SYFA_HUMAN
Evidence for PS localization
Functions
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYFA_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 29.7872 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 27.6596 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.6596 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.6596 | 4 | yes |
| GO:0005524 | ATP binding | 17.0213 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 17.0213 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.0213 | 5 | yes |
| GO:0004812 | aminoacyl-tRNA ligase activity | 8.5106 | 4 | yes |
| GO:0004826 | phenylalanine-tRNA ligase activity | 8.5106 | 5 | yes |
| GO:0140101 | catalytic activity, acting on a tRNA | 8.5106 | 4 | yes |
| GO:0000049 | tRNA binding | 4.2553 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYFA_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 53.1915 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.0638 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.0638 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 51.0638 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.9362 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.9362 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.6809 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.5532 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 42.5532 | 5 | no |
| GO:0009966 | regulation of signal transduction | 40.4255 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.2979 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.2979 | 5 | no |
| GO:0036211 | protein modification process | 38.2979 | 4 | no |
| GO:0043412 | macromolecule modification | 38.2979 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.1702 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.1702 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.1702 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.1702 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.1702 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.0426 | 5 | no |
| GO:0006996 | organelle organization | 34.0426 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 34.0426 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.0426 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.9149 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.9149 | 5 | no |
| GO:0010941 | regulation of cell death | 31.9149 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.9149 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.9149 | 5 | no |
| GO:0022607 | cellular component assembly | 31.9149 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 29.7872 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 29.7872 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.7872 | 6 | no |
| GO:0009894 | regulation of catabolic process | 29.7872 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.7872 | 4 | no |
| GO:0031399 | regulation of protein modification process | 29.7872 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.7872 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.7872 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.7872 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.7872 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.6596 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.6596 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 27.6596 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 27.6596 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.6596 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.5319 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.5319 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 25.5319 | 7 | no |
| GO:0043408 | regulation of MAPK cascade | 25.5319 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.5319 | 6 | no |
| GO:0080134 | regulation of response to stress | 25.5319 | 4 | no |
| GO:0006508 | proteolysis | 25.5319 | 4 | no |
| GO:0008104 | protein localization | 25.5319 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.4043 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.4043 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.4043 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 23.4043 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.4043 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 23.4043 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.4043 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.4043 | 5 | no |
| GO:0080135 | regulation of cellular response to stress | 23.4043 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.2766 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.2766 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.2766 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.2766 | 4 | no |
| GO:0051338 | regulation of transferase activity | 21.2766 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 21.2766 | 4 | no |
| GO:0060548 | negative regulation of cell death | 21.2766 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 21.2766 | 4 | no |
| GO:0051049 | regulation of transport | 21.2766 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 19.1489 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 19.1489 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 17.0213 | 4 | yes |
| GO:0016070 | RNA metabolic process | 12.7660 | 5 | yes |
| GO:0019752 | carboxylic acid metabolic process | 10.6383 | 5 | yes |
| GO:0034660 | ncRNA metabolic process | 10.6383 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 10.6383 | 4 | yes |
| GO:0006399 | tRNA metabolic process | 8.5106 | 7 | yes |
| GO:0006418 | tRNA aminoacylation for protein translation | 8.5106 | 6 | yes |
| GO:0006432 | phenylalanyl-tRNA aminoacylation | 8.5106 | 7 | yes |
| GO:0043038 | amino acid activation | 8.5106 | 4 | yes |
| GO:0043039 | tRNA aminoacylation | 8.5106 | 5 | yes |
| GO:0051262 | protein tetramerization | 6.3830 | 7 | yes |
| GO:0051290 | protein heterotetramerization | 6.3830 | 8 | yes |
| GO:0051291 | protein heterooligomerization | 6.3830 | 7 | yes |
| GO:0051259 | protein complex oligomerization | 6.3830 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYFA_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 4.2553 | 4 | no |
| DOID:331 | central nervous system disease | 4.2553 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYFB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECSIT_HUMAN | [view interactions] | Low throughput | no | yes |
| SYFA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| TDGF1_HUMAN | [view interactions] | High throughput | no | no |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COG4_HUMAN | [view interactions] | High throughput | no | no |
| PDC10_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF32_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| ASB4_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFRN2_HUMAN | [view interactions] | High throughput | no | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGF_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2L_HUMAN | [view interactions] | High throughput | no | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASCC3_HUMAN | [view interactions] | High throughput | no | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM5_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUA_HUMAN | [view interactions] | High throughput | no | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I2BP1_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMG2_HUMAN | [view interactions] | High throughput | no | yes |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| SYNC_HUMAN | [view interactions] | Computational | no | yes |
| SYYC_HUMAN | [view interactions] | Computational | no | yes |
| SYFM_HUMAN | [view interactions] | Computational | no | yes |
| SYK_HUMAN | [view interactions] | Computational | no | yes |
| SYEP_HUMAN | [view interactions] | Computational | no | yes |
| LRC47_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYVC_HUMAN | [view interactions] | Computational | no | yes |