Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CLAP2_HUMAN

GO
G2C
SynGO

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed, PubMed). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI001287 LIG_SxIP_EBH_1 LIG 492 502 -
ELMI001288 LIG_SxIP_EBH_1 LIG 515 525 -

Molecular function

Term Name % Distance from the top of the tree Annotated in CLAP2_HUMAN
GO:0003723 RNA binding 29.0323 4 no
GO:0019900 kinase binding 27.4194 4 yes
GO:0019901 protein kinase binding 27.4194 5 yes
GO:0045296 cadherin binding 24.1935 4 no
GO:0046872 metal ion binding 22.5806 4 no
GO:0017076 purine nucleotide binding 20.9677 4 no
GO:0032555 purine ribonucleotide binding 20.9677 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.9677 4 no
GO:0008017 microtubule binding 17.7419 5 yes
GO:0015631 tubulin binding 17.7419 4 yes
GO:0051010 microtubule plus-end binding 14.5161 6 yes
GO:0003779 actin binding 11.2903 4 yes
GO:1990782 protein tyrosine kinase binding 3.2258 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CLAP2_HUMAN
GO:0048522 positive regulation of cellular process 64.5161 4 yes
GO:0051128 regulation of cellular component organization 54.8387 4 yes
GO:0048523 negative regulation of cellular process 53.2258 4 yes
GO:0031323 regulation of cellular metabolic process 51.6129 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010646 regulation of cell communication 48.3871 4 no
GO:0006996 organelle organization 46.7742 4 yes
GO:0009966 regulation of signal transduction 45.1613 4 no
GO:0009893 positive regulation of metabolic process 41.9355 4 no
GO:0051246 regulation of protein metabolic process 38.7097 5 no
GO:0033043 regulation of organelle organization 37.0968 5 yes
GO:0031325 positive regulation of cellular metabolic process 35.4839 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.4839 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.8710 5 no
GO:0008104 protein localization 33.8710 4 yes
GO:0051049 regulation of transport 32.2581 4 yes
GO:0031399 regulation of protein modification process 32.2581 6 no
GO:0007010 cytoskeleton organization 30.6452 5 yes
GO:0051130 positive regulation of cellular component organization 30.6452 5 yes
GO:0051493 regulation of cytoskeleton organization 30.6452 6 yes
GO:0009892 negative regulation of metabolic process 30.6452 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.0323 5 no
GO:0051247 positive regulation of protein metabolic process 29.0323 6 no
GO:0010468 regulation of gene expression 29.0323 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.0323 5 no
GO:0036211 protein modification process 29.0323 4 no
GO:0043412 macromolecule modification 29.0323 4 no
GO:0019220 regulation of phosphate metabolic process 27.4194 6 no
GO:0031324 negative regulation of cellular metabolic process 27.4194 5 no
GO:0043085 positive regulation of catalytic activity 27.4194 4 no
GO:0051174 regulation of phosphorus metabolic process 27.4194 5 no
GO:0051726 regulation of cell cycle 27.4194 4 no
GO:0022607 cellular component assembly 27.4194 4 yes
GO:0044087 regulation of cellular component biogenesis 27.4194 4 yes
GO:0071702 organic substance transport 25.8065 4 no
GO:1902531 regulation of intracellular signal transduction 25.8065 5 no
GO:0032886 regulation of microtubule-based process 25.8065 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.1935 5 no
GO:0071705 nitrogen compound transport 24.1935 4 no
GO:0048585 negative regulation of response to stimulus 24.1935 4 yes
GO:0031401 positive regulation of protein modification process 24.1935 7 no
GO:0051248 negative regulation of protein metabolic process 22.5806 6 no
GO:0009889 regulation of biosynthetic process 22.5806 4 no
GO:0015031 protein transport 22.5806 4 no
GO:0031326 regulation of cellular biosynthetic process 22.5806 5 no
GO:0042325 regulation of phosphorylation 22.5806 7 no
GO:0048584 positive regulation of response to stimulus 22.5806 4 no
GO:0060341 regulation of cellular localization 20.9677 4 no
GO:0001932 regulation of protein phosphorylation 20.9677 7 no
GO:0010556 regulation of macromolecule biosynthetic process 20.9677 5 no
GO:0010562 positive regulation of phosphorus metabolic process 20.9677 6 no
GO:0042327 positive regulation of phosphorylation 20.9677 8 no
GO:0045937 positive regulation of phosphate metabolic process 20.9677 7 no
GO:0051336 regulation of hydrolase activity 20.9677 4 no
GO:0051338 regulation of transferase activity 20.9677 4 no
GO:0071310 cellular response to organic substance 20.9677 4 no
GO:0010638 positive regulation of organelle organization 20.9677 6 no
GO:0010647 positive regulation of cell communication 20.9677 5 no
GO:0023056 positive regulation of signaling 20.9677 4 no
GO:0045595 regulation of cell differentiation 20.9677 4 yes
GO:0051050 positive regulation of transport 20.9677 4 yes
GO:0070507 regulation of microtubule cytoskeleton organization 20.9677 5 yes
GO:0043254 regulation of protein-containing complex assembly 19.3548 5 yes
GO:0051129 negative regulation of cellular component organization 19.3548 5 yes
GO:0080134 regulation of response to stress 19.3548 4 yes
GO:1902903 regulation of supramolecular fiber organization 19.3548 5 yes
GO:0044089 positive regulation of cellular component biogenesis 17.7419 5 yes
GO:0051094 positive regulation of developmental process 17.7419 4 yes
GO:2000026 regulation of multicellular organismal development 17.7419 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 16.1290 4 yes
GO:0032271 regulation of protein polymerization 16.1290 6 yes
GO:0070925 organelle assembly 16.1290 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 14.5161 6 yes
GO:0031113 regulation of microtubule polymerization 14.5161 6 yes
GO:0001558 regulation of cell growth 12.9032 4 yes
GO:0030334 regulation of cell migration 12.9032 5 yes
GO:2000145 regulation of cell motility 12.9032 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 11.2903 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 11.2903 5 yes
GO:0030155 regulation of cell adhesion 11.2903 4 yes
GO:0048638 regulation of developmental growth 11.2903 4 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 11.2903 4 yes
GO:0010639 negative regulation of organelle organization 9.6774 6 yes
GO:0030335 positive regulation of cell migration 9.6774 6 yes
GO:0032956 regulation of actin cytoskeleton organization 9.6774 5 yes
GO:0032970 regulation of actin filament-based process 9.6774 4 yes
GO:0040017 positive regulation of locomotion 9.6774 4 yes
GO:0044772 mitotic cell cycle phase transition 9.6774 4 yes
GO:0060627 regulation of vesicle-mediated transport 9.6774 4 yes
GO:0140694 non-membrane-bounded organelle assembly 9.6774 6 yes
GO:2000147 positive regulation of cell motility 9.6774 5 yes
GO:0001952 regulation of cell-matrix adhesion 8.0645 6 yes
GO:0007052 mitotic spindle organization 8.0645 4 yes
GO:0010810 regulation of cell-substrate adhesion 8.0645 5 yes
GO:0030516 regulation of axon extension 8.0645 5 yes
GO:0051293 establishment of spindle localization 8.0645 4 yes
GO:0061387 regulation of extent of cell growth 8.0645 5 yes
GO:0110053 regulation of actin filament organization 8.0645 6 yes
GO:0007030 Golgi organization 6.4516 5 yes
GO:0007162 negative regulation of cell adhesion 6.4516 5 yes
GO:0010632 regulation of epithelial cell migration 6.4516 4 yes
GO:0017157 regulation of exocytosis 6.4516 5 yes
GO:0030336 negative regulation of cell migration 6.4516 6 yes
GO:0032101 regulation of response to external stimulus 6.4516 4 yes
GO:0040001 establishment of mitotic spindle localization 6.4516 5 yes
GO:0040013 negative regulation of locomotion 6.4516 4 yes
GO:0051046 regulation of secretion 6.4516 5 yes
GO:0051225 spindle assembly 6.4516 4 yes
GO:0051494 negative regulation of cytoskeleton organization 6.4516 7 yes
GO:0051893 regulation of focal adhesion assembly 6.4516 7 yes
GO:0072657 protein localization to membrane 6.4516 4 yes
GO:0090109 regulation of cell-substrate junction assembly 6.4516 6 yes
GO:0150116 regulation of cell-substrate junction organization 6.4516 5 yes
GO:1901888 regulation of cell junction assembly 6.4516 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 6.4516 6 yes
GO:1903530 regulation of secretion by cell 6.4516 4 yes
GO:2000146 negative regulation of cell motility 6.4516 5 yes
GO:0007020 microtubule nucleation 4.8387 4 yes
GO:0010634 positive regulation of epithelial cell migration 4.8387 5 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 4.8387 7 yes
GO:0032231 regulation of actin filament bundle assembly 4.8387 5 yes
GO:0032232 negative regulation of actin filament bundle assembly 4.8387 6 yes
GO:0034453 microtubule anchoring 4.8387 4 yes
GO:0043244 regulation of protein-containing complex disassembly 4.8387 5 yes
GO:0045995 regulation of embryonic development 4.8387 5 yes
GO:0001953 negative regulation of cell-matrix adhesion 3.2258 7 yes
GO:0007026 negative regulation of microtubule depolymerization 3.2258 7 yes
GO:0010458 exit from mitosis 3.2258 5 yes
GO:0010470 regulation of gastrulation 3.2258 5 yes
GO:0010715 regulation of extracellular matrix disassembly 3.2258 6 yes
GO:0010717 regulation of epithelial to mesenchymal transition 3.2258 5 yes
GO:0010812 negative regulation of cell-substrate adhesion 3.2258 6 yes
GO:0031114 regulation of microtubule depolymerization 3.2258 6 yes
GO:0032102 negative regulation of response to external stimulus 3.2258 5 yes
GO:0043242 negative regulation of protein-containing complex disassembly 3.2258 6 yes
GO:0045921 positive regulation of exocytosis 3.2258 6 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 3.2258 6 yes
GO:0051047 positive regulation of secretion 3.2258 5 yes
GO:0051492 regulation of stress fiber assembly 3.2258 6 yes
GO:0051497 negative regulation of stress fiber assembly 3.2258 7 yes
GO:0051895 negative regulation of focal adhesion assembly 3.2258 7 yes
GO:0061041 regulation of wound healing 3.2258 6 yes
GO:0061045 negative regulation of wound healing 3.2258 6 yes
GO:0072659 protein localization to plasma membrane 3.2258 5 yes
GO:0090091 positive regulation of extracellular matrix disassembly 3.2258 7 yes
GO:0090307 mitotic spindle assembly 3.2258 5 yes
GO:0110011 regulation of basement membrane organization 3.2258 6 yes
GO:0110020 regulation of actomyosin structure organization 3.2258 6 yes
GO:0150118 negative regulation of cell-substrate junction organization 3.2258 6 yes
GO:1901201 regulation of extracellular matrix assembly 3.2258 5 yes
GO:1901203 positive regulation of extracellular matrix assembly 3.2258 6 yes
GO:1901879 regulation of protein depolymerization 3.2258 6 yes
GO:1901880 negative regulation of protein depolymerization 3.2258 7 yes
GO:1901889 negative regulation of cell junction assembly 3.2258 6 yes
GO:1903034 regulation of response to wounding 3.2258 5 yes
GO:1903035 negative regulation of response to wounding 3.2258 5 yes
GO:1903053 regulation of extracellular matrix organization 3.2258 5 yes
GO:1903055 positive regulation of extracellular matrix organization 3.2258 6 yes
GO:1903532 positive regulation of secretion by cell 3.2258 5 yes
GO:1903689 regulation of wound healing, spreading of epidermal cells 3.2258 6 yes
GO:1903690 negative regulation of wound healing, spreading of epidermal cells 3.2258 7 yes
GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis 3.2258 6 yes
GO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis 3.2258 5 yes
GO:1990778 protein localization to cell periphery 3.2258 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in CLAP2_HUMAN
DOID:0050700 cardiomyopathy 4.8387 4 no
DOID:0060036 intrinsic cardiomyopathy 4.8387 5 no
DOID:114 heart disease 4.8387 3 no
DOID:2843 long QT syndrome 4.8387 6 no
DOID:0050686 organ system cancer 3.2258 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MARE1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKAP9_HUMAN [view entry] [view interactions] Low throughput yes yes
FEZ1_HUMAN [view interactions] Low throughput no no
MARK3_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
CLIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
MACF1_HUMAN [view entry] [view interactions] Low throughput yes yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CDC6_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
CROCC_HUMAN [view interactions] High throughput no no
CENPE_HUMAN [view interactions] High throughput no no
PRD16_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PP4C_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
BICD2_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
ERI1_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDV3_HUMAN [view interactions] High throughput no no
STMN1_HUMAN [view interactions] High throughput no yes
TAGL_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
PTBP3_HUMAN [view interactions] High throughput no no
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
MYOME_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CCR4_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PYGM_HUMAN [view entry] [view interactions] High throughput yes no
NIN_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FEZ2_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SMYD2_HUMAN [view interactions] High throughput no yes
LXN_HUMAN [view interactions] High throughput no yes
RAD21_HUMAN [view interactions] High throughput no yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
FOXP3_HUMAN [view interactions] High throughput no no
SMUF1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
3MG_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
ASB3_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
LYPD3_HUMAN [view interactions] High throughput no no
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
FA43A_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
UBIP1_HUMAN [view interactions] High throughput no no
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
IBTK_HUMAN [view interactions] High throughput no yes
PPHLN_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
RC3H1_HUMAN [view interactions] High throughput no yes
KLDC3_HUMAN [view interactions] High throughput no yes
CGAT2_HUMAN [view interactions] High throughput no yes
GORS1_HUMAN [view interactions] High throughput no yes
ID2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
TRIP4_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
RU17_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
PD1L1_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
PAGE4_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CT197_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
PNMA2_HUMAN [view interactions] High throughput no yes
PEA15_HUMAN [view entry] [view interactions] High throughput yes no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
APC15_HUMAN [view interactions] High throughput no yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
FAXC_HUMAN [view interactions] High throughput no no
PEN2_HUMAN [view interactions] High throughput no yes
HYPM_HUMAN [view interactions] High throughput no no
UBR3_HUMAN [view interactions] High throughput no yes
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
PSA5_HUMAN [view interactions] High throughput no yes
GCC2_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
JKIP1_HUMAN [view interactions] High throughput no no
UBE2O_HUMAN [view interactions] High throughput no yes
UBP12_HUMAN [view interactions] High throughput no yes
CLIP4_HUMAN [view interactions] High throughput no yes
STRAA_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
TAF5L_HUMAN [view interactions] High throughput no no
RCBT2_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
ARMD3_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
BUB3_HUMAN [view interactions] High throughput no yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
GSKIP_HUMAN [view interactions] High throughput no yes
PRUN1_HUMAN [view interactions] High throughput no no
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
DYLT3_HUMAN [view interactions] High throughput no yes
TRI36_HUMAN [view interactions] High throughput no no
CTND1_HUMAN [view entry] [view interactions] Computational yes no
IQGA1_HUMAN [view entry] [view interactions] Computational yes no