VPS4A_HUMAN
(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
203 | Gly | Glu | CIMDAGsyndrome(CIMDAG) | - |
206 | Glu | Lys | CIMDAGsyndrome(CIMDAG) | - |
284 | Arg | Gly | CIMDAGsyndrome(CIMDAG) | - |
284 | Arg | Trp | CIMDAGsyndrome(CIMDAG) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in VPS4A_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 37.5000 | 4 | no |
GO:0046872 | metal ion binding | 37.5000 | 5 | no |
GO:0043168 | anion binding | 33.3333 | 4 | yes |
GO:0000166 | nucleotide binding | 29.1667 | 4 | yes |
GO:0017076 | purine nucleotide binding | 29.1667 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 29.1667 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 20.8333 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 20.8333 | 5 | yes |
GO:0031625 | ubiquitin protein ligase binding | 20.8333 | 5 | no |
GO:0019900 | kinase binding | 20.8333 | 4 | no |
GO:0005524 | ATP binding | 16.6667 | 5 | yes |
GO:0016462 | pyrophosphatase activity | 16.6667 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.6667 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.6667 | 6 | yes |
GO:0016887 | ATP hydrolysis activity | 12.5000 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in VPS4A_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 62.5000 | 4 | yes |
GO:0008104 | protein localization | 58.3333 | 4 | yes |
GO:0022607 | cellular component assembly | 54.1667 | 4 | yes |
GO:0043933 | protein-containing complex organization | 54.1667 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | yes |
GO:0006508 | proteolysis | 45.8333 | 4 | yes |
GO:0016050 | vesicle organization | 45.8333 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 45.8333 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 45.8333 | 4 | yes |
GO:0071702 | organic substance transport | 45.8333 | 4 | yes |
GO:0071705 | nitrogen compound transport | 45.8333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | no |
GO:0015031 | protein transport | 41.6667 | 4 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 41.6667 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
GO:0010646 | regulation of cell communication | 41.6667 | 4 | no |
GO:0006511 | ubiquitin-dependent protein catabolic process | 37.5000 | 7 | yes |
GO:0007032 | endosome organization | 37.5000 | 6 | yes |
GO:0009057 | macromolecule catabolic process | 37.5000 | 4 | yes |
GO:0016236 | macroautophagy | 37.5000 | 4 | yes |
GO:0019941 | modification-dependent protein catabolic process | 37.5000 | 6 | yes |
GO:0043632 | modification-dependent macromolecule catabolic process | 37.5000 | 5 | yes |
GO:0051726 | regulation of cell cycle | 37.5000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
GO:0009894 | regulation of catabolic process | 37.5000 | 4 | no |
GO:0007034 | vacuolar transport | 33.3333 | 4 | yes |
GO:0010564 | regulation of cell cycle process | 33.3333 | 5 | yes |
GO:0022411 | cellular component disassembly | 33.3333 | 4 | yes |
GO:0036257 | multivesicular body organization | 33.3333 | 7 | yes |
GO:0036258 | multivesicular body assembly | 33.3333 | 6 | yes |
GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
GO:0061024 | membrane organization | 33.3333 | 4 | yes |
GO:0070925 | organelle assembly | 33.3333 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
GO:0007041 | lysosomal transport | 29.1667 | 5 | yes |
GO:0032509 | endosome transport via multivesicular body sorting pathway | 29.1667 | 4 | yes |
GO:0006915 | apoptotic process | 29.1667 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 29.1667 | 4 | no |
GO:0033043 | regulation of organelle organization | 29.1667 | 5 | no |
GO:0065003 | protein-containing complex assembly | 29.1667 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 29.1667 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 29.1667 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
GO:0006906 | vesicle fusion | 25.0000 | 6 | yes |
GO:0007033 | vacuole organization | 25.0000 | 5 | yes |
GO:0007080 | mitotic metaphase chromosome alignment | 25.0000 | 4 | yes |
GO:0032880 | regulation of protein localization | 25.0000 | 5 | yes |
GO:0032984 | protein-containing complex disassembly | 25.0000 | 5 | yes |
GO:0033365 | protein localization to organelle | 25.0000 | 5 | yes |
GO:0048284 | organelle fusion | 25.0000 | 5 | yes |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | yes |
GO:0051303 | establishment of chromosome localization | 25.0000 | 4 | yes |
GO:0051310 | metaphase chromosome alignment | 25.0000 | 5 | yes |
GO:0060341 | regulation of cellular localization | 25.0000 | 4 | yes |
GO:0061025 | membrane fusion | 25.0000 | 5 | yes |
GO:0061952 | midbody abscission | 25.0000 | 5 | yes |
GO:0090148 | membrane fission | 25.0000 | 5 | yes |
GO:0090174 | organelle membrane fusion | 25.0000 | 6 | yes |
GO:1902410 | mitotic cytokinetic process | 25.0000 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
GO:0042176 | regulation of protein catabolic process | 25.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
GO:0001778 | plasma membrane repair | 20.8333 | 6 | yes |
GO:0006886 | intracellular protein transport | 20.8333 | 4 | yes |
GO:0006997 | nucleus organization | 20.8333 | 5 | yes |
GO:0007009 | plasma membrane organization | 20.8333 | 5 | yes |
GO:0017157 | regulation of exocytosis | 20.8333 | 5 | yes |
GO:0031468 | nuclear membrane reassembly | 20.8333 | 6 | yes |
GO:0035891 | exit from host cell | 20.8333 | 4 | yes |
GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 20.8333 | 8 | yes |
GO:0044089 | positive regulation of cellular component biogenesis | 20.8333 | 5 | yes |
GO:0051046 | regulation of secretion | 20.8333 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 20.8333 | 4 | yes |
GO:0061640 | cytoskeleton-dependent cytokinesis | 20.8333 | 4 | yes |
GO:0071709 | membrane assembly | 20.8333 | 5 | yes |
GO:0071763 | nuclear membrane organization | 20.8333 | 5 | yes |
GO:0072594 | establishment of protein localization to organelle | 20.8333 | 4 | yes |
GO:0097352 | autophagosome maturation | 20.8333 | 6 | yes |
GO:1902774 | late endosome to lysosome transport | 20.8333 | 6 | yes |
GO:1903530 | regulation of secretion by cell | 20.8333 | 4 | yes |
GO:1903541 | regulation of exosomal secretion | 20.8333 | 6 | yes |
GO:1904896 | ESCRT complex disassembly | 20.8333 | 6 | yes |
GO:1904903 | ESCRT III complex disassembly | 20.8333 | 7 | yes |
GO:0098657 | import into cell | 20.8333 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 20.8333 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 20.8333 | 6 | no |
GO:1902115 | regulation of organelle assembly | 20.8333 | 5 | no |
GO:0010243 | response to organonitrogen compound | 20.8333 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 20.8333 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
GO:0051241 | negative regulation of multicellular organismal process | 20.8333 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 20.8333 | 6 | no |
GO:0006605 | protein targeting | 16.6667 | 4 | yes |
GO:0032465 | regulation of cytokinesis | 16.6667 | 5 | yes |
GO:0045921 | positive regulation of exocytosis | 16.6667 | 6 | yes |
GO:0051047 | positive regulation of secretion | 16.6667 | 5 | yes |
GO:0051302 | regulation of cell division | 16.6667 | 4 | yes |
GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway | 16.6667 | 6 | yes |
GO:1903532 | positive regulation of secretion by cell | 16.6667 | 5 | yes |
GO:1903543 | positive regulation of exosomal secretion | 16.6667 | 6 | yes |
GO:1905475 | regulation of protein localization to membrane | 16.6667 | 6 | yes |
GO:0006622 | protein targeting to lysosome | 12.5000 | 6 | yes |
GO:0006623 | protein targeting to vacuole | 12.5000 | 5 | yes |
GO:0006900 | vesicle budding from membrane | 12.5000 | 5 | yes |
GO:0007346 | regulation of mitotic cell cycle | 12.5000 | 5 | yes |
GO:0015850 | organic hydroxy compound transport | 12.5000 | 5 | yes |
GO:0061462 | protein localization to lysosome | 12.5000 | 7 | yes |
GO:0072665 | protein localization to vacuole | 12.5000 | 6 | yes |
GO:0072666 | establishment of protein localization to vacuole | 12.5000 | 5 | yes |
GO:1901987 | regulation of cell cycle phase transition | 12.5000 | 6 | yes |
GO:1901990 | regulation of mitotic cell cycle phase transition | 12.5000 | 6 | yes |
GO:1904375 | regulation of protein localization to cell periphery | 12.5000 | 6 | yes |
GO:0000075 | cell cycle checkpoint signaling | 8.3333 | 4 | yes |
GO:0000916 | actomyosin contractile ring contraction | 8.3333 | 5 | yes |
GO:0006869 | lipid transport | 8.3333 | 5 | yes |
GO:0006998 | nuclear envelope organization | 8.3333 | 5 | yes |
GO:0007084 | mitotic nuclear membrane reassembly | 8.3333 | 5 | yes |
GO:0007093 | mitotic cell cycle checkpoint signaling | 8.3333 | 4 | yes |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 8.3333 | 7 | yes |
GO:0010948 | negative regulation of cell cycle process | 8.3333 | 6 | yes |
GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 8.3333 | 8 | yes |
GO:0015918 | sterol transport | 8.3333 | 6 | yes |
GO:0016237 | microautophagy | 8.3333 | 4 | yes |
GO:0030301 | cholesterol transport | 8.3333 | 7 | yes |
GO:0032365 | intracellular lipid transport | 8.3333 | 4 | yes |
GO:0032366 | intracellular sterol transport | 8.3333 | 5 | yes |
GO:0032367 | intracellular cholesterol transport | 8.3333 | 6 | yes |
GO:0032466 | negative regulation of cytokinesis | 8.3333 | 6 | yes |
GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway | 8.3333 | 4 | yes |
GO:0034058 | endosomal vesicle fusion | 8.3333 | 7 | yes |
GO:0036213 | contractile ring contraction | 8.3333 | 4 | yes |
GO:0044878 | mitotic cytokinesis checkpoint signaling | 8.3333 | 5 | yes |
GO:0045786 | negative regulation of cell cycle | 8.3333 | 5 | yes |
GO:0045930 | negative regulation of mitotic cell cycle | 8.3333 | 6 | yes |
GO:0048524 | positive regulation of viral process | 8.3333 | 4 | yes |
GO:0051261 | protein depolymerization | 8.3333 | 6 | yes |
GO:0051782 | negative regulation of cell division | 8.3333 | 5 | yes |
GO:0061738 | late endosomal microautophagy | 8.3333 | 5 | yes |
GO:0061764 | late endosome to lysosome transport via multivesicular body sorting pathway | 8.3333 | 4 | yes |
GO:0072319 | vesicle uncoating | 8.3333 | 7 | yes |
GO:0101024 | mitotic nuclear membrane organization | 8.3333 | 4 | yes |
GO:1901988 | negative regulation of cell cycle phase transition | 8.3333 | 7 | yes |
GO:1901991 | negative regulation of mitotic cell cycle phase transition | 8.3333 | 7 | yes |
GO:1902749 | regulation of cell cycle G2/M phase transition | 8.3333 | 7 | yes |
GO:1902750 | negative regulation of cell cycle G2/M phase transition | 8.3333 | 8 | yes |
GO:1903076 | regulation of protein localization to plasma membrane | 8.3333 | 7 | yes |
GO:1903772 | regulation of viral budding via host ESCRT complex | 8.3333 | 4 | yes |
GO:1903774 | positive regulation of viral budding via host ESCRT complex | 8.3333 | 5 | yes |
GO:1903900 | regulation of viral life cycle | 8.3333 | 4 | yes |
GO:1903902 | positive regulation of viral life cycle | 8.3333 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CHM1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CHM4A_HUMAN | [view interactions] | Low throughput | no | no |
CHM1B_HUMAN | [view interactions] | Low throughput | no | yes |
VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
VTA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANCHR_HUMAN | [view interactions] | Low throughput | no | yes |
CHM4C_HUMAN | [view interactions] | Low throughput | no | yes |
CHMP3_HUMAN | [view interactions] | Low throughput | no | yes |
CHM2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NPC1_HUMAN | [view interactions] | Low throughput | no | yes |
HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CHMP5_HUMAN | [view interactions] | Low throughput | no | yes |
SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LTOR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CHMP6_HUMAN | [view interactions] | Low throughput | no | yes |
CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BABA1_HUMAN | [view interactions] | High throughput | no | yes |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
SMO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM248_HUMAN | [view interactions] | High throughput | no | yes |
SOSB1_HUMAN | [view interactions] | High throughput | no | yes |
CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
MTA70_HUMAN | [view interactions] | High throughput | no | no |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
IRF7_HUMAN | [view interactions] | High throughput | no | yes |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
SATB2_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
CLIC3_HUMAN | [view interactions] | High throughput | no | no |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
INTU_HUMAN | [view interactions] | High throughput | no | yes |
SPAG6_HUMAN | [view interactions] | High throughput | no | no |
KCND3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KMT2E_HUMAN | [view interactions] | High throughput | no | no |
DUS12_HUMAN | [view interactions] | High throughput | no | no |
DUS2_HUMAN | [view interactions] | High throughput | no | no |
DUS6_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
LZTR1_HUMAN | [view interactions] | High throughput | no | no |
CGAS_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
S15A3_HUMAN | [view interactions] | High throughput | no | yes |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRD1_HUMAN | [view interactions] | High throughput | no | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
TRI13_HUMAN | [view interactions] | High throughput | no | no |
M4K1_HUMAN | [view interactions] | High throughput | no | no |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
IST1_HUMAN | [view interactions] | High throughput | no | yes |
THTPA_HUMAN | [view interactions] | High throughput | no | yes |
PCBP4_HUMAN | [view interactions] | High throughput | no | no |
SESQ1_HUMAN | [view interactions] | High throughput | no | no |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
SEC20_HUMAN | [view interactions] | High throughput | no | yes |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
NSE1_HUMAN | [view interactions] | High throughput | no | yes |
PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RINT1_HUMAN | [view interactions] | High throughput | no | yes |
RTF1_HUMAN | [view interactions] | High throughput | no | yes |
SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
USE1_HUMAN | [view interactions] | High throughput | no | yes |
ZN574_HUMAN | [view interactions] | High throughput | no | yes |
ATG10_HUMAN | [view interactions] | High throughput | no | yes |
ATG3_HUMAN | [view interactions] | High throughput | no | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |