KCNQ5_HUMAN
Evidence for PS localization
Functions
Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 145 | Val | Gly | Intellectualdevelopmentaldisorder,autosomaldominant46(MRD46) | - |
| 341 | Leu | Ile | Intellectualdevelopmentaldisorder,autosomaldominant46(MRD46) | - |
| 369 | Pro | Arg | Intellectualdevelopmentaldisorder,autosomaldominant46(MRD46) | - |
| 429 | Ser | Ile | Intellectualdevelopmentaldisorder,autosomaldominant46(MRD46) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCNQ5_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 30.0000 | 4 | yes |
| GO:0015267 | channel activity | 30.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 30.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 20.0000 | 5 | yes |
| GO:0005249 | voltage-gated potassium channel activity | 20.0000 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 20.0000 | 5 | yes |
| GO:0005267 | potassium channel activity | 20.0000 | 6 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 20.0000 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 20.0000 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 20.0000 | 6 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 20.0000 | 6 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 20.0000 | 5 | yes |
| GO:0099508 | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 10.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCNQ5_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 55.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 45.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 45.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 45.0000 | 4 | no |
| GO:0051049 | regulation of transport | 45.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 35.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0006605 | protein targeting | 30.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 30.0000 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 30.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0006811 | monoatomic ion transport | 25.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0021762 | substantia nigra development | 25.0000 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 25.0000 | 5 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0006812 | monoatomic cation transport | 20.0000 | 5 | yes |
| GO:0006813 | potassium ion transport | 20.0000 | 7 | yes |
| GO:0030001 | metal ion transport | 20.0000 | 6 | yes |
| GO:0071805 | potassium ion transmembrane transport | 20.0000 | 5 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 20.0000 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 20.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNQ3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| GBRE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNS3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |