Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHSA9_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHSA9_HUMAN
GO:0005216 ion channel activity 37.5000 4 no
GO:0005261 cation channel activity 37.5000 5 no
GO:0008324 cation transmembrane transporter activity 37.5000 4 no
GO:0015267 channel activity 37.5000 4 no
GO:0022836 gated channel activity 37.5000 5 no
GO:0022890 inorganic cation transmembrane transporter activity 37.5000 4 no
GO:0019900 kinase binding 31.2500 4 no
GO:0001540 amyloid-beta binding 25.0000 4 no
GO:0004970 ionotropic glutamate receptor activity 25.0000 5 no
GO:0004971 AMPA glutamate receptor activity 25.0000 6 no
GO:0005230 extracellular ligand-gated ion channel activity 25.0000 6 no
GO:0008066 glutamate receptor activity 25.0000 4 no
GO:0015276 ligand-gated ion channel activity 25.0000 5 no
GO:0022824 transmitter-gated ion channel activity 25.0000 5 no
GO:0022834 ligand-gated channel activity 25.0000 6 no
GO:0022835 transmitter-gated channel activity 25.0000 4 no
GO:0099094 ligand-gated cation channel activity 25.0000 6 no
GO:0030165 PDZ domain binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SHSA9_HUMAN
GO:0010646 regulation of cell communication 56.2500 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0009966 regulation of signal transduction 43.7500 4 yes
GO:0022898 regulation of transmembrane transporter activity 43.7500 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 43.7500 5 yes
GO:0034762 regulation of transmembrane transport 43.7500 4 yes
GO:0034765 regulation of ion transmembrane transport 43.7500 5 yes
GO:0043269 regulation of ion transport 43.7500 5 yes
GO:0050804 modulation of chemical synaptic transmission 43.7500 5 yes
GO:0099177 regulation of trans-synaptic signaling 43.7500 4 yes
GO:1904062 regulation of cation transmembrane transport 43.7500 6 yes
GO:2001257 regulation of cation channel activity 43.7500 6 yes
GO:0008104 protein localization 43.7500 4 no
GO:0048522 positive regulation of cellular process 43.7500 4 no
GO:0099601 regulation of neurotransmitter receptor activity 37.5000 4 yes
GO:0072657 protein localization to membrane 37.5000 4 no
GO:0007268 chemical synaptic transmission 37.5000 6 no
GO:0098916 anterograde trans-synaptic signaling 37.5000 5 no
GO:0099537 trans-synaptic signaling 37.5000 4 no
GO:0016192 vesicle-mediated transport 37.5000 4 no
GO:2000311 regulation of AMPA receptor activity 31.2500 5 yes
GO:0051128 regulation of cellular component organization 31.2500 4 no
GO:0043113 receptor clustering 31.2500 5 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:0071702 organic substance transport 31.2500 4 no
GO:0071705 nitrogen compound transport 31.2500 4 no
GO:0044057 regulation of system process 25.0000 4 yes
GO:0006996 organelle organization 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0035418 protein localization to synapse 25.0000 6 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:1902414 protein localization to cell junction 25.0000 5 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0031644 regulation of nervous system process 18.7500 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 12.5000 4 yes
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 12.5000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CK087_HUMAN [view interactions] Low throughput no yes
GCP60_HUMAN [view interactions] Low throughput no yes
ATRN_HUMAN [view interactions] Low throughput no yes
CKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
CXXC5_HUMAN [view interactions] Low throughput no yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
HM20A_HUMAN [view interactions] Low throughput no yes
HTRA1_HUMAN [view interactions] Low throughput no yes
KHDR1_HUMAN [view interactions] Low throughput no yes
LNX1_HUMAN [view interactions] Low throughput no yes
LNX2_HUMAN [view interactions] Low throughput no yes
MAGI1_HUMAN [view interactions] Low throughput no no
MAGI3_HUMAN [view interactions] Low throughput no no
M3K9_HUMAN [view interactions] Low throughput no yes
AFAD_HUMAN [view interactions] Low throughput no yes
PALS1_HUMAN [view interactions] Low throughput no no
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
RBM4B_HUMAN [view interactions] Low throughput no yes
TAF1_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] Low throughput no yes
TTC13_HUMAN [view interactions] Low throughput no no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
CNIH3_HUMAN [view entry] [view interactions] Computational yes no
CCG8_HUMAN [view entry] [view interactions] Computational yes no
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no
CNIH2_HUMAN [view entry] [view interactions] Computational yes no
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes