RN19A_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RN19A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 80.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 80.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 80.0000 | 4 | no |
| GO:0005524 | ATP binding | 60.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 60.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 60.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 60.0000 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 60.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 60.0000 | 5 | no |
| GO:0046872 | metal ion binding | 40.0000 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 40.0000 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RN19A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 100.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 80.0000 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 80.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 80.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 80.0000 | 6 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 80.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 80.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 80.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 80.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 80.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 80.0000 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 60.0000 | 7 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 60.0000 | 5 | yes |
| GO:0061136 | regulation of proteasomal protein catabolic process | 60.0000 | 6 | yes |
| GO:1901800 | positive regulation of proteasomal protein catabolic process | 60.0000 | 7 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 60.0000 | 7 | yes |
| GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 60.0000 | 8 | yes |
| GO:0009889 | regulation of biosynthetic process | 60.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 60.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 60.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 60.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 60.0000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 60.0000 | 6 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:0006508 | proteolysis | 60.0000 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 60.0000 | 7 | yes |
| GO:0006996 | organelle organization | 60.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 60.0000 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 60.0000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 60.0000 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 60.0000 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 60.0000 | 6 | yes |
| GO:0030162 | regulation of proteolysis | 60.0000 | 6 | yes |
| GO:0036211 | protein modification process | 60.0000 | 4 | yes |
| GO:0042176 | regulation of protein catabolic process | 60.0000 | 5 | yes |
| GO:0043412 | macromolecule modification | 60.0000 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 60.0000 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 60.0000 | 4 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 60.0000 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 40.0000 | 5 | yes |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 40.0000 | 6 | yes |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 40.0000 | 7 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 40.0000 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 40.0000 | 7 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0010498 | proteasomal protein catabolic process | 40.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 40.0000 | 6 | no |
| GO:0030163 | protein catabolic process | 40.0000 | 4 | no |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 40.0000 | 6 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 40.0000 | 7 | no |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 40.0000 | 8 | no |
| GO:0051252 | regulation of RNA metabolic process | 40.0000 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 40.0000 | 6 | no |
| GO:1901565 | organonitrogen compound catabolic process | 40.0000 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 40.0000 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 40.0000 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 40.0000 | 8 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 40.0000 | 6 | no |
| GO:0006886 | intracellular protein transport | 40.0000 | 4 | no |
| GO:0007034 | vacuolar transport | 40.0000 | 4 | no |
| GO:0007041 | lysosomal transport | 40.0000 | 5 | no |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0008333 | endosome to lysosome transport | 40.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 40.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 40.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 40.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 40.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0071702 | organic substance transport | 40.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 40.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 40.0000 | 7 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0016567 | protein ubiquitination | 40.0000 | 7 | yes |
| GO:0031329 | regulation of cellular catabolic process | 40.0000 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 40.0000 | 6 | yes |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 40.0000 | 7 | yes |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 40.0000 | 8 | yes |
| GO:0032446 | protein modification by small protein conjugation | 40.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SODC_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L6_HUMAN | [view interactions] | Low throughput | no | no |
| CASR_HUMAN | [view interactions] | Low throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNCAP_HUMAN | [view interactions] | Low throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| SUFU_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA3_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |