Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IQEC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003592 LIG_CaM_IQ_9 LIG 351 367 -
ELMI003592 LIG_CaM_IQ_9 LIG 351 367 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IQEC2_HUMAN
GO:0019900 kinase binding 40.5405 4 no
GO:0043169 cation binding 32.4324 4 no
GO:0046872 metal ion binding 32.4324 5 no
GO:0043168 anion binding 29.7297 4 no
GO:0019901 protein kinase binding 29.7297 5 no
GO:0000166 nucleotide binding 27.0270 4 no
GO:0017076 purine nucleotide binding 27.0270 5 no
GO:0032555 purine ribonucleotide binding 27.0270 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.3243 4 no
GO:0030695 GTPase regulator activity 13.5135 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 8.1081 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IQEC2_HUMAN
GO:0010646 regulation of cell communication 70.2703 4 yes
GO:0048522 positive regulation of cellular process 70.2703 4 yes
GO:0048523 negative regulation of cellular process 67.5676 4 no
GO:0060255 regulation of macromolecule metabolic process 67.5676 4 no
GO:0080090 regulation of primary metabolic process 64.8649 4 no
GO:0031323 regulation of cellular metabolic process 62.1622 4 no
GO:0009966 regulation of signal transduction 56.7568 4 yes
GO:0008104 protein localization 56.7568 4 no
GO:0051049 regulation of transport 51.3514 4 no
GO:0051128 regulation of cellular component organization 48.6486 4 no
GO:0051246 regulation of protein metabolic process 48.6486 5 no
GO:0010605 negative regulation of macromolecule metabolic process 45.9459 5 no
GO:0009893 positive regulation of metabolic process 45.9459 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.9459 5 no
GO:0009892 negative regulation of metabolic process 45.9459 4 no
GO:0031325 positive regulation of cellular metabolic process 43.2432 5 no
GO:0031324 negative regulation of cellular metabolic process 40.5405 5 no
GO:0006996 organelle organization 40.5405 4 yes
GO:0050804 modulation of chemical synaptic transmission 40.5405 5 yes
GO:0099177 regulation of trans-synaptic signaling 40.5405 4 yes
GO:1902531 regulation of intracellular signal transduction 40.5405 5 yes
GO:0019220 regulation of phosphate metabolic process 40.5405 6 no
GO:0031399 regulation of protein modification process 40.5405 6 no
GO:0051174 regulation of phosphorus metabolic process 40.5405 5 no
GO:0022607 cellular component assembly 37.8378 4 no
GO:0051247 positive regulation of protein metabolic process 37.8378 6 no
GO:0034762 regulation of transmembrane transport 35.1351 4 no
GO:0043269 regulation of monoatomic ion transport 35.1351 5 no
GO:0001932 regulation of protein phosphorylation 35.1351 7 no
GO:0042325 regulation of phosphorylation 35.1351 7 no
GO:0034765 regulation of monoatomic ion transmembrane transport 32.4324 5 no
GO:0051248 negative regulation of protein metabolic process 32.4324 6 no
GO:0009889 regulation of biosynthetic process 32.4324 4 no
GO:0010468 regulation of gene expression 32.4324 6 no
GO:0010556 regulation of macromolecule biosynthetic process 32.4324 5 no
GO:0031326 regulation of cellular biosynthetic process 32.4324 5 no
GO:0010647 positive regulation of cell communication 32.4324 5 yes
GO:0023056 positive regulation of signaling 32.4324 4 yes
GO:0031401 positive regulation of protein modification process 32.4324 7 no
GO:0043085 positive regulation of catalytic activity 29.7297 4 no
GO:0051050 positive regulation of transport 29.7297 4 no
GO:0001934 positive regulation of protein phosphorylation 29.7297 8 no
GO:0010562 positive regulation of phosphorus metabolic process 29.7297 6 no
GO:0022603 regulation of anatomical structure morphogenesis 29.7297 4 no
GO:0031344 regulation of cell projection organization 29.7297 5 no
GO:0042327 positive regulation of phosphorylation 29.7297 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.7297 7 no
GO:0141124 intracellular signaling cassette 29.7297 4 no
GO:0010959 regulation of metal ion transport 27.0270 6 no
GO:0043549 regulation of kinase activity 27.0270 5 no
GO:0044057 regulation of system process 27.0270 4 no
GO:0051051 negative regulation of transport 27.0270 4 no
GO:0051338 regulation of transferase activity 27.0270 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 27.0270 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.0270 5 no
GO:0051252 regulation of RNA metabolic process 27.0270 5 no
GO:0071702 organic substance transport 27.0270 4 no
GO:0071705 nitrogen compound transport 27.0270 4 no
GO:0048584 positive regulation of response to stimulus 27.0270 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.0270 6 no
GO:0010563 negative regulation of phosphorus metabolic process 24.3243 6 no
GO:0022898 regulation of transmembrane transporter activity 24.3243 4 no
GO:0031400 negative regulation of protein modification process 24.3243 7 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 24.3243 5 no
GO:0045859 regulation of protein kinase activity 24.3243 6 no
GO:0045936 negative regulation of phosphate metabolic process 24.3243 7 no
GO:0010648 negative regulation of cell communication 24.3243 5 no
GO:0023057 negative regulation of signaling 24.3243 4 no
GO:0051130 positive regulation of cellular component organization 24.3243 5 no
GO:0060341 regulation of cellular localization 24.3243 4 yes
GO:0009967 positive regulation of signal transduction 24.3243 5 no
GO:0030030 cell projection organization 24.3243 4 no
GO:0072657 protein localization to membrane 24.3243 4 no
GO:0120036 plasma membrane bounded cell projection organization 24.3243 5 no
GO:0007268 chemical synaptic transmission 24.3243 7 no
GO:0098916 anterograde trans-synaptic signaling 24.3243 6 no
GO:0099536 synaptic signaling 24.3243 4 no
GO:0099537 trans-synaptic signaling 24.3243 5 no
GO:0010038 response to metal ion 21.6216 4 no
GO:0033674 positive regulation of kinase activity 21.6216 6 no
GO:0045860 positive regulation of protein kinase activity 21.6216 7 no
GO:0051347 positive regulation of transferase activity 21.6216 5 no
GO:0051726 regulation of cell cycle 21.6216 4 no
GO:0051924 regulation of calcium ion transport 21.6216 7 no
GO:0006355 regulation of DNA-templated transcription 21.6216 7 no
GO:0009890 negative regulation of biosynthetic process 21.6216 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.6216 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.6216 6 no
GO:2001141 regulation of RNA biosynthetic process 21.6216 6 no
GO:0042981 regulation of apoptotic process 21.6216 5 no
GO:0043067 regulation of programmed cell death 21.6216 4 no
GO:0050890 cognition 21.6216 4 no
GO:0051129 negative regulation of cellular component organization 21.6216 5 no
GO:0043933 protein-containing complex organization 21.6216 4 no
GO:0065003 protein-containing complex assembly 21.6216 5 no
GO:0015031 protein transport 21.6216 4 no
GO:0007010 cytoskeleton organization 21.6216 5 yes
GO:0032880 regulation of protein localization 21.6216 5 yes
GO:0010243 response to organonitrogen compound 21.6216 4 no
GO:0050806 positive regulation of synaptic transmission 18.9189 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 16.2162 6 yes
GO:1905475 regulation of protein localization to membrane 13.5135 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 10.8108 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 10.8108 6 yes
GO:1904375 regulation of protein localization to cell periphery 10.8108 6 yes
GO:1900452 regulation of long-term synaptic depression 8.1081 4 yes
GO:0032012 regulation of ARF protein signal transduction 5.4054 7 yes
GO:1902473 regulation of protein localization to synapse 5.4054 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BI2L1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD3_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANM2_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CCDC8_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TSP3_HUMAN [view interactions] High throughput no yes
APBA2_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
AVR2B_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CCD96_HUMAN [view interactions] High throughput no no
ZN460_HUMAN [view interactions] High throughput no no
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
CIA2A_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CYH4_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes