Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CP1B1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed, PubMed, PubMed, PubMed, PubMed). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed, PubMed, PubMed, PubMed, PubMed). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed, PubMed). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed, PubMed). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CP1B1_HUMAN
GO:0020037 heme binding 28.5714 4 yes
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0042803 protein homodimerization activity 28.5714 4 no
GO:0046982 protein heterodimerization activity 28.5714 4 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0003924 GTPase activity 28.5714 7 no
GO:0005525 GTP binding 28.5714 5 no
GO:0016462 pyrophosphatase activity 28.5714 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.5714 6 no
GO:0019001 guanyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032561 guanyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CP1B1_HUMAN
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0009893 positive regulation of metabolic process 57.1429 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 yes
GO:0048584 positive regulation of response to stimulus 57.1429 4 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0051247 positive regulation of protein metabolic process 57.1429 6 yes
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 yes
GO:0080090 regulation of primary metabolic process 57.1429 4 yes
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0009966 regulation of signal transduction 42.8571 4 yes
GO:0009967 positive regulation of signal transduction 42.8571 5 yes
GO:0010468 regulation of gene expression 42.8571 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 yes
GO:0010646 regulation of cell communication 42.8571 4 yes
GO:0010647 positive regulation of cell communication 42.8571 5 yes
GO:0023056 positive regulation of signaling 42.8571 4 yes
GO:0030155 regulation of cell adhesion 42.8571 4 yes
GO:0030334 regulation of cell migration 42.8571 5 yes
GO:0030335 positive regulation of cell migration 42.8571 6 yes
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 yes
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 yes
GO:0040017 positive regulation of locomotion 42.8571 4 yes
GO:0042127 regulation of cell population proliferation 42.8571 4 yes
GO:0048523 negative regulation of cellular process 42.8571 4 yes
GO:0097435 supramolecular fiber organization 42.8571 4 yes
GO:2000145 regulation of cell motility 42.8571 4 yes
GO:2000147 positive regulation of cell motility 42.8571 5 yes
GO:2000377 regulation of reactive oxygen species metabolic process 42.8571 5 yes
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0032101 regulation of response to external stimulus 42.8571 4 no
GO:0030030 cell projection organization 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0032880 regulation of protein localization 42.8571 5 no
GO:0060341 regulation of cellular localization 42.8571 4 no
GO:1903829 positive regulation of protein localization 42.8571 5 no
GO:0001817 regulation of cytokine production 42.8571 4 yes
GO:0009891 positive regulation of biosynthetic process 28.5714 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 yes
GO:0010574 regulation of vascular endothelial growth factor production 28.5714 5 yes
GO:0010575 positive regulation of vascular endothelial growth factor production 28.5714 6 yes
GO:0010628 positive regulation of gene expression 28.5714 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 yes
GO:0030336 negative regulation of cell migration 28.5714 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 yes
GO:0040013 negative regulation of locomotion 28.5714 4 yes
GO:0043412 macromolecule modification 28.5714 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 5 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 yes
GO:0051252 regulation of RNA metabolic process 28.5714 5 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:2000146 negative regulation of cell motility 28.5714 5 yes
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 yes
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0033233 regulation of protein sumoylation 28.5714 9 no
GO:0033235 positive regulation of protein sumoylation 28.5714 10 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:1901873 regulation of post-translational protein modification 28.5714 7 no
GO:1901875 positive regulation of post-translational protein modification 28.5714 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 28.5714 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 28.5714 9 no
GO:0002684 positive regulation of immune system process 28.5714 4 no
GO:0002685 regulation of leukocyte migration 28.5714 4 no
GO:0002687 positive regulation of leukocyte migration 28.5714 5 no
GO:0002688 regulation of leukocyte chemotaxis 28.5714 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 28.5714 6 no
GO:0007015 actin filament organization 28.5714 5 no
GO:0007264 small GTPase-mediated signal transduction 28.5714 5 no
GO:0007411 axon guidance 28.5714 8 no
GO:0010310 regulation of hydrogen peroxide metabolic process 28.5714 6 no
GO:0010591 regulation of lamellipodium assembly 28.5714 7 no
GO:0010592 positive regulation of lamellipodium assembly 28.5714 7 no
GO:0010810 regulation of cell-substrate adhesion 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0030031 cell projection assembly 28.5714 5 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0032103 positive regulation of response to external stimulus 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0050920 regulation of chemotaxis 28.5714 4 no
GO:0050921 positive regulation of chemotaxis 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0060263 regulation of respiratory burst 28.5714 4 no
GO:0060491 regulation of cell projection assembly 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0071622 regulation of granulocyte chemotaxis 28.5714 6 no
GO:0071624 positive regulation of granulocyte chemotaxis 28.5714 7 no
GO:0090022 regulation of neutrophil chemotaxis 28.5714 6 no
GO:0090023 positive regulation of neutrophil chemotaxis 28.5714 7 no
GO:0097485 neuron projection guidance 28.5714 7 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 28.5714 6 no
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 28.5714 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:1902622 regulation of neutrophil migration 28.5714 5 no
GO:1902624 positive regulation of neutrophil migration 28.5714 6 no
GO:1902743 regulation of lamellipodium organization 28.5714 7 no
GO:1902745 positive regulation of lamellipodium organization 28.5714 7 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:1903214 regulation of protein targeting to mitochondrion 28.5714 8 no
GO:1903533 regulation of protein targeting 28.5714 7 no
GO:1903747 regulation of establishment of protein localization to mitochondrion 28.5714 7 no
GO:1903749 positive regulation of establishment of protein localization to mitochondrion 28.5714 7 no
GO:1903955 positive regulation of protein targeting to mitochondrion 28.5714 8 no
GO:1904951 positive regulation of establishment of protein localization 28.5714 6 no
GO:0001819 positive regulation of cytokine production 28.5714 5 yes
GO:0006355 regulation of DNA-templated transcription 28.5714 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TIE2_HUMAN [view interactions] Low throughput no no
AHR_HUMAN [view interactions] Low throughput no yes
ARNT_HUMAN [view entry] [view interactions] Low throughput yes yes
EP300_HUMAN [view interactions] Low throughput no yes
H31_HUMAN [view interactions] Low throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
SAE1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CNPY3_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes