Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PPR1B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Inhibitor of protein-phosphatase 1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001078 DOC_PP1_RVXF_1 DOC 5 12 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PPR1B_HUMAN
GO:0046872 metal ion binding 48.0000 4 no
GO:0017076 purine nucleotide binding 44.0000 4 no
GO:0030554 adenyl nucleotide binding 44.0000 5 no
GO:0032555 purine ribonucleotide binding 44.0000 4 no
GO:0032559 adenyl ribonucleotide binding 44.0000 5 no
GO:0042578 phosphoric ester hydrolase activity 40.0000 4 no
GO:0016791 phosphatase activity 36.0000 5 no
GO:0019900 kinase binding 36.0000 4 no
GO:0019901 protein kinase binding 36.0000 5 no
GO:0004722 protein serine/threonine phosphatase activity 32.0000 4 no
GO:0016301 kinase activity 32.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 32.0000 4 no
GO:0019887 protein kinase regulator activity 28.0000 4 yes
GO:0004674 protein serine/threonine kinase activity 28.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 24.0000 4 no
GO:0005524 ATP binding 24.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 24.0000 4 no
GO:0106310 protein serine kinase activity 24.0000 4 no
GO:0004860 protein kinase inhibitor activity 20.0000 5 yes
GO:0004862 cAMP-dependent protein kinase inhibitor activity 20.0000 6 yes
GO:0008603 cAMP-dependent protein kinase regulator activity 20.0000 5 yes
GO:0019210 kinase inhibitor activity 20.0000 4 yes
GO:0030291 protein serine/threonine kinase inhibitor activity 20.0000 6 yes
GO:0019888 protein phosphatase regulator activity 16.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PPR1B_HUMAN
GO:0060255 regulation of macromolecule metabolic process 96.0000 4 yes
GO:0080090 regulation of primary metabolic process 88.0000 4 yes
GO:0031323 regulation of cellular metabolic process 84.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 84.0000 4 yes
GO:0010646 regulation of cell communication 72.0000 4 no
GO:0048523 negative regulation of cellular process 72.0000 4 yes
GO:0051246 regulation of protein metabolic process 72.0000 5 yes
GO:0006796 phosphate-containing compound metabolic process 72.0000 4 no
GO:0036211 protein modification process 68.0000 4 no
GO:0043412 macromolecule modification 68.0000 4 no
GO:0048522 positive regulation of cellular process 64.0000 4 no
GO:0010468 regulation of gene expression 64.0000 5 no
GO:0019220 regulation of phosphate metabolic process 52.0000 6 yes
GO:0031399 regulation of protein modification process 52.0000 6 yes
GO:0051174 regulation of phosphorus metabolic process 52.0000 5 yes
GO:0009893 positive regulation of metabolic process 48.0000 4 no
GO:0009966 regulation of signal transduction 48.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.0000 5 no
GO:0009892 negative regulation of metabolic process 48.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 48.0000 5 yes
GO:0031324 negative regulation of cellular metabolic process 48.0000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 48.0000 5 yes
GO:0001932 regulation of protein phosphorylation 44.0000 7 no
GO:0042325 regulation of phosphorylation 44.0000 7 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0006468 protein phosphorylation 40.0000 5 no
GO:0016310 phosphorylation 40.0000 5 no
GO:0051248 negative regulation of protein metabolic process 40.0000 6 yes
GO:0010648 negative regulation of cell communication 36.0000 5 no
GO:0023057 negative regulation of signaling 36.0000 4 no
GO:0048585 negative regulation of response to stimulus 36.0000 4 no
GO:0051128 regulation of cellular component organization 36.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.0000 5 no
GO:0045595 regulation of cell differentiation 32.0000 4 no
GO:0006355 regulation of DNA-templated transcription 32.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 32.0000 5 no
GO:0051252 regulation of RNA metabolic process 32.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 32.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 32.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 32.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 32.0000 4 no
GO:0009894 regulation of catabolic process 32.0000 4 no
GO:0031329 regulation of cellular catabolic process 32.0000 5 no
GO:0031400 negative regulation of protein modification process 32.0000 7 yes
GO:0006470 protein dephosphorylation 32.0000 5 no
GO:0016311 dephosphorylation 32.0000 5 no
GO:0060341 regulation of cellular localization 28.0000 4 no
GO:0009968 negative regulation of signal transduction 28.0000 5 no
GO:0043549 regulation of kinase activity 28.0000 5 no
GO:0045859 regulation of protein kinase activity 28.0000 6 no
