Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DPM1_HUMAN

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
92 Arg Gly Congenitaldisorderofglycosylation1E(CDG1E) -
248 Ser Pro Congenitaldisorderofglycosylation1E(CDG1E) -
152 Gly Val Congenitaldisorderofglycosylation1E(CDG1E) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DPM1_HUMAN
GO:0000166 nucleotide binding 47.2222 4 no
GO:0017076 purine nucleotide binding 47.2222 5 no
GO:0032555 purine ribonucleotide binding 47.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 47.2222 4 no
GO:0043168 anion binding 47.2222 4 no
GO:0005524 ATP binding 36.1111 5 no
GO:0030554 adenyl nucleotide binding 36.1111 6 no
GO:0032559 adenyl ribonucleotide binding 36.1111 5 no
GO:0043169 cation binding 30.5556 4 yes
GO:0046872 metal ion binding 30.5556 5 yes
GO:0016301 kinase activity 30.5556 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.5556 4 no
GO:0004674 protein serine/threonine kinase activity 22.2222 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0005537 mannose binding 5.5556 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DPM1_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0031323 regulation of cellular metabolic process 69.4444 4 no
GO:0080090 regulation of primary metabolic process 69.4444 4 no
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0009966 regulation of signal transduction 63.8889 4 no
GO:0051128 regulation of cellular component organization 63.8889 4 no
GO:0048523 negative regulation of cellular process 61.1111 4 no
GO:0009893 positive regulation of metabolic process 58.3333 4 no
GO:0009889 regulation of biosynthetic process 55.5556 4 no
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 no
GO:0010604 positive regulation of macromolecule metabolic process 52.7778 5 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0048584 positive regulation of response to stimulus 47.2222 4 no
GO:0051246 regulation of protein metabolic process 47.2222 5 no
GO:0010468 regulation of gene expression 47.2222 6 no
GO:0006996 organelle organization 44.4444 4 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0036211 protein modification process 41.6667 4 yes
GO:0043412 macromolecule modification 41.6667 4 yes
GO:0042127 regulation of cell population proliferation 41.6667 4 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0010648 negative regulation of cell communication 41.6667 5 no
GO:0022607 cellular component assembly 41.6667 4 no
GO:0023057 negative regulation of signaling 41.6667 4 no
GO:0048585 negative regulation of response to stimulus 41.6667 4 no
GO:0006796 phosphate-containing compound metabolic process 38.8889 4 yes
GO:0009967 positive regulation of signal transduction 38.8889 5 no
GO:0031399 regulation of protein modification process 38.8889 6 no
GO:0031401 positive regulation of protein modification process 38.8889 7 no
GO:0051130 positive regulation of cellular component organization 38.8889 5 no
GO:0006355 regulation of DNA-templated transcription 38.8889 7 no
GO:0009968 negative regulation of signal transduction 38.8889 5 no
GO:0042981 regulation of apoptotic process 38.8889 5 no
GO:0043067 regulation of programmed cell death 38.8889 4 no
GO:0051252 regulation of RNA metabolic process 38.8889 5 no
GO:2001141 regulation of RNA biosynthetic process 38.8889 6 no
GO:0019220 regulation of phosphate metabolic process 36.1111 6 no
GO:0051174 regulation of phosphorus metabolic process 36.1111 5 no
GO:0051049 regulation of transport 36.1111 4 no
GO:0031324 negative regulation of cellular metabolic process 36.1111 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 30.5556 7 no
GO:0008104 protein localization 30.5556 4 no
GO:0008284 positive regulation of cell population proliferation 30.5556 5 no
GO:0016310 phosphorylation 30.5556 5 no
GO:0042325 regulation of phosphorylation 30.5556 7 no
GO:0043933 protein-containing complex organization 30.5556 4 no
GO:0009891 positive regulation of biosynthetic process 30.5556 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.5556 5 no
GO:0030162 regulation of proteolysis 30.5556 6 no
GO:0031328 positive regulation of cellular biosynthetic process 30.5556 6 no
GO:0051726 regulation of cell cycle 30.5556 4 no
GO:0071310 cellular response to organic substance 30.5556 4 no
GO:0032880 regulation of protein localization 30.5556 5 no
GO:0007010 cytoskeleton organization 27.7778 5 no
GO:0010562 positive regulation of phosphorus metabolic process 27.7778 6 no
GO:0031344 regulation of cell projection organization 27.7778 5 no
GO:0033043 regulation of organelle organization 27.7778 5 no
GO:0045937 positive regulation of phosphate metabolic process 27.7778 7 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.7778 6 no
GO:1902533 positive regulation of intracellular signal transduction 27.7778 6 no
GO:2000145 regulation of cell motility 27.7778 4 no
GO:0006357 regulation of transcription by RNA polymerase II 27.7778 8 no
GO:0051248 negative regulation of protein metabolic process 27.7778 6 no
GO:0051240 positive regulation of multicellular organismal process 27.7778 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0006468 protein phosphorylation 22.2222 5 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0043066 negative regulation of apoptotic process 22.2222 6 no
GO:0043069 negative regulation of programmed cell death 22.2222 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:0010564 regulation of cell cycle process 22.2222 5 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:0043065 positive regulation of apoptotic process 22.2222 6 no
GO:0043068 positive regulation of programmed cell death 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:0008610 lipid biosynthetic process 11.1111 4 yes
GO:0006644 phospholipid metabolic process 8.3333 4 yes
GO:0006497 protein lipidation 5.5556 5 yes
GO:0006650 glycerophospholipid metabolic process 5.5556 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 5.5556 6 yes
GO:0008654 phospholipid biosynthetic process 5.5556 5 yes
GO:0045017 glycerolipid biosynthetic process 5.5556 4 yes
GO:0046474 glycerophospholipid biosynthetic process 5.5556 5 yes
GO:0046486 glycerolipid metabolic process 5.5556 4 yes
GO:0046488 phosphatidylinositol metabolic process 5.5556 6 yes
GO:0090407 organophosphate biosynthetic process 5.5556 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DPM3_HUMAN [view interactions] Low throughput no yes
DPM2_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
SPPL3_HUMAN [view interactions] High throughput no no
TRI14_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
BROMI_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
CLPP_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
MPRD_HUMAN [view interactions] High throughput no yes
CP131_HUMAN [view interactions] High throughput no no
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
MDEAS_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
MK07_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
M3K14_HUMAN [view interactions] High throughput no yes
ELK1_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
B2L14_HUMAN [view interactions] High throughput no yes
BST2_HUMAN [view interactions] High throughput no yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KLF16_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
MAGD1_HUMAN [view interactions] High throughput no no
T22D1_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
BRF2_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
TNR14_HUMAN [view interactions] High throughput no no
PHLA3_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
T23O_HUMAN [view interactions] High throughput no no
ZBT16_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CBX4_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
AKIP_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
DDR2_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
MERTK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROS1_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
PHF12_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
HIF1A_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
MFRN2_HUMAN [view interactions] High throughput no no
CLUA1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
BRD1_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
SKA3_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
SPRTN_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
FOXA1_HUMAN [view interactions] High throughput no no
MYCN_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
MEN1_HUMAN [view interactions] High throughput no yes
CAVN3_HUMAN [view interactions] High throughput no no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK7_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
RUFY1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
PP14B_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
GOLI_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
GRM2_HUMAN [view entry] [view interactions] High throughput yes yes
RECQ1_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
UBP36_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
HAPR1_HUMAN [view interactions] High throughput no yes