Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KKCC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KKCC1_HUMAN
GO:0005524 ATP binding 42.8571 5 yes
GO:0017076 purine nucleotide binding 42.8571 4 yes
GO:0030554 adenyl nucleotide binding 42.8571 5 yes
GO:0032555 purine ribonucleotide binding 42.8571 4 yes
GO:0032559 adenyl ribonucleotide binding 42.8571 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 42.8571 4 yes
GO:0004674 protein serine/threonine kinase activity 33.3333 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 33.3333 4 yes
GO:0016301 kinase activity 33.3333 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 yes
GO:0106310 protein serine kinase activity 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0003723 RNA binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 4 no
GO:0019887 protein kinase regulator activity 28.5714 4 no
GO:0004683 calmodulin-dependent protein kinase activity 23.8095 5 yes
GO:0042803 protein homodimerization activity 23.8095 4 no
GO:0005509 calcium ion binding 23.8095 5 no
GO:0097718 disordered domain specific binding 23.8095 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KKCC1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 90.4762 4 yes
GO:0031323 regulation of cellular metabolic process 85.7143 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 85.7143 4 yes
GO:0080090 regulation of primary metabolic process 85.7143 4 yes
GO:0048522 positive regulation of cellular process 76.1905 4 yes
GO:0051246 regulation of protein metabolic process 71.4286 5 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 yes
GO:0019220 regulation of phosphate metabolic process 66.6667 6 yes
GO:0031325 positive regulation of cellular metabolic process 66.6667 5 yes
GO:0031399 regulation of protein modification process 66.6667 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 66.6667 5 yes
GO:0051174 regulation of phosphorus metabolic process 66.6667 5 yes
GO:0001932 regulation of protein phosphorylation 57.1429 7 yes
GO:0042325 regulation of phosphorylation 57.1429 7 yes
GO:0051247 positive regulation of protein metabolic process 57.1429 6 yes
GO:0010468 regulation of gene expression 57.1429 5 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0001934 positive regulation of protein phosphorylation 52.3810 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 52.3810 6 yes
GO:0031401 positive regulation of protein modification process 52.3810 7 yes
GO:0042327 positive regulation of phosphorylation 52.3810 8 yes
GO:0043085 positive regulation of catalytic activity 52.3810 4 yes
GO:0043549 regulation of kinase activity 52.3810 5 yes
GO:0045859 regulation of protein kinase activity 52.3810 6 yes
GO:0045937 positive regulation of phosphate metabolic process 52.3810 7 yes
GO:0051338 regulation of transferase activity 52.3810 4 yes
GO:0009892 negative regulation of metabolic process 52.3810 4 no
GO:0010605 negative regulation of macromolecule metabolic process 52.3810 5 no
GO:0051049 regulation of transport 52.3810 4 no
GO:0009889 regulation of biosynthetic process 47.6190 4 no
GO:0009966 regulation of signal transduction 47.6190 4 no
GO:0010556 regulation of macromolecule biosynthetic process 47.6190 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.6190 5 no
GO:0031324 negative regulation of cellular metabolic process 47.6190 5 no
GO:0031326 regulation of cellular biosynthetic process 47.6190 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 47.6190 5 no
GO:0033674 positive regulation of kinase activity 42.8571 6 yes
GO:0045860 positive regulation of protein kinase activity 42.8571 7 yes
GO:0051347 positive regulation of transferase activity 42.8571 5 yes
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0036211 protein modification process 42.8571 4 no
GO:0043269 regulation of ion transport 42.8571 5 no
GO:0043412 macromolecule modification 42.8571 4 no
GO:0045595 regulation of cell differentiation 42.8571 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 42.8571 6 no
GO:0051050 positive regulation of transport 42.8571 4 no
GO:0006355 regulation of DNA-templated transcription 38.0952 6 no
GO:0006468 protein phosphorylation 38.0952 5 no
GO:0006796 phosphate-containing compound metabolic process 38.0952 4 no
GO:0008104 protein localization 38.0952 4 no
GO:0010959 regulation of metal ion transport 38.0952 6 no
GO:0016310 phosphorylation 38.0952 5 no
GO:0034762 regulation of transmembrane transport 38.0952 4 no
GO:0051128 regulation of cellular component organization 38.0952 4 no
GO:0051248 negative regulation of protein metabolic process 38.0952 6 no
GO:0051252 regulation of RNA metabolic process 38.0952 5 no
GO:0060341 regulation of cellular localization 38.0952 4 no
GO:1903506 regulation of nucleic acid-templated transcription 38.0952 7 no
GO:2001141 regulation of RNA biosynthetic process 38.0952 6 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0015031 protein transport 33.3333 4 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 33.3333 8 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 33.3333 8 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0032412 regulation of ion transmembrane transporter activity 33.3333 5 no
GO:0034765 regulation of ion transmembrane transport 33.3333 5 no
GO:0044057 regulation of system process 33.3333 4 no
GO:1904062 regulation of cation transmembrane transport 33.3333 6 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0033135 regulation of peptidyl-serine phosphorylation 28.5714 8 no
GO:0033138 positive regulation of peptidyl-serine phosphorylation 28.5714 9 no
GO:0034763 negative regulation of transmembrane transport 28.5714 5 no
GO:0045597 positive regulation of cell differentiation 28.5714 5 no
GO:0051051 negative regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051345 positive regulation of hydrolase activity 28.5714 5 no
GO:0019932 second-messenger-mediated signaling 28.5714 4 no
GO:0021762 substantia nigra development 28.5714 4 no
GO:0035303 regulation of dephosphorylation 28.5714 7 no
GO:0035304 regulation of protein dephosphorylation 28.5714 7 no
GO:0051924 regulation of calcium ion transport 28.5714 7 no
GO:1903522 regulation of blood circulation 28.5714 5 no
GO:0001933 negative regulation of protein phosphorylation 23.8095 8 no
GO:0009896 positive regulation of catabolic process 23.8095 5 no
GO:0010038 response to metal ion 23.8095 4 no
GO:0010243 response to organonitrogen compound 23.8095 4 no
GO:0010564 regulation of cell cycle process 23.8095 5 no
GO:0010941 regulation of cell death 23.8095 4 no
GO:0018193 peptidyl-amino acid modification 23.8095 5 no
GO:0031329 regulation of cellular catabolic process 23.8095 5 no
GO:0031344 regulation of cell projection organization 23.8095 5 no
GO:0034764 positive regulation of transmembrane transport 23.8095 5 no
GO:0042176 regulation of protein catabolic process 23.8095 5 no
GO:0042326 negative regulation of phosphorylation 23.8095 8 no
GO:0042981 regulation of apoptotic process 23.8095 6 no
GO:0043067 regulation of programmed cell death 23.8095 5 no
GO:0043270 positive regulation of ion transport 23.8095 5 no
GO:0043393 regulation of protein binding 23.8095 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 23.8095 4 no
GO:0046777 protein autophosphorylation 23.8095 6 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.8095 6 no
GO:1903829 positive regulation of protein localization 23.8095 5 no
GO:0050804 modulation of chemical synaptic transmission 23.8095 5 no
GO:0099177 regulation of trans-synaptic signaling 23.8095 4 no
GO:0008016 regulation of heart contraction 23.8095 6 no
GO:0019722 calcium-mediated signaling 23.8095 5 no
GO:0034766 negative regulation of ion transmembrane transport 23.8095 6 no
GO:0043271 negative regulation of ion transport 23.8095 5 no
GO:0051099 positive regulation of binding 23.8095 4 no
GO:0051926 negative regulation of calcium ion transport 23.8095 6 no
GO:0090257 regulation of muscle system process 23.8095 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 23.8095 6 no
GO:1903169 regulation of calcium ion transmembrane transport 23.8095 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 23.8095 7 no
GO:1904063 negative regulation of cation transmembrane transport 23.8095 7 no
GO:2001257 regulation of cation channel activity 23.8095 6 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no

Disease

Term Name % Distance from top the of the tree Annotated in KKCC1_HUMAN
DOID:0050700 cardiomyopathy 9.5238 4 no
DOID:0060036 intrinsic cardiomyopathy 9.5238 5 no
DOID:114 heart disease 9.5238 3 no
DOID:2843 long QT syndrome 9.5238 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS2_HUMAN [view interactions] Low throughput no yes
AAPK1_HUMAN [view interactions] Low throughput no no
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
GCH1_HUMAN [view interactions] High throughput no no
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
H33_HUMAN [view interactions] High throughput no yes
NEPRO_HUMAN [view interactions] High throughput no no
BRNP1_HUMAN [view interactions] High throughput no yes
TRI11_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
PADI6_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SBP1_HUMAN [view interactions] High throughput no no
IRGM_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC1D_HUMAN [view interactions] High throughput no yes
NSA2_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
FBXL6_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
SAFB2_HUMAN [view interactions] High throughput no yes
NTH_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
GRRE1_HUMAN [view interactions] High throughput no no
LPIN3_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B5_HUMAN [view interactions] High throughput no yes
FHL3_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
BGAL_HUMAN [view interactions] High throughput no yes
PPGB_HUMAN [view interactions] High throughput no yes
MKNK1_HUMAN [view interactions] High throughput no yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
KKCC2_HUMAN [view entry] [view interactions] Computational yes yes