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CP1B1_HUMAN

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed, PubMed, PubMed, PubMed, PubMed). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed, PubMed, PubMed, PubMed, PubMed). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed, PubMed). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed, PubMed). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CP1B1_HUMAN
GO:0046872 metal ion binding 30.0000 4 yes
GO:0019900 kinase binding 30.0000 4 no
GO:0019901 protein kinase binding 30.0000 5 no
GO:0042803 protein homodimerization activity 30.0000 4 no
GO:0020037 heme binding 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CP1B1_HUMAN
GO:0048522 positive regulation of cellular process 80.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:2000377 regulation of reactive oxygen species metabolic process 40.0000 5 yes
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0001817 regulation of cytokine production 40.0000 4 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 yes
GO:0009966 regulation of signal transduction 40.0000 4 yes
GO:0010468 regulation of gene expression 40.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 yes
GO:0010646 regulation of cell communication 40.0000 4 yes
GO:0030155 regulation of cell adhesion 40.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0042127 regulation of cell population proliferation 40.0000 4 yes
GO:0048523 negative regulation of cellular process 40.0000 4 yes
GO:0048584 positive regulation of response to stimulus 40.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 40.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 40.0000 6 yes
GO:0097435 supramolecular fiber organization 30.0000 4 yes
GO:2000145 regulation of cell motility 30.0000 4 yes
GO:2000147 positive regulation of cell motility 30.0000 5 yes
GO:0007411 axon guidance 30.0000 8 no
GO:0010810 regulation of cell-substrate adhesion 30.0000 5 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0031175 neuron projection development 30.0000 6 no
GO:0032101 regulation of response to external stimulus 30.0000 4 no
GO:0032880 regulation of protein localization 30.0000 5 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0060341 regulation of cellular localization 30.0000 4 no
GO:0097485 neuron projection guidance 30.0000 7 no
GO:0120036 plasma membrane bounded cell projection organization 30.0000 5 no
GO:1903829 positive regulation of protein localization 30.0000 5 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0031401 positive regulation of protein modification process 30.0000 7 no
GO:0042325 regulation of phosphorylation 30.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:0043603 cellular amide metabolic process 30.0000 4 no
GO:1901566 organonitrogen compound biosynthetic process 30.0000 4 no
GO:0006631 fatty acid metabolic process 30.0000 4 yes
GO:0009967 positive regulation of signal transduction 30.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 yes
GO:0010647 positive regulation of cell communication 30.0000 5 yes
GO:0019752 carboxylic acid metabolic process 30.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 yes
GO:0023056 positive regulation of signaling 30.0000 4 yes
GO:0030334 regulation of cell migration 30.0000 5 yes
GO:0030335 positive regulation of cell migration 30.0000 6 yes
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 yes
GO:0032787 monocarboxylic acid metabolic process 30.0000 6 yes
GO:0040017 positive regulation of locomotion 30.0000 4 yes
GO:0043436 oxoacid metabolic process 30.0000 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 30.0000 4 yes
GO:0051094 positive regulation of developmental process 30.0000 4 yes
GO:0071396 cellular response to lipid 20.0000 5 yes
GO:1901701 cellular response to oxygen-containing compound 20.0000 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 20.0000 7 yes
GO:2000026 regulation of multicellular organismal development 20.0000 4 yes
GO:2000146 negative regulation of cell motility 20.0000 5 yes
GO:2000379 positive regulation of reactive oxygen species metabolic process 20.0000 6 yes
GO:2001141 regulation of RNA biosynthetic process 20.0000 6 yes
GO:0000302 response to reactive oxygen species 20.0000 4 yes
GO:0001676 long-chain fatty acid metabolic process 20.0000 5 yes
GO:0001819 positive regulation of cytokine production 20.0000 5 yes
GO:0006355 regulation of DNA-templated transcription 20.0000 6 yes
GO:0006690 icosanoid metabolic process 20.0000 6 yes
GO:0008202 steroid metabolic process 20.0000 4 yes
GO:0008210 estrogen metabolic process 20.0000 4 yes
GO:0008285 negative regulation of cell population proliferation 20.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 20.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 20.0000 6 yes
GO:0010574 regulation of vascular endothelial growth factor production 20.0000 5 yes
GO:0010575 positive regulation of vascular endothelial growth factor production 20.0000 6 yes
GO:0010628 positive regulation of gene expression 20.0000 6 yes
GO:0010941 regulation of cell death 20.0000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.0000 5 yes
GO:0030198 extracellular matrix organization 20.0000 5 yes
GO:0030336 negative regulation of cell migration 20.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 20.0000 6 yes
GO:0031667 response to nutrient levels 20.0000 4 yes
GO:0033559 unsaturated fatty acid metabolic process 20.0000 5 yes
GO:0033993 response to lipid 20.0000 4 yes
GO:0040013 negative regulation of locomotion 20.0000 4 yes
GO:0042537 benzene-containing compound metabolic process 20.0000 4 yes
GO:0042981 regulation of apoptotic process 20.0000 6 yes
GO:0043062 extracellular structure organization 20.0000 4 yes
GO:0043067 regulation of programmed cell death 20.0000 5 yes
GO:0043412 macromolecule modification 20.0000 4 yes
GO:0045229 external encapsulating structure organization 20.0000 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.0000 6 yes
GO:0051240 positive regulation of multicellular organismal process 20.0000 4 yes
GO:0051252 regulation of RNA metabolic process 20.0000 5 yes
GO:0071310 cellular response to organic substance 20.0000 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TIE2_HUMAN [view interactions] Low throughput no no
AHR_HUMAN [view interactions] Low throughput no yes
ARNT_HUMAN [view entry] [view interactions] Low throughput yes yes
EP300_HUMAN [view interactions] Low throughput no yes
H31_HUMAN [view interactions] Low throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
SAE1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
COMT_HUMAN [view entry] [view interactions] Computational yes yes
UD18_HUMAN [view interactions] Computational no no
ASMT_HUMAN [view interactions] Computational no no
GSTA1_HUMAN [view interactions] Computational no no
I23O1_HUMAN [view interactions] Computational no no
UD11_HUMAN [view interactions] Computational no no
ST1A2_HUMAN [view interactions] Computational no no
CP1A1_HUMAN [view interactions] Computational no yes
GSTM3_HUMAN [view entry] [view interactions] Computational yes yes
ST2A1_HUMAN [view interactions] Computational no no
UD2A3_HUMAN [view interactions] Computational no no
H17B6_HUMAN [view interactions] Computational no yes
HYEP_HUMAN [view interactions] Computational no no
UD2B7_HUMAN [view interactions] Computational no no
DHB8_HUMAN [view interactions] Computational no yes
DHB2_HUMAN [view interactions] Computational no no
DHB12_HUMAN [view entry] [view interactions] Computational yes yes
GSTM1_HUMAN [view interactions] Computational no yes
UD16_HUMAN [view interactions] Computational no no
GSTP1_HUMAN [view entry] [view interactions] Computational yes no
DHB1_HUMAN [view interactions] Computational no no
MYOC_HUMAN [view interactions] Computational no no
CP2B6_HUMAN [view interactions] Computational no no
HPGDS_HUMAN [view interactions] Computational no no
AK1C3_HUMAN [view interactions] Computational no yes
CP1A2_HUMAN [view interactions] Computational no no
DHB7_HUMAN [view interactions] Computational no yes
PPIG_HUMAN [view interactions] Computational no yes
I23O2_HUMAN [view interactions] Computational no no