Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IKBE_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001305 DEG_SCF_TRCP1_1 DEG 156 161 -
ELMI001305 DEG_SCF_TRCP1_1 DEG 156 161 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IKBE_HUMAN
GO:0003723 RNA binding 50.0000 4 no
GO:0000166 nucleotide binding 46.6667 4 no
GO:0043168 anion binding 46.6667 4 no
GO:0017076 purine nucleotide binding 43.3333 5 no
GO:0030554 adenyl nucleotide binding 43.3333 6 no
GO:0031625 ubiquitin protein ligase binding 43.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 43.3333 4 no
GO:0005524 ATP binding 40.0000 5 no
GO:0032555 purine ribonucleotide binding 40.0000 4 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0016887 ATP hydrolysis activity 33.3333 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0019900 kinase binding 26.6667 4 no
GO:0043169 cation binding 23.3333 4 no
GO:0046872 metal ion binding 23.3333 5 no
GO:0019901 protein kinase binding 23.3333 5 no
GO:0042826 histone deacetylase binding 23.3333 4 no
GO:0045296 cadherin binding 23.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in IKBE_HUMAN
GO:0060255 regulation of macromolecule metabolic process 80.0000 4 yes
GO:0080090 regulation of primary metabolic process 80.0000 4 yes
GO:0031323 regulation of cellular metabolic process 73.3333 4 yes
GO:0009889 regulation of biosynthetic process 70.0000 4 yes
GO:0048522 positive regulation of cellular process 70.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 66.6667 5 yes
GO:0031326 regulation of cellular biosynthetic process 66.6667 5 yes
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0009893 positive regulation of metabolic process 63.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 63.3333 5 no
GO:0010468 regulation of gene expression 60.0000 6 yes
GO:0031325 positive regulation of cellular metabolic process 60.0000 5 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 56.6667 5 yes
GO:0009891 positive regulation of biosynthetic process 56.6667 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 53.3333 6 no
GO:0010646 regulation of cell communication 53.3333 4 no
GO:0031328 positive regulation of cellular biosynthetic process 53.3333 6 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0042981 regulation of apoptotic process 50.0000 5 no
GO:0043067 regulation of programmed cell death 50.0000 4 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0008104 protein localization 50.0000 4 no
GO:0006355 regulation of DNA-templated transcription 46.6667 7 yes
GO:0051252 regulation of RNA metabolic process 46.6667 5 yes
GO:2001141 regulation of RNA biosynthetic process 46.6667 6 yes
GO:0009892 negative regulation of metabolic process 46.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 46.6667 5 no
GO:0071310 cellular response to organic substance 46.6667 4 no
GO:0031399 regulation of protein modification process 43.3333 6 no
GO:0080134 regulation of response to stress 43.3333 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0009894 regulation of catabolic process 40.0000 4 no
GO:0010628 positive regulation of gene expression 40.0000 7 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0090304 nucleic acid metabolic process 40.0000 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0071702 organic substance transport 40.0000 4 no
GO:0071705 nitrogen compound transport 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0009967 positive regulation of signal transduction 36.6667 5 no
GO:0010647 positive regulation of cell communication 36.6667 5 no
GO:0023056 positive regulation of signaling 36.6667 4 no
GO:0051240 positive regulation of multicellular organismal process 36.6667 4 no
GO:0042176 regulation of protein catabolic process 36.6667 5 no
GO:0043066 negative regulation of apoptotic process 36.6667 6 no
GO:0043069 negative regulation of programmed cell death 36.6667 5 no
GO:0043933 protein-containing complex organization 36.6667 4 no
GO:0015031 protein transport 36.6667 4 no
GO:0032880 regulation of protein localization 36.6667 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0050821 protein stabilization 33.3333 4 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0002684 positive regulation of immune system process 33.3333 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0031347 regulation of defense response 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0032103 positive regulation of response to external stimulus 33.3333 5 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0050776 regulation of immune response 33.3333 4 no
GO:0050778 positive regulation of immune response 33.3333 5 no
GO:1901873 regulation of post-translational protein modification 33.3333 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 33.3333 8 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0001817 regulation of cytokine production 30.0000 4 no
GO:0010243 response to organonitrogen compound 30.0000 4 no
GO:0014070 response to organic cyclic compound 30.0000 4 no
GO:0002831 regulation of response to biotic stimulus 30.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 30.0000 8 no
GO:0031349 positive regulation of defense response 30.0000 5 no
GO:0045088 regulation of innate immune response 30.0000 5 no
GO:0051094 positive regulation of developmental process 30.0000 4 no
GO:0051254 positive regulation of RNA metabolic process 30.0000 6 no
GO:0006886 intracellular protein transport 30.0000 4 no
GO:0001819 positive regulation of cytokine production 26.6667 5 no
GO:0006753 nucleoside phosphate metabolic process 26.6667 4 no
GO:0009117 nucleotide metabolic process 26.6667 5 no
GO:0002833 positive regulation of response to biotic stimulus 26.6667 5 no
GO:0031400 negative regulation of protein modification process 26.6667 7 no
GO:0045089 positive regulation of innate immune response 26.6667 6 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0045893 positive regulation of DNA-templated transcription 26.6667 8 no
GO:1901701 cellular response to oxygen-containing compound 26.6667 4 no
GO:1902680 positive regulation of RNA biosynthetic process 26.6667 7 no
GO:0019220 regulation of phosphate metabolic process 26.6667 6 no
GO:0031396 regulation of protein ubiquitination 26.6667 9 no
GO:0031401 positive regulation of protein modification process 26.6667 7 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0051129 negative regulation of cellular component organization 26.6667 5 no
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 no
GO:0061136 regulation of proteasomal protein catabolic process 26.6667 6 no
GO:0070201 regulation of establishment of protein localization 26.6667 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 26.6667 7 no
GO:0009259 ribonucleotide metabolic process 23.3333 5 no
GO:0019693 ribose phosphate metabolic process 23.3333 4 no
GO:0036211 protein modification process 23.3333 4 no
GO:0043412 macromolecule modification 23.3333 4 no
GO:0051336 regulation of hydrolase activity 23.3333 4 no
GO:1901565 organonitrogen compound catabolic process 23.3333 4 no
GO:0009057 macromolecule catabolic process 23.3333 4 no
GO:0016070 RNA metabolic process 23.3333 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 23.3333 9 no
GO:2000026 regulation of multicellular organismal development 23.3333 4 no
GO:2001233 regulation of apoptotic signaling pathway 23.3333 5 no
GO:0001932 regulation of protein phosphorylation 23.3333 7 no
GO:0006259 DNA metabolic process 23.3333 5 no
GO:0007005 mitochondrion organization 23.3333 5 no
GO:0009896 positive regulation of catabolic process 23.3333 5 no
GO:0032386 regulation of intracellular transport 23.3333 5 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 23.3333 6 no
GO:0042325 regulation of phosphorylation 23.3333 7 no
GO:0043085 positive regulation of catalytic activity 23.3333 4 no
GO:0043254 regulation of protein-containing complex assembly 23.3333 5 no
GO:0051223 regulation of protein transport 23.3333 5 no
GO:1903829 positive regulation of protein localization 23.3333 5 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 23.3333 5 no
GO:0006986 response to unfolded protein 23.3333 4 no
GO:0033365 protein localization to organelle 23.3333 5 no
GO:0065003 protein-containing complex assembly 23.3333 5 no
GO:0051726 regulation of cell cycle 23.3333 4 no
GO:0042994 cytoplasmic sequestering of transcription factor 6.6667 5 yes
GO:0043433 negative regulation of DNA-binding transcription factor activity 6.6667 4 yes
GO:0051220 cytoplasmic sequestering of protein 6.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
PP6R1_HUMAN [view interactions] Low throughput no no
PP6R2_HUMAN [view interactions] Low throughput no no
REL_HUMAN [view interactions] Low throughput no yes
NFKB1_HUMAN [view interactions] Low throughput no yes
NFKB2_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
NCOR2_HUMAN [view interactions] Low throughput no yes
HDAC4_HUMAN [view interactions] Low throughput no yes
HDAC5_HUMAN [view interactions] Low throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1N_HUMAN [view interactions] High throughput no yes
TPX2_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
PRP4_HUMAN [view interactions] High throughput no yes
IKBA_HUMAN [view interactions] High throughput no yes
YETS4_HUMAN [view interactions] High throughput no no
RELB_HUMAN [view interactions] High throughput no yes
CB27B_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PINK1_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANKH1_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
PSA5_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SYRC_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB2_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
UACA_HUMAN [view interactions] High throughput no yes
ANR17_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3D_HUMAN [view interactions] High throughput no no
PSME3_HUMAN [view interactions] High throughput no yes
IKBE_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1B_HUMAN [view interactions] High throughput no yes
IKKA_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
CB27A_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
HOOK1_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
WWTR1_HUMAN [view interactions] High throughput no yes