Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IKBE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001305 DEG_SCF_TRCP1_1 DEG 156 161 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IKBE_HUMAN
GO:0003723 RNA binding 45.4545 4 no
GO:0031625 ubiquitin protein ligase binding 45.4545 5 no
GO:0044389 ubiquitin-like protein ligase binding 45.4545 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0019901 protein kinase binding 30.3030 5 no
GO:0046872 metal ion binding 30.3030 4 no
GO:0005524 ATP binding 30.3030 5 no
GO:0032555 purine ribonucleotide binding 30.3030 4 no
GO:0032559 adenyl ribonucleotide binding 30.3030 5 no
GO:0035639 purine ribonucleoside triphosphate binding 30.3030 4 no
GO:0016462 pyrophosphatase activity 24.2424 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.2424 4 no
GO:0016887 ATP hydrolysis activity 24.2424 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.2424 6 no
GO:0097718 disordered domain specific binding 21.2121 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in IKBE_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 75.7576 4 yes
GO:0060255 regulation of macromolecule metabolic process 75.7576 4 yes
GO:0080090 regulation of primary metabolic process 75.7576 4 yes
GO:0031323 regulation of cellular metabolic process 63.6364 4 yes
GO:0009893 positive regulation of metabolic process 63.6364 4 no
GO:0010604 positive regulation of macromolecule metabolic process 63.6364 5 no
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0048523 negative regulation of cellular process 60.6061 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 60.6061 5 no
GO:0051246 regulation of protein metabolic process 57.5758 5 no
GO:0009889 regulation of biosynthetic process 54.5455 4 yes
GO:0010468 regulation of gene expression 54.5455 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 51.5152 5 yes
GO:0031326 regulation of cellular biosynthetic process 51.5152 5 yes
GO:0010646 regulation of cell communication 51.5152 4 no
GO:0031325 positive regulation of cellular metabolic process 51.5152 5 no
GO:0051247 positive regulation of protein metabolic process 48.4848 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 48.4848 5 yes
GO:0009966 regulation of signal transduction 48.4848 4 no
GO:0008104 protein localization 45.4545 4 no
GO:0010941 regulation of cell death 45.4545 4 no
GO:0042981 regulation of apoptotic process 45.4545 6 no
GO:0043067 regulation of programmed cell death 45.4545 5 no
GO:0071310 cellular response to organic substance 42.4242 4 no
GO:0036211 protein modification process 42.4242 4 no
GO:0043412 macromolecule modification 42.4242 4 no
GO:0006996 organelle organization 42.4242 4 no
GO:0009892 negative regulation of metabolic process 42.4242 4 no
GO:0010605 negative regulation of macromolecule metabolic process 42.4242 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 42.4242 5 no
GO:0031399 regulation of protein modification process 42.4242 6 no
GO:1902531 regulation of intracellular signal transduction 39.3939 5 no
GO:0048584 positive regulation of response to stimulus 39.3939 4 no
GO:0006355 regulation of DNA-templated transcription 39.3939 6 yes
GO:0051252 regulation of RNA metabolic process 39.3939 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 39.3939 7 yes
GO:2001141 regulation of RNA biosynthetic process 39.3939 6 yes
GO:0009891 positive regulation of biosynthetic process 39.3939 5 no
GO:0031328 positive regulation of cellular biosynthetic process 39.3939 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 39.3939 6 no
GO:0031324 negative regulation of cellular metabolic process 36.3636 5 no
GO:0071702 organic substance transport 36.3636 4 no
GO:0071705 nitrogen compound transport 36.3636 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 36.3636 6 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0015031 protein transport 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0010628 positive regulation of gene expression 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0051254 positive regulation of RNA metabolic process 30.3030 6 no
GO:0080134 regulation of response to stress 30.3030 4 no
GO:0051248 negative regulation of protein metabolic process 30.3030 6 no
GO:0090304 nucleic acid metabolic process 30.3030 4 no
GO:0042176 regulation of protein catabolic process 30.3030 5 no
GO:0006886 intracellular protein transport 30.3030 4 no
GO:0010243 response to organonitrogen compound 30.3030 4 no
GO:0019220 regulation of phosphate metabolic process 30.3030 6 no
GO:0051174 regulation of phosphorus metabolic process 30.3030 5 no
GO:0060548 negative regulation of cell death 27.2727 5 no
GO:1901701 cellular response to oxygen-containing compound 27.2727 4 no
GO:1902680 positive regulation of RNA biosynthetic process 27.2727 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 27.2727 8 no
GO:0009057 macromolecule catabolic process 27.2727 4 no
GO:0006796 phosphate-containing compound metabolic process 27.2727 4 no
GO:0030162 regulation of proteolysis 27.2727 6 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:0051050 positive regulation of transport 27.2727 4 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 27.2727 7 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:0001932 regulation of protein phosphorylation 27.2727 7 no
GO:0006357 regulation of transcription by RNA polymerase II 27.2727 7 no
GO:0042325 regulation of phosphorylation 27.2727 7 no
GO:0043066 negative regulation of apoptotic process 27.2727 7 no
GO:0043069 negative regulation of programmed cell death 27.2727 6 no
GO:0045893 positive regulation of DNA-templated transcription 27.2727 7 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:0006508 proteolysis 24.2424 4 no
GO:0051336 regulation of hydrolase activity 24.2424 4 no
GO:0031400 negative regulation of protein modification process 24.2424 7 no
GO:0043085 positive regulation of catalytic activity 24.2424 4 no
GO:0051338 regulation of transferase activity 24.2424 4 no
GO:0050776 regulation of immune response 24.2424 4 no
GO:0051223 regulation of protein transport 24.2424 5 no
GO:0070201 regulation of establishment of protein localization 24.2424 6 no
GO:0044271 cellular nitrogen compound biosynthetic process 24.2424 4 no
GO:0006986 response to unfolded protein 24.2424 4 no
GO:0009890 negative regulation of biosynthetic process 24.2424 5 no
GO:0043933 protein-containing complex organization 24.2424 4 no
GO:0001817 regulation of cytokine production 24.2424 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.2424 6 no
GO:0010648 negative regulation of cell communication 24.2424 5 no
GO:0023057 negative regulation of signaling 24.2424 4 no
GO:0045937 positive regulation of phosphate metabolic process 24.2424 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 24.2424 8 no
GO:0071417 cellular response to organonitrogen compound 21.2121 4 no
GO:1901699 cellular response to nitrogen compound 21.2121 4 no
GO:0019941 modification-dependent protein catabolic process 21.2121 6 no
GO:0043632 modification-dependent macromolecule catabolic process 21.2121 5 no
GO:0044265 cellular macromolecule catabolic process 21.2121 4 no
GO:0051603 proteolysis involved in protein catabolic process 21.2121 5 no
GO:0050821 protein stabilization 21.2121 4 no
GO:0043549 regulation of kinase activity 21.2121 5 no
GO:0002684 positive regulation of immune system process 21.2121 4 no
GO:0002831 regulation of response to biotic stimulus 21.2121 4 no
GO:0010942 positive regulation of cell death 21.2121 5 no
GO:0031347 regulation of defense response 21.2121 5 no
GO:0032101 regulation of response to external stimulus 21.2121 4 no
GO:0043065 positive regulation of apoptotic process 21.2121 7 no
GO:0043068 positive regulation of programmed cell death 21.2121 6 no
GO:0050778 positive regulation of immune response 21.2121 5 no
GO:0014070 response to organic cyclic compound 21.2121 4 no
GO:0032386 regulation of intracellular transport 21.2121 5 no
GO:0033157 regulation of intracellular protein transport 21.2121 6 no
GO:0006259 DNA metabolic process 21.2121 4 no
GO:0007005 mitochondrion organization 21.2121 5 no
GO:0031396 regulation of protein ubiquitination 21.2121 8 no
GO:0033365 protein localization to organelle 21.2121 5 no
GO:0061136 regulation of proteasomal protein catabolic process 21.2121 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 21.2121 7 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.2121 6 no
GO:0010564 regulation of cell cycle process 21.2121 5 no
GO:0001934 positive regulation of protein phosphorylation 21.2121 8 no
GO:0009968 negative regulation of signal transduction 21.2121 5 no
GO:0042327 positive regulation of phosphorylation 21.2121 8 no
GO:0048585 negative regulation of response to stimulus 21.2121 4 no
GO:0042994 cytoplasmic sequestering of transcription factor 6.0606 5 yes
GO:0043433 negative regulation of DNA-binding transcription factor activity 6.0606 4 yes
GO:0051220 cytoplasmic sequestering of protein 6.0606 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in IKBE_HUMAN
DOID:0050700 cardiomyopathy 6.0606 4 no
DOID:0060036 intrinsic cardiomyopathy 6.0606 5 no
DOID:114 heart disease 6.0606 3 no
DOID:2843 long QT syndrome 6.0606 6 no
DOID:0050890 synucleinopathy 6.0606 5 no
DOID:0060894 early-onset Parkinsons disease 6.0606 7 no
DOID:1289 neurodegenerative disease 6.0606 4 no
DOID:14330 Parkinsons disease 6.0606 6 no
DOID:331 central nervous system disease 6.0606 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
PP6R1_HUMAN [view interactions] Low throughput no no
PP6R2_HUMAN [view interactions] Low throughput no no
REL_HUMAN [view interactions] Low throughput no yes
NFKB1_HUMAN [view interactions] Low throughput no yes
NFKB2_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
NCOR2_HUMAN [view interactions] Low throughput no yes
HDAC4_HUMAN [view interactions] Low throughput no yes
HDAC5_HUMAN [view interactions] Low throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1N_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
PRP4_HUMAN [view interactions] High throughput no yes
IKBA_HUMAN [view interactions] High throughput no yes
YETS4_HUMAN [view interactions] High throughput no no
CB27B_HUMAN [view interactions] High throughput no no
RELB_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PINK1_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
ANKH1_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
PSA5_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SYRC_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB2_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
UACA_HUMAN [view interactions] High throughput no yes
ANR17_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
PSME3_HUMAN [view interactions] High throughput no yes
IKBE_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1B_HUMAN [view interactions] High throughput no yes
IKKA_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
CB27A_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
HOOK1_HUMAN [view interactions] High throughput no no
RS27A_HUMAN [view entry] [view interactions] Computational yes yes
UBB_HUMAN [view entry] [view interactions] Computational yes yes
UBC_HUMAN [view entry] [view interactions] Computational yes yes
RL40_HUMAN [view entry] [view interactions] Computational yes yes
IKKB_HUMAN [view interactions] Computational no yes
IKBB_HUMAN [view interactions] Computational no no