MTMRD_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed, PubMed). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed, PubMed). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Acts as an adapter for the phosphatase MTMR2 . Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MTMRD_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 33.3333 | 4 | no |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 13.3333 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 13.3333 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 13.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MTMRD_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 53.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 46.6667 | 4 | no |
| GO:0009894 | regulation of catabolic process | 46.6667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 46.6667 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.6667 | 4 | no |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 33.3333 | 4 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009895 | negative regulation of catabolic process | 33.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0006508 | proteolysis | 26.6667 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 26.6667 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 26.6667 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 26.6667 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0051049 | regulation of transport | 26.6667 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.6667 | 4 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0030162 | regulation of proteolysis | 26.6667 | 6 | no |
| GO:0033365 | protein localization to organelle | 26.6667 | 5 | no |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 26.6667 | 7 | no |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 26.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.6667 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| H2AW_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| DCTP1_HUMAN | [view interactions] | High throughput | no | no |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| SQOR_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |