TMM33_HUMAN
Evidence for PS localization
Functions
Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TMM33_HUMAN |
|---|---|---|---|---|
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.4324 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.4324 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.4324 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.0270 | 5 | no |
| GO:0005524 | ATP binding | 27.0270 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 27.0270 | 5 | no |
| GO:0003723 | RNA binding | 24.3243 | 4 | no |
| GO:0046872 | metal ion binding | 21.6216 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TMM33_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 48.6486 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.6486 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.6486 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.9459 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.9459 | 4 | yes |
| GO:0036211 | protein modification process | 45.9459 | 4 | no |
| GO:0043412 | macromolecule modification | 45.9459 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.9459 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.2432 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.2432 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.5405 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.5405 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 32.4324 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 32.4324 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 32.4324 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 32.4324 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.4324 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.4324 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.4324 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.4324 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.4324 | 5 | no |
| GO:0022607 | cellular component assembly | 29.7297 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.7297 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.7297 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.7297 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.7297 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.7297 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.0270 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 27.0270 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 27.0270 | 5 | no |
| GO:0023057 | negative regulation of signaling | 27.0270 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.0270 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.0270 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.0270 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.3243 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 24.3243 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.3243 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.3243 | 5 | no |
| GO:0010941 | regulation of cell death | 24.3243 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.3243 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.3243 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.3243 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.3243 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.3243 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.3243 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 24.3243 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.3243 | 7 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.3243 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.3243 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3243 | 6 | no |
| GO:0008104 | protein localization | 24.3243 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.6216 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.6216 | 8 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.6216 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.6216 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.6216 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.6216 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.6216 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.6216 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.6216 | 8 | no |
| GO:0042981 | regulation of apoptotic process | 21.6216 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.6216 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.6216 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.6216 | 6 | no |
| GO:0071702 | organic substance transport | 21.6216 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.6216 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.6216 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.6216 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.6216 | 4 | no |
| GO:0061024 | membrane organization | 16.2162 | 4 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 13.5135 | 4 | yes |
| GO:0080134 | regulation of response to stress | 13.5135 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 10.8108 | 4 | yes |
| GO:1905897 | regulation of response to endoplasmic reticulum stress | 8.1081 | 5 | yes |
| GO:0007029 | endoplasmic reticulum organization | 5.4054 | 5 | yes |
| GO:1900101 | regulation of endoplasmic reticulum unfolded protein response | 5.4054 | 5 | yes |
| GO:1903894 | regulation of IRE1-mediated unfolded protein response | 5.4054 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RNF26_HUMAN | [view interactions] | Low throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP19_HUMAN | [view interactions] | High throughput | no | no |
| FANCL_HUMAN | [view interactions] | High throughput | no | yes |
| MPP8_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| CAV2_HUMAN | [view interactions] | High throughput | no | no |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG2_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| BRF2_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLR9_HUMAN | [view interactions] | High throughput | no | no |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| S29A2_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| CTCF_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| OXLA_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC3_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| NCLN_HUMAN | [view interactions] | High throughput | no | yes |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |