Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DPM1_HUMAN

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
92 Arg Gly Congenitaldisorderofglycosylation1E(CDG1E) -
248 Ser Pro Congenitaldisorderofglycosylation1E(CDG1E) -
152 Gly Val Congenitaldisorderofglycosylation1E(CDG1E) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DPM1_HUMAN
GO:0017076 purine nucleotide binding 53.8462 4 no
GO:0032555 purine ribonucleotide binding 53.8462 4 no
GO:0035639 purine ribonucleoside triphosphate binding 53.8462 4 no
GO:0005524 ATP binding 38.4615 5 no
GO:0030554 adenyl nucleotide binding 38.4615 5 no
GO:0032559 adenyl ribonucleotide binding 38.4615 5 no
GO:0016301 kinase activity 34.6154 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 34.6154 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 30.7692 4 no
GO:0019900 kinase binding 23.0769 4 no
GO:0004674 protein serine/threonine kinase activity 23.0769 4 no
GO:0005537 mannose binding 7.6923 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DPM1_HUMAN
GO:0048522 positive regulation of cellular process 76.9231 4 no
GO:0031323 regulation of cellular metabolic process 73.0769 4 no
GO:0051171 regulation of nitrogen compound metabolic process 69.2308 4 no
GO:0060255 regulation of macromolecule metabolic process 69.2308 4 no
GO:0080090 regulation of primary metabolic process 69.2308 4 no
GO:0051128 regulation of cellular component organization 65.3846 4 no
GO:0036211 protein modification process 61.5385 4 yes
GO:0043412 macromolecule modification 61.5385 4 yes
GO:0009893 positive regulation of metabolic process 61.5385 4 no
GO:0010646 regulation of cell communication 61.5385 4 no
GO:0048523 negative regulation of cellular process 61.5385 4 no
GO:0009966 regulation of signal transduction 57.6923 4 no
GO:0031325 positive regulation of cellular metabolic process 57.6923 5 no
GO:0006996 organelle organization 53.8462 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.8462 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 53.8462 5 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0010941 regulation of cell death 50.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0043085 positive regulation of catalytic activity 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0009967 positive regulation of signal transduction 46.1538 5 no
GO:0010556 regulation of macromolecule biosynthetic process 46.1538 5 no
GO:0010647 positive regulation of cell communication 46.1538 5 no
GO:0019220 regulation of phosphate metabolic process 46.1538 6 no
GO:0023056 positive regulation of signaling 46.1538 4 no
GO:0042127 regulation of cell population proliferation 46.1538 4 no
GO:0042325 regulation of phosphorylation 46.1538 7 no
GO:0042981 regulation of apoptotic process 46.1538 6 no
GO:0043067 regulation of programmed cell death 46.1538 5 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0051174 regulation of phosphorus metabolic process 46.1538 5 no
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:0006355 regulation of DNA-templated transcription 42.3077 6 no
GO:0031399 regulation of protein modification process 42.3077 6 no
GO:0051252 regulation of RNA metabolic process 42.3077 5 no
GO:0051338 regulation of transferase activity 42.3077 4 no
GO:1902531 regulation of intracellular signal transduction 42.3077 5 no
GO:1903506 regulation of nucleic acid-templated transcription 42.3077 7 no
GO:2001141 regulation of RNA biosynthetic process 42.3077 6 no
GO:0051130 positive regulation of cellular component organization 42.3077 5 no
GO:0009892 negative regulation of metabolic process 38.4615 4 no
GO:0010562 positive regulation of phosphorus metabolic process 38.4615 6 no
GO:0031401 positive regulation of protein modification process 38.4615 7 no
GO:0042327 positive regulation of phosphorylation 38.4615 8 no
GO:0045937 positive regulation of phosphate metabolic process 38.4615 7 no
GO:0051247 positive regulation of protein metabolic process 38.4615 6 no
GO:0051347 positive regulation of transferase activity 38.4615 5 no
GO:1902533 positive regulation of intracellular signal transduction 38.4615 6 no
GO:0008284 positive regulation of cell population proliferation 34.6154 5 no
GO:0009968 negative regulation of signal transduction 34.6154 5 no
GO:0010648 negative regulation of cell communication 34.6154 5 no
GO:0023057 negative regulation of signaling 34.6154 4 no
GO:0043408 regulation of MAPK cascade 34.6154 6 no
GO:0043549 regulation of kinase activity 34.6154 5 no
GO:0048585 negative regulation of response to stimulus 34.6154 4 no
GO:0071310 cellular response to organic substance 34.6154 4 no
GO:0007010 cytoskeleton organization 34.6154 5 no
GO:0044087 regulation of cellular component biogenesis 34.6154 4 no
GO:0045595 regulation of cell differentiation 34.6154 4 no
GO:0006468 protein phosphorylation 34.6154 5 no
GO:0016310 phosphorylation 34.6154 5 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0006357 regulation of transcription by RNA polymerase II 30.7692 7 no
GO:0009891 positive regulation of biosynthetic process 30.7692 5 no
GO:0009894 regulation of catabolic process 30.7692 4 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.7692 6 no
GO:0043410 positive regulation of MAPK cascade 30.7692 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 30.7692 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0051240 positive regulation of multicellular organismal process 30.7692 4 no
GO:0031344 regulation of cell projection organization 30.7692 5 no
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0051049 regulation of transport 30.7692 4 no
GO:0051094 positive regulation of developmental process 30.7692 4 no
GO:0060548 negative regulation of cell death 30.7692 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.7692 6 no
GO:2000145 regulation of cell motility 30.7692 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.9231 6 no
GO:0010605 negative regulation of macromolecule metabolic process 26.9231 5 no
GO:0010628 positive regulation of gene expression 26.9231 6 no
GO:0010942 positive regulation of cell death 26.9231 5 no
GO:0033674 positive regulation of kinase activity 26.9231 6 no
GO:0051248 negative regulation of protein metabolic process 26.9231 6 no
GO:0051336 regulation of hydrolase activity 26.9231 4 no
GO:0010564 regulation of cell cycle process 26.9231 5 no
GO:0010638 positive regulation of organelle organization 26.9231 6 no
GO:0010975 regulation of neuron projection development 26.9231 7 no
GO:0022607 cellular component assembly 26.9231 4 no
GO:0030162 regulation of proteolysis 26.9231 6 no
GO:0030334 regulation of cell migration 26.9231 5 no
GO:0032956 regulation of actin cytoskeleton organization 26.9231 5 no
GO:0032970 regulation of actin filament-based process 26.9231 4 no
GO:0043066 negative regulation of apoptotic process 26.9231 7 no
GO:0043069 negative regulation of programmed cell death 26.9231 6 no
GO:0051493 regulation of cytoskeleton organization 26.9231 6 no
GO:0051726 regulation of cell cycle 26.9231 4 no
GO:0060341 regulation of cellular localization 26.9231 4 no
GO:0008104 protein localization 26.9231 4 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:1902532 negative regulation of intracellular signal transduction 23.0769 6 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0030335 positive regulation of cell migration 23.0769 6 no
GO:0040017 positive regulation of locomotion 23.0769 4 no
GO:0043065 positive regulation of apoptotic process 23.0769 7 no
GO:0043068 positive regulation of programmed cell death 23.0769 6 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:1902903 regulation of supramolecular fiber organization 23.0769 5 no
GO:2000026 regulation of multicellular organismal development 23.0769 4 no
GO:2000147 positive regulation of cell motility 23.0769 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 23.0769 5 no
GO:0016192 vesicle-mediated transport 23.0769 4 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:0009896 positive regulation of catabolic process 23.0769 5 no
GO:0031329 regulation of cellular catabolic process 23.0769 5 no
GO:0031331 positive regulation of cellular catabolic process 23.0769 6 no
GO:0008610 lipid biosynthetic process 15.3846 4 yes
GO:0006644 phospholipid metabolic process 11.5385 4 yes
GO:0006650 glycerophospholipid metabolic process 11.5385 5 yes
GO:0006661 phosphatidylinositol biosynthetic process 11.5385 6 yes
GO:0008654 phospholipid biosynthetic process 11.5385 4 yes
GO:0045017 glycerolipid biosynthetic process 11.5385 4 yes
GO:0046474 glycerophospholipid biosynthetic process 11.5385 5 yes
GO:0046486 glycerolipid metabolic process 11.5385 4 yes
GO:0046488 phosphatidylinositol metabolic process 11.5385 6 yes
GO:0090407 organophosphate biosynthetic process 11.5385 4 yes
GO:0006497 protein lipidation 7.6923 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DPM3_HUMAN [view interactions] Low throughput no yes
DPM2_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
MPRD_HUMAN [view interactions] High throughput no yes
CP131_HUMAN [view interactions] High throughput no no
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
MDEAS_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SOCS1_HUMAN [view interactions] High throughput no yes
MK07_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
M3K14_HUMAN [view interactions] High throughput no yes
ELK1_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
B2L14_HUMAN [view interactions] High throughput no yes
BST2_HUMAN [view interactions] High throughput no yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KLF16_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
MAGD1_HUMAN [view interactions] High throughput no no
T22D1_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
BRF2_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
TNR14_HUMAN [view interactions] High throughput no no
PHLA3_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
T23O_HUMAN [view interactions] High throughput no no
ZBT16_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CBX4_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
AKIP_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
DDR2_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
MERTK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROS1_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
PHF12_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
HIF1A_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
MFRN2_HUMAN [view interactions] High throughput no no
CLUA1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
BRD1_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
SKA3_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
SPRTN_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
TMEDA_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
BROMI_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
PMGT1_HUMAN [view interactions] Computational no yes
POMT2_HUMAN [view interactions] Computational no yes
SG196_HUMAN [view interactions] Computational no yes
ALG3_HUMAN [view interactions] Computational no yes
GMPPB_HUMAN [view interactions] Computational no yes
PIGB_HUMAN [view interactions] Computational no yes
MPU1_HUMAN [view interactions] Computational no yes
DOPP1_HUMAN [view interactions] Computational no yes
RXLT1_HUMAN [view interactions] Computational no no
SAC1_HUMAN [view entry] [view interactions] Computational yes yes
ALG12_HUMAN [view interactions] Computational no yes
PIGM_HUMAN [view interactions] Computational no no
PIGV_HUMAN [view interactions] Computational no no
DHDDS_HUMAN [view interactions] Computational no no
ALG5_HUMAN [view interactions] Computational no yes
B3GL2_HUMAN [view interactions] Computational no yes
ALG1_HUMAN [view interactions] Computational no yes
PMGT2_HUMAN [view interactions] Computational no yes
POMT1_HUMAN [view interactions] Computational no no
GPT_HUMAN [view interactions] Computational no yes
DOLK_HUMAN [view interactions] Computational no no
GMPPA_HUMAN [view interactions] Computational no no
GMDS_HUMAN [view interactions] Computational no yes