ARK72_HUMAN
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARK72_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 28.5714 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 23.8095 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 23.8095 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | 14.2857 | 7 | yes |
GO:0004033 | aldo-keto reductase (NADP) activity | 14.2857 | 5 | yes |
GO:0008106 | alcohol dehydrogenase (NADP+) activity | 14.2857 | 6 | yes |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 14.2857 | 4 | yes |
GO:0047834 | D-threo-aldose 1-dehydrogenase activity | 14.2857 | 5 | yes |
GO:0004301 | epoxide hydrolase activity | 9.5238 | 5 | yes |
GO:0016803 | ether hydrolase activity | 9.5238 | 4 | yes |
GO:0019118 | phenanthrene-epoxide hydrolase activity | 9.5238 | 6 | yes |
GO:0019119 | phenanthrene-9,10-epoxide hydrolase activity | 9.5238 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARK72_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
GO:0006996 | organelle organization | 28.5714 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
GO:0048523 | negative regulation of cellular process | 23.8095 | 4 | no |
GO:0007010 | cytoskeleton organization | 23.8095 | 5 | no |
GO:0008104 | protein localization | 23.8095 | 4 | no |
GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.8095 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 23.8095 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 23.8095 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 23.8095 | 4 | no |
GO:0016137 | glycoside metabolic process | 14.2857 | 5 | yes |
GO:0030647 | aminoglycoside antibiotic metabolic process | 14.2857 | 6 | yes |
GO:0034308 | primary alcohol metabolic process | 14.2857 | 4 | yes |
GO:1901657 | glycosyl compound metabolic process | 14.2857 | 4 | yes |
GO:1901661 | quinone metabolic process | 14.2857 | 4 | yes |
GO:1902644 | tertiary alcohol metabolic process | 14.2857 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CYGB_HUMAN | [view interactions] | Low throughput | no | yes |
ARK72_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
CTR9_HUMAN | [view interactions] | High throughput | no | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
CP131_HUMAN | [view interactions] | High throughput | no | no |
SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
DDA1_HUMAN | [view interactions] | High throughput | no | yes |
TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSH6_HUMAN | [view interactions] | High throughput | no | yes |
SLAI2_HUMAN | [view interactions] | High throughput | no | no |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCNB1_HUMAN | [view interactions] | High throughput | no | no |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
STRN3_HUMAN | [view interactions] | High throughput | no | yes |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
TPX2_HUMAN | [view interactions] | High throughput | no | yes |
NDC80_HUMAN | [view interactions] | High throughput | no | no |
MIS12_HUMAN | [view interactions] | High throughput | no | yes |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
FAN1_HUMAN | [view interactions] | High throughput | no | no |
CF298_HUMAN | [view interactions] | High throughput | no | yes |
KTNA1_HUMAN | [view interactions] | High throughput | no | yes |
RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARK73_HUMAN | [view interactions] | High throughput | no | no |
CISD3_HUMAN | [view interactions] | High throughput | no | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHC10_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
SAP_HUMAN | [view interactions] | High throughput | no | yes |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
ZBTB1_HUMAN | [view interactions] | High throughput | no | no |
CEP70_HUMAN | [view interactions] | High throughput | no | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEMO_HUMAN | [view interactions] | High throughput | no | yes |
TRADD_HUMAN | [view interactions] | High throughput | no | yes |
BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
FADD_HUMAN | [view interactions] | High throughput | no | yes |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
MCPH1_HUMAN | [view interactions] | High throughput | no | yes |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ITA4_HUMAN | [view interactions] | High throughput | no | no |
EYA2_HUMAN | [view interactions] | High throughput | no | yes |
MTM1_HUMAN | [view interactions] | High throughput | no | yes |
MTMRC_HUMAN | [view interactions] | High throughput | no | yes |
MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN21_HUMAN | [view interactions] | High throughput | no | yes |
PTN22_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
ARP10_HUMAN | [view interactions] | High throughput | no | no |
MB12A_HUMAN | [view interactions] | High throughput | no | yes |
DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN6_HUMAN | [view interactions] | High throughput | no | no |
VP37B_HUMAN | [view interactions] | High throughput | no | yes |
ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
DUS12_HUMAN | [view interactions] | High throughput | no | no |
PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NF2L2_HUMAN | [view interactions] | Computational | no | yes |
FOS_HUMAN | [view interactions] | Computational | no | yes |
AK1A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ATNG_HUMAN | [view interactions] | Computational | no | no |
JUN_HUMAN | [view interactions] | Computational | no | yes |
CREB1_HUMAN | [view interactions] | Computational | no | yes |