Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PPR1B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inhibitor of protein-phosphatase 1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001078 DOC_PP1_RVXF_1 DOC 5 12 -
ELMI001078 DOC_PP1_RVXF_1 DOC 5 12 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PPR1B_HUMAN
GO:0000166 nucleotide binding 44.4444 4 no
GO:0004674 protein serine/threonine kinase activity 44.4444 4 no
GO:0005524 ATP binding 44.4444 5 no
GO:0016301 kinase activity 44.4444 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 44.4444 4 no
GO:0017076 purine nucleotide binding 44.4444 5 no
GO:0030554 adenyl nucleotide binding 44.4444 6 no
GO:0032555 purine ribonucleotide binding 44.4444 4 no
GO:0032559 adenyl ribonucleotide binding 44.4444 5 no
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 no
GO:0043168 anion binding 44.4444 4 no
GO:0106310 protein serine kinase activity 44.4444 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0051879 Hsp90 protein binding 22.2222 4 no
GO:0004722 protein serine/threonine phosphatase activity 22.2222 4 no
GO:0008157 protein phosphatase 1 binding 22.2222 6 no
GO:0016791 phosphatase activity 22.2222 5 no
GO:0017018 myosin phosphatase activity 22.2222 5 no
GO:0019902 phosphatase binding 22.2222 4 no
GO:0019903 protein phosphatase binding 22.2222 5 no
GO:0042578 phosphoric ester hydrolase activity 22.2222 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PPR1B_HUMAN
GO:0031323 regulation of cellular metabolic process 77.7778 4 yes
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 yes
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0006796 phosphate-containing compound metabolic process 66.6667 4 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0036211 protein modification process 66.6667 4 no
GO:0043412 macromolecule modification 66.6667 4 no
GO:0009892 negative regulation of metabolic process 55.5556 4 yes
GO:0009889 regulation of biosynthetic process 55.5556 4 no
GO:0009894 regulation of catabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0010468 regulation of gene expression 55.5556 6 no
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 no
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 no
GO:0051128 regulation of cellular component organization 55.5556 4 no
GO:0009416 response to light stimulus 44.4444 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 yes
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 yes
GO:0051248 negative regulation of protein metabolic process 44.4444 6 yes
GO:0071310 cellular response to organic substance 44.4444 4 yes
GO:0090304 nucleic acid metabolic process 44.4444 4 yes
GO:0006468 protein phosphorylation 44.4444 5 no
GO:0006915 apoptotic process 44.4444 4 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0016310 phosphorylation 44.4444 5 no
GO:0018105 peptidyl-serine phosphorylation 44.4444 6 no
GO:0018193 peptidyl-amino acid modification 44.4444 5 no
GO:0018209 peptidyl-serine modification 44.4444 6 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0030162 regulation of proteolysis 44.4444 6 no
GO:0042981 regulation of apoptotic process 44.4444 5 no
GO:0043067 regulation of programmed cell death 44.4444 4 no
GO:0048585 negative regulation of response to stimulus 44.4444 4 no
GO:0051726 regulation of cell cycle 44.4444 4 no
GO:0045595 regulation of cell differentiation 44.4444 4 no
GO:0060341 regulation of cellular localization 44.4444 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 yes
GO:0071417 cellular response to organonitrogen compound 33.3333 4 yes
GO:1901699 cellular response to nitrogen compound 33.3333 4 yes
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 yes
GO:0009895 negative regulation of catabolic process 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0045861 negative regulation of proteolysis 33.3333 7 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 33.3333 7 no
GO:2001233 regulation of apoptotic signaling pathway 33.3333 5 no
GO:0050767 regulation of neurogenesis 33.3333 6 no
GO:0051960 regulation of nervous system development 33.3333 5 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0010506 regulation of autophagy 33.3333 6 no
GO:0031329 regulation of cellular catabolic process 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0070201 regulation of establishment of protein localization 33.3333 6 no
GO:1903829 positive regulation of protein localization 33.3333 5 no
GO:1904951 positive regulation of establishment of protein localization 33.3333 6 no
GO:0032386 regulation of intracellular transport 33.3333 5 no
GO:0046822 regulation of nucleocytoplasmic transport 33.3333 6 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0007612 learning 22.2222 4 yes
GO:0008306 associative learning 22.2222 5 yes
GO:0008542 visual learning 22.2222 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 yes
GO:0016070 RNA metabolic process 22.2222 5 yes
GO:0019220 regulation of phosphate metabolic process 22.2222 6 yes
GO:0031399 regulation of protein modification process 22.2222 6 yes
GO:0031400 negative regulation of protein modification process 22.2222 7 yes
GO:0043086 negative regulation of catalytic activity 22.2222 4 yes
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 yes
GO:0048148 behavioral response to cocaine 22.2222 4 yes
GO:0050890 cognition 22.2222 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 yes
GO:0051336 regulation of hydrolase activity 22.2222 4 yes
GO:0051346 negative regulation of hydrolase activity 22.2222 5 yes
GO:0001558 regulation of cell growth 22.2222 4 no
GO:0006259 DNA metabolic process 22.2222 5 no
GO:0006281 DNA repair 22.2222 5 no
GO:0006302 double-strand break repair 22.2222 6 no
GO:0006417 regulation of translation 22.2222 6 no
GO:0006974 DNA damage response 22.2222 4 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010564 regulation of cell cycle process 22.2222 5 no
GO:0010608 post-transcriptional regulation of gene expression 22.2222 7 no
GO:0016055 Wnt signaling pathway 22.2222 4 no
GO:0018107 peptidyl-threonine phosphorylation 22.2222 6 no
GO:0018210 peptidyl-threonine modification 22.2222 6 no
GO:0030111 regulation of Wnt signaling pathway 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0051983 regulation of chromosome segregation 22.2222 6 no
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 22.2222 8 no
GO:1905818 regulation of chromosome separation 22.2222 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 22.2222 5 no
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 22.2222 6 no
GO:2001234 negative regulation of apoptotic signaling pathway 22.2222 6 no
GO:0005976 polysaccharide metabolic process 22.2222 4 no
GO:0005977 glycogen metabolic process 22.2222 6 no
GO:0006109 regulation of carbohydrate metabolic process 22.2222 5 no
GO:0006112 energy reserve metabolic process 22.2222 5 no
GO:0006470 protein dephosphorylation 22.2222 5 no
GO:0009648 photoperiodism 22.2222 5 no
GO:0015980 energy derivation by oxidation of organic compounds 22.2222 4 no
GO:0016311 dephosphorylation 22.2222 5 no
GO:0043065 positive regulation of apoptotic process 22.2222 6 no
GO:0043068 positive regulation of programmed cell death 22.2222 5 no
GO:0043153 entrainment of circadian clock by photoperiod 22.2222 4 no
GO:0043255 regulation of carbohydrate biosynthetic process 22.2222 5 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:0043467 regulation of generation of precursor metabolites and energy 22.2222 5 no
GO:0043470 regulation of carbohydrate catabolic process 22.2222 5 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0044042 glucan metabolic process 22.2222 5 no
GO:0007411 axon guidance 22.2222 8 no
GO:0010720 positive regulation of cell development 22.2222 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0032870 cellular response to hormone stimulus 22.2222 4 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0048666 neuron development 22.2222 4 no
GO:0050769 positive regulation of neurogenesis 22.2222 6 no
GO:0050770 regulation of axonogenesis 22.2222 5 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 no
GO:0051961 negative regulation of nervous system development 22.2222 5 no
GO:0051962 positive regulation of nervous system development 22.2222 5 no
GO:0097485 neuron projection guidance 22.2222 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:1901888 regulation of cell junction assembly 22.2222 5 no
GO:0048232 male gamete generation 22.2222 4 no
GO:1903533 regulation of protein targeting 22.2222 7 no
GO:0006886 intracellular protein transport 22.2222 4 no
GO:0008104 protein localization 22.2222 4 no
GO:0015031 protein transport 22.2222 4 no
GO:0016241 regulation of macroautophagy 22.2222 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0033157 regulation of intracellular protein transport 22.2222 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0046825 regulation of protein export from nucleus 22.2222 7 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051047 positive regulation of secretion 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:1903532 positive regulation of secretion by cell 22.2222 5 no
GO:0030182 neuron differentiation 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
TFCP2_HUMAN [view interactions] High throughput no no
KLHL6_HUMAN [view interactions] High throughput no no
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
ROBO2_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTBL_HUMAN [view interactions] High throughput no no
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes