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MARE2_HUMAN

May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MARE2_HUMAN
GO:0043169 cation binding 29.5455 4 no
GO:0046872 metal ion binding 29.5455 5 no
GO:0043168 anion binding 29.5455 4 no
GO:0015631 tubulin binding 27.2727 4 yes
GO:0000166 nucleotide binding 27.2727 4 no
GO:0017076 purine nucleotide binding 27.2727 5 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0008017 microtubule binding 25.0000 5 yes
GO:0019900 kinase binding 25.0000 4 yes
GO:0019901 protein kinase binding 25.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 22.7273 6 no
GO:0032559 adenyl ribonucleotide binding 22.7273 5 no
GO:0005524 ATP binding 20.4545 5 no
GO:0051010 microtubule plus-end binding 15.9091 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MARE2_HUMAN
GO:0048522 positive regulation of cellular process 68.1818 4 yes
GO:0051128 regulation of cellular component organization 61.3636 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0048523 negative regulation of cellular process 47.7273 4 no
GO:0006996 organelle organization 47.7273 4 yes
GO:0031323 regulation of cellular metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0022607 cellular component assembly 43.1818 4 yes
GO:0009966 regulation of signal transduction 40.9091 4 yes
GO:0009889 regulation of biosynthetic process 38.6364 4 no
GO:0010468 regulation of gene expression 38.6364 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.6364 5 no
GO:0031326 regulation of cellular biosynthetic process 38.6364 5 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0030030 cell projection organization 36.3636 4 no
GO:0007010 cytoskeleton organization 36.3636 5 yes
GO:0033043 regulation of organelle organization 36.3636 5 yes
GO:0051130 positive regulation of cellular component organization 34.0909 5 yes
GO:0051246 regulation of protein metabolic process 34.0909 5 no
GO:0008104 protein localization 34.0909 4 yes
GO:0051493 regulation of cytoskeleton organization 31.8182 6 yes
GO:0031325 positive regulation of cellular metabolic process 31.8182 5 no
GO:0044087 regulation of cellular component biogenesis 31.8182 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.8182 5 no
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.8182 5 no
GO:0051726 regulation of cell cycle 29.5455 4 no
GO:1902903 regulation of supramolecular fiber organization 29.5455 5 no
GO:0051129 negative regulation of cellular component organization 29.5455 5 no
GO:0032886 regulation of microtubule-based process 29.5455 4 yes
GO:0070507 regulation of microtubule cytoskeleton organization 27.2727 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0031399 regulation of protein modification process 27.2727 6 no
GO:0045595 regulation of cell differentiation 27.2727 4 no
GO:0050804 modulation of chemical synaptic transmission 27.2727 5 no
GO:0099177 regulation of trans-synaptic signaling 27.2727 4 no
GO:0051049 regulation of transport 27.2727 4 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 yes
GO:0023056 positive regulation of signaling 27.2727 4 yes
GO:0048584 positive regulation of response to stimulus 25.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 25.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 25.0000 6 yes
GO:0070925 organelle assembly 22.7273 5 yes
GO:0009891 positive regulation of biosynthetic process 22.7273 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.7273 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.7273 6 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 no
GO:0042981 regulation of apoptotic process 22.7273 5 no
GO:0043067 regulation of programmed cell death 22.7273 4 no
GO:0050890 cognition 22.7273 4 no
GO:0009890 negative regulation of biosynthetic process 22.7273 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.7273 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.7273 6 no
GO:0043933 protein-containing complex organization 22.7273 4 no
GO:0006796 phosphate-containing compound metabolic process 22.7273 4 no
GO:0051240 positive regulation of multicellular organismal process 22.7273 4 no
GO:0006355 regulation of DNA-templated transcription 20.4545 7 no
GO:0019220 regulation of phosphate metabolic process 20.4545 6 no
GO:0042325 regulation of phosphorylation 20.4545 7 no
GO:0043254 regulation of protein-containing complex assembly 20.4545 5 no
GO:0051174 regulation of phosphorus metabolic process 20.4545 5 no
GO:0051338 regulation of transferase activity 20.4545 4 no
GO:2001141 regulation of RNA biosynthetic process 20.4545 6 no
GO:0031175 neuron projection development 20.4545 6 no
GO:0031344 regulation of cell projection organization 20.4545 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.4545 6 no
GO:0009894 regulation of catabolic process 20.4545 4 no
GO:0051248 negative regulation of protein metabolic process 20.4545 6 no
GO:0008285 negative regulation of cell population proliferation 20.4545 5 no
GO:0051094 positive regulation of developmental process 20.4545 4 no
GO:0033365 protein localization to organelle 18.1818 5 yes
GO:0043085 positive regulation of catalytic activity 18.1818 4 yes
GO:0140694 non-membrane-bounded organelle assembly 15.9091 6 yes
GO:0051225 spindle assembly 13.6364 4 yes
GO:0051336 regulation of hydrolase activity 13.6364 4 yes
GO:2000145 regulation of cell motility 13.6364 4 yes
GO:0030334 regulation of cell migration 13.6364 5 yes
GO:0051345 positive regulation of hydrolase activity 11.3636 5 yes
GO:0072698 protein localization to microtubule cytoskeleton 11.3636 7 yes
GO:2000147 positive regulation of cell motility 11.3636 5 yes
GO:0030335 positive regulation of cell migration 11.3636 6 yes
GO:0040017 positive regulation of locomotion 11.3636 4 yes
GO:0044380 protein localization to cytoskeleton 11.3636 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 9.0909 6 yes
GO:1902533 positive regulation of intracellular signal transduction 9.0909 6 yes
GO:0035372 protein localization to microtubule 9.0909 8 yes
GO:0010632 regulation of epithelial cell migration 6.8182 4 yes
GO:0010634 positive regulation of epithelial cell migration 6.8182 5 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 4.5455 7 yes
GO:0051547 regulation of keratinocyte migration 4.5455 5 yes
GO:0051549 positive regulation of keratinocyte migration 4.5455 6 yes
GO:0120182 regulation of focal adhesion disassembly 4.5455 6 yes
GO:0120183 positive regulation of focal adhesion disassembly 4.5455 7 yes
GO:0150116 regulation of cell-substrate junction organization 4.5455 5 yes
GO:0150117 positive regulation of cell-substrate junction organization 4.5455 6 yes
GO:0032012 regulation of ARF protein signal transduction 4.5455 7 yes
GO:0032014 positive regulation of ARF protein signal transduction 4.5455 8 yes
GO:0043087 regulation of GTPase activity 4.5455 5 yes
GO:0043547 positive regulation of GTPase activity 4.5455 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ADNP_HUMAN [view interactions] Low throughput no yes
APC_HUMAN [view entry] [view interactions] Low throughput yes no
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
AURKB_HUMAN [view interactions] Low throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
FGL1_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CAB45_HUMAN [view interactions] High throughput no no
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PHLA3_HUMAN [view interactions] High throughput no yes
MIPT3_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
CDK4_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
TRAF1_HUMAN [view interactions] High throughput no no
CRAC1_HUMAN [view entry] [view interactions] High throughput yes yes
THIOM_HUMAN [view interactions] High throughput no yes
TRAIP_HUMAN [view interactions] High throughput no yes
MARE2_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
GA2L2_HUMAN [view interactions] High throughput no no
DDT4L_HUMAN [view interactions] High throughput no no
NIF3L_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
PSB1_HUMAN [view interactions] High throughput no yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CE104_HUMAN [view interactions] High throughput no yes
POC1A_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
H31_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FHI2B_HUMAN [view interactions] High throughput no yes
SWAP1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
DYT2B_HUMAN [view interactions] High throughput no no
PAXI1_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
RBM6_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
SLAI2_HUMAN [view interactions] High throughput no no
RBM10_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
PRP6_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
LLPH_HUMAN [view interactions] High throughput no no
RN185_HUMAN [view interactions] High throughput no no
FOXP3_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
CTCF_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
INS_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
KDF1_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
TCPQM_HUMAN [view interactions] High throughput no no
SPSB4_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
HNRC2_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
RA51B_HUMAN [view interactions] High throughput no yes
PI51B_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
RN175_HUMAN [view interactions] High throughput no no
UBP32_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
NPAS1_HUMAN [view interactions] High throughput no no
GA2L1_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
KLK15_HUMAN [view interactions] High throughput no no
DNAI2_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
RFXK_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
RPAC2_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
SPOP_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC1_HUMAN [view interactions] High throughput no yes
MCM4_HUMAN [view interactions] High throughput no yes
MCM7_HUMAN [view interactions] High throughput no no
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
MCM6_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA2_HUMAN [view interactions] High throughput no no
KDM3B_HUMAN [view interactions] High throughput no yes
SYF1_HUMAN [view interactions] High throughput no no
CC14A_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
CAMP2_HUMAN [view interactions] High throughput no yes
TRI36_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes