Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG3_HUMAN
GO:0019900 kinase binding 41.6667 4 no
GO:0005216 monoatomic ion channel activity 33.3333 4 yes
GO:0015267 channel activity 33.3333 4 yes
GO:0022836 gated channel activity 33.3333 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 yes
GO:0030165 PDZ domain binding 33.3333 4 yes
GO:0035254 glutamate receptor binding 33.3333 4 yes
GO:0035255 ionotropic glutamate receptor binding 25.0000 5 yes
GO:0019902 phosphatase binding 25.0000 4 no
GO:0001664 G protein-coupled receptor binding 25.0000 4 no
GO:0031690 adrenergic receptor binding 25.0000 5 no
GO:0005244 voltage-gated monoatomic ion channel activity 16.6667 5 yes
GO:0005245 voltage-gated calcium channel activity 16.6667 7 yes
GO:0005261 monoatomic cation channel activity 16.6667 5 yes
GO:0005262 calcium channel activity 16.6667 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 16.6667 4 yes
GO:0015085 calcium ion transmembrane transporter activity 16.6667 6 yes
GO:0022832 voltage-gated channel activity 16.6667 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 16.6667 6 yes
GO:0046873 metal ion transmembrane transporter activity 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCG3_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0008104 protein localization 58.3333 4 yes
GO:0050804 modulation of chemical synaptic transmission 58.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 58.3333 4 yes
GO:0009893 positive regulation of metabolic process 58.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 58.3333 5 no
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 58.3333 5 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0072657 protein localization to membrane 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0035418 protein localization to synapse 41.6667 6 yes
GO:0050806 positive regulation of synaptic transmission 41.6667 5 yes
GO:0051049 regulation of transport 41.6667 4 yes
GO:0098657 import into cell 41.6667 4 yes
GO:1902414 protein localization to cell junction 41.6667 5 yes
GO:0007268 chemical synaptic transmission 41.6667 7 no
GO:0098916 anterograde trans-synaptic signaling 41.6667 6 no
GO:0099536 synaptic signaling 41.6667 4 no
GO:0099537 trans-synaptic signaling 41.6667 5 no
GO:0010562 positive regulation of phosphorus metabolic process 41.6667 6 no
GO:0019220 regulation of phosphate metabolic process 41.6667 6 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0031401 positive regulation of protein modification process 41.6667 7 no
GO:0045937 positive regulation of phosphate metabolic process 41.6667 7 no
GO:0051174 regulation of phosphorus metabolic process 41.6667 5 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0006886 intracellular protein transport 33.3333 4 yes
GO:0006898 receptor-mediated endocytosis 33.3333 4 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 yes
GO:0034762 regulation of transmembrane transport 33.3333 4 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 33.3333 4 yes
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043113 receptor clustering 33.3333 5 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 33.3333 8 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0061097 regulation of protein tyrosine kinase activity 33.3333 7 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0050890 cognition 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031623 receptor internalization 25.0000 5 yes
GO:0033365 protein localization to organelle 25.0000 5 yes
GO:0062237 protein localization to postsynapse 25.0000 7 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 25.0000 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 25.0000 4 yes
GO:0099633 protein localization to postsynaptic specialization membrane 25.0000 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 25.0000 4 yes
GO:1903539 protein localization to postsynaptic membrane 25.0000 5 yes
GO:1990778 protein localization to cell periphery 25.0000 5 yes
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 25.0000 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 25.0000 5 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007399 nervous system development 25.0000 4 no
GO:0007612 learning 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 5 no
GO:0050905 neuromuscular process 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0008088 axo-dendritic transport 25.0000 5 no
GO:0010970 transport along microtubule 25.0000 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 25.0000 4 no
GO:0099111 microtubule-based transport 25.0000 4 no
GO:0006605 protein targeting 16.6667 4 yes
GO:0006811 monoatomic ion transport 16.6667 4 yes
GO:0006812 monoatomic cation transport 16.6667 5 yes
GO:0006816 calcium ion transport 16.6667 7 yes
GO:0007034 vacuolar transport 16.6667 4 yes
GO:0007041 lysosomal transport 16.6667 5 yes
GO:0019226 transmission of nerve impulse 16.6667 4 yes
GO:0030001 metal ion transport 16.6667 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 16.6667 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 16.6667 6 yes
GO:0061462 protein localization to lysosome 16.6667 7 yes
GO:0072594 establishment of protein localization to organelle 16.6667 4 yes
GO:0072665 protein localization to vacuole 16.6667 6 yes
GO:0072666 establishment of protein localization to vacuole 16.6667 5 yes
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 16.6667 4 yes
GO:2000311 regulation of AMPA receptor activity 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
CCG3_HUMAN [view entry] [view interactions] Low throughput yes no
POTEF_HUMAN [view interactions] High throughput no no
PLK1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV2_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
RGP1_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
SEC63_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes