Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

F1711_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in F1711_HUMAN
GO:0017076 purine nucleotide binding 66.6667 4 no
GO:0032555 purine ribonucleotide binding 66.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 66.6667 4 no
GO:0019900 kinase binding 39.3939 4 no
GO:0019901 protein kinase binding 39.3939 5 no
GO:0005524 ATP binding 36.3636 5 no
GO:0030554 adenyl nucleotide binding 36.3636 5 no
GO:0032559 adenyl ribonucleotide binding 36.3636 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 30.3030 4 no
GO:0004713 protein tyrosine kinase activity 30.3030 4 no
GO:0016301 kinase activity 30.3030 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.3030 4 no
GO:0003924 GTPase activity 30.3030 7 no
GO:0005525 GTP binding 30.3030 5 no
GO:0016462 pyrophosphatase activity 30.3030 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.3030 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.3030 6 no
GO:0019001 guanyl nucleotide binding 30.3030 5 no
GO:0032561 guanyl ribonucleotide binding 30.3030 5 no
GO:0004714 transmembrane receptor protein tyrosine kinase activity 24.2424 5 no
GO:0019199 transmembrane receptor protein kinase activity 24.2424 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in F1711_HUMAN
GO:0048522 positive regulation of cellular process 81.8182 4 no
GO:0051128 regulation of cellular component organization 69.6970 4 no
GO:0060255 regulation of macromolecule metabolic process 69.6970 4 no
GO:0009893 positive regulation of metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 63.6364 5 no
GO:0031323 regulation of cellular metabolic process 63.6364 4 no
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 no
GO:0010646 regulation of cell communication 60.6061 4 no
GO:0048523 negative regulation of cellular process 60.6061 4 no
GO:0048584 positive regulation of response to stimulus 60.6061 4 no
GO:0009966 regulation of signal transduction 57.5758 4 no
GO:0010647 positive regulation of cell communication 57.5758 5 no
GO:0023056 positive regulation of signaling 57.5758 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 57.5758 5 no
GO:0031325 positive regulation of cellular metabolic process 54.5455 5 no
GO:1902531 regulation of intracellular signal transduction 54.5455 5 no
GO:0009967 positive regulation of signal transduction 51.5152 5 no
GO:0019220 regulation of phosphate metabolic process 51.5152 6 no
GO:0030030 cell projection organization 51.5152 4 no
GO:0042325 regulation of phosphorylation 51.5152 7 no
GO:0051174 regulation of phosphorus metabolic process 51.5152 5 no
GO:0010468 regulation of gene expression 51.5152 5 no
GO:0006996 organelle organization 48.4848 4 yes
GO:0022607 cellular component assembly 48.4848 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 48.4848 6 no
GO:0042327 positive regulation of phosphorylation 48.4848 8 no
GO:0045937 positive regulation of phosphate metabolic process 48.4848 7 no
GO:0051246 regulation of protein metabolic process 48.4848 5 no
GO:1902533 positive regulation of intracellular signal transduction 48.4848 6 no
GO:0042127 regulation of cell population proliferation 45.4545 4 no
GO:0045595 regulation of cell differentiation 45.4545 4 no
GO:0051094 positive regulation of developmental process 45.4545 4 no
GO:0051247 positive regulation of protein metabolic process 45.4545 6 no
GO:0120036 plasma membrane bounded cell projection organization 45.4545 5 no
GO:0051049 regulation of transport 45.4545 4 no
GO:0022603 regulation of anatomical structure morphogenesis 42.4242 4 yes
GO:0031344 regulation of cell projection organization 42.4242 5 no
GO:0051130 positive regulation of cellular component organization 42.4242 5 no
GO:0071310 cellular response to organic substance 42.4242 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.4242 6 no
GO:0001932 regulation of protein phosphorylation 39.3939 7 no
GO:0031399 regulation of protein modification process 39.3939 6 no
GO:0043085 positive regulation of catalytic activity 39.3939 4 no
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 no
GO:0007167 enzyme-linked receptor protein signaling pathway 36.3636 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 36.3636 5 no
GO:0008284 positive regulation of cell population proliferation 36.3636 5 no
GO:0030155 regulation of cell adhesion 36.3636 4 no
GO:0030334 regulation of cell migration 36.3636 5 no
GO:0031346 positive regulation of cell projection organization 36.3636 6 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0043408 regulation of MAPK cascade 36.3636 6 no
GO:2000145 regulation of cell motility 36.3636 4 no
GO:0044087 regulation of cellular component biogenesis 36.3636 4 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0022604 regulation of cell morphogenesis 33.3333 5 yes
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0010628 positive regulation of gene expression 33.3333 6 no
GO:0007015 actin filament organization 30.3030 5 yes
GO:0097435 supramolecular fiber organization 30.3030 4 yes
GO:0010648 negative regulation of cell communication 30.3030 5 no
GO:0023057 negative regulation of signaling 30.3030 4 no
GO:0030335 positive regulation of cell migration 30.3030 6 no
GO:0031175 neuron projection development 30.3030 6 no
GO:0036211 protein modification process 30.3030 4 no
GO:0040017 positive regulation of locomotion 30.3030 4 no
GO:0043410 positive regulation of MAPK cascade 30.3030 7 no
GO:0043412 macromolecule modification 30.3030 4 no
GO:0045597 positive regulation of cell differentiation 30.3030 5 no
GO:0045785 positive regulation of cell adhesion 30.3030 5 no
GO:1901701 cellular response to oxygen-containing compound 30.3030 4 no
GO:2000147 positive regulation of cell motility 30.3030 5 no
GO:0008104 protein localization 30.3030 4 no
GO:0009889 regulation of biosynthetic process 30.3030 4 no
GO:0016192 vesicle-mediated transport 30.3030 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.3030 5 no
GO:0031326 regulation of cellular biosynthetic process 30.3030 5 no
GO:0010941 regulation of cell death 30.3030 4 no
GO:0032970 regulation of actin filament-based process 30.3030 4 no
GO:0061024 membrane organization 30.3030 4 no
GO:0006468 protein phosphorylation 27.2727 5 no
GO:0010975 regulation of neuron projection development 27.2727 7 no
GO:0016310 phosphorylation 27.2727 5 no
GO:0051241 negative regulation of multicellular organismal process 27.2727 4 no
GO:0002684 positive regulation of immune system process 27.2727 4 no
GO:0007264 small GTPase mediated signal transduction 27.2727 4 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0042981 regulation of apoptotic process 27.2727 6 no
GO:0043067 regulation of programmed cell death 27.2727 5 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0051050 positive regulation of transport 27.2727 4 no
GO:0008360 regulation of cell shape 24.2424 6 yes
GO:0010243 response to organonitrogen compound 24.2424 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.2424 5 no
GO:0032101 regulation of response to external stimulus 24.2424 4 no
GO:0045596 negative regulation of cell differentiation 24.2424 5 no
GO:0051093 negative regulation of developmental process 24.2424 4 no
GO:0051336 regulation of hydrolase activity 24.2424 4 no
GO:0060284 regulation of cell development 24.2424 5 no
GO:1901699 cellular response to nitrogen compound 24.2424 4 no
GO:0010556 regulation of macromolecule biosynthetic process 24.2424 5 no
GO:0051252 regulation of RNA metabolic process 24.2424 5 no
GO:0007265 Ras protein signal transduction 24.2424 5 no
GO:0032956 regulation of actin cytoskeleton organization 24.2424 5 no
GO:0051493 regulation of cytoskeleton organization 24.2424 6 no
GO:0009968 negative regulation of signal transduction 21.2121 5 no
GO:0010720 positive regulation of cell development 21.2121 6 no
GO:0032990 cell part morphogenesis 21.2121 4 no
GO:0045859 regulation of protein kinase activity 21.2121 6 no
GO:0048585 negative regulation of response to stimulus 21.2121 4 no
GO:0048812 neuron projection morphogenesis 21.2121 7 no
GO:0048858 cell projection morphogenesis 21.2121 5 no
GO:0050804 modulation of chemical synaptic transmission 21.2121 5 no
GO:0051345 positive regulation of hydrolase activity 21.2121 5 no
GO:0080134 regulation of response to stress 21.2121 4 no
GO:0099177 regulation of trans-synaptic signaling 21.2121 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.2121 6 no
GO:0006355 regulation of DNA-templated transcription 21.2121 6 no
GO:0009891 positive regulation of biosynthetic process 21.2121 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.2121 6 no
GO:0051046 regulation of secretion 21.2121 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.2121 7 no
GO:2001141 regulation of RNA biosynthetic process 21.2121 6 no
GO:0002694 regulation of leukocyte activation 21.2121 4 no
GO:0031324 negative regulation of cellular metabolic process 21.2121 5 no
GO:0050865 regulation of cell activation 21.2121 4 no
GO:0051249 regulation of lymphocyte activation 21.2121 5 no
GO:0032880 regulation of protein localization 21.2121 5 no
GO:0050776 regulation of immune response 21.2121 4 no
GO:0060341 regulation of cellular localization 21.2121 4 no
GO:0060627 regulation of vesicle-mediated transport 21.2121 4 no
GO:0030031 cell projection assembly 21.2121 5 no
GO:0010976 positive regulation of neuron projection development 21.2121 7 no
GO:0031032 actomyosin structure organization 9.0909 4 yes
GO:0051017 actin filament bundle assembly 9.0909 5 yes
GO:0061572 actin filament bundle organization 9.0909 6 yes
GO:0030038 contractile actin filament bundle assembly 6.0606 6 yes
GO:0043149 stress fiber assembly 6.0606 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in F1711_HUMAN
DOID:0050155 sensory system disease 6.0606 3 no
DOID:0050563 nonsyndromic deafness 6.0606 5 no
DOID:0050564 autosomal dominant nonsyndromic deafness 6.0606 6 no
DOID:2742 auditory system disease 6.0606 4 no
DOID:0111962 combined immunodeficiency 6.0606 4 no
DOID:612 primary immunodeficiency disease 6.0606 3 no
DOID:0050686 organ system cancer 6.0606 3 no
DOID:193 reproductive organ cancer 6.0606 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EGLN3_HUMAN [view interactions] High throughput no no
F171B_HUMAN [view interactions] High throughput no yes
TNR17_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
RASFA_HUMAN [view interactions] High throughput no no
MDM2_HUMAN [view interactions] High throughput no yes
ETS1_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
DYRK2_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
DDR1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
EPHA3_HUMAN [view interactions] High throughput no yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRA_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
ROR1_HUMAN [view interactions] High throughput no no
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view interactions] High throughput no no
STYK1_HUMAN [view interactions] High throughput no yes
PCDGD_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
TMM74_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
BACE2_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes