GRIK3_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIK3_HUMAN |
|---|---|---|---|---|
| GO:0004970 | glutamate-gated receptor activity | 85.7143 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 85.7143 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 85.7143 | 6 | yes |
| GO:0005261 | monoatomic cation channel activity | 85.7143 | 5 | yes |
| GO:0005267 | potassium channel activity | 85.7143 | 6 | yes |
| GO:0005272 | sodium channel activity | 85.7143 | 6 | yes |
| GO:0008066 | glutamate receptor activity | 85.7143 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 85.7143 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 85.7143 | 6 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 85.7143 | 6 | yes |
| GO:0015267 | channel activity | 85.7143 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 85.7143 | 5 | yes |
| GO:0015277 | kainate selective glutamate receptor activity | 85.7143 | 5 | yes |
| GO:0015280 | ligand-gated sodium channel activity | 85.7143 | 7 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 85.7143 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 85.7143 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 85.7143 | 4 | yes |
| GO:0022836 | gated channel activity | 85.7143 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 85.7143 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 85.7143 | 5 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 85.7143 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 85.7143 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 85.7143 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 85.7143 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 85.7143 | 6 | yes |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 71.4286 | 6 | yes |
| GO:0001640 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | 28.5714 | 6 | yes |
| GO:0004930 | G protein-coupled receptor activity | 28.5714 | 4 | yes |
| GO:0098988 | G protein-coupled glutamate receptor activity | 28.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIK3_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 100.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 100.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 100.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 85.7143 | 7 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 85.7143 | 8 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 85.7143 | 6 | yes |
| GO:0099536 | synaptic signaling | 85.7143 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 85.7143 | 5 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 71.4286 | 4 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 71.4286 | 6 | yes |
| GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 42.8571 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 42.8571 | 4 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 42.8571 | 5 | yes |
| GO:0051967 | negative regulation of synaptic transmission, glutamatergic | 42.8571 | 6 | yes |
| GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 28.5714 | 4 | yes |
| GO:0006915 | apoptotic process | 28.5714 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 28.5714 | 4 | no |
| GO:0060078 | regulation of postsynaptic membrane potential | 28.5714 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIK4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| GRIK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |