Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PHAR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed, PubMed). Involved in the regulation of cortical neuron migration and dendrite arborization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PHAR1_HUMAN
GO:0003779 actin binding 33.3333 4 yes
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0019900 kinase binding 33.3333 4 no
GO:0004864 protein phosphatase inhibitor activity 22.2222 5 yes
GO:0019212 phosphatase inhibitor activity 22.2222 4 yes
GO:0019888 protein phosphatase regulator activity 22.2222 4 yes
GO:0019902 phosphatase binding 22.2222 4 no
GO:0019903 protein phosphatase binding 22.2222 5 no
GO:0035254 glutamate receptor binding 22.2222 4 no
GO:0000166 nucleotide binding 22.2222 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0017076 purine nucleotide binding 22.2222 5 no
GO:0030554 adenyl nucleotide binding 22.2222 6 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0043168 anion binding 22.2222 4 no
GO:0003723 RNA binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PHAR1_HUMAN
GO:0031323 regulation of cellular metabolic process 77.7778 4 no
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 no
GO:0080090 regulation of primary metabolic process 77.7778 4 no
GO:0006996 organelle organization 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0051246 regulation of protein metabolic process 66.6667 5 no
GO:0007010 cytoskeleton organization 44.4444 5 yes
GO:0022607 cellular component assembly 44.4444 4 yes
GO:0030030 cell projection organization 44.4444 4 yes
GO:0030334 regulation of cell migration 44.4444 5 yes
GO:2000145 regulation of cell motility 44.4444 4 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0009967 positive regulation of signal transduction 44.4444 5 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0048812 neuron projection morphogenesis 33.3333 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 yes
GO:2001222 regulation of neuron migration 33.3333 6 yes
GO:0006417 regulation of translation 33.3333 6 no
GO:0010608 post-transcriptional regulation of gene expression 33.3333 7 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0007015 actin filament organization 22.2222 5 yes
GO:0030038 contractile actin filament bundle assembly 22.2222 6 yes
GO:0031032 actomyosin structure organization 22.2222 4 yes
GO:0043149 stress fiber assembly 22.2222 5 yes
GO:0048813 dendrite morphogenesis 22.2222 6 yes
GO:0051017 actin filament bundle assembly 22.2222 5 yes
GO:0061572 actin filament bundle organization 22.2222 6 yes
GO:0097435 supramolecular fiber organization 22.2222 4 yes
GO:0140058 neuron projection arborization 22.2222 6 yes
GO:0140059 dendrite arborization 22.2222 7 yes
GO:0006446 regulation of translational initiation 22.2222 7 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0032535 regulation of cellular component size 22.2222 4 no
GO:0036211 protein modification process 22.2222 4 no
GO:0043065 positive regulation of apoptotic process 22.2222 6 no
GO:0043068 positive regulation of programmed cell death 22.2222 5 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0008104 protein localization 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0050890 cognition 22.2222 4 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0061097 regulation of protein tyrosine kinase activity 22.2222 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 22.2222 8 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTS_HUMAN [view interactions] Low throughput no no
PHAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1H_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CBX8_HUMAN [view interactions] High throughput no yes
CN119_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
PHAR3_HUMAN [view interactions] High throughput no no
PTK7_HUMAN [view interactions] High throughput no yes