Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PPM1E_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 . Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PPM1E_HUMAN
GO:0000166 nucleotide binding 47.0588 4 no
GO:0017076 purine nucleotide binding 47.0588 5 no
GO:0030554 adenyl nucleotide binding 47.0588 6 no
GO:0005524 ATP binding 41.1765 5 no
GO:0032555 purine ribonucleotide binding 41.1765 4 no
GO:0032559 adenyl ribonucleotide binding 41.1765 5 no
GO:0035639 purine ribonucleoside triphosphate binding 41.1765 4 no
GO:0043168 anion binding 41.1765 4 no
GO:0043169 cation binding 29.4118 4 yes
GO:0046872 metal ion binding 29.4118 5 yes
GO:0004674 protein serine/threonine kinase activity 29.4118 4 no
GO:0016301 kinase activity 29.4118 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 29.4118 4 no
GO:0106310 protein serine kinase activity 29.4118 4 no
GO:0015631 tubulin binding 23.5294 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PPM1E_HUMAN
GO:0048522 positive regulation of cellular process 82.3529 4 yes
GO:0031323 regulation of cellular metabolic process 70.5882 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.7059 4 yes
GO:0080090 regulation of primary metabolic process 64.7059 4 yes
GO:0009893 positive regulation of metabolic process 58.8235 4 no
GO:0051246 regulation of protein metabolic process 52.9412 5 yes
GO:0006996 organelle organization 52.9412 4 no
GO:0010604 positive regulation of macromolecule metabolic process 52.9412 5 no
GO:0006796 phosphate-containing compound metabolic process 47.0588 4 yes
GO:0036211 protein modification process 47.0588 4 yes
GO:0043412 macromolecule modification 47.0588 4 yes
GO:0048523 negative regulation of cellular process 47.0588 4 yes
GO:0051128 regulation of cellular component organization 47.0588 4 yes
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0010646 regulation of cell communication 47.0588 4 no
GO:0031325 positive regulation of cellular metabolic process 47.0588 5 no
GO:0019220 regulation of phosphate metabolic process 41.1765 6 yes
GO:0031399 regulation of protein modification process 41.1765 6 yes
GO:0042325 regulation of phosphorylation 41.1765 7 yes
GO:0051130 positive regulation of cellular component organization 41.1765 5 yes
GO:0051174 regulation of phosphorus metabolic process 41.1765 5 yes
GO:0009889 regulation of biosynthetic process 41.1765 4 no
GO:0010556 regulation of macromolecule biosynthetic process 41.1765 5 no
GO:0031326 regulation of cellular biosynthetic process 41.1765 5 no
GO:0051247 positive regulation of protein metabolic process 41.1765 6 no
GO:0043085 positive regulation of catalytic activity 41.1765 4 no
GO:0001932 regulation of protein phosphorylation 35.2941 7 yes
GO:0051338 regulation of transferase activity 35.2941 4 yes
GO:0010468 regulation of gene expression 35.2941 6 no
GO:0009892 negative regulation of metabolic process 29.4118 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 yes
GO:0033043 regulation of organelle organization 29.4118 5 yes
GO:0043086 negative regulation of catalytic activity 29.4118 4 yes
GO:0043549 regulation of kinase activity 29.4118 5 yes
GO:0051248 negative regulation of protein metabolic process 29.4118 6 yes
GO:0071310 cellular response to organic substance 29.4118 4 yes
GO:0007010 cytoskeleton organization 29.4118 5 no
GO:0009894 regulation of catabolic process 29.4118 4 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0034097 response to cytokine 29.4118 4 no
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:0051336 regulation of hydrolase activity 29.4118 4 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0006468 protein phosphorylation 29.4118 5 no
GO:0010562 positive regulation of phosphorus metabolic process 29.4118 6 no
GO:0016310 phosphorylation 29.4118 5 no
GO:0022603 regulation of anatomical structure morphogenesis 29.4118 4 no
GO:0022607 cellular component assembly 29.4118 4 no
GO:0031344 regulation of cell projection organization 29.4118 5 no
GO:0031401 positive regulation of protein modification process 29.4118 7 no
GO:0042327 positive regulation of phosphorylation 29.4118 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.4118 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0042981 regulation of apoptotic process 29.4118 5 no
GO:0043067 regulation of programmed cell death 29.4118 4 no
GO:0051049 regulation of transport 29.4118 4 no
GO:0045595 regulation of cell differentiation 29.4118 4 no
GO:0010638 positive regulation of organelle organization 23.5294 6 yes
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 yes
GO:0045859 regulation of protein kinase activity 23.5294 6 yes
GO:0051493 regulation of cytoskeleton organization 23.5294 6 yes
GO:0009891 positive regulation of biosynthetic process 23.5294 5 no
GO:0009967 positive regulation of signal transduction 23.5294 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0030162 regulation of proteolysis 23.5294 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0071345 cellular response to cytokine stimulus 23.5294 5 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0008104 protein localization 23.5294 4 no
GO:0010975 regulation of neuron projection development 23.5294 7 no
GO:0030030 cell projection organization 23.5294 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.5294 5 no
GO:0141124 intracellular signaling cassette 23.5294 4 no
GO:0006355 regulation of DNA-templated transcription 23.5294 7 no
GO:0007005 mitochondrion organization 23.5294 5 no
GO:0008284 positive regulation of cell population proliferation 23.5294 5 no
GO:0042127 regulation of cell population proliferation 23.5294 4 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:0031346 positive regulation of cell projection organization 23.5294 6 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:0051347 positive regulation of transferase activity 23.5294 5 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:0010563 negative regulation of phosphorus metabolic process 17.6471 6 yes
GO:0031400 negative regulation of protein modification process 17.6471 7 yes
GO:0033673 negative regulation of kinase activity 17.6471 6 yes
GO:0042326 negative regulation of phosphorylation 17.6471 8 yes
GO:0044087 regulation of cellular component biogenesis 17.6471 4 yes
GO:0045936 negative regulation of phosphate metabolic process 17.6471 7 yes
GO:0051348 negative regulation of transferase activity 17.6471 5 yes
GO:1901701 cellular response to oxygen-containing compound 17.6471 4 yes
GO:1902903 regulation of supramolecular fiber organization 17.6471 5 yes
GO:0001933 negative regulation of protein phosphorylation 11.7647 8 yes
GO:0006469 negative regulation of protein kinase activity 11.7647 7 yes
GO:0044089 positive regulation of cellular component biogenesis 11.7647 5 yes
GO:0051495 positive regulation of cytoskeleton organization 11.7647 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 11.7647 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ALDOA_HUMAN [view entry] [view interactions] Low throughput yes no
G3P_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC4_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] Low throughput yes yes
AAPK2_HUMAN [view interactions] Low throughput no yes
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
AAPK1_HUMAN [view interactions] Low throughput no no
TADBP_HUMAN [view interactions] High throughput no yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
NDUF5_HUMAN [view interactions] High throughput no yes
ANM2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
TROP_HUMAN [view interactions] High throughput no no
PSMG4_HUMAN [view interactions] High throughput no yes
PSMG3_HUMAN [view interactions] High throughput no yes
BRCA2_HUMAN [view interactions] High throughput no no
FA83H_HUMAN [view interactions] High throughput no yes
PIP30_HUMAN [view interactions] High throughput no yes
PSME3_HUMAN [view interactions] High throughput no yes
SPB4_HUMAN [view interactions] High throughput no no
ICMT_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
HS12B_HUMAN [view interactions] High throughput no yes
ERD22_HUMAN [view interactions] High throughput no yes
S100P_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
HDAC1_HUMAN [view interactions] High throughput no no
GCP60_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
FCGR1_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
HLAC_HUMAN [view interactions] High throughput no no
MD2L1_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
SLN11_HUMAN [view interactions] High throughput no yes
SSRD_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes