GRIK4_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIK4_HUMAN |
|---|---|---|---|---|
| GO:0004970 | ionotropic glutamate receptor activity | 75.0000 | 5 | yes |
| GO:0005216 | ion channel activity | 75.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 75.0000 | 6 | yes |
| GO:0005261 | cation channel activity | 75.0000 | 5 | yes |
| GO:0005267 | potassium channel activity | 75.0000 | 6 | yes |
| GO:0005272 | sodium channel activity | 75.0000 | 6 | yes |
| GO:0008066 | glutamate receptor activity | 75.0000 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 75.0000 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 75.0000 | 6 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 75.0000 | 6 | yes |
| GO:0015267 | channel activity | 75.0000 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 75.0000 | 5 | yes |
| GO:0015277 | kainate selective glutamate receptor activity | 75.0000 | 6 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 75.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 75.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 75.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 75.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 75.0000 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 75.0000 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 75.0000 | 4 | yes |
| GO:0099094 | ligand-gated cation channel activity | 75.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 75.0000 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 75.0000 | 6 | yes |
| GO:0099507 | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential | 50.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIK4_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 100.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 100.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 100.0000 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 75.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 75.0000 | 6 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 75.0000 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 75.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 75.0000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 50.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0050805 | negative regulation of synaptic transmission | 50.0000 | 5 | no |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 50.0000 | 6 | no |
| GO:0051967 | negative regulation of synaptic transmission, glutamatergic | 50.0000 | 6 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 50.0000 | 4 | no |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 50.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MARK4_HUMAN | [view interactions] | Computational | no | yes |
| GRM4_HUMAN | [view interactions] | Computational | no | no |