulation of GTPase activity 14.2857 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in MTMRD_HUMAN
DOID:10595 Charcot-Marie-Tooth disease 14.2857 6 no
DOID:440 neuromuscular disease 14.2857 5 no
DOID:574 peripheral nervous system disease 14.2857 3 no
DOID:870 neuropathy 14.2857 4 no
DOID:0050541 Charcot-Marie-Tooth disease type 4 9.5238 7 no
DOID:0050700 cardiomyopathy 9.5238 4 no
DOID:0060036 intrinsic cardiomyopathy 9.5238 5 no
DOID:114 heart disease 9.5238 3 no
DOID:2843 long QT syndrome 9.5238 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MTMR2_HUMAN [view entry] [view interactions] High throughput yes no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
SORT_HUMAN [view interactions] High throughput no yes
MTMR1_HUMAN [view interactions] High throughput no yes
MTMR5_HUMAN [view entry] [view interactions] High throughput yes no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
RBPMS_HUMAN [view interactions] High throughput no no
FHL3_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
FOS_HUMAN [view interactions] High throughput no yes
DCTP1_HUMAN [view interactions] High throughput no no
TXD12_HUMAN [view interactions] High throughput no no
MPPB_HUMAN [view interactions] High throughput no yes
KAD2_HUMAN [view interactions] High throughput no no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
FTO_HUMAN [view interactions] High throughput no yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
H2AW_HUMAN [view interactions] High throughput no yes
PMS1_HUMAN [view interactions] High throughput no no
FBW1B_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
SMD2_HUMAN [view interactions] High throughput no yes
SQOR_HUMAN [view interactions] High throughput no yes
PPM1G_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
LSM7_HUMAN [view interactions] High throughput no yes
DYR_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPU_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
GDIA_HUMAN [view entry] [view interactions] Computational yes yes
RAB21_HUMAN [view entry] [view interactions] Computational yes yes
GDIB_HUMAN [view entry] [view interactions] Computational yes yes
RAE2_HUMAN [view interactions] Computational no yes
S3TC2_HUMAN [view interactions] Computational no yes
FIG4_HUMAN [view interactions] Computational no yes
RAE1_HUMAN [view interactions] Computational no yes
FGD4_HUMAN [view entry] [view interactions] Computational yes yes