Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIK4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIK4_HUMAN
GO:0004970 glutamate-gated receptor activity 71.4286 4 yes
GO:0005216 monoatomic ion channel activity 71.4286 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 71.4286 6 yes
GO:0005261 monoatomic cation channel activity 71.4286 5 yes
GO:0005267 potassium channel activity 71.4286 6 yes
GO:0005272 sodium channel activity 71.4286 6 yes
GO:0008066 glutamate receptor activity 71.4286 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 71.4286 4 yes
GO:0015079 potassium ion transmembrane transporter activity 71.4286 6 yes
GO:0015081 sodium ion transmembrane transporter activity 71.4286 6 yes
GO:0015267 channel activity 71.4286 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 71.4286 5 yes
GO:0015277 kainate selective glutamate receptor activity 71.4286 5 yes
GO:0015280 ligand-gated sodium channel activity 71.4286 7 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 71.4286 5 yes
GO:0022834 ligand-gated channel activity 71.4286 6 yes
GO:0022835 transmitter-gated channel activity 71.4286 4 yes
GO:0022836 gated channel activity 71.4286 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 71.4286 4 yes
GO:0046873 metal ion transmembrane transporter activity 71.4286 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 71.4286 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 71.4286 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 71.4286 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 71.4286 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 71.4286 6 yes
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 57.1429 6 yes
GO:0030165 PDZ domain binding 28.5714 4 no
GO:0031624 ubiquitin conjugating enzyme binding 28.5714 5 no
GO:0031625 ubiquitin protein ligase binding 28.5714 5 no
GO:0044389 ubiquitin-like protein ligase binding 28.5714 4 no
GO:0044390 ubiquitin-like protein conjugating enzyme binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GRIK4_HUMAN
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 100.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 100.0000 4 yes
GO:0007268 chemical synaptic transmission 85.7143 7 yes
GO:0035249 synaptic transmission, glutamatergic 85.7143 8 yes
GO:0098916 anterograde trans-synaptic signaling 85.7143 6 yes
GO:0099536 synaptic signaling 85.7143 4 yes
GO:0099537 trans-synaptic signaling 85.7143 5 yes
GO:0007215 glutamate receptor signaling pathway 71.4286 4 yes
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 42.8571 6 no
GO:0008104 protein localization 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0050805 negative regulation of synaptic transmission 28.5714 5 no
GO:0051967 negative regulation of synaptic transmission, glutamatergic 28.5714 6 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043066 negative regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043069 negative regulation of programmed cell death 28.5714 5 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0043523 regulation of neuron apoptotic process 28.5714 6 no
GO:0043524 negative regulation of neuron apoptotic process 28.5714 7 no
GO:0046328 regulation of JNK cascade 28.5714 7 no
GO:0048168 regulation of neuronal synaptic plasticity 28.5714 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0007417 central nervous system development 28.5714 4 no
GO:0017157 regulation of exocytosis 28.5714 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0044788 modulation by host of viral process 28.5714 5 no
GO:0046928 regulation of neurotransmitter secretion 28.5714 5 no
GO:0051046 regulation of secretion 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051588 regulation of neurotransmitter transport 28.5714 5 no
GO:0051851 modulation by host of symbiont process 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0098657 import into cell 28.5714 4 no
GO:1903530 regulation of secretion by cell 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK3_HUMAN [view entry] [view interactions] Low throughput yes no
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
RUFY1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
GRIK1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIK4_HUMAN [view entry] [view interactions] High throughput yes yes