MARE2_HUMAN
Evidence for PS localization
Functions
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MARE2_HUMAN |
|---|---|---|---|---|
| GO:0015631 | tubulin binding | 33.3333 | 4 | yes |
| GO:0008017 | microtubule binding | 30.7692 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 28.2051 | 4 | no |
| GO:0019900 | kinase binding | 25.6410 | 4 | yes |
| GO:0019901 | protein kinase binding | 25.6410 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.6410 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.6410 | 4 | no |
| GO:0051010 | microtubule plus-end binding | 23.0769 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.5128 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.5128 | 4 | no |
| GO:0005524 | ATP binding | 20.5128 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 20.5128 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5128 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5128 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.5128 | 5 | no |
| GO:0046872 | metal ion binding | 20.5128 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MARE2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.2308 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 64.1026 | 4 | yes |
| GO:0006996 | organelle organization | 53.8462 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.1538 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 46.1538 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.5897 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.5897 | 4 | no |
| GO:0007010 | cytoskeleton organization | 43.5897 | 5 | yes |
| GO:0022607 | cellular component assembly | 43.5897 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.0256 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 38.4615 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 38.4615 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 38.4615 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.8974 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.8974 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8974 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 35.8974 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.8974 | 4 | yes |
| GO:0032886 | regulation of microtubule-based process | 35.8974 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 33.3333 | 5 | yes |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0051726 | regulation of cell cycle | 30.7692 | 4 | no |
| GO:0008104 | protein localization | 30.7692 | 4 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 30.7692 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.2051 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.2051 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.2051 | 5 | no |
| GO:0070925 | organelle assembly | 25.6410 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.6410 | 5 | yes |
| GO:0010941 | regulation of cell death | 25.6410 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 25.6410 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.6410 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.6410 | 4 | no |
| GO:0051049 | regulation of transport | 25.6410 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0030162 | regulation of proteolysis | 23.0769 | 6 | no |
| GO:0032271 | regulation of protein polymerization | 23.0769 | 6 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.0769 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0008285 | negative regulation of cell population proliferation | 23.0769 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.0769 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.0769 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.0769 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 23.0769 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 20.5128 | 6 | no |
| GO:0010639 | negative regulation of organelle organization | 20.5128 | 6 | no |
| GO:0031113 | regulation of microtubule polymerization | 20.5128 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.5128 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.5128 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.5128 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.5128 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.5128 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5128 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 20.5128 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.5128 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.5128 | 6 | no |
| GO:1902905 | positive regulation of supramolecular fiber organization | 20.5128 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 20.5128 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5128 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5128 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 20.5128 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5128 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5128 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5128 | 5 | no |
| GO:0050807 | regulation of synapse organization | 20.5128 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.5128 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5128 | 5 | yes |
| GO:0033365 | protein localization to organelle | 20.5128 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 20.5128 | 4 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 17.9487 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 17.9487 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 17.9487 | 4 | yes |
| GO:0051225 | spindle assembly | 15.3846 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 12.8205 | 5 | yes |
| GO:0072698 | protein localization to microtubule cytoskeleton | 12.8205 | 7 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 12.8205 | 6 | yes |
| GO:2000145 | regulation of cell motility | 12.8205 | 4 | yes |
| GO:0030334 | regulation of cell migration | 12.8205 | 5 | yes |
| GO:0044380 | protein localization to cytoskeleton | 12.8205 | 6 | yes |
| GO:1904825 | protein localization to microtubule plus-end | 10.2564 | 10 | yes |
| GO:1905725 | protein localization to microtubule end | 10.2564 | 9 | yes |
| GO:2000147 | positive regulation of cell motility | 10.2564 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 10.2564 | 6 | yes |
| GO:0035372 | protein localization to microtubule | 10.2564 | 8 | yes |
| GO:0040017 | positive regulation of locomotion | 10.2564 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 7.6923 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 7.6923 | 6 | yes |
| GO:0051547 | regulation of keratinocyte migration | 5.1282 | 5 | yes |
| GO:0051549 | positive regulation of keratinocyte migration | 5.1282 | 6 | yes |
| GO:0120182 | regulation of focal adhesion disassembly | 5.1282 | 6 | yes |
| GO:0120183 | positive regulation of focal adhesion disassembly | 5.1282 | 7 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 5.1282 | 5 | yes |
| GO:0150117 | positive regulation of cell-substrate junction organization | 5.1282 | 6 | yes |
| GO:0010632 | regulation of epithelial cell migration | 5.1282 | 4 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 5.1282 | 5 | yes |
| GO:0032012 | regulation of ARF protein signal transduction | 5.1282 | 8 | yes |
| GO:0032014 | positive regulation of ARF protein signal transduction | 5.1282 | 9 | yes |
| GO:0043547 | positive regulation of GTPase activity | 5.1282 | 6 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 5.1282 | 7 | yes |
| GO:0046579 | positive regulation of Ras protein signal transduction | 5.1282 | 8 | yes |
| GO:0051057 | positive regulation of small GTPase mediated signal transduction | 5.1282 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MARE2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.1282 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ADNP_HUMAN | [view interactions] | Low throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AURKB_HUMAN | [view interactions] | Low throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| CRAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| TRAIP_HUMAN | [view interactions] | High throughput | no | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| GA2L2_HUMAN | [view interactions] | High throughput | no | no |
| DDT4L_HUMAN | [view interactions] | High throughput | no | no |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM6_HUMAN | [view interactions] | High throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| RBM10_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| LLPH_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| CTCF_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LGI1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RA51B_HUMAN | [view interactions] | High throughput | no | yes |
| PI51B_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN175_HUMAN | [view interactions] | High throughput | no | no |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| DGCR8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| RB15B_HUMAN | [view interactions] | Computational | no | yes |
| CENPE_HUMAN | [view interactions] | Computational | no | no |
| CKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NXF1_HUMAN | [view interactions] | Computational | no | yes |