Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CACO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CACO1_HUMAN
GO:0043168 anion binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0000166 nucleotide binding 21.4286 4 no
GO:0005524 ATP binding 21.4286 5 no
GO:0017076 purine nucleotide binding 21.4286 5 no
GO:0030554 adenyl nucleotide binding 21.4286 6 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0032559 adenyl ribonucleotide binding 21.4286 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0043169 cation binding 17.8571 4 yes
GO:0046872 metal ion binding 17.8571 5 yes
GO:0000976 transcription cis-regulatory region binding 10.7143 5 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 10.7143 6 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 10.7143 7 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 10.7143 6 yes
GO:0001067 transcription regulatory region nucleic acid binding 10.7143 4 yes
GO:0003677 DNA binding 10.7143 4 yes
GO:0003690 double-stranded DNA binding 10.7143 5 yes
GO:0043565 sequence-specific DNA binding 10.7143 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 10.7143 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CACO1_HUMAN
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0009893 positive regulation of metabolic process 53.5714 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.5714 4 yes
GO:0010646 regulation of cell communication 53.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0009966 regulation of signal transduction 46.4286 4 no
GO:0048523 negative regulation of cellular process 46.4286 4 no
GO:0008104 protein localization 46.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 yes
GO:0006996 organelle organization 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051246 regulation of protein metabolic process 39.2857 5 no
GO:0009889 regulation of biosynthetic process 35.7143 4 yes
GO:0010468 regulation of gene expression 35.7143 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 yes
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 yes
GO:0051049 regulation of transport 35.7143 4 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:1902531 regulation of intracellular signal transduction 32.1429 5 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 yes
GO:0051252 regulation of RNA metabolic process 28.5714 5 yes
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0070925 organelle assembly 28.5714 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0010628 positive regulation of gene expression 25.0000 7 yes
GO:0098657 import into cell 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 yes
GO:0051254 positive regulation of RNA metabolic process 21.4286 6 yes
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 yes
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0044057 regulation of system process 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0015031 protein transport 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0031344 regulation of cell projection organization 21.4286 5 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0050804 modulation of chemical synaptic transmission 21.4286 5 no
GO:0099177 regulation of trans-synaptic signaling 21.4286 4 no
GO:0045893 positive regulation of DNA-templated transcription 17.8571 8 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 17.8571 9 yes
GO:1902680 positive regulation of RNA biosynthetic process 17.8571 7 yes
GO:0016055 Wnt signaling pathway 10.7143 4 yes
GO:0030518 intracellular steroid hormone receptor signaling pathway 7.1429 5 yes
GO:0043401 steroid hormone mediated signaling pathway 7.1429 4 yes
GO:0141193 nuclear receptor signaling pathway 7.1429 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRL2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRL1_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
AHR_HUMAN [view interactions] Low throughput no yes
ARNT_HUMAN [view entry] [view interactions] Low throughput yes yes
MLP3C_HUMAN [view interactions] Low throughput no no
GBRAP_HUMAN [view entry] [view interactions] Low throughput yes no
MLP3B_HUMAN [view interactions] Low throughput no yes
MLP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
RPB1_HUMAN [view interactions] Low throughput no no
MYH6_HUMAN [view entry] [view interactions] Low throughput yes no
APTX_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
GRIK2_HUMAN [view entry] [view interactions] High throughput yes yes
C19L2_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
F161A_HUMAN [view interactions] High throughput no no
TBC15_HUMAN [view interactions] High throughput no yes
ISOC1_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
DS13B_HUMAN [view interactions] High throughput no no
AAPK2_HUMAN [view interactions] High throughput no yes
BFSP2_HUMAN [view interactions] High throughput no no
ZMAT2_HUMAN [view interactions] High throughput no yes
ENKD1_HUMAN [view interactions] High throughput no yes
RNF8_HUMAN [view interactions] High throughput no yes
PHS_HUMAN [view interactions] High throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
K1C15_HUMAN [view interactions] High throughput no no
CRBA2_HUMAN [view interactions] High throughput no no
CYH3_HUMAN [view entry] [view interactions] High throughput yes yes
FOSL1_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
DS13A_HUMAN [view interactions] High throughput no no
PGTB2_HUMAN [view interactions] High throughput no yes
CAH10_HUMAN [view interactions] High throughput no yes
FOSL2_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
MAFF_HUMAN [view interactions] High throughput no yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TXLNB_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
SYCE1_HUMAN [view interactions] High throughput no no
SLU7_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
IQIP1_HUMAN [view interactions] High throughput no yes
SCHI1_HUMAN [view interactions] High throughput no yes
CYH1_HUMAN [view interactions] High throughput no no
K1C14_HUMAN [view interactions] High throughput no no
MAFK_HUMAN [view interactions] High throughput no no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C23_HUMAN [view interactions] High throughput no no
KRT37_HUMAN [view interactions] High throughput no no
K1C16_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
PAAT_HUMAN [view interactions] High throughput no yes
RHG18_HUMAN [view interactions] High throughput no yes
CP51A_HUMAN [view interactions] High throughput no no
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
SRP14_HUMAN [view interactions] High throughput no no
SRP09_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
K1C19_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no