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VPS4A_HUMAN

(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). [View more on UniProt]

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No data found.

Position Amino acid Mutation Disease Overlap with binding region
203 Gly Glu CIMDAGsyndrome(CIMDAG) -
206 Glu Lys CIMDAGsyndrome(CIMDAG) -
284 Arg Gly CIMDAGsyndrome(CIMDAG) -
284 Arg Trp CIMDAGsyndrome(CIMDAG) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VPS4A_HUMAN
GO:0043169 cation binding 37.5000 4 no
GO:0046872 metal ion binding 37.5000 5 no
GO:0043168 anion binding 33.3333 4 yes
GO:0000166 nucleotide binding 29.1667 4 yes
GO:0017076 purine nucleotide binding 29.1667 5 yes
GO:0032555 purine ribonucleotide binding 29.1667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 yes
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 20.8333 6 yes
GO:0032559 adenyl ribonucleotide binding 20.8333 5 yes
GO:0031625 ubiquitin protein ligase binding 20.8333 5 no
GO:0019900 kinase binding 20.8333 4 no
GO:0005524 ATP binding 16.6667 5 yes
GO:0016462 pyrophosphatase activity 16.6667 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 16.6667 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 16.6667 6 yes
GO:0016887 ATP hydrolysis activity 12.5000 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VPS4A_HUMAN
GO:0006996 organelle organization 62.5000 4 yes
GO:0008104 protein localization 58.3333 4 yes
GO:0022607 cellular component assembly 54.1667 4 yes
GO:0043933 protein-containing complex organization 54.1667 4 yes
GO:0048522 positive regulation of cellular process 54.1667 4 yes
GO:0006508 proteolysis 45.8333 4 yes
GO:0016050 vesicle organization 45.8333 5 yes
GO:0044087 regulation of cellular component biogenesis 45.8333 4 yes
GO:0048523 negative regulation of cellular process 45.8333 4 yes
GO:0071702 organic substance transport 45.8333 4 yes
GO:0071705 nitrogen compound transport 45.8333 4 yes
GO:0051128 regulation of cellular component organization 45.8333 4 no
GO:0015031 protein transport 41.6667 4 yes
GO:0051603 proteolysis involved in protein catabolic process 41.6667 5 yes
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 37.5000 7 yes
GO:0007032 endosome organization 37.5000 6 yes
GO:0009057 macromolecule catabolic process 37.5000 4 yes
GO:0016236 macroautophagy 37.5000 4 yes
GO:0019941 modification-dependent protein catabolic process 37.5000 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 37.5000 5 yes
GO:0051726 regulation of cell cycle 37.5000 4 yes
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0007034 vacuolar transport 33.3333 4 yes
GO:0010564 regulation of cell cycle process 33.3333 5 yes
GO:0022411 cellular component disassembly 33.3333 4 yes
GO:0036257 multivesicular body organization 33.3333 7 yes
GO:0036258 multivesicular body assembly 33.3333 6 yes
GO:0051049 regulation of transport 33.3333 4 yes
GO:0061024 membrane organization 33.3333 4 yes
GO:0070925 organelle assembly 33.3333 5 yes
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0007041 lysosomal transport 29.1667 5 yes
GO:0032509 endosome transport via multivesicular body sorting pathway 29.1667 4 yes
GO:0006915 apoptotic process 29.1667 4 no
GO:0009892 negative regulation of metabolic process 29.1667 4 no
GO:0033043 regulation of organelle organization 29.1667 5 no
GO:0065003 protein-containing complex assembly 29.1667 5 no
GO:0009893 positive regulation of metabolic process 29.1667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.1667 5 no
GO:0048584 positive regulation of response to stimulus 29.1667 4 no
GO:0006906 vesicle fusion 25.0000 6 yes
GO:0007033 vacuole organization 25.0000 5 yes
GO:0007080 mitotic metaphase chromosome alignment 25.0000 4 yes
GO:0032880 regulation of protein localization 25.0000 5 yes
GO:0032984 protein-containing complex disassembly 25.0000 5 yes
GO:0033365 protein localization to organelle 25.0000 5 yes
GO:0048284 organelle fusion 25.0000 5 yes
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0051303 establishment of chromosome localization 25.0000 4 yes
GO:0051310 metaphase chromosome alignment 25.0000 5 yes
GO:0060341 regulation of cellular localization 25.0000 4 yes
GO:0061025 membrane fusion 25.0000 5 yes
GO:0061952 midbody abscission 25.0000 5 yes
GO:0090148 membrane fission 25.0000 5 yes
GO:0090174 organelle membrane fusion 25.0000 6 yes
GO:1902410 mitotic cytokinetic process 25.0000 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0001778 plasma membrane repair 20.8333 6 yes
GO:0006886 intracellular protein transport 20.8333 4 yes
GO:0006997 nucleus organization 20.8333 5 yes
GO:0007009 plasma membrane organization 20.8333 5 yes
GO:0017157 regulation of exocytosis 20.8333 5 yes
GO:0031468 nuclear membrane reassembly 20.8333 6 yes
GO:0035891 exit from host cell 20.8333 4 yes
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 20.8333 8 yes
GO:0044089 positive regulation of cellular component biogenesis 20.8333 5 yes
GO:0051046 regulation of secretion 20.8333 5 yes
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 yes
GO:0061640 cytoskeleton-dependent cytokinesis 20.8333 4 yes
GO:0071709 membrane assembly 20.8333 5 yes
GO:0071763 nuclear membrane organization 20.8333 5 yes
GO:0072594 establishment of protein localization to organelle 20.8333 4 yes
GO:0097352 autophagosome maturation 20.8333 6 yes
GO:1902774 late endosome to lysosome transport 20.8333 6 yes
GO:1903530 regulation of secretion by cell 20.8333 4 yes
GO:1903541 regulation of exosomal secretion 20.8333 6 yes
GO:1904896 ESCRT complex disassembly 20.8333 6 yes
GO:1904903 ESCRT III complex disassembly 20.8333 7 yes
GO:0098657 import into cell 20.8333 4 no
GO:0009890 negative regulation of biosynthetic process 20.8333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 20.8333 6 no
GO:1902115 regulation of organelle assembly 20.8333 5 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:1901701 cellular response to oxygen-containing compound 20.8333 4 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:0051241 negative regulation of multicellular organismal process 20.8333 4 no
GO:1902533 positive regulation of intracellular signal transduction 20.8333 6 no
GO:0006605 protein targeting 16.6667 4 yes
GO:0032465 regulation of cytokinesis 16.6667 5 yes
GO:0045921 positive regulation of exocytosis 16.6667 6 yes
GO:0051047 positive regulation of secretion 16.6667 5 yes
GO:0051302 regulation of cell division 16.6667 4 yes
GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway 16.6667 6 yes
GO:1903532 positive regulation of secretion by cell 16.6667 5 yes
GO:1903543 positive regulation of exosomal secretion 16.6667 6 yes
GO:1905475 regulation of protein localization to membrane 16.6667 6 yes
GO:0006622 protein targeting to lysosome 12.5000 6 yes
GO:0006623 protein targeting to vacuole 12.5000 5 yes
GO:0006900 vesicle budding from membrane 12.5000 5 yes
GO:0007346 regulation of mitotic cell cycle 12.5000 5 yes
GO:0015850 organic hydroxy compound transport 12.5000 5 yes
GO:0061462 protein localization to lysosome 12.5000 7 yes
GO:0072665 protein localization to vacuole 12.5000 6 yes
GO:0072666 establishment of protein localization to vacuole 12.5000 5 yes
GO:1901987 regulation of cell cycle phase transition 12.5000 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 12.5000 6 yes
GO:1904375 regulation of protein localization to cell periphery 12.5000 6 yes
GO:0000075 cell cycle checkpoint signaling 8.3333 4 yes
GO:0000916 actomyosin contractile ring contraction 8.3333 5 yes
GO:0006869 lipid transport 8.3333 5 yes
GO:0006998 nuclear envelope organization 8.3333 5 yes
GO:0007084 mitotic nuclear membrane reassembly 8.3333 5 yes
GO:0007093 mitotic cell cycle checkpoint signaling 8.3333 4 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 8.3333 7 yes
GO:0010948 negative regulation of cell cycle process 8.3333 6 yes
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 8.3333 8 yes
GO:0015918 sterol transport 8.3333 6 yes
GO:0016237 microautophagy 8.3333 4 yes
GO:0030301 cholesterol transport 8.3333 7 yes
GO:0032365 intracellular lipid transport 8.3333 4 yes
GO:0032366 intracellular sterol transport 8.3333 5 yes
GO:0032367 intracellular cholesterol transport 8.3333 6 yes
GO:0032466 negative regulation of cytokinesis 8.3333 6 yes
GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway 8.3333 4 yes
GO:0034058 endosomal vesicle fusion 8.3333 7 yes
GO:0036213 contractile ring contraction 8.3333 4 yes
GO:0044878 mitotic cytokinesis checkpoint signaling 8.3333 5 yes
GO:0045786 negative regulation of cell cycle 8.3333 5 yes
GO:0045930 negative regulation of mitotic cell cycle 8.3333 6 yes
GO:0048524 positive regulation of viral process 8.3333 4 yes
GO:0051261 protein depolymerization 8.3333 6 yes
GO:0051782 negative regulation of cell division 8.3333 5 yes
GO:0061738 late endosomal microautophagy 8.3333 5 yes
GO:0061764 late endosome to lysosome transport via multivesicular body sorting pathway 8.3333 4 yes
GO:0072319 vesicle uncoating 8.3333 7 yes
GO:0101024 mitotic nuclear membrane organization 8.3333 4 yes
GO:1901988 negative regulation of cell cycle phase transition 8.3333 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 8.3333 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 8.3333 7 yes
GO:1902750 negative regulation of cell cycle G2/M phase transition 8.3333 8 yes
GO:1903076 regulation of protein localization to plasma membrane 8.3333 7 yes
GO:1903772 regulation of viral budding via host ESCRT complex 8.3333 4 yes
GO:1903774 positive regulation of viral budding via host ESCRT complex 8.3333 5 yes
GO:1903900 regulation of viral life cycle 8.3333 4 yes
GO:1903902 positive regulation of viral life cycle 8.3333 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CHM1A_HUMAN [view entry] [view interactions] Low throughput yes no
CHM4A_HUMAN [view interactions] Low throughput no no
CHM1B_HUMAN [view interactions] Low throughput no yes
VPS4B_HUMAN [view interactions] Low throughput no yes
VTA1_HUMAN [view entry] [view interactions] Low throughput yes yes
ANCHR_HUMAN [view interactions] Low throughput no yes
CHM4C_HUMAN [view interactions] Low throughput no yes
CHMP3_HUMAN [view interactions] Low throughput no yes
CHM2B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
NPC1_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
CHMP5_HUMAN [view interactions] Low throughput no yes
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] Low throughput yes yes
CHMP6_HUMAN [view interactions] Low throughput no yes
CHM2A_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
VPS4A_HUMAN [view entry] [view interactions] High throughput yes yes
BABA1_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
SMO_HUMAN [view entry] [view interactions] High throughput yes yes
TM248_HUMAN [view interactions] High throughput no yes
SOSB1_HUMAN [view interactions] High throughput no yes
CENPQ_HUMAN [view interactions] High throughput no yes
ARL8B_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
IRF7_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
SATB2_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CLIC3_HUMAN [view interactions] High throughput no no
NFKB1_HUMAN [view interactions] High throughput no yes
INTU_HUMAN [view interactions] High throughput no yes
SPAG6_HUMAN [view interactions] High throughput no no
KCND3_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
KMT2E_HUMAN [view interactions] High throughput no no
DUS12_HUMAN [view interactions] High throughput no no
DUS2_HUMAN [view interactions] High throughput no no
DUS6_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
LZTR1_HUMAN [view interactions] High throughput no no
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
BRD1_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
TRI13_HUMAN [view interactions] High throughput no no
M4K1_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
IST1_HUMAN [view interactions] High throughput no yes
THTPA_HUMAN [view interactions] High throughput no yes
PCBP4_HUMAN [view interactions] High throughput no no
SESQ1_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
SEC20_HUMAN [view interactions] High throughput no yes
COPE_HUMAN [view interactions] High throughput no yes
NSE1_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
RINT1_HUMAN [view interactions] High throughput no yes
RTF1_HUMAN [view interactions] High throughput no yes
SCYL1_HUMAN [view interactions] High throughput no yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
SRSF7_HUMAN [view interactions] High throughput no yes
TRA2B_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
ZN574_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes