Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG3_HUMAN
GO:0005216 ion channel activity 61.7647 4 yes
GO:0005261 cation channel activity 61.7647 5 yes
GO:0008324 cation transmembrane transporter activity 61.7647 4 yes
GO:0015267 channel activity 61.7647 4 yes
GO:0022836 gated channel activity 61.7647 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 61.7647 4 yes
GO:0005244 voltage-gated ion channel activity 50.0000 4 yes
GO:0005262 calcium channel activity 50.0000 6 yes
GO:0015085 calcium ion transmembrane transporter activity 50.0000 6 yes
GO:0022832 voltage-gated channel activity 50.0000 6 yes
GO:0022843 voltage-gated cation channel activity 50.0000 5 yes
GO:0046873 metal ion transmembrane transporter activity 50.0000 5 yes
GO:0005245 voltage-gated calcium channel activity 35.2941 6 yes
GO:0004970 ionotropic glutamate receptor activity 26.4706 5 no
GO:0005230 extracellular ligand-gated ion channel activity 26.4706 6 no
GO:0008066 glutamate receptor activity 26.4706 4 no
GO:0015276 ligand-gated ion channel activity 26.4706 5 no
GO:0022824 transmitter-gated ion channel activity 26.4706 5 no
GO:0022834 ligand-gated channel activity 26.4706 6 no
GO:0022835 transmitter-gated channel activity 26.4706 4 no
GO:0099094 ligand-gated cation channel activity 26.4706 6 no
GO:0046872 metal ion binding 23.5294 4 no
GO:0001540 amyloid-beta binding 20.5882 4 no
GO:0035254 glutamate receptor binding 14.7059 4 yes
GO:0035255 ionotropic glutamate receptor binding 11.7647 5 yes
GO:0030165 PDZ domain binding 8.8235 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCG3_HUMAN
GO:0048522 positive regulation of cellular process 67.6471 4 yes
GO:0051049 regulation of transport 67.6471 4 yes
GO:0010646 regulation of cell communication 55.8824 4 yes
GO:0043269 regulation of ion transport 52.9412 5 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 50.0000 5 yes
GO:0050804 modulation of chemical synaptic transmission 47.0588 5 yes
GO:0099177 regulation of trans-synaptic signaling 47.0588 4 yes
GO:0008104 protein localization 44.1176 4 yes
GO:1904062 regulation of cation transmembrane transport 44.1176 6 yes
GO:0051171 regulation of nitrogen compound metabolic process 41.1765 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0080090 regulation of primary metabolic process 41.1765 4 no
GO:0007268 chemical synaptic transmission 41.1765 6 no
GO:0098916 anterograde trans-synaptic signaling 41.1765 5 no
GO:0099537 trans-synaptic signaling 41.1765 4 no
GO:0006811 ion transport 38.2353 4 yes
GO:0006812 cation transport 38.2353 5 yes
GO:0006816 calcium ion transport 38.2353 7 yes
GO:0022898 regulation of transmembrane transporter activity 38.2353 4 yes
GO:0030001 metal ion transport 38.2353 6 yes
GO:0032412 regulation of ion transmembrane transporter activity 38.2353 5 yes
GO:2001257 regulation of cation channel activity 38.2353 6 yes
GO:0010647 positive regulation of cell communication 35.2941 5 yes
GO:0023056 positive regulation of signaling 35.2941 4 yes
GO:0051246 regulation of protein metabolic process 35.2941 5 no
GO:0009966 regulation of signal transduction 32.3529 4 yes
GO:0050806 positive regulation of synaptic transmission 32.3529 5 yes
GO:0051050 positive regulation of transport 32.3529 4 yes
GO:0072657 protein localization to membrane 32.3529 4 yes
GO:0031323 regulation of cellular metabolic process 32.3529 4 no
GO:0043085 positive regulation of catalytic activity 32.3529 4 no
GO:0048523 negative regulation of cellular process 32.3529 4 no
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 no
GO:0044057 regulation of system process 29.4118 4 no
GO:0051128 regulation of cellular component organization 29.4118 4 no
GO:0016192 vesicle-mediated transport 26.4706 4 yes
GO:0035418 protein localization to synapse 26.4706 6 yes
GO:1902414 protein localization to cell junction 26.4706 5 yes
GO:0007215 glutamate receptor signaling pathway 26.4706 4 no
GO:0010959 regulation of metal ion transport 26.4706 6 no
GO:0051247 positive regulation of protein metabolic process 26.4706 6 no
GO:0060341 regulation of cellular localization 26.4706 4 no
GO:0006886 intracellular protein transport 23.5294 4 yes
GO:0006897 endocytosis 23.5294 5 yes
GO:0015031 protein transport 23.5294 4 yes
GO:0071702 organic substance transport 23.5294 4 yes
GO:0071705 nitrogen compound transport 23.5294 4 yes
GO:1990778 protein localization to cell periphery 23.5294 5 yes
GO:0031325 positive regulation of cellular metabolic process 23.5294 5 no
GO:0051924 regulation of calcium ion transport 23.5294 7 no
GO:0098655 cation transmembrane transport 23.5294 4 no
GO:0098660 inorganic ion transmembrane transport 23.5294 4 no
GO:0098662 inorganic cation transmembrane transport 23.5294 5 no
GO:0032880 regulation of protein localization 20.5882 5 no
GO:0033365 protein localization to organelle 20.5882 5 yes
GO:0043270 positive regulation of ion transport 20.5882 5 yes
GO:0062237 protein localization to postsynapse 20.5882 7 yes
GO:0099601 regulation of neurotransmitter receptor activity 20.5882 4 yes
GO:1903539 protein localization to postsynaptic membrane 20.5882 5 yes
GO:0050890 cognition 20.5882 4 no
GO:0070588 calcium ion transmembrane transport 20.5882 6 no
GO:0097553 calcium ion transmembrane import into cytosol 20.5882 7 no
GO:1903169 regulation of calcium ion transmembrane transport 20.5882 7 no
GO:0031399 regulation of protein modification process 20.5882 6 no
GO:0006898 receptor-mediated endocytosis 17.6471 6 yes
GO:0031623 receptor internalization 17.6471 7 yes
GO:0034764 positive regulation of transmembrane transport 17.6471 5 yes
GO:0034767 positive regulation of ion transmembrane transport 17.6471 6 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 17.6471 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 17.6471 4 yes
GO:1904064 positive regulation of cation transmembrane transport 17.6471 7 yes
GO:0007034 vacuolar transport 14.7059 4 yes
GO:0007041 lysosomal transport 14.7059 5 yes
GO:0008333 endosome to lysosome transport 14.7059 5 yes
GO:0032411 positive regulation of transporter activity 14.7059 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 14.7059 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 14.7059 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 14.7059 6 yes
GO:0061462 protein localization to lysosome 14.7059 7 yes
GO:0072594 establishment of protein localization to organelle 14.7059 4 yes
GO:0072665 protein localization to vacuole 14.7059 6 yes
GO:0072666 establishment of protein localization to vacuole 14.7059 5 yes
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 14.7059 4 yes
GO:0099633 protein localization to postsynaptic specialization membrane 14.7059 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 14.7059 4 yes
GO:2000311 regulation of AMPA receptor activity 14.7059 5 yes
GO:2001259 positive regulation of cation channel activity 14.7059 6 yes
GO:2000273 positive regulation of signaling receptor activity 8.8235 4 yes
GO:2000969 positive regulation of AMPA receptor activity 8.8235 5 yes
GO:0006605 protein targeting 5.8824 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
POTEF_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV2_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
RGP1_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1D_HUMAN [view interactions] Computational no yes
CAC1F_HUMAN [view interactions] Computational no no
CAC1S_HUMAN [view interactions] Computational no no
CCG6_HUMAN [view interactions] Computational no no
CACB4_HUMAN [view entry] [view interactions] Computational yes yes
CA2D4_HUMAN [view interactions] Computational no no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
CCG1_HUMAN [view interactions] Computational no no
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
CACB1_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CCG7_HUMAN [view entry] [view interactions] Computational yes no
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
CAC1B_HUMAN [view interactions] Computational no yes
AKAP5_HUMAN [view entry] [view interactions] Computational yes yes
MYO6_HUMAN [view entry] [view interactions] Computational yes no
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
E41L1_HUMAN [view entry] [view interactions] Computational yes yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
DLG1_HUMAN [view entry] [view interactions] Computational yes yes
CCG8_HUMAN [view entry] [view interactions] Computational yes no
CA2D1_HUMAN [view entry] [view interactions] Computational yes yes
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
NMD3A_HUMAN [view entry] [view interactions] Computational yes no
CAC1H_HUMAN [view entry] [view interactions] Computational yes yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
CAC1E_HUMAN [view entry] [view interactions] Computational yes no
CCG4_HUMAN [view entry] [view interactions] Computational yes no