Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RN19A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RN19A_HUMAN
GO:0000166 nucleotide binding 71.4286 4 no
GO:0017076 purine nucleotide binding 71.4286 5 no
GO:0032555 purine ribonucleotide binding 71.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 71.4286 4 no
GO:0043168 anion binding 71.4286 4 no
GO:0005524 ATP binding 57.1429 5 no
GO:0030554 adenyl nucleotide binding 57.1429 6 no
GO:0032559 adenyl ribonucleotide binding 57.1429 5 no
GO:0043169 cation binding 42.8571 4 yes
GO:0046872 metal ion binding 42.8571 5 yes
GO:0016462 pyrophosphatase activity 42.8571 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 42.8571 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 42.8571 6 no
GO:0008270 zinc ion binding 28.5714 7 yes
GO:0016755 aminoacyltransferase activity 28.5714 4 yes
GO:0046914 transition metal ion binding 28.5714 6 yes
GO:0061659 ubiquitin-like protein ligase activity 28.5714 4 yes
GO:0016887 ATP hydrolysis activity 28.5714 7 no
GO:0019902 phosphatase binding 28.5714 4 no
GO:0019903 protein phosphatase binding 28.5714 5 no
GO:0031625 ubiquitin protein ligase binding 28.5714 5 no
GO:0044389 ubiquitin-like protein ligase binding 28.5714 4 no
GO:0004674 protein serine/threonine kinase activity 28.5714 4 no
GO:0016301 kinase activity 28.5714 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.5714 4 no
GO:0106310 protein serine kinase activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RN19A_HUMAN
GO:0009893 positive regulation of metabolic process 85.7143 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 85.7143 5 yes
GO:0060255 regulation of macromolecule metabolic process 85.7143 4 yes
GO:0080090 regulation of primary metabolic process 85.7143 4 yes
GO:0048522 positive regulation of cellular process 85.7143 4 no
GO:0009894 regulation of catabolic process 71.4286 4 yes
GO:0009896 positive regulation of catabolic process 71.4286 5 yes
GO:0036211 protein modification process 71.4286 4 yes
GO:0043412 macromolecule modification 71.4286 4 yes
GO:0051246 regulation of protein metabolic process 71.4286 5 yes
GO:0051247 positive regulation of protein metabolic process 71.4286 6 yes
GO:0048523 negative regulation of cellular process 71.4286 4 no
GO:0009889 regulation of biosynthetic process 71.4286 4 no
GO:0009891 positive regulation of biosynthetic process 71.4286 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 71.4286 5 no
GO:0031323 regulation of cellular metabolic process 71.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 71.4286 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 71.4286 5 no
GO:0030162 regulation of proteolysis 57.1429 6 yes
GO:0042176 regulation of protein catabolic process 57.1429 5 yes
GO:0043687 post-translational protein modification 57.1429 5 yes
GO:0045732 positive regulation of protein catabolic process 57.1429 6 yes
GO:0045862 positive regulation of proteolysis 57.1429 7 yes
GO:0061136 regulation of proteasomal protein catabolic process 57.1429 6 yes
GO:1901800 positive regulation of proteasomal protein catabolic process 57.1429 7 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 57.1429 7 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 57.1429 8 yes
GO:0006355 regulation of DNA-templated transcription 57.1429 7 no
GO:0006357 regulation of transcription by RNA polymerase II 57.1429 8 no
GO:0010468 regulation of gene expression 57.1429 6 no
GO:0010556 regulation of macromolecule biosynthetic process 57.1429 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 57.1429 6 no
GO:0031326 regulation of cellular biosynthetic process 57.1429 5 no
GO:0031328 positive regulation of cellular biosynthetic process 57.1429 6 no
GO:0045893 positive regulation of DNA-templated transcription 57.1429 8 no
GO:0051252 regulation of RNA metabolic process 57.1429 5 no
GO:0051254 positive regulation of RNA metabolic process 57.1429 6 no
GO:1902680 positive regulation of RNA biosynthetic process 57.1429 7 no
GO:2001141 regulation of RNA biosynthetic process 57.1429 6 no
GO:0006508 proteolysis 42.8571 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 42.8571 7 yes
GO:0009057 macromolecule catabolic process 42.8571 4 yes
GO:0010646 regulation of cell communication 42.8571 4 yes
GO:0019941 modification-dependent protein catabolic process 42.8571 6 yes
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 42.8571 6 yes
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 42.8571 7 yes
GO:0032446 protein modification by small protein conjugation 42.8571 7 yes
GO:0043632 modification-dependent macromolecule catabolic process 42.8571 5 yes
GO:0051603 proteolysis involved in protein catabolic process 42.8571 5 yes
GO:0070647 protein modification by small protein conjugation or removal 42.8571 6 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 42.8571 5 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 42.8571 6 yes
GO:0042981 regulation of apoptotic process 42.8571 5 no
GO:0043067 regulation of programmed cell death 42.8571 4 no
GO:0050807 regulation of synapse organization 42.8571 5 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0006796 phosphate-containing compound metabolic process 42.8571 4 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0009890 negative regulation of biosynthetic process 42.8571 5 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0031327 negative regulation of cellular biosynthetic process 42.8571 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 42.8571 9 no
GO:0006996 organelle organization 28.5714 4 yes
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0016567 protein ubiquitination 28.5714 8 yes
GO:0006886 intracellular protein transport 28.5714 4 no
GO:0007034 vacuolar transport 28.5714 4 no
GO:0007041 lysosomal transport 28.5714 5 no
GO:0008104 protein localization 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010498 proteasomal protein catabolic process 28.5714 5 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0030163 protein catabolic process 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28.5714 6 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:1901565 organonitrogen compound catabolic process 28.5714 4 no
GO:1901873 regulation of post-translational protein modification 28.5714 7 no
GO:1901875 positive regulation of post-translational protein modification 28.5714 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 28.5714 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 28.5714 9 no
GO:0001817 regulation of cytokine production 28.5714 4 no
GO:0006468 protein phosphorylation 28.5714 5 no
GO:0006954 inflammatory response 28.5714 4 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0016310 phosphorylation 28.5714 5 no
GO:0019221 cytokine-mediated signaling pathway 28.5714 4 no
GO:0045892 negative regulation of DNA-templated transcription 28.5714 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0051253 negative regulation of RNA metabolic process 28.5714 6 no
GO:1902679 negative regulation of RNA biosynthetic process 28.5714 7 no
GO:0018193 peptidyl-amino acid modification 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SODC_HUMAN [view interactions] Low throughput no yes
UB2L3_HUMAN [view interactions] Low throughput no yes
UB2L6_HUMAN [view interactions] Low throughput no no
CASR_HUMAN [view interactions] Low throughput no no
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
SNCAP_HUMAN [view interactions] Low throughput no no
PRS6A_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SUFU_HUMAN [view interactions] High throughput no yes
NCOA3_HUMAN [view interactions] High throughput no yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
SMAP_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
CPSF5_HUMAN [view interactions] High throughput no yes
KS6A5_HUMAN [view entry] [view interactions] High throughput yes yes
M3K20_HUMAN [view interactions] High throughput no yes
TRPM7_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
UB2D2_HUMAN [view interactions] High throughput no yes