GO:0051338 regulation of transferase activity 28.0000 4 no
GO:0051726 regulation of cell cycle 28.0000 4 no
GO:0048584 positive regulation of response to stimulus 28.0000 4 no
GO:0051050 positive regulation of transport 28.0000 4 no
GO:0010647 positive regulation of cell communication 28.0000 5 no
GO:0018193 peptidyl-amino acid modification 28.0000 5 no
GO:0022607 cellular component assembly 28.0000 4 no
GO:0023056 positive regulation of signaling 28.0000 4 no
GO:0010243 response to organonitrogen compound 28.0000 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 28.0000 6 yes
GO:0045936 negative regulation of phosphate metabolic process 28.0000 7 yes
GO:0071310 cellular response to organic substance 28.0000 4 yes
GO:0001933 negative regulation of protein phosphorylation 24.0000 8 no
GO:0019932 second-messenger-mediated signaling 24.0000 4 no
GO:0042326 negative regulation of phosphorylation 24.0000 8 no
GO:0051241 negative regulation of multicellular organismal process 24.0000 4 no
GO:0051247 positive regulation of protein metabolic process 24.0000 6 no
GO:0071900 regulation of protein serine/threonine kinase activity 24.0000 7 no
GO:0032880 regulation of protein localization 24.0000 5 no
GO:0051223 regulation of protein transport 24.0000 5 no
GO:0060627 regulation of vesicle-mediated transport 24.0000 4 no
GO:0070201 regulation of establishment of protein localization 24.0000 6 no
GO:0018107 peptidyl-threonine phosphorylation 24.0000 6 no
GO:0018210 peptidyl-threonine modification 24.0000 6 no
GO:0043933 protein-containing complex organization 24.0000 4 no
GO:0010941 regulation of cell death 24.0000 4 no
GO:0018105 peptidyl-serine phosphorylation 24.0000 6 no
GO:0018209 peptidyl-serine modification 24.0000 6 no
GO:0042981 regulation of apoptotic process 24.0000 6 no
GO:0043067 regulation of programmed cell death 24.0000 5 no
GO:0030162 regulation of proteolysis 24.0000 6 no
GO:0009416 response to light stimulus 24.0000 4 yes
GO:0043086 negative regulation of catalytic activity 24.0000 4 yes
GO:0050890 cognition 24.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 24.0000 4 yes
GO:0007612 learning 20.0000 4 yes
GO:0014070 response to organic cyclic compound 20.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 20.0000 4 yes
GO:1901699 cellular response to nitrogen compound 20.0000 4 yes
GO:0016070 RNA metabolic process 16.0000 5 yes
GO:0071407 cellular response to organic cyclic compound 16.0000 5 yes
GO:0090304 nucleic acid metabolic process 16.0000 4 yes
GO:0001975 response to amphetamine 12.0000 6 yes
GO:0008306 associative learning 12.0000 5 yes
GO:0008542 visual learning 12.0000 4 yes
GO:0014075 response to amine 12.0000 5 yes
GO:0035303 regulation of dephosphorylation 12.0000 7 yes
GO:0035304 regulation of protein dephosphorylation 12.0000 7 yes
GO:0048148 behavioral response to cocaine 12.0000 4 yes
GO:0051336 regulation of hydrolase activity 12.0000 4 yes
GO:0010921 regulation of phosphatase activity 8.0000 5 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 8.0000 6 yes
GO:0051346 negative regulation of hydrolase activity 8.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
KLHL6_HUMAN [view interactions] High throughput no no
TFCP2_HUMAN [view interactions] High throughput no no
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
ROBO2_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTBL_HUMAN [view interactions] High throughput no no
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BB_HUMAN [view entry] [view interactions] Computational yes yes
PP2BC_HUMAN [view interactions] Computational no yes
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no
KAP2_HUMAN [view entry] [view interactions] Computational yes yes
KAP3_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
KC1D_HUMAN [view entry] [view interactions] Computational yes yes
2AAB_HUMAN [view interactions] Computational no yes
PP1B_HUMAN [view entry] [view interactions] Computational yes yes
PP2AB_HUMAN [view interactions] Computational no yes
KAP1_HUMAN [view entry] [view interactions] Computational yes yes
2AAA_HUMAN [view entry] [view interactions] Computational yes no
PP2AA_HUMAN [view entry] [view interactions] Computational yes yes
DRD1_HUMAN [view entry] [view interactions] Computational yes no
PP2BA_HUMAN [view entry] [view interactions] Computational yes yes
PDE4B_HUMAN [view entry] [view interactions] Computational yes yes
CD5R1_HUMAN [view entry] [view interactions] Computational yes no
KAP0_HUMAN [view entry] [view interactions] Computational yes yes
CANB1_HUMAN [view entry] [view interactions] Computational yes yes
CSK2B_HUMAN [view entry] [view interactions] Computational yes yes