GDAP1_HUMAN
Evidence for PS localization
Functions
Regulates the mitochondrial network by promoting mitochondrial fission. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 120 | Arg | Gln | Charcot-Marie-Toothdisease4A(CMT4A) | - |
| 161 | Arg | His | Charcot-Marie-Toothdisease4A(CMT4A) | - |
| 282 | Arg | Cys | Charcot-Marie-Toothdisease,recessive,intermediatetype,A(CMTRIA) | - |
| 310 | Arg | Gln | Charcot-Marie-Toothdisease,axonal,withvocalcordparesis,autosomalrecessive(CMT2RV) | - |
| 256 | His | Arg | Charcot-Marie-Toothdisease2K(CMT2K) | - |
| 282 | Arg | His | Charcot-Marie-Toothdisease2K(CMT2K) | - |
| 120 | Arg | Gly | Charcot-Marie-Toothdisease2K(CMT2K) | - |
| 120 | Arg | Trp | Charcot-Marie-Toothdisease2K(CMT2K) | - |
| 123 | His | Arg | Charcot-Marie-Toothdisease2K(CMT2K) | - |
| 156 | Ala | Gly | Charcot-Marie-Toothdisease2K(CMT2K) | - |
| 310 | Arg | Trp | Charcot-Marie-Toothdisease2K(CMT2K) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDAP1_HUMAN |
|---|---|---|---|---|
| GO:0042803 | protein homodimerization activity | 37.5000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.2500 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.2500 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDAP1_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0006996 | organelle organization | 43.7500 | 4 | yes |
| GO:0008104 | protein localization | 37.5000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.5000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0006886 | intracellular protein transport | 31.2500 | 4 | yes |
| GO:0015031 | protein transport | 31.2500 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 31.2500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.2500 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.2500 | 4 | no |
| GO:0006605 | protein targeting | 25.0000 | 5 | yes |
| GO:0006626 | protein targeting to mitochondrion | 25.0000 | 5 | yes |
| GO:0006839 | mitochondrial transport | 25.0000 | 4 | yes |
| GO:0007005 | mitochondrion organization | 25.0000 | 5 | yes |
| GO:0008053 | mitochondrial fusion | 25.0000 | 6 | yes |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | yes |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | yes |
| GO:0043603 | cellular amide metabolic process | 25.0000 | 4 | yes |
| GO:0048284 | organelle fusion | 25.0000 | 5 | yes |
| GO:0048285 | organelle fission | 25.0000 | 5 | yes |
| GO:0070585 | protein localization to mitochondrion | 25.0000 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 25.0000 | 4 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 25.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0000266 | mitochondrial fission | 18.7500 | 6 | yes |
| GO:0031667 | response to nutrient levels | 18.7500 | 4 | yes |
| GO:0032526 | response to retinoic acid | 18.7500 | 4 | yes |
| GO:0033993 | response to lipid | 18.7500 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 18.7500 | 4 | yes |
| GO:0071396 | cellular response to lipid | 18.7500 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 18.7500 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 18.7500 | 4 | yes |
| GO:0006518 | peptide metabolic process | 12.5000 | 4 | yes |
| GO:0006749 | glutathione metabolic process | 12.5000 | 4 | yes |
| GO:0031669 | cellular response to nutrient levels | 12.5000 | 4 | yes |
| GO:0031670 | cellular response to nutrient | 12.5000 | 4 | yes |
| GO:0033273 | response to vitamin | 12.5000 | 4 | yes |
| GO:0033280 | response to vitamin D | 12.5000 | 4 | yes |
| GO:0071295 | cellular response to vitamin | 12.5000 | 5 | yes |
| GO:0071305 | cellular response to vitamin D | 12.5000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GDAP1_HUMAN |
|---|---|---|---|---|
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 18.7500 | 7 | yes |
| DOID:10595 | Charcot-Marie-Tooth disease | 18.7500 | 6 | yes |
| DOID:440 | neuromuscular disease | 18.7500 | 5 | yes |
| DOID:574 | peripheral nervous system disease | 18.7500 | 3 | yes |
| DOID:870 | neuropathy | 18.7500 | 4 | yes |
| DOID:0050541 | Charcot-Marie-Tooth disease type 4 | 12.5000 | 7 | yes |
| DOID:0050543 | Charcot-Marie-Tooth disease intermediate type | 12.5000 | 7 | yes |
| DOID:0110167 | Charcot-Marie-Tooth disease axonal type 2K | 12.5000 | 8 | yes |
| DOID:0110185 | Charcot-Marie-Tooth disease type 4A | 12.5000 | 8 | yes |
| DOID:0110201 | Charcot-Marie-Tooth disease recessive intermediate A | 12.5000 | 8 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GDAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| NXP20_HUMAN | [view interactions] | High throughput | no | yes |
| LIPR1_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| ABHGA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAR4_HUMAN | [view interactions] | High throughput | no | yes |
| TM218_HUMAN | [view interactions] | High throughput | no | no |
| CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HXC4_HUMAN | [view interactions] | High throughput | no | no |
| BOK_HUMAN | [view interactions] | High throughput | no | no |
| BIRC5_HUMAN | [view interactions] | High throughput | no | no |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| SPT12_HUMAN | [view interactions] | High throughput | no | no |
| KRA81_HUMAN | [view interactions] | High throughput | no | no |
| FOXR1_HUMAN | [view interactions] | High throughput | no | no |
| IQUB_HUMAN | [view interactions] | High throughput | no | no |
| VP37A_HUMAN | [view interactions] | High throughput | no | yes |
| MOFA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN697_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| WDR61_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| AAMDC_HUMAN | [view interactions] | High throughput | no | no |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| DCBD2_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAMP2_HUMAN | [view interactions] | High throughput | no | no |
| CBPQ_HUMAN | [view interactions] | High throughput | no | no |
| OS9_HUMAN | [view interactions] | High throughput | no | yes |
| ASM_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| PEX16_HUMAN | [view interactions] | Computational | no | yes |
| PEX14_HUMAN | [view interactions] | Computational | no | yes |
| ABCD1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATAD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PXMP2_HUMAN | [view interactions] | Computational | no | no |
| PEX26_HUMAN | [view interactions] | Computational | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABCD2_HUMAN | [view interactions] | Computational | no | no |
| PEX2_HUMAN | [view interactions] | Computational | no | yes |
| MFN1_HUMAN | [view interactions] | Computational | no | yes |
| S3TC2_HUMAN | [view interactions] | Computational | no | yes |
| MYP2_HUMAN | [view interactions] | Computational | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PM34_HUMAN | [view interactions] | Computational | no | yes |
| PX11B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PXMP4_HUMAN | [view interactions] | Computational | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MFN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PEX13_HUMAN | [view interactions] | Computational | no | yes |
| PEX19_HUMAN | [view interactions] | Computational | no | yes |
| MYP0_HUMAN | [view interactions] | Computational | no | no |