ARK72_HUMAN
Evidence for PS localization
Functions
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARK72_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 29.6296 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.6296 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.6296 | 4 | no |
| GO:0005524 | ATP binding | 25.9259 | 5 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0004032 | aldose reductase (NADPH) activity | 7.4074 | 7 | yes |
| GO:0004033 | aldo-keto reductase (NADPH) activity | 7.4074 | 5 | yes |
| GO:0004301 | epoxide hydrolase activity | 7.4074 | 5 | yes |
| GO:0008106 | alcohol dehydrogenase (NADP+) activity | 7.4074 | 6 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 7.4074 | 4 | yes |
| GO:0016803 | ether hydrolase activity | 7.4074 | 4 | yes |
| GO:0019118 | phenanthrene-epoxide hydrolase activity | 7.4074 | 6 | yes |
| GO:0019119 | phenanthrene-9,10-epoxide hydrolase activity | 7.4074 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARK72_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.7407 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.7407 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.0370 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.0370 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.0370 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.0370 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.6296 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.6296 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 29.6296 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.9259 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.9259 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.9259 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.9259 | 4 | no |
| GO:0006996 | organelle organization | 25.9259 | 4 | no |
| GO:0008104 | protein localization | 25.9259 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.9259 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.9259 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.9259 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.9259 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0022607 | cellular component assembly | 22.2222 | 4 | no |
| GO:0033365 | protein localization to organelle | 22.2222 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.2222 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0016137 | glycoside metabolic process | 7.4074 | 5 | yes |
| GO:0030647 | aminoglycoside antibiotic metabolic process | 7.4074 | 6 | yes |
| GO:0034308 | primary alcohol metabolic process | 7.4074 | 4 | yes |
| GO:0044597 | daunorubicin metabolic process | 7.4074 | 4 | yes |
| GO:0044598 | doxorubicin metabolic process | 7.4074 | 4 | yes |
| GO:1901657 | glycosyl compound metabolic process | 7.4074 | 4 | yes |
| GO:1902644 | tertiary alcohol metabolic process | 7.4074 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CYGB_HUMAN | [view interactions] | Low throughput | no | yes |
| ARK72_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNB1_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| FAN1_HUMAN | [view interactions] | High throughput | no | no |
| CF298_HUMAN | [view interactions] | High throughput | no | yes |
| KTNA1_HUMAN | [view interactions] | High throughput | no | yes |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARK73_HUMAN | [view interactions] | High throughput | no | no |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB1_HUMAN | [view interactions] | High throughput | no | no |
| CEP70_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| FADD_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| MCPH1_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRC_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN21_HUMAN | [view interactions] | High throughput | no | yes |
| PTN22_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| MB12A_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN6_HUMAN | [view interactions] | High throughput | no | no |
| VP37B_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |