Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CRIPT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
3 Cys Tyr Shortstaturewithmicrocephalyanddistinctivefacies(SSMCF) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CRIPT_HUMAN
GO:0019900 kinase binding 50.0000 4 no
GO:0019902 phosphatase binding 37.5000 4 no
GO:0019901 protein kinase binding 37.5000 5 no
GO:0030165 PDZ domain binding 25.0000 4 yes
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0098879 structural constituent of postsynaptic specialization 25.0000 4 no
GO:0098919 structural constituent of postsynaptic density 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CRIPT_HUMAN
GO:0008104 protein localization 75.0000 4 yes
GO:0009893 positive regulation of metabolic process 75.0000 4 no
GO:0031323 regulation of cellular metabolic process 75.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 62.5000 5 no
GO:0051246 regulation of protein metabolic process 62.5000 5 no
GO:0051247 positive regulation of protein metabolic process 62.5000 6 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0033365 protein localization to organelle 50.0000 5 yes
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0032880 regulation of protein localization 37.5000 5 yes
GO:0051128 regulation of cellular component organization 37.5000 4 yes
GO:0060341 regulation of cellular localization 37.5000 4 yes
GO:1905475 regulation of protein localization to membrane 37.5000 6 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 37.5000 6 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0051253 negative regulation of RNA metabolic process 37.5000 6 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0033674 positive regulation of kinase activity 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042327 positive regulation of phosphorylation 37.5000 8 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0043113 receptor clustering 37.5000 5 no
GO:0043549 regulation of kinase activity 37.5000 5 no
GO:0045859 regulation of protein kinase activity 37.5000 6 no
GO:0045860 positive regulation of protein kinase activity 37.5000 7 no
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:0051347 positive regulation of transferase activity 37.5000 5 no
GO:0072657 protein localization to membrane 37.5000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0031122 cytoplasmic microtubule organization 25.0000 4 yes
GO:0033043 regulation of organelle organization 25.0000 5 yes
GO:0097435 supramolecular fiber organization 25.0000 4 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0045892 negative regulation of DNA-templated transcription 25.0000 7 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 25.0000 8 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 25.0000 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0061097 regulation of protein tyrosine kinase activity 25.0000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 no
GO:0007268 chemical synaptic transmission 25.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of ion transmembrane transport 25.0000 5 no
GO:0035418 protein localization to synapse 25.0000 6 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0062237 protein localization to postsynapse 25.0000 7 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 5 no
GO:0099537 trans-synaptic signaling 25.0000 4 no
GO:0099633 protein localization to postsynaptic specialization membrane 25.0000 6 no
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 25.0000 4 no
GO:1902414 protein localization to cell junction 25.0000 5 no
GO:1903539 protein localization to postsynaptic membrane 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:1904062 regulation of cation transmembrane transport 25.0000 6 no
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 no
GO:1990778 protein localization to cell periphery 25.0000 5 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
RYR1_HUMAN [view interactions] High throughput no no
UBQL4_HUMAN [view interactions] High throughput no yes
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
THOC2_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
C170L_HUMAN [view entry] [view interactions] High throughput yes no
MORC3_HUMAN [view interactions] High throughput no yes
CCNA2_HUMAN [view interactions] High throughput no no
TZAP_HUMAN [view interactions] High throughput no no
NALP2_HUMAN [view interactions] High throughput no no
MED4_HUMAN [view interactions] High throughput no yes
MED23_HUMAN [view interactions] High throughput no no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC7_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
CZIB_HUMAN [view interactions] High throughput no no