Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CRFR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CRFR1_HUMAN
GO:0019900 kinase binding 38.0952 4 no
GO:0001664 G protein-coupled receptor binding 38.0952 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0003924 GTPase activity 23.8095 7 no
GO:0016462 pyrophosphatase activity 23.8095 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.8095 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.8095 6 no
GO:0004930 G protein-coupled receptor activity 9.5238 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CRFR1_HUMAN
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0010646 regulation of cell communication 61.9048 4 yes
GO:0051049 regulation of transport 61.9048 4 yes
GO:0031323 regulation of cellular metabolic process 61.9048 4 no
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0009966 regulation of signal transduction 57.1429 4 no
GO:0009893 positive regulation of metabolic process 52.3810 4 no
GO:0031325 positive regulation of cellular metabolic process 52.3810 5 no
GO:0080090 regulation of primary metabolic process 52.3810 4 no
GO:1902531 regulation of intracellular signal transduction 47.6190 5 no
GO:0043085 positive regulation of catalytic activity 47.6190 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 47.6190 5 no
GO:0019220 regulation of phosphate metabolic process 47.6190 6 no
GO:0031399 regulation of protein modification process 47.6190 6 no
GO:0051174 regulation of phosphorus metabolic process 47.6190 5 no
GO:0051246 regulation of protein metabolic process 47.6190 5 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0008104 protein localization 42.8571 4 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 38.0952 4 yes
GO:0034762 regulation of transmembrane transport 38.0952 4 yes
GO:0043269 regulation of monoatomic ion transport 38.0952 5 yes
GO:0001934 positive regulation of protein phosphorylation 38.0952 8 no
GO:0042327 positive regulation of phosphorylation 38.0952 8 no
GO:0009892 negative regulation of metabolic process 38.0952 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.0952 5 no
GO:0031324 negative regulation of cellular metabolic process 38.0952 5 no
GO:0051050 positive regulation of transport 38.0952 4 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0051726 regulation of cell cycle 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0010959 regulation of metal ion transport 33.3333 6 yes
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 33.3333 5 yes
GO:0044057 regulation of system process 33.3333 4 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 28.5714 5 yes
GO:0051924 regulation of calcium ion transport 28.5714 7 yes
GO:0071310 cellular response to organic substance 28.5714 4 yes
GO:0071702 organic substance transport 28.5714 4 yes
GO:0071705 nitrogen compound transport 28.5714 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 28.5714 6 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0043113 receptor clustering 28.5714 5 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0010564 regulation of cell cycle process 28.5714 5 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0090257 regulation of muscle system process 23.8095 5 no
GO:0015031 protein transport 23.8095 4 no
GO:0002090 regulation of receptor internalization 23.8095 7 no
GO:0009889 regulation of biosynthetic process 23.8095 4 no
GO:0010468 regulation of gene expression 23.8095 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.8095 5 no
GO:0030100 regulation of endocytosis 23.8095 5 no
GO:0031326 regulation of cellular biosynthetic process 23.8095 5 no
GO:0048259 regulation of receptor-mediated endocytosis 23.8095 6 no
GO:0043408 regulation of MAPK cascade 23.8095 6 no
GO:0070372 regulation of ERK1 and ERK2 cascade 23.8095 7 no
GO:0010243 response to organonitrogen compound 23.8095 4 yes
GO:0032410 negative regulation of transporter activity 23.8095 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 23.8095 5 yes
GO:0034763 negative regulation of transmembrane transport 23.8095 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 23.8095 6 yes
GO:0043271 negative regulation of monoatomic ion transport 23.8095 5 yes
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 23.8095 7 yes
GO:2001257 regulation of cation channel activity 23.8095 6 yes
GO:0008285 negative regulation of cell population proliferation 23.8095 5 no
GO:0033674 positive regulation of kinase activity 23.8095 6 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 23.8095 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 23.8095 5 no
GO:0045860 positive regulation of protein kinase activity 23.8095 7 no
GO:0051347 positive regulation of transferase activity 23.8095 5 no
GO:0001933 negative regulation of protein phosphorylation 23.8095 8 no
GO:0006937 regulation of muscle contraction 23.8095 6 no
GO:0010038 response to metal ion 23.8095 4 no
GO:0010563 negative regulation of phosphorus metabolic process 23.8095 6 no
GO:0042326 negative regulation of phosphorylation 23.8095 8 no
GO:0043270 positive regulation of monoatomic ion transport 23.8095 5 no
GO:0045936 negative regulation of phosphate metabolic process 23.8095 7 no
GO:0032870 cellular response to hormone stimulus 19.0476 4 yes
GO:0051926 negative regulation of calcium ion transport 19.0476 6 yes
GO:0071417 cellular response to organonitrogen compound 19.0476 4 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 19.0476 6 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 19.0476 6 yes
GO:1901699 cellular response to nitrogen compound 19.0476 4 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 19.0476 7 yes
GO:1904063 negative regulation of cation transmembrane transport 19.0476 7 yes
GO:2001258 negative regulation of cation channel activity 19.0476 6 yes
GO:0043434 response to peptide hormone 14.2857 4 yes
GO:0051046 regulation of secretion 14.2857 5 yes
GO:1901385 regulation of voltage-gated calcium channel activity 14.2857 7 yes
GO:1901386 negative regulation of voltage-gated calcium channel activity 14.2857 7 yes
GO:1903530 regulation of secretion by cell 14.2857 4 yes
GO:0031279 regulation of cyclase activity 9.5238 4 yes
GO:0045761 regulation of adenylate cyclase activity 9.5238 5 yes
GO:0046883 regulation of hormone secretion 9.5238 4 yes
GO:0051339 regulation of lyase activity 9.5238 4 yes
GO:0071375 cellular response to peptide hormone stimulus 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
UCN1_HUMAN [view interactions] Low throughput no yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
CRF_HUMAN [view interactions] Low throughput no no
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI1_HUMAN [view interactions] Low throughput no no
MAGI3_HUMAN [view interactions] Low throughput no no
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN13_HUMAN [view interactions] Low throughput no yes
NHRF3_HUMAN [view interactions] Low throughput no no
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPER1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no