ASTN2_HUMAN
Evidence for PS localization
Functions
Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 . Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ASTN2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 75.0000 | 4 | yes |
| GO:0000166 | nucleotide binding | 50.0000 | 4 | no |
| GO:0005524 | ATP binding | 50.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 50.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 50.0000 | 4 | no |
| GO:0016887 | ATP hydrolysis activity | 50.0000 | 7 | no |
| GO:0017076 | purine nucleotide binding | 50.0000 | 5 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 50.0000 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 50.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 50.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ASTN2_HUMAN |
|---|---|---|---|---|
| GO:0032880 | regulation of protein localization | 50.0000 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL12_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| AL3B1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |