SHSA9_HUMAN
Evidence for PS localization
Functions
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SHSA9_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 50.0000 | 4 | no |
| GO:0030165 | PDZ domain binding | 33.3333 | 4 | yes |
| GO:0045296 | cadherin binding | 33.3333 | 4 | no |
| GO:0019902 | phosphatase binding | 25.0000 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 25.0000 | 4 | no |
| GO:0003779 | actin binding | 25.0000 | 4 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SHSA9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 7 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 6 | no |
| GO:0099536 | synaptic signaling | 50.0000 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 5 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0072657 | protein localization to membrane | 50.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 41.6667 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 41.6667 | 4 | yes |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0043933 | protein-containing complex organization | 41.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.6667 | 4 | no |
| GO:0043113 | receptor clustering | 41.6667 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 33.3333 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 33.3333 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 33.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 33.3333 | 4 | no |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 33.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0032271 | regulation of protein polymerization | 25.0000 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 25.0000 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 25.0000 | 4 | no |
| GO:0034329 | cell junction assembly | 25.0000 | 5 | no |
| GO:0034330 | cell junction organization | 25.0000 | 4 | no |
| GO:0035418 | protein localization to synapse | 25.0000 | 6 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 25.0000 | 6 | no |
| GO:1902414 | protein localization to cell junction | 25.0000 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 25.0000 | 5 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CK087_HUMAN | [view interactions] | Low throughput | no | yes |
| GCP60_HUMAN | [view interactions] | Low throughput | no | yes |
| ATRN_HUMAN | [view interactions] | Low throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CXXC5_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HM20A_HUMAN | [view interactions] | Low throughput | no | yes |
| HTRA1_HUMAN | [view interactions] | Low throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | Low throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LNX2_HUMAN | [view interactions] | Low throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | Low throughput | no | no |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| M3K9_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PALS1_HUMAN | [view interactions] | Low throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBM4B_HUMAN | [view interactions] | Low throughput | no | yes |
| TAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| TTC13_HUMAN | [view interactions] | Low throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |