VPS4A_HUMAN
Evidence for PS localization
Functions
(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 203 | Gly | Glu | CIMDAGsyndrome(CIMDAG) | - |
| 206 | Glu | Lys | CIMDAGsyndrome(CIMDAG) | - |
| 284 | Arg | Gly | CIMDAGsyndrome(CIMDAG) | - |
| 284 | Arg | Trp | CIMDAGsyndrome(CIMDAG) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS4A_HUMAN |
|---|---|---|---|---|
| GO:0044389 | ubiquitin-like protein ligase binding | 37.5000 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 33.3333 | 5 | no |
| GO:0046872 | metal ion binding | 29.1667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 20.8333 | 4 | no |
| GO:0005524 | ATP binding | 16.6667 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 16.6667 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.6667 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.6667 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 16.6667 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.6667 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 8.3333 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS4A_HUMAN |
|---|---|---|---|---|
| GO:0006508 | proteolysis | 62.5000 | 4 | yes |
| GO:0006996 | organelle organization | 62.5000 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 58.3333 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 54.1667 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 54.1667 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 54.1667 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 54.1667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 45.8333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 45.8333 | 4 | yes |
| GO:0008104 | protein localization | 45.8333 | 4 | yes |
| GO:0015031 | protein transport | 45.8333 | 4 | yes |
| GO:0016050 | vesicle organization | 45.8333 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 45.8333 | 4 | yes |
| GO:0022607 | cellular component assembly | 45.8333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.8333 | 4 | yes |
| GO:0070925 | organelle assembly | 41.6667 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 41.6667 | 4 | no |
| GO:0007032 | endosome organization | 41.6667 | 6 | yes |
| GO:0036257 | multivesicular body organization | 41.6667 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 41.6667 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 41.6667 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 37.5000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 37.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 37.5000 | 7 | yes |
| GO:0007034 | vacuolar transport | 37.5000 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 37.5000 | 4 | yes |
| GO:0061024 | membrane organization | 33.3333 | 4 | yes |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0016197 | endosomal transport | 33.3333 | 4 | yes |
| GO:0016236 | macroautophagy | 33.3333 | 4 | yes |
| GO:0051049 | regulation of transport | 29.1667 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 29.1667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.1667 | 4 | no |
| GO:0042176 | regulation of protein catabolic process | 29.1667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.1667 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.1667 | 4 | no |
| GO:0007041 | lysosomal transport | 29.1667 | 5 | yes |
| GO:0010564 | regulation of cell cycle process | 29.1667 | 5 | yes |
| GO:0022411 | cellular component disassembly | 29.1667 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 29.1667 | 5 | yes |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 29.1667 | 8 | yes |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0061952 | midbody abscission | 25.0000 | 5 | yes |
| GO:1902410 | mitotic cytokinetic process | 25.0000 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 25.0000 | 5 | no |
| GO:0016567 | protein ubiquitination | 25.0000 | 7 | no |
| GO:0032446 | protein modification by small protein conjugation | 25.0000 | 6 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0035891 | exit from host cell | 25.0000 | 5 | yes |
| GO:0044000 | movement in host | 25.0000 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | yes |
| GO:0051046 | regulation of secretion | 20.8333 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 20.8333 | 5 | yes |
| GO:0051303 | establishment of chromosome localization | 20.8333 | 4 | yes |
| GO:0051310 | metaphase plate congression | 20.8333 | 5 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 20.8333 | 4 | yes |
| GO:0071709 | membrane assembly | 20.8333 | 5 | yes |
| GO:0071763 | nuclear membrane organization | 20.8333 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 20.8333 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 20.8333 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 20.8333 | 5 | yes |
| GO:1903541 | regulation of exosomal secretion | 20.8333 | 6 | yes |
| GO:1903543 | positive regulation of exosomal secretion | 20.8333 | 6 | yes |
| GO:1904896 | ESCRT complex disassembly | 20.8333 | 6 | yes |
| GO:1904903 | ESCRT III complex disassembly | 20.8333 | 7 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.8333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.8333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0010941 | regulation of cell death | 20.8333 | 4 | no |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 20.8333 | 5 | no |
| GO:0045324 | late endosome to vacuole transport | 20.8333 | 5 | no |
| GO:0071985 | multivesicular body sorting pathway | 20.8333 | 5 | no |
| GO:0006886 | intracellular protein transport | 20.8333 | 4 | yes |
| GO:0006997 | nucleus organization | 20.8333 | 5 | yes |
| GO:0007080 | mitotic metaphase plate congression | 20.8333 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 20.8333 | 5 | yes |
| GO:0031468 | nuclear membrane reassembly | 20.8333 | 6 | yes |
| GO:0033365 | protein localization to organelle | 20.8333 | 5 | yes |
| GO:0045921 | positive regulation of exocytosis | 20.8333 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 16.6667 | 4 | yes |
| GO:0061025 | membrane fusion | 16.6667 | 5 | yes |
| GO:0072665 | protein localization to vacuole | 16.6667 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 16.6667 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 16.6667 | 6 | yes |
| GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway | 16.6667 | 6 | yes |
| GO:0006605 | protein targeting | 16.6667 | 5 | yes |
| GO:0006906 | vesicle fusion | 16.6667 | 6 | yes |
| GO:0032880 | regulation of protein localization | 16.6667 | 5 | yes |
| GO:0048284 | organelle fusion | 16.6667 | 5 | yes |
| GO:0048524 | positive regulation of viral process | 12.5000 | 4 | yes |
| GO:0051302 | regulation of cell division | 12.5000 | 4 | yes |
| GO:0061462 | protein localization to lysosome | 12.5000 | 7 | yes |
| GO:1903772 | regulation of viral budding via host ESCRT complex | 12.5000 | 4 | yes |
| GO:1903774 | positive regulation of viral budding via host ESCRT complex | 12.5000 | 5 | yes |
| GO:1903900 | regulation of viral life cycle | 12.5000 | 4 | yes |
| GO:1903902 | positive regulation of viral life cycle | 12.5000 | 5 | yes |
| GO:0006622 | protein targeting to lysosome | 12.5000 | 6 | yes |
| GO:0006623 | protein targeting to vacuole | 12.5000 | 5 | yes |
| GO:0006900 | vesicle budding from membrane | 12.5000 | 5 | yes |
| GO:0032465 | regulation of cytokinesis | 12.5000 | 5 | yes |
| GO:0045786 | negative regulation of cell cycle | 12.5000 | 5 | yes |
| GO:0051261 | protein depolymerization | 8.3333 | 6 | yes |
| GO:0051782 | negative regulation of cell division | 8.3333 | 5 | yes |
| GO:0061738 | late endosomal microautophagy | 8.3333 | 4 | yes |
| GO:0072319 | vesicle uncoating | 8.3333 | 7 | yes |
| GO:0101024 | mitotic nuclear membrane organization | 8.3333 | 4 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 8.3333 | 6 | yes |
| GO:1901988 | negative regulation of cell cycle phase transition | 8.3333 | 7 | yes |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 8.3333 | 6 | yes |
| GO:1901991 | negative regulation of mitotic cell cycle phase transition | 8.3333 | 7 | yes |
| GO:1902749 | regulation of cell cycle G2/M phase transition | 8.3333 | 7 | yes |
| GO:1902750 | negative regulation of cell cycle G2/M phase transition | 8.3333 | 8 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 8.3333 | 7 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 8.3333 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.3333 | 6 | yes |
| GO:0000075 | cell cycle checkpoint signaling | 8.3333 | 4 | yes |
| GO:0000916 | actomyosin contractile ring contraction | 8.3333 | 5 | yes |
| GO:0006869 | lipid transport | 8.3333 | 5 | yes |
| GO:0006998 | nuclear envelope organization | 8.3333 | 5 | yes |
| GO:0007033 | vacuole organization | 8.3333 | 5 | yes |
| GO:0007084 | mitotic nuclear membrane reassembly | 8.3333 | 5 | yes |
| GO:0007093 | mitotic cell cycle checkpoint signaling | 8.3333 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 8.3333 | 5 | yes |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 8.3333 | 7 | yes |
| GO:0010948 | negative regulation of cell cycle process | 8.3333 | 6 | yes |
| GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 8.3333 | 8 | yes |
| GO:0015850 | organic hydroxy compound transport | 8.3333 | 5 | yes |
| GO:0015918 | sterol transport | 8.3333 | 6 | yes |
| GO:0030301 | cholesterol transport | 8.3333 | 7 | yes |
| GO:0032365 | intracellular lipid transport | 8.3333 | 4 | yes |
| GO:0032366 | intracellular sterol transport | 8.3333 | 5 | yes |
| GO:0032367 | intracellular cholesterol transport | 8.3333 | 6 | yes |
| GO:0032466 | negative regulation of cytokinesis | 8.3333 | 6 | yes |
| GO:0034058 | endosomal vesicle fusion | 8.3333 | 7 | yes |
| GO:0036213 | contractile ring contraction | 8.3333 | 4 | yes |
| GO:0044878 | mitotic cytokinesis checkpoint signaling | 8.3333 | 5 | yes |
| GO:0045930 | negative regulation of mitotic cell cycle | 8.3333 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | Low throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHMP5_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHMP6_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CHM4A_HUMAN | [view interactions] | Low throughput | no | no |
| CHM1B_HUMAN | [view interactions] | Low throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
| ANCHR_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | Low throughput | no | yes |
| CHMP3_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CLIC3_HUMAN | [view interactions] | High throughput | no | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| KCND3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KMT2E_HUMAN | [view interactions] | High throughput | no | no |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| IST1_HUMAN | [view interactions] | High throughput | no | yes |
| THTPA_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP4_HUMAN | [view interactions] | High throughput | no | no |
| SESQ1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| NSE1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| RTF1_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN574_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BABA1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| SMO_HUMAN | [view interactions] | High throughput | no | yes |
| TM248_HUMAN | [view interactions] | High throughput | no | yes |
| SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS28_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VP37C_HUMAN | [view interactions] | Computational | no | yes |
| CHMP7_HUMAN | [view interactions] | Computational | no | yes |
| VP37B_HUMAN | [view interactions] | Computational | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VPS36_HUMAN | [view interactions] | Computational | no | yes |
| VPS25_HUMAN | [view interactions] | Computational | no | yes |
| SNF8_HUMAN | [view interactions] | Computational | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | Computational | yes | yes |