Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CRIPT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
3 Cys Tyr Shortstaturewithmicrocephalyanddistinctivefacies(SSMCF) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CRIPT_HUMAN
GO:0019900 kinase binding 40.0000 4 no
GO:0019902 phosphatase binding 30.0000 4 no
GO:0031625 ubiquitin protein ligase binding 30.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 30.0000 4 no
GO:0030165 PDZ domain binding 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CRIPT_HUMAN
GO:0031323 regulation of cellular metabolic process 80.0000 4 no
GO:0048522 positive regulation of cellular process 80.0000 4 no
GO:0008104 protein localization 70.0000 4 yes
GO:0009893 positive regulation of metabolic process 70.0000 4 no
GO:0048523 negative regulation of cellular process 70.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 70.0000 4 no
GO:0080090 regulation of primary metabolic process 70.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0051247 positive regulation of protein metabolic process 60.0000 6 no
GO:0006996 organelle organization 60.0000 4 yes
GO:0022607 cellular component assembly 60.0000 4 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0065003 protein-containing complex assembly 50.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 40.0000 6 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0007010 cytoskeleton organization 40.0000 5 yes
GO:0033365 protein localization to organelle 40.0000 5 yes
GO:0009894 regulation of catabolic process 40.0000 4 no
GO:0006355 regulation of DNA-templated transcription 40.0000 7 no
GO:0006357 regulation of transcription by RNA polymerase II 40.0000 8 no
GO:0009890 negative regulation of biosynthetic process 40.0000 5 no
GO:0009968 negative regulation of signal transduction 40.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0010648 negative regulation of cell communication 40.0000 5 no
GO:0023057 negative regulation of signaling 40.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 40.0000 6 no
GO:0042127 regulation of cell population proliferation 40.0000 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0048585 negative regulation of response to stimulus 40.0000 4 no
GO:0051253 negative regulation of RNA metabolic process 40.0000 6 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:1902679 negative regulation of RNA biosynthetic process 30.0000 7 no
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 30.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0042325 regulation of phosphorylation 30.0000 7 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0043085 positive regulation of catalytic activity 30.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0010629 negative regulation of gene expression 30.0000 7 no
GO:0033043 regulation of organelle organization 30.0000 5 yes
GO:0044087 regulation of cellular component biogenesis 30.0000 4 yes
GO:0097435 supramolecular fiber organization 30.0000 4 yes
GO:0015031 protein transport 30.0000 4 no
GO:0036211 protein modification process 30.0000 4 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0071705 nitrogen compound transport 30.0000 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 30.0000 9 no
GO:0007268 chemical synaptic transmission 30.0000 7 no
GO:0008285 negative regulation of cell population proliferation 30.0000 5 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 30.0000 4 no
GO:0043113 receptor clustering 30.0000 5 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 30.0000 5 no
GO:0045892 negative regulation of DNA-templated transcription 30.0000 8 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0051130 positive regulation of cellular component organization 30.0000 5 no
GO:0072657 protein localization to membrane 30.0000 4 no
GO:0098916 anterograde trans-synaptic signaling 30.0000 6 no
GO:0099536 synaptic signaling 30.0000 4 no
GO:0099537 trans-synaptic signaling 30.0000 5 no
GO:1902532 negative regulation of intracellular signal transduction 30.0000 6 no
GO:0016070 RNA metabolic process 20.0000 5 yes
GO:0031122 cytoplasmic microtubule organization 20.0000 4 yes
GO:0032880 regulation of protein localization 20.0000 5 yes
GO:0060341 regulation of cellular localization 20.0000 4 yes
GO:0090304 nucleic acid metabolic process 20.0000 4 yes
GO:1905475 regulation of protein localization to membrane 20.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
MED23_HUMAN [view interactions] High throughput no no
ITF2_HUMAN [view interactions] High throughput no yes
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC7_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
UBE2O_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
CZIB_HUMAN [view interactions] High throughput no no
CCD25_HUMAN [view interactions] High throughput no yes
RYR1_HUMAN [view interactions] High throughput no no
UBQL4_HUMAN [view interactions] High throughput no yes
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
THOC2_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
C170L_HUMAN [view entry] [view interactions] High throughput yes no
MORC3_HUMAN [view interactions] High throughput no yes
CCNA2_HUMAN [view interactions] High throughput no no
TZAP_HUMAN [view interactions] High throughput no no
NALP2_HUMAN [view interactions] High throughput no no
GRHL1_HUMAN [view interactions] High throughput no yes