Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PHAR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed, PubMed). Involved in the regulation of cortical neuron migration and dendrite arborization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PHAR1_HUMAN
GO:0019902 phosphatase binding 40.0000 4 yes
GO:0019903 protein phosphatase binding 40.0000 5 yes
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 40.0000 5 no
GO:0046872 metal ion binding 40.0000 4 no
GO:0003779 actin binding 30.0000 4 yes
GO:0008157 protein phosphatase 1 binding 30.0000 6 yes
GO:0004864 protein phosphatase inhibitor activity 20.0000 5 yes
GO:0019212 phosphatase inhibitor activity 20.0000 4 yes
GO:0019888 protein phosphatase regulator activity 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PHAR1_HUMAN
GO:0031323 regulation of cellular metabolic process 80.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 80.0000 4 no
GO:0080090 regulation of primary metabolic process 80.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 70.0000 4 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0030030 cell projection organization 40.0000 4 yes
GO:0030334 regulation of cell migration 40.0000 5 yes
GO:2000145 regulation of cell motility 40.0000 4 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 40.0000 6 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0007010 cytoskeleton organization 30.0000 5 yes
GO:0032990 cell part morphogenesis 30.0000 4 yes
GO:0048812 neuron projection morphogenesis 30.0000 7 yes
GO:0048858 cell projection morphogenesis 30.0000 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 30.0000 6 yes
GO:2001222 regulation of neuron migration 30.0000 6 yes
GO:0006417 regulation of translation 30.0000 6 no
GO:0010608 post-transcriptional regulation of gene expression 30.0000 6 no
GO:0034248 regulation of cellular amide metabolic process 30.0000 5 no
GO:0043933 protein-containing complex organization 30.0000 4 no
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 30.0000 8 no
GO:0009893 positive regulation of metabolic process 30.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 30.0000 5 no
GO:0031344 regulation of cell projection organization 30.0000 5 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:0031401 positive regulation of protein modification process 30.0000 7 no
GO:0033674 positive regulation of kinase activity 30.0000 6 no
GO:0042325 regulation of phosphorylation 30.0000 7 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0043085 positive regulation of catalytic activity 30.0000 4 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0045859 regulation of protein kinase activity 30.0000 6 no
GO:0045860 positive regulation of protein kinase activity 30.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0048523 negative regulation of cellular process 30.0000 4 no
GO:0051051 negative regulation of transport 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0051347 positive regulation of transferase activity 30.0000 5 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 30.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 30.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0010941 regulation of cell death 30.0000 4 no
GO:0036211 protein modification process 30.0000 4 no
GO:0042981 regulation of apoptotic process 30.0000 6 no
GO:0043067 regulation of programmed cell death 30.0000 5 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0007015 actin filament organization 20.0000 5 yes
GO:0030038 contractile actin filament bundle assembly 20.0000 6 yes
GO:0031032 actomyosin structure organization 20.0000 4 yes
GO:0031532 actin cytoskeleton reorganization 20.0000 4 yes
GO:0043149 stress fiber assembly 20.0000 5 yes
GO:0048813 dendrite morphogenesis 20.0000 8 yes
GO:0051017 actin filament bundle assembly 20.0000 5 yes
GO:0061572 actin filament bundle organization 20.0000 6 yes
GO:0097435 supramolecular fiber organization 20.0000 4 yes
GO:0140058 neuron projection arborization 20.0000 8 yes
GO:0140059 dendrite arborization 20.0000 9 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTS_HUMAN [view interactions] Low throughput no no
PHAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1H_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CBX8_HUMAN [view interactions] High throughput no yes
CN119_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
PHAR3_HUMAN [view interactions] High throughput no no
PP1B_HUMAN [view entry] [view interactions] Computational yes yes