FARP1_HUMAN
Evidence for PS localization
Functions
Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FARP1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 36.8421 | 4 | no |
| GO:0043168 | anion binding | 36.8421 | 4 | no |
| GO:0017076 | purine nucleotide binding | 35.0877 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.0877 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0019900 | kinase binding | 21.0526 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
| GO:0003924 | GTPase activity | 21.0526 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 21.0526 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.0526 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.0526 | 6 | no |
| GO:0051020 | GTPase binding | 10.5263 | 4 | yes |
| GO:0031267 | small GTPase binding | 8.7719 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 7.0175 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 3.5088 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FARP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.1754 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.8772 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.8772 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.8772 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.1228 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.6140 | 4 | no |
| GO:0006996 | organelle organization | 43.8596 | 4 | yes |
| GO:0022607 | cellular component assembly | 42.1053 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.3509 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.3509 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.3509 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.3509 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.3509 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 40.3509 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.5965 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.5965 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 36.8421 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.8421 | 4 | no |
| GO:0008104 | protein localization | 36.8421 | 4 | no |
| GO:0023056 | positive regulation of signaling | 35.0877 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.0877 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.5789 | 4 | yes |
| GO:0051049 | regulation of transport | 31.5789 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.5789 | 5 | no |
| GO:0071702 | organic substance transport | 31.5789 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 29.8246 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.8246 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 28.0702 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 28.0702 | 4 | no |
| GO:0030030 | cell projection organization | 26.3158 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0061024 | membrane organization | 26.3158 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.5614 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 24.5614 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.5614 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.5614 | 4 | no |
| GO:2000145 | regulation of cell motility | 24.5614 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.5614 | 6 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 22.8070 | 5 | yes |
| GO:0030334 | regulation of cell migration | 22.8070 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.8070 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.8070 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.8070 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.8070 | 6 | no |
| GO:0032970 | regulation of actin filament-based process | 22.8070 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.8070 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.0526 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 21.0526 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.0526 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.0526 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 21.0526 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.0526 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.0526 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.0526 | 6 | no |
| GO:0032880 | regulation of protein localization | 19.2982 | 5 | yes |
| GO:0034330 | cell junction organization | 19.2982 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 19.2982 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 17.5439 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 15.7895 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 15.7895 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 14.0351 | 5 | yes |
| GO:0050808 | synapse organization | 14.0351 | 5 | yes |
| GO:0016601 | Rac protein signal transduction | 10.5263 | 6 | yes |
| GO:0048812 | neuron projection morphogenesis | 10.5263 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 10.5263 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 10.5263 | 6 | yes |
| GO:0034329 | cell junction assembly | 8.7719 | 5 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 8.7719 | 6 | yes |
| GO:0099536 | synaptic signaling | 7.0175 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 7.0175 | 5 | yes |
| GO:0048813 | dendrite morphogenesis | 5.2632 | 6 | yes |
| GO:0051963 | regulation of synapse assembly | 5.2632 | 6 | yes |
| GO:0099174 | regulation of presynapse organization | 5.2632 | 6 | yes |
| GO:1905606 | regulation of presynapse assembly | 5.2632 | 7 | yes |
| GO:0098974 | postsynaptic actin cytoskeleton organization | 3.5088 | 4 | yes |
| GO:0099188 | postsynaptic cytoskeleton organization | 3.5088 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| RSMN_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KDM4D_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| H2AB2_HUMAN | [view interactions] | High throughput | no | no |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM3_HUMAN | [view interactions] | High throughput | no | yes |
| FGF4_HUMAN | [view interactions] | High throughput | no | no |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASCL1_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| PSD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| SDC3_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOB1B_HUMAN | [view interactions] | High throughput | no | yes |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| MOB2_HUMAN | [view interactions] | High throughput | no | no |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC8_HUMAN | [view interactions] | High throughput | no | yes |