Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KKCC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KKCC1_HUMAN
GO:0019900 kinase binding 42.8571 4 no
GO:0019901 protein kinase binding 42.8571 5 no
GO:0000166 nucleotide binding 38.0952 4 yes
GO:0017076 purine nucleotide binding 38.0952 5 yes
GO:0030554 adenyl nucleotide binding 38.0952 6 yes
GO:0043168 anion binding 38.0952 4 yes
GO:0019887 protein kinase regulator activity 38.0952 4 no
GO:0005524 ATP binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0003723 RNA binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0099106 ion channel regulator activity 28.5714 4 no
GO:0004674 protein serine/threonine kinase activity 23.8095 4 yes
GO:0016301 kinase activity 23.8095 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.8095 4 yes
GO:0106310 protein serine kinase activity 23.8095 4 yes
GO:0042826 histone deacetylase binding 23.8095 4 no
GO:0004683 calmodulin-dependent protein kinase activity 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KKCC1_HUMAN
GO:0031323 regulation of cellular metabolic process 90.4762 4 no
GO:0060255 regulation of macromolecule metabolic process 90.4762 4 no
GO:0080090 regulation of primary metabolic process 85.7143 4 no
GO:0048523 negative regulation of cellular process 76.1905 4 no
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0051246 regulation of protein metabolic process 71.4286 5 no
GO:0019220 regulation of phosphate metabolic process 66.6667 6 no
GO:0031399 regulation of protein modification process 66.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 66.6667 5 no
GO:0009889 regulation of biosynthetic process 61.9048 4 no
GO:0009892 negative regulation of metabolic process 61.9048 4 no
GO:0010556 regulation of macromolecule biosynthetic process 61.9048 5 no
GO:0010605 negative regulation of macromolecule metabolic process 61.9048 5 no
GO:0031326 regulation of cellular biosynthetic process 61.9048 5 no
GO:0051049 regulation of transport 61.9048 4 no
GO:0009893 positive regulation of metabolic process 61.9048 4 no
GO:0010604 positive regulation of macromolecule metabolic process 61.9048 5 no
GO:0010468 regulation of gene expression 57.1429 6 no
GO:0031324 negative regulation of cellular metabolic process 57.1429 5 no
GO:0001932 regulation of protein phosphorylation 57.1429 7 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 no
GO:0042325 regulation of phosphorylation 57.1429 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 52.3810 5 no
GO:0009966 regulation of signal transduction 52.3810 4 no
GO:0051247 positive regulation of protein metabolic process 52.3810 6 no
GO:0043549 regulation of kinase activity 52.3810 5 no
GO:0051338 regulation of transferase activity 52.3810 4 no
GO:0008104 protein localization 47.6190 4 no
GO:0031401 positive regulation of protein modification process 47.6190 7 no
GO:0051050 positive regulation of transport 47.6190 4 no
GO:0045859 regulation of protein kinase activity 47.6190 6 no
GO:0051248 negative regulation of protein metabolic process 47.6190 6 no
GO:0006355 regulation of DNA-templated transcription 42.8571 7 no
GO:0034762 regulation of transmembrane transport 42.8571 4 no
GO:0051252 regulation of RNA metabolic process 42.8571 5 no
GO:2001141 regulation of RNA biosynthetic process 42.8571 6 no
GO:0001934 positive regulation of protein phosphorylation 42.8571 8 no
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0042327 positive regulation of phosphorylation 42.8571 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 42.8571 5 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0060341 regulation of cellular localization 42.8571 4 no
GO:0010563 negative regulation of phosphorus metabolic process 42.8571 6 no
GO:0031400 negative regulation of protein modification process 42.8571 7 no
GO:0045936 negative regulation of phosphate metabolic process 42.8571 7 no
GO:0043269 regulation of monoatomic ion transport 38.0952 5 no
GO:0051051 negative regulation of transport 38.0952 4 no
GO:0032880 regulation of protein localization 38.0952 5 no
GO:0043085 positive regulation of catalytic activity 38.0952 4 no
GO:0045595 regulation of cell differentiation 38.0952 4 no
GO:0051726 regulation of cell cycle 38.0952 4 no
GO:0034763 negative regulation of transmembrane transport 33.3333 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 33.3333 5 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010959 regulation of metal ion transport 33.3333 6 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1903829 positive regulation of protein localization 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 yes
GO:0016310 phosphorylation 28.5714 5 yes
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0021762 substantia nigra development 28.5714 4 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 28.5714 6 no
GO:0043271 negative regulation of monoatomic ion transport 28.5714 5 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0008016 regulation of heart contraction 28.5714 6 no
GO:1903522 regulation of blood circulation 28.5714 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 28.5714 6 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0035303 regulation of dephosphorylation 28.5714 7 no
GO:0035304 regulation of protein dephosphorylation 28.5714 7 no
GO:0006937 regulation of muscle contraction 23.8095 6 no
GO:0006942 regulation of striated muscle contraction 23.8095 7 no
GO:0034764 positive regulation of transmembrane transport 23.8095 5 no
GO:0043086 negative regulation of catalytic activity 23.8095 4 no
GO:0043270 positive regulation of monoatomic ion transport 23.8095 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 23.8095 9 no
GO:0051924 regulation of calcium ion transport 23.8095 7 no
GO:0051926 negative regulation of calcium ion transport 23.8095 6 no
GO:0055117 regulation of cardiac muscle contraction 23.8095 7 no
GO:0090257 regulation of muscle system process 23.8095 5 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 23.8095 6 no
GO:1903169 regulation of calcium ion transmembrane transport 23.8095 7 no
GO:1903170 negative regulation of calcium ion transmembrane transport 23.8095 7 no
GO:1904063 negative regulation of cation transmembrane transport 23.8095 7 no
GO:0006468 protein phosphorylation 23.8095 5 no
GO:0006996 organelle organization 23.8095 4 no
GO:0009896 positive regulation of catabolic process 23.8095 5 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0010038 response to metal ion 23.8095 4 no
GO:0010243 response to organonitrogen compound 23.8095 4 no
GO:0010564 regulation of cell cycle process 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0030162 regulation of proteolysis 23.8095 6 no
GO:0042176 regulation of protein catabolic process 23.8095 5 no
GO:0042981 regulation of apoptotic process 23.8095 5 no
GO:0043067 regulation of programmed cell death 23.8095 4 no
GO:0043393 regulation of protein binding 23.8095 4 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0051345 positive regulation of hydrolase activity 23.8095 5 no
GO:0071702 organic substance transport 23.8095 4 no
GO:0071705 nitrogen compound transport 23.8095 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 23.8095 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 23.8095 8 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:0032386 regulation of intracellular transport 23.8095 5 no
GO:0032388 positive regulation of intracellular transport 23.8095 5 no
GO:0051223 regulation of protein transport 23.8095 5 no
GO:0070201 regulation of establishment of protein localization 23.8095 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
NOS2_HUMAN [view interactions] Low throughput no yes
AAPK1_HUMAN [view interactions] Low throughput no no
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
NTH_HUMAN [view interactions] High throughput no yes
SAFB2_HUMAN [view interactions] High throughput no yes
K2013_HUMAN [view interactions] High throughput no yes
FBXL6_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
NSA2_HUMAN [view interactions] High throughput no yes
GRRE1_HUMAN [view interactions] High throughput no no
LPIN3_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
PPGB_HUMAN [view interactions] High throughput no yes
BGAL_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
FHL3_HUMAN [view interactions] High throughput no no
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B5_HUMAN [view interactions] High throughput no yes
MKNK1_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
GCH1_HUMAN [view interactions] High throughput no no
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
H33_HUMAN [view interactions] High throughput no yes
NEPRO_HUMAN [view interactions] High throughput no no
BRNP1_HUMAN [view interactions] High throughput no yes
TRI11_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
PADI6_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SBP1_HUMAN [view interactions] High throughput no no
IRGM_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CCNE1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC1D_HUMAN [view interactions] High throughput no yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
RNZ2_HUMAN [view interactions] High throughput no yes