CP1B1_HUMAN
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed, PubMed, PubMed, PubMed, PubMed). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed, PubMed, PubMed, PubMed, PubMed). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed, PubMed). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed, PubMed). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CP1B1_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 30.0000 | 4 | yes |
GO:0019900 | kinase binding | 30.0000 | 4 | no |
GO:0019901 | protein kinase binding | 30.0000 | 5 | no |
GO:0042803 | protein homodimerization activity | 30.0000 | 4 | no |
GO:0020037 | heme binding | 20.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CP1B1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
GO:2000377 | regulation of reactive oxygen species metabolic process | 40.0000 | 5 | yes |
GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
GO:0001817 | regulation of cytokine production | 40.0000 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
GO:0010468 | regulation of gene expression | 40.0000 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
GO:0030155 | regulation of cell adhesion | 40.0000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | yes |
GO:0042127 | regulation of cell population proliferation | 40.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | yes |
GO:0097435 | supramolecular fiber organization | 30.0000 | 4 | yes |
GO:2000145 | regulation of cell motility | 30.0000 | 4 | yes |
GO:2000147 | positive regulation of cell motility | 30.0000 | 5 | yes |
GO:0007411 | axon guidance | 30.0000 | 8 | no |
GO:0010810 | regulation of cell-substrate adhesion | 30.0000 | 5 | no |
GO:0030030 | cell projection organization | 30.0000 | 4 | no |
GO:0031175 | neuron projection development | 30.0000 | 6 | no |
GO:0032101 | regulation of response to external stimulus | 30.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
GO:0051049 | regulation of transport | 30.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
GO:0097485 | neuron projection guidance | 30.0000 | 7 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 30.0000 | 5 | no |
GO:1903829 | positive regulation of protein localization | 30.0000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
GO:0043603 | cellular amide metabolic process | 30.0000 | 4 | no |
GO:1901566 | organonitrogen compound biosynthetic process | 30.0000 | 4 | no |
GO:0006631 | fatty acid metabolic process | 30.0000 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | yes |
GO:0019752 | carboxylic acid metabolic process | 30.0000 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 30.0000 | 4 | yes |
GO:0023056 | positive regulation of signaling | 30.0000 | 4 | yes |
GO:0030334 | regulation of cell migration | 30.0000 | 5 | yes |
GO:0030335 | positive regulation of cell migration | 30.0000 | 6 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 30.0000 | 6 | yes |
GO:0040017 | positive regulation of locomotion | 30.0000 | 4 | yes |
GO:0043436 | oxoacid metabolic process | 30.0000 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 30.0000 | 4 | yes |
GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | yes |
GO:0071396 | cellular response to lipid | 20.0000 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 20.0000 | 4 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 20.0000 | 7 | yes |
GO:2000026 | regulation of multicellular organismal development | 20.0000 | 4 | yes |
GO:2000146 | negative regulation of cell motility | 20.0000 | 5 | yes |
GO:2000379 | positive regulation of reactive oxygen species metabolic process | 20.0000 | 6 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 20.0000 | 6 | yes |
GO:0000302 | response to reactive oxygen species | 20.0000 | 4 | yes |
GO:0001676 | long-chain fatty acid metabolic process | 20.0000 | 5 | yes |
GO:0001819 | positive regulation of cytokine production | 20.0000 | 5 | yes |
GO:0006355 | regulation of DNA-templated transcription | 20.0000 | 6 | yes |
GO:0006690 | icosanoid metabolic process | 20.0000 | 6 | yes |
GO:0008202 | steroid metabolic process | 20.0000 | 4 | yes |
GO:0008210 | estrogen metabolic process | 20.0000 | 4 | yes |
GO:0008285 | negative regulation of cell population proliferation | 20.0000 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 20.0000 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
GO:0010574 | regulation of vascular endothelial growth factor production | 20.0000 | 5 | yes |
GO:0010575 | positive regulation of vascular endothelial growth factor production | 20.0000 | 6 | yes |
GO:0010628 | positive regulation of gene expression | 20.0000 | 6 | yes |
GO:0010941 | regulation of cell death | 20.0000 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.0000 | 5 | yes |
GO:0030198 | extracellular matrix organization | 20.0000 | 5 | yes |
GO:0030336 | negative regulation of cell migration | 20.0000 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
GO:0031667 | response to nutrient levels | 20.0000 | 4 | yes |
GO:0033559 | unsaturated fatty acid metabolic process | 20.0000 | 5 | yes |
GO:0033993 | response to lipid | 20.0000 | 4 | yes |
GO:0040013 | negative regulation of locomotion | 20.0000 | 4 | yes |
GO:0042537 | benzene-containing compound metabolic process | 20.0000 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 20.0000 | 6 | yes |
GO:0043062 | extracellular structure organization | 20.0000 | 4 | yes |
GO:0043067 | regulation of programmed cell death | 20.0000 | 5 | yes |
GO:0043412 | macromolecule modification | 20.0000 | 4 | yes |
GO:0045229 | external encapsulating structure organization | 20.0000 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.0000 | 6 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 20.0000 | 4 | yes |
GO:0051252 | regulation of RNA metabolic process | 20.0000 | 5 | yes |
GO:0071310 | cellular response to organic substance | 20.0000 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TIE2_HUMAN | [view interactions] | Low throughput | no | no |
AHR_HUMAN | [view interactions] | Low throughput | no | yes |
ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EP300_HUMAN | [view interactions] | Low throughput | no | yes |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COMT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UD18_HUMAN | [view interactions] | Computational | no | no |
ASMT_HUMAN | [view interactions] | Computational | no | no |
GSTA1_HUMAN | [view interactions] | Computational | no | no |
I23O1_HUMAN | [view interactions] | Computational | no | no |
UD11_HUMAN | [view interactions] | Computational | no | no |
ST1A2_HUMAN | [view interactions] | Computational | no | no |
CP1A1_HUMAN | [view interactions] | Computational | no | yes |
GSTM3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ST2A1_HUMAN | [view interactions] | Computational | no | no |
UD2A3_HUMAN | [view interactions] | Computational | no | no |
H17B6_HUMAN | [view interactions] | Computational | no | yes |
HYEP_HUMAN | [view interactions] | Computational | no | no |
UD2B7_HUMAN | [view interactions] | Computational | no | no |
DHB8_HUMAN | [view interactions] | Computational | no | yes |
DHB2_HUMAN | [view interactions] | Computational | no | no |
DHB12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GSTM1_HUMAN | [view interactions] | Computational | no | yes |
UD16_HUMAN | [view interactions] | Computational | no | no |
GSTP1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DHB1_HUMAN | [view interactions] | Computational | no | no |
MYOC_HUMAN | [view interactions] | Computational | no | no |
CP2B6_HUMAN | [view interactions] | Computational | no | no |
HPGDS_HUMAN | [view interactions] | Computational | no | no |
AK1C3_HUMAN | [view interactions] | Computational | no | yes |
CP1A2_HUMAN | [view interactions] | Computational | no | no |
DHB7_HUMAN | [view interactions] | Computational | no | yes |
PPIG_HUMAN | [view interactions] | Computational | no | yes |
I23O2_HUMAN | [view interactions] | Computational | no | no |