CYH3_HUMAN
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization . [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CYH3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 41.1765 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 41.1765 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 41.1765 | 4 | no |
GO:0003924 | GTPase activity | 41.1765 | 7 | no |
GO:0016462 | pyrophosphatase activity | 41.1765 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 41.1765 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 41.1765 | 6 | no |
GO:0005525 | GTP binding | 35.2941 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 35.2941 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 35.2941 | 5 | no |
GO:0030695 | GTPase regulator activity | 29.4118 | 4 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 23.5294 | 5 | yes |
GO:0046872 | metal ion binding | 23.5294 | 4 | no |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | 11.7647 | 4 | yes |
GO:0035091 | phosphatidylinositol binding | 11.7647 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 11.7647 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CYH3_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 76.4706 | 4 | yes |
GO:0009966 | regulation of signal transduction | 70.5882 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 47.0588 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 41.1765 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 41.1765 | 4 | no |
GO:0016192 | vesicle-mediated transport | 41.1765 | 4 | yes |
GO:0051049 | regulation of transport | 35.2941 | 4 | no |
GO:0051056 | regulation of small GTPase mediated signal transduction | 29.4118 | 6 | yes |
GO:0008104 | protein localization | 29.4118 | 4 | no |
GO:0051128 | regulation of cellular component organization | 29.4118 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 29.4118 | 4 | no |
GO:0071310 | cellular response to organic substance | 29.4118 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 29.4118 | 4 | no |
GO:0030155 | regulation of cell adhesion | 23.5294 | 4 | yes |
GO:0045785 | positive regulation of cell adhesion | 23.5294 | 5 | yes |
GO:0046578 | regulation of Ras protein signal transduction | 23.5294 | 7 | yes |
GO:0090162 | establishment of epithelial cell polarity | 23.5294 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
GO:0048878 | chemical homeostasis | 23.5294 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
GO:0006996 | organelle organization | 23.5294 | 4 | no |
GO:0007010 | cytoskeleton organization | 23.5294 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 23.5294 | 4 | no |
GO:0010243 | response to organonitrogen compound | 23.5294 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 23.5294 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 23.5294 | 4 | no |
GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
GO:0033993 | response to lipid | 23.5294 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 23.5294 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 23.5294 | 6 | no |
GO:0110053 | regulation of actin filament organization | 23.5294 | 6 | no |
GO:1901701 | cellular response to oxygen-containing compound | 23.5294 | 4 | no |
GO:1902903 | regulation of supramolecular fiber organization | 23.5294 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
GO:0032012 | regulation of ARF protein signal transduction | 17.6471 | 8 | yes |
GO:0048193 | Golgi vesicle transport | 17.6471 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
INAVA_HUMAN | [view interactions] | Low throughput | no | yes |
SODC_HUMAN | [view interactions] | Low throughput | no | yes |
INSR_HUMAN | [view interactions] | Low throughput | no | yes |
IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ICEF1_HUMAN | [view interactions] | Low throughput | no | yes |
GRASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FRM4B_HUMAN | [view interactions] | Low throughput | no | no |
GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYH3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYCE1_HUMAN | [view interactions] | High throughput | no | no |
CNKR1_HUMAN | [view interactions] | High throughput | no | no |
CACO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CC120_HUMAN | [view interactions] | High throughput | no | no |
IN35_HUMAN | [view interactions] | High throughput | no | yes |
ARFP2_HUMAN | [view interactions] | High throughput | no | no |
MS18B_HUMAN | [view interactions] | High throughput | no | no |
WDR83_HUMAN | [view interactions] | High throughput | no | yes |
GPS2_HUMAN | [view interactions] | High throughput | no | yes |
CYTIP_HUMAN | [view interactions] | High throughput | no | yes |
FOSL2_HUMAN | [view interactions] | High throughput | no | yes |
MTMR7_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
CYH1_HUMAN | [view interactions] | High throughput | no | no |
ODAD1_HUMAN | [view interactions] | High throughput | no | no |
IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARF5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CYH4_HUMAN | [view interactions] | Computational | no | yes |
CYH2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNA13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG1_HUMAN | [view interactions] | Computational | no | no |
GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNA12_HUMAN | [view interactions] | Computational | no | no |
DMAP1_HUMAN | [view interactions] | Computational | no | yes |