MKLN1_HUMAN
Evidence for PS localization
Functions
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation . Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MKLN1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 31.5789 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.5789 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.3158 | 6 | no |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | no |
| GO:0043168 | anion binding | 21.0526 | 4 | no |
| GO:0042803 | protein homodimerization activity | 15.7895 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MKLN1_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0006996 | organelle organization | 36.8421 | 4 | yes |
| GO:0010646 | regulation of cell communication | 26.3158 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.3158 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 26.3158 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.3158 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.3158 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.3158 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 26.3158 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 26.3158 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 26.3158 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.3158 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 26.3158 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 26.3158 | 4 | no |
| GO:0051049 | regulation of transport | 26.3158 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.0526 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 21.0526 | 4 | no |
| GO:0009966 | regulation of signal transduction | 21.0526 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.0526 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.0526 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 21.0526 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 21.0526 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 21.0526 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.0526 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 21.0526 | 4 | yes |
| GO:0002090 | regulation of receptor internalization | 10.5263 | 7 | yes |
| GO:0007160 | cell-matrix adhesion | 10.5263 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 10.5263 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 10.5263 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 10.5263 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 10.5263 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GID8_HUMAN | [view interactions] | Low throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
| MKLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAEA_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PE2R3_HUMAN | [view interactions] | Low throughput | no | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| YPEL5_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE192_HUMAN | [view interactions] | High throughput | no | yes |
| NAB1_HUMAN | [view interactions] | High throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIGD5_HUMAN | [view interactions] | High throughput | no | no |
| INSL6_HUMAN | [view interactions] | High throughput | no | no |
| MMP7_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| PRG3_HUMAN | [view interactions] | High throughput | no | no |
| TDGF1_HUMAN | [view interactions] | High throughput | no | no |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| PIGT_HUMAN | [view interactions] | High throughput | no | no |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| SFRP2_HUMAN | [view interactions] | High throughput | no | no |
| HPF1_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| E2F1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| CYREN_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| MMAD_HUMAN | [view interactions] | High throughput | no | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| R10B1_HUMAN | [view interactions] | High throughput | no | no |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
| AAMP_HUMAN | [view interactions] | High throughput | no | yes |
| PMFBP_HUMAN | [view interactions] | High throughput | no | yes |
| GID4_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR26_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP10_HUMAN | [view interactions] | High throughput | no | no |
| RMD5B_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDNF_HUMAN | [view interactions] | High throughput | no | yes |
| GRPL2_HUMAN | [view interactions] | High throughput | no | no |
| RM04_HUMAN | [view interactions] | High throughput | no | yes |
| NR1H3_HUMAN | [view interactions] | High throughput | no | yes |
| PACA_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| MKNK1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFAC1_HUMAN | [view interactions] | High throughput | no | no |
| LIRB4_HUMAN | [view interactions] | High throughput | no | no |
| NNRD_HUMAN | [view interactions] | High throughput | no | yes |
| IKZF1_HUMAN | [view interactions] | High throughput | no | no |
| TLE4_HUMAN | [view interactions] | High throughput | no | no |
| R10B2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| HBP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| GNLY_HUMAN | [view interactions] | High throughput | no | no |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| CST8_HUMAN | [view interactions] | High throughput | no | no |
| LECT2_HUMAN | [view interactions] | High throughput | no | no |
| JPH4_HUMAN | [view interactions] | High throughput | no | no |
| MTG16_HUMAN | [view interactions] | High throughput | no | yes |
| COQ4_HUMAN | [view interactions] | High throughput | no | yes |
| WN10A_HUMAN | [view interactions] | High throughput | no | no |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| EMIL3_HUMAN | [view interactions] | High throughput | no | yes |
| CRDL2_HUMAN | [view interactions] | High throughput | no | yes |
| LAD1_HUMAN | [view interactions] | High throughput | no | no |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| MMP13_HUMAN | [view interactions] | High throughput | no | no |
| SPON1_HUMAN | [view interactions] | High throughput | no | no |
| TCAL9_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| LY6H_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GREM2_HUMAN | [view interactions] | High throughput | no | no |
| ATS1_HUMAN | [view interactions] | High throughput | no | no |
| DDX50_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD6_HUMAN | [view interactions] | High throughput | no | yes |
| SG11A_HUMAN | [view interactions] | High throughput | no | no |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| ANGL4_HUMAN | [view interactions] | High throughput | no | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| IL17B_HUMAN | [view interactions] | High throughput | no | no |
| LPD6B_HUMAN | [view interactions] | High throughput | no | no |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| RM18_HUMAN | [view interactions] | High throughput | no | yes |
| NMB_HUMAN | [view interactions] | High throughput | no | no |