Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed). Plays also a role in the regulation of exocytosis independently of its electrical function . Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel . Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells . Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels . In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus . Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions . Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
347 Ser Arg Developmentalandepilepticencephalopathy26(DEE26) -
374 Thr Ile Developmentalandepilepticencephalopathy26(DEE26) -
379 Gly Arg Developmentalandepilepticencephalopathy26(DEE26) -
306 Arg Cys Developmentalandepilepticencephalopathy26(DEE26) -
378 Val Ala Developmentalandepilepticencephalopathy26(DEE26) -
401 Gly Arg Developmentalandepilepticencephalopathy26(DEE26) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNB1_HUMAN
GO:0008324 cation transmembrane transporter activity 41.6667 4 yes
GO:0015267 channel activity 41.6667 4 yes
GO:0022832 voltage-gated channel activity 41.6667 6 yes
GO:0022836 gated channel activity 41.6667 5 yes
GO:0022843 voltage-gated cation channel activity 41.6667 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 41.6667 4 yes
GO:0046873 metal ion transmembrane transporter activity 41.6667 5 yes
GO:0005216 ion channel activity 41.6667 4 yes
GO:0005244 voltage-gated ion channel activity 41.6667 4 yes
GO:0005261 cation channel activity 41.6667 5 yes
GO:0005267 potassium channel activity 37.5000 6 yes
GO:0015079 potassium ion transmembrane transporter activity 37.5000 6 yes
GO:0005249 voltage-gated potassium channel activity 37.5000 6 yes
GO:0019900 kinase binding 29.1667 4 no
GO:0046872 metal ion binding 29.1667 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0005524 ATP binding 25.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0005251 delayed rectifier potassium channel activity 25.0000 7 yes
GO:0097718 disordered domain specific binding 20.8333 4 no
GO:0031625 ubiquitin protein ligase binding 20.8333 5 no
GO:0044389 ubiquitin-like protein ligase binding 20.8333 4 no
GO:0015271 outward rectifier potassium channel activity 16.6667 7 yes
GO:0046982 protein heterodimerization activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCNB1_HUMAN
GO:0051049 regulation of transport 75.0000 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 62.5000 4 yes
GO:0043269 regulation of ion transport 58.3333 5 yes
GO:0022607 cellular component assembly 54.1667 4 yes
GO:0034762 regulation of transmembrane transport 54.1667 4 yes
GO:0034765 regulation of ion transmembrane transport 54.1667 5 yes
GO:0009966 regulation of signal transduction 54.1667 4 no
GO:0043933 protein-containing complex organization 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0065003 protein-containing complex assembly 50.0000 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 45.8333 4 no
GO:0051246 regulation of protein metabolic process 45.8333 5 no
GO:0060255 regulation of macromolecule metabolic process 45.8333 4 no
GO:0080090 regulation of primary metabolic process 45.8333 4 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0006811 ion transport 37.5000 4 yes
GO:0006812 cation transport 37.5000 5 yes
GO:0030001 metal ion transport 37.5000 6 yes
GO:0051050 positive regulation of transport 37.5000 4 yes
GO:0098655 cation transmembrane transport 37.5000 4 yes
GO:0098660 inorganic ion transmembrane transport 37.5000 4 yes
GO:0098662 inorganic cation transmembrane transport 37.5000 5 yes
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0006813 potassium ion transport 33.3333 7 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 yes
GO:0071805 potassium ion transmembrane transport 33.3333 6 yes
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 yes
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0051247 positive regulation of protein metabolic process 29.1667 6 no
GO:0051248 negative regulation of protein metabolic process 29.1667 6 no
GO:0051726 regulation of cell cycle 29.1667 4 no
GO:1904062 regulation of cation transmembrane transport 29.1667 6 no
GO:0009967 positive regulation of signal transduction 29.1667 5 no
GO:0036211 protein modification process 29.1667 4 no
GO:0043412 macromolecule modification 29.1667 4 no
GO:0044087 regulation of cellular component biogenesis 29.1667 4 no
GO:0048584 positive regulation of response to stimulus 29.1667 4 no
GO:0008104 protein localization 29.1667 4 yes
GO:0010941 regulation of cell death 29.1667 4 yes
GO:0032880 regulation of protein localization 29.1667 5 yes
GO:0042981 regulation of apoptotic process 29.1667 6 yes
GO:0043067 regulation of programmed cell death 29.1667 5 yes
GO:0043270 positive regulation of ion transport 29.1667 5 yes
GO:0060341 regulation of cellular localization 29.1667 4 yes
GO:0071310 cellular response to organic substance 29.1667 4 yes
GO:0006996 organelle organization 29.1667 4 no
GO:0016192 vesicle-mediated transport 29.1667 4 no
GO:0009892 negative regulation of metabolic process 29.1667 4 no
GO:0009893 positive regulation of metabolic process 29.1667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.1667 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.1667 5 no
GO:0010959 regulation of metal ion transport 29.1667 6 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 no
GO:0043085 positive regulation of catalytic activity 29.1667 4 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0090257 regulation of muscle system process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0001508 action potential 25.0000 4 yes
GO:0048878 chemical homeostasis 25.0000 4 yes
GO:0051046 regulation of secretion 25.0000 5 yes
GO:0051051 negative regulation of transport 25.0000 4 yes
GO:0051223 regulation of protein transport 25.0000 5 yes
GO:0070201 regulation of establishment of protein localization 25.0000 6 yes
GO:1903530 regulation of secretion by cell 25.0000 4 yes
GO:0061024 membrane organization 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0006937 regulation of muscle contraction 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045860 positive regulation of protein kinase activity 20.8333 7 no
GO:0045937 positive regulation of phosphate metabolic process 20.8333 7 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 20.8333 5 no
GO:0051282 regulation of sequestering of calcium ion 20.8333 4 no
GO:0051347 positive regulation of transferase activity 20.8333 5 no
GO:0051924 regulation of calcium ion transport 20.8333 7 no
GO:0055117 regulation of cardiac muscle contraction 20.8333 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 20.8333 7 no
GO:1903169 regulation of calcium ion transmembrane transport 20.8333 7 no
GO:1903522 regulation of blood circulation 20.8333 5 no
GO:2001257 regulation of cation channel activity 20.8333 6 no
GO:0043254 regulation of protein-containing complex assembly 20.8333 5 no
GO:0006468 protein phosphorylation 20.8333 5 no
GO:0016310 phosphorylation 20.8333 5 no
GO:0009894 regulation of catabolic process 20.8333 4 no
GO:0014070 response to organic cyclic compound 20.8333 4 no
GO:0031329 regulation of cellular catabolic process 20.8333 5 no
GO:0032870 cellular response to hormone stimulus 20.8333 4 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:1902533 positive regulation of intracellular signal transduction 20.8333 6 no
GO:0051259 protein complex oligomerization 20.8333 6 yes
GO:0051260 protein homooligomerization 20.8333 7 yes
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 yes
GO:1901701 cellular response to oxygen-containing compound 20.8333 4 yes
GO:0001934 positive regulation of protein phosphorylation 20.8333 8 no
GO:0006942 regulation of striated muscle contraction 20.8333 7 no
GO:0008016 regulation of heart contraction 20.8333 6 no
GO:0010038 response to metal ion 20.8333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 20.8333 6 no
GO:0010564 regulation of cell cycle process 20.8333 5 no
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 20.8333 6 no
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 20.8333 7 no
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 20.8333 6 no
GO:0019722 calcium-mediated signaling 20.8333 5 no
GO:0019932 second-messenger-mediated signaling 20.8333 4 no
GO:0022898 regulation of transmembrane transporter activity 20.8333 4 no
GO:0031401 positive regulation of protein modification process 20.8333 7 no
GO:0032412 regulation of ion transmembrane transporter activity 20.8333 5 no
GO:0033674 positive regulation of kinase activity 20.8333 6 no
GO:0042327 positive regulation of phosphorylation 20.8333 8 no
GO:0002791 regulation of peptide secretion 16.6667 6 yes
GO:0017157 regulation of exocytosis 16.6667 5 yes
GO:0032386 regulation of intracellular transport 16.6667 5 yes
GO:0046883 regulation of hormone secretion 16.6667 4 yes
GO:0048278 vesicle docking 16.6667 4 yes
GO:0050433 regulation of catecholamine secretion 16.6667 5 yes
GO:0050708 regulation of protein secretion 16.6667 5 yes
GO:0050796 regulation of insulin secretion 16.6667 6 yes
GO:0051222 positive regulation of protein transport 16.6667 5 yes
GO:0051952 regulation of amine transport 16.6667 5 yes
GO:0072657 protein localization to membrane 16.6667 4 yes
GO:0090087 regulation of peptide transport 16.6667 5 yes
GO:0090276 regulation of peptide hormone secretion 16.6667 5 yes
GO:1903305 regulation of regulated secretory pathway 16.6667 6 yes
GO:1903829 positive regulation of protein localization 16.6667 5 yes
GO:1904951 positive regulation of establishment of protein localization 16.6667 6 yes
GO:0001678 cellular glucose homeostasis 12.5000 4 yes
GO:0009743 response to carbohydrate 12.5000 4 yes
GO:0009746 response to hexose 12.5000 6 yes
GO:0009749 response to glucose 12.5000 7 yes
GO:0010701 positive regulation of norepinephrine secretion 12.5000 6 yes
GO:0014061 regulation of norepinephrine secretion 12.5000 6 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 12.5000 7 yes
GO:0031667 response to nutrient levels 12.5000 4 yes
GO:0032388 positive regulation of intracellular transport 12.5000 5 yes
GO:0033157 regulation of intracellular protein transport 12.5000 6 yes
GO:0033500 carbohydrate homeostasis 12.5000 5 yes
GO:0033605 positive regulation of catecholamine secretion 12.5000 6 yes
GO:0034284 response to monosaccharide 12.5000 5 yes
GO:0042593 glucose homeostasis 12.5000 6 yes
GO:0045921 positive regulation of exocytosis 12.5000 6 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 12.5000 8 yes
GO:0051047 positive regulation of secretion 12.5000 5 yes
GO:0051954 positive regulation of amine transport 12.5000 5 yes
GO:0071322 cellular response to carbohydrate stimulus 12.5000 5 yes
GO:0071326 cellular response to monosaccharide stimulus 12.5000 6 yes
GO:0071331 cellular response to hexose stimulus 12.5000 7 yes
GO:0071333 cellular response to glucose stimulus 12.5000 5 yes
GO:0090316 positive regulation of intracellular protein transport 12.5000 6 yes
GO:0097623 potassium ion export across plasma membrane 12.5000 4 yes
GO:1903307 positive regulation of regulated secretory pathway 12.5000 7 yes
GO:1903532 positive regulation of secretion by cell 12.5000 5 yes
GO:0002792 negative regulation of peptide secretion 8.3333 6 yes
GO:0007215 glutamate receptor signaling pathway 8.3333 4 yes
GO:0031669 cellular response to nutrient levels 8.3333 4 yes
GO:0043523 regulation of neuron apoptotic process 8.3333 6 yes
GO:0046676 negative regulation of insulin secretion 8.3333 7 yes
GO:0046888 negative regulation of hormone secretion 8.3333 5 yes
GO:0050709 negative regulation of protein secretion 8.3333 6 yes
GO:0051048 negative regulation of secretion 8.3333 5 yes
GO:0051224 negative regulation of protein transport 8.3333 5 yes
GO:0072659 protein localization to plasma membrane 8.3333 5 yes
GO:0090278 negative regulation of peptide hormone secretion 8.3333 6 yes
GO:0090313 regulation of protein targeting to membrane 8.3333 7 yes
GO:0090314 positive regulation of protein targeting to membrane 8.3333 7 yes
GO:1900452 regulation of long-term synaptic depression 8.3333 4 yes
GO:1900454 positive regulation of long-term synaptic depression 8.3333 4 yes
GO:1901214 regulation of neuron death 8.3333 5 yes
GO:1903531 negative regulation of secretion by cell 8.3333 5 yes
GO:1903533 regulation of protein targeting 8.3333 7 yes
GO:1903828 negative regulation of protein localization 8.3333 5 yes
GO:1904950 negative regulation of establishment of protein localization 8.3333 6 yes
GO:1905475 regulation of protein localization to membrane 8.3333 6 yes
GO:1905477 positive regulation of protein localization to membrane 8.3333 6 yes
GO:1990778 protein localization to cell periphery 8.3333 5 yes
GO:2000671 regulation of motor neuron apoptotic process 8.3333 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCNB1_HUMAN
DOID:331 central nervous system disease 29.1667 3 yes
DOID:0050701 electroclinical syndrome 16.6667 6 yes
DOID:0112202 developmental and epileptic encephalopathy 16.6667 7 yes
DOID:1826 epilepsy 16.6667 5 yes
DOID:936 brain disease 16.6667 4 yes
DOID:0080461 developmental and epileptic encephalopathy 26 8.3333 8 yes
DOID:0050700 cardiomyopathy 8.3333 4 no
DOID:0060036 intrinsic cardiomyopathy 8.3333 5 no
DOID:114 heart disease 8.3333 3 no
DOID:2843 long QT syndrome 8.3333 6 no
DOID:1289 neurodegenerative disease 8.3333 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRE_HUMAN [view interactions] Low throughput no no
AMGO1_HUMAN [view interactions] Low throughput no yes
KCNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNS3_HUMAN [view interactions] Low throughput no yes
KCNG2_HUMAN [view interactions] Low throughput no no
KCNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNG3_HUMAN [view interactions] Low throughput no no
KCNH1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNV2_HUMAN [view interactions] Low throughput no no
KCNG1_HUMAN [view interactions] Low throughput no yes
KCNB2_HUMAN [view interactions] Low throughput no no
KCNG4_HUMAN [view interactions] Low throughput no no
HS71B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS71A_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
VAPA_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
AMGO2_HUMAN [view interactions] Low throughput no no
AMGO3_HUMAN [view interactions] Low throughput no no
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNV1_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
SUMO2_HUMAN [view interactions] Low throughput no yes
SUMO3_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
KCNE5_HUMAN [view interactions] Low throughput no no
VAPB_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1D_HUMAN [view interactions] Low throughput no yes
KCND2_HUMAN [view entry] [view interactions] Low throughput yes yes
ZN579_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
RB40B_HUMAN [view interactions] High throughput no no
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view interactions] High throughput no yes
KCNA1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNS1_HUMAN [view interactions] High throughput no no
KCNS2_HUMAN [view interactions] High throughput no no
KCNQ2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNQ3_HUMAN [view interactions] High throughput no no
KCNH5_HUMAN [view interactions] Computational no no
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
KCAB1_HUMAN [view interactions] Computational no no
KCAB2_HUMAN [view entry] [view interactions] Computational yes yes
KCNH2_HUMAN [view interactions] Computational no no
KCAB3_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no