Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIK3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIK3_HUMAN
GO:0004970 ionotropic glutamate receptor activity 83.3333 5 yes
GO:0005216 ion channel activity 83.3333 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 83.3333 6 yes
GO:0005261 cation channel activity 83.3333 5 yes
GO:0005267 potassium channel activity 83.3333 6 yes
GO:0005272 sodium channel activity 83.3333 6 yes
GO:0008066 glutamate receptor activity 83.3333 4 yes
GO:0008324 cation transmembrane transporter activity 83.3333 4 yes
GO:0015079 potassium ion transmembrane transporter activity 83.3333 6 yes
GO:0015081 sodium ion transmembrane transporter activity 83.3333 6 yes
GO:0015267 channel activity 83.3333 4 yes
GO:0015276 ligand-gated ion channel activity 83.3333 5 yes
GO:0015277 kainate selective glutamate receptor activity 83.3333 6 yes
GO:0022824 transmitter-gated ion channel activity 83.3333 5 yes
GO:0022834 ligand-gated channel activity 83.3333 6 yes
GO:0022835 transmitter-gated channel activity 83.3333 4 yes
GO:0022836 gated channel activity 83.3333 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 83.3333 4 yes
GO:0046873 metal ion transmembrane transporter activity 83.3333 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 83.3333 4 yes
GO:0099094 ligand-gated cation channel activity 83.3333 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 83.3333 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 83.3333 6 yes
GO:0099507 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential 50.0000 6 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 33.3333 6 yes
GO:0004930 G protein-coupled receptor activity 33.3333 4 yes
GO:0098988 G protein-coupled glutamate receptor activity 33.3333 5 yes
GO:0030165 PDZ domain binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRIK3_HUMAN
GO:0007268 chemical synaptic transmission 83.3333 6 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0035249 synaptic transmission, glutamatergic 83.3333 7 yes
GO:0050804 modulation of chemical synaptic transmission 83.3333 5 yes
GO:0098916 anterograde trans-synaptic signaling 83.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 83.3333 4 yes
GO:0099537 trans-synaptic signaling 83.3333 4 yes
GO:0007215 glutamate receptor signaling pathway 66.6667 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0010648 negative regulation of cell communication 50.0000 5 yes
GO:0023057 negative regulation of signaling 50.0000 4 yes
GO:0050805 negative regulation of synaptic transmission 50.0000 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 50.0000 6 yes
GO:0051967 negative regulation of synaptic transmission, glutamatergic 50.0000 6 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 33.3333 4 yes
GO:0006915 apoptotic process 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0080135 regulation of cellular response to stress 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0010942 positive regulation of cell death 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043065 positive regulation of apoptotic process 33.3333 7 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0043068 positive regulation of programmed cell death 33.3333 6 no
GO:0043113 receptor clustering 33.3333 5 no
GO:0043523 regulation of neuron apoptotic process 33.3333 6 no
GO:0043525 positive regulation of neuron apoptotic process 33.3333 7 no
GO:0048878 chemical homeostasis 33.3333 4 no
GO:0060078 regulation of postsynaptic membrane potential 33.3333 4 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:1901214 regulation of neuron death 33.3333 5 no
GO:1901216 positive regulation of neuron death 33.3333 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIK4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK5_HUMAN [view entry] [view interactions] Low throughput yes no
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK3_HUMAN [view entry] [view interactions] Low throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
SSRG_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes