CACO1_HUMAN
Evidence for PS localization
Functions
Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CACO1_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 24.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 24.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.0000 | 4 | no |
| GO:0046872 | metal ion binding | 20.0000 | 4 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 12.0000 | 5 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 12.0000 | 6 | yes |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 12.0000 | 7 | yes |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding | 12.0000 | 6 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 12.0000 | 4 | yes |
| GO:0003677 | DNA binding | 12.0000 | 4 | yes |
| GO:0003690 | double-stranded DNA binding | 12.0000 | 5 | yes |
| GO:0043565 | sequence-specific DNA binding | 12.0000 | 5 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 12.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CACO1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 76.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 48.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 48.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.0000 | 4 | no |
| GO:0008104 | protein localization | 44.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.0000 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.0000 | 5 | yes |
| GO:0006996 | organelle organization | 36.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 36.0000 | 4 | no |
| GO:0051049 | regulation of transport | 36.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 36.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.0000 | 6 | no |
| GO:0071702 | organic substance transport | 32.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.0000 | 5 | no |
| GO:0036211 | protein modification process | 32.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 32.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.0000 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 28.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 28.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.0000 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 28.0000 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0000 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 24.0000 | 4 | no |
| GO:0070925 | organelle assembly | 24.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0000 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 24.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.0000 | 7 | no |
| GO:0006897 | endocytosis | 24.0000 | 5 | no |
| GO:0015031 | protein transport | 24.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.0000 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 24.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 24.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.0000 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.0000 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.0000 | 7 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 16.0000 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 16.0000 | 6 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 16.0000 | 8 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 16.0000 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 16.0000 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 16.0000 | 8 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 12.0000 | 4 | yes |
| GO:0016055 | Wnt signaling pathway | 12.0000 | 5 | yes |
| GO:0043401 | steroid hormone mediated signaling pathway | 8.0000 | 4 | yes |
| GO:0030518 | intracellular steroid hormone receptor signaling pathway | 8.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| AHR_HUMAN | [view interactions] | Low throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MLP3C_HUMAN | [view interactions] | Low throughput | no | no |
| GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| MYH6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| CRBA2_HUMAN | [view interactions] | High throughput | no | no |
| CYH3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOSL1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| CAH10_HUMAN | [view interactions] | High throughput | no | yes |
| FOSL2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFF_HUMAN | [view interactions] | High throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
| CYH1_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| MAFK_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C23_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| CP51A_HUMAN | [view interactions] | High throughput | no | no |
| ARBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| DS13B_HUMAN | [view interactions] | High throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP2_HUMAN | [view interactions] | High throughput | no | no |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| PHS_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCOA2_HUMAN | [view interactions] | Computational | no | no |
| ESR1_HUMAN | [view interactions] | Computational | no | no |