GPER1_HUMAN
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GPER1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 50.0000 | 4 | no |
GO:0019900 | kinase binding | 50.0000 | 4 | no |
GO:0019901 | protein kinase binding | 50.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
GO:0001664 | G protein-coupled receptor binding | 37.5000 | 4 | no |
GO:0004930 | G protein-coupled receptor activity | 25.0000 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 25.0000 | 4 | no |
GO:0004713 | protein tyrosine kinase activity | 25.0000 | 4 | no |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 25.0000 | 5 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0016301 | kinase activity | 25.0000 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.0000 | 4 | no |
GO:0019902 | phosphatase binding | 25.0000 | 4 | no |
GO:0019903 | protein phosphatase binding | 25.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
GO:0042169 | SH2 domain binding | 25.0000 | 4 | no |
GO:0030165 | PDZ domain binding | 25.0000 | 4 | no |
GO:0031690 | adrenergic receptor binding | 25.0000 | 5 | no |
GO:0031698 | beta-2 adrenergic receptor binding | 25.0000 | 6 | no |
GO:0031748 | D1 dopamine receptor binding | 25.0000 | 6 | no |
GO:0035254 | glutamate receptor binding | 25.0000 | 4 | no |
GO:0035255 | ionotropic glutamate receptor binding | 25.0000 | 5 | no |
GO:0050780 | dopamine receptor binding | 25.0000 | 5 | no |
GO:0003924 | GTPase activity | 25.0000 | 7 | no |
GO:0005525 | GTP binding | 25.0000 | 5 | no |
GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 25.0000 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 25.0000 | 5 | no |
GO:0046872 | metal ion binding | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GPER1_HUMAN |
---|---|---|---|---|
GO:0009966 | regulation of signal transduction | 87.5000 | 4 | yes |
GO:0010646 | regulation of cell communication | 87.5000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 75.0000 | 4 | yes |
GO:0031399 | regulation of protein modification process | 75.0000 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 75.0000 | 7 | yes |
GO:0043085 | positive regulation of catalytic activity | 75.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 75.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 75.0000 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 75.0000 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 75.0000 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 75.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 75.0000 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 75.0000 | 7 | yes |
GO:0009893 | positive regulation of metabolic process | 75.0000 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 75.0000 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 75.0000 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 75.0000 | 6 | yes |
GO:0023056 | positive regulation of signaling | 75.0000 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 62.5000 | 5 | yes |
GO:0031401 | positive regulation of protein modification process | 62.5000 | 7 | yes |
GO:0043549 | regulation of kinase activity | 62.5000 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 62.5000 | 6 | no |
GO:0051338 | regulation of transferase activity | 62.5000 | 4 | no |
GO:0044057 | regulation of system process | 62.5000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 62.5000 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 62.5000 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 62.5000 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 62.5000 | 6 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 62.5000 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 62.5000 | 5 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 62.5000 | 6 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 62.5000 | 5 | yes |
GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 50.0000 | 4 | yes |
GO:0051347 | positive regulation of transferase activity | 50.0000 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 50.0000 | 8 | yes |
GO:0042981 | regulation of apoptotic process | 50.0000 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 50.0000 | 5 | yes |
GO:0043408 | regulation of MAPK cascade | 50.0000 | 6 | yes |
GO:0043410 | positive regulation of MAPK cascade | 50.0000 | 7 | yes |
GO:0031644 | regulation of nervous system process | 50.0000 | 5 | no |
GO:0045862 | positive regulation of proteolysis | 50.0000 | 7 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 50.0000 | 7 | yes |
GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
GO:0051336 | regulation of hydrolase activity | 50.0000 | 4 | yes |
GO:0051896 | regulation of protein kinase B signaling | 50.0000 | 6 | yes |
GO:0080134 | regulation of response to stress | 50.0000 | 4 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 50.0000 | 8 | yes |
GO:0006996 | organelle organization | 50.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 50.0000 | 6 | yes |
GO:2000145 | regulation of cell motility | 50.0000 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0010941 | regulation of cell death | 50.0000 | 4 | yes |
GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 50.0000 | 6 | yes |
GO:0030162 | regulation of proteolysis | 50.0000 | 6 | yes |
GO:0030334 | regulation of cell migration | 50.0000 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 37.5000 | 5 | no |
GO:0030030 | cell projection organization | 37.5000 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | yes |
GO:0030155 | regulation of cell adhesion | 37.5000 | 4 | no |
GO:0031175 | neuron projection development | 37.5000 | 6 | no |
GO:0033674 | positive regulation of kinase activity | 37.5000 | 6 | no |
GO:0036211 | protein modification process | 37.5000 | 4 | no |
GO:0032102 | negative regulation of response to external stimulus | 37.5000 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 37.5000 | 7 | no |
GO:0032880 | regulation of protein localization | 37.5000 | 5 | yes |
GO:0043069 | negative regulation of programmed cell death | 37.5000 | 6 | no |
GO:0043412 | macromolecule modification | 37.5000 | 4 | no |
GO:0033043 | regulation of organelle organization | 37.5000 | 5 | yes |
GO:0043933 | protein-containing complex organization | 37.5000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 37.5000 | 4 | no |
GO:0045860 | positive regulation of protein kinase activity | 37.5000 | 7 | no |
GO:0040017 | positive regulation of locomotion | 37.5000 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 37.5000 | 4 | yes |
GO:0051893 | regulation of focal adhesion assembly | 37.5000 | 7 | no |
GO:0060548 | negative regulation of cell death | 37.5000 | 5 | no |
GO:0065003 | protein-containing complex assembly | 37.5000 | 5 | no |
GO:0043065 | positive regulation of apoptotic process | 37.5000 | 7 | yes |
GO:0090109 | regulation of cell-substrate junction assembly | 37.5000 | 6 | no |
GO:0043068 | positive regulation of programmed cell death | 37.5000 | 6 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 37.5000 | 5 | no |
GO:0150116 | regulation of cell-substrate junction organization | 37.5000 | 5 | no |
GO:1901888 | regulation of cell junction assembly | 37.5000 | 5 | no |
GO:0007268 | chemical synaptic transmission | 37.5000 | 6 | no |
GO:0031344 | regulation of cell projection organization | 37.5000 | 5 | no |
GO:0045595 | regulation of cell differentiation | 37.5000 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 37.5000 | 5 | no |
GO:0098916 | anterograde trans-synaptic signaling | 37.5000 | 5 | no |
GO:0099537 | trans-synaptic signaling | 37.5000 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 37.5000 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 37.5000 | 5 | no |
GO:0050806 | positive regulation of synaptic transmission | 37.5000 | 5 | yes |
GO:0043086 | negative regulation of catalytic activity | 37.5000 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 37.5000 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 37.5000 | 6 | no |
GO:0051348 | negative regulation of transferase activity | 37.5000 | 5 | no |
GO:0051094 | positive regulation of developmental process | 37.5000 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 37.5000 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 37.5000 | 4 | yes |
GO:0051252 | regulation of RNA metabolic process | 37.5000 | 5 | yes |
GO:0051726 | regulation of cell cycle | 37.5000 | 4 | yes |
GO:0060341 | regulation of cellular localization | 37.5000 | 4 | yes |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 37.5000 | 7 | yes |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 37.5000 | 8 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 37.5000 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 37.5000 | 6 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 37.5000 | 7 | yes |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 37.5000 | 4 | yes |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 37.5000 | 5 | yes |
GO:1903829 | positive regulation of protein localization | 37.5000 | 5 | yes |
GO:0008284 | positive regulation of cell population proliferation | 37.5000 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 37.5000 | 5 | yes |
GO:0010468 | regulation of gene expression | 37.5000 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | yes |
GO:2000147 | positive regulation of cell motility | 37.5000 | 5 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 37.5000 | 6 | yes |
GO:0010648 | negative regulation of cell communication | 37.5000 | 5 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 37.5000 | 5 | yes |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 37.5000 | 6 | yes |
GO:0001952 | regulation of cell-matrix adhesion | 37.5000 | 6 | no |
GO:0010942 | positive regulation of cell death | 37.5000 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 37.5000 | 4 | no |
GO:0007162 | negative regulation of cell adhesion | 37.5000 | 5 | no |
GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 37.5000 | 7 | yes |
GO:0019216 | regulation of lipid metabolic process | 37.5000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.5000 | 5 | yes |
GO:0023057 | negative regulation of signaling | 37.5000 | 4 | yes |
GO:0010632 | regulation of epithelial cell migration | 37.5000 | 4 | no |
GO:0010810 | regulation of cell-substrate adhesion | 37.5000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 37.5000 | 6 | yes |
GO:0030518 | intracellular steroid hormone receptor signaling pathway | 25.0000 | 4 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | yes |
GO:0031347 | regulation of defense response | 25.0000 | 5 | yes |
GO:0031329 | regulation of cellular catabolic process | 25.0000 | 5 | no |
GO:0031348 | negative regulation of defense response | 25.0000 | 5 | yes |
GO:0031331 | positive regulation of cellular catabolic process | 25.0000 | 6 | no |
GO:0032103 | positive regulation of response to external stimulus | 25.0000 | 5 | no |
GO:0031960 | response to corticosteroid | 25.0000 | 5 | yes |
GO:0038093 | Fc receptor signaling pathway | 25.0000 | 5 | no |
GO:0038094 | Fc-gamma receptor signaling pathway | 25.0000 | 6 | no |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 25.0000 | 4 | no |
GO:0038127 | ERBB signaling pathway | 25.0000 | 6 | no |
GO:0032870 | cellular response to hormone stimulus | 25.0000 | 4 | yes |
GO:0043550 | regulation of lipid kinase activity | 25.0000 | 6 | no |
GO:0043551 | regulation of phosphatidylinositol 3-kinase activity | 25.0000 | 7 | no |
GO:0033993 | response to lipid | 25.0000 | 4 | yes |
GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 25.0000 | 7 | no |
GO:0034097 | response to cytokine | 25.0000 | 4 | yes |
GO:0045834 | positive regulation of lipid metabolic process | 25.0000 | 5 | no |
GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | yes |
GO:0046777 | protein autophosphorylation | 25.0000 | 6 | no |
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 25.0000 | 6 | no |
GO:0048013 | ephrin receptor signaling pathway | 25.0000 | 6 | no |
GO:0050776 | regulation of immune response | 25.0000 | 4 | no |
GO:0050778 | positive regulation of immune response | 25.0000 | 5 | no |
GO:0051897 | positive regulation of protein kinase B signaling | 25.0000 | 7 | no |
GO:0061041 | regulation of wound healing | 25.0000 | 6 | no |
GO:0090218 | positive regulation of lipid kinase activity | 25.0000 | 6 | no |
GO:0043269 | regulation of ion transport | 25.0000 | 5 | yes |
GO:1903034 | regulation of response to wounding | 25.0000 | 5 | no |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 25.0000 | 7 | no |
GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 25.0000 | 8 | no |
GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 25.0000 | 8 | yes |
GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 25.0000 | 6 | no |
GO:0043401 | steroid hormone mediated signaling pathway | 25.0000 | 4 | yes |
GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 25.0000 | 7 | no |
GO:2000209 | regulation of anoikis | 25.0000 | 7 | no |
GO:0043409 | negative regulation of MAPK cascade | 25.0000 | 7 | yes |
GO:2000811 | negative regulation of anoikis | 25.0000 | 8 | no |
GO:0043434 | response to peptide hormone | 25.0000 | 4 | yes |
GO:0030100 | regulation of endocytosis | 25.0000 | 5 | no |
GO:0031346 | positive regulation of cell projection organization | 25.0000 | 6 | no |
GO:0045596 | negative regulation of cell differentiation | 25.0000 | 5 | yes |
GO:0032990 | cell part morphogenesis | 25.0000 | 4 | no |
GO:0048812 | neuron projection morphogenesis | 25.0000 | 7 | no |
GO:0048858 | cell projection morphogenesis | 25.0000 | 5 | no |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 25.0000 | 8 | no |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 25.0000 | 9 | no |
GO:0045786 | negative regulation of cell cycle | 25.0000 | 5 | yes |
GO:0050890 | cognition | 25.0000 | 4 | no |
GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 25.0000 | 7 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
GO:0045913 | positive regulation of carbohydrate metabolic process | 25.0000 | 5 | yes |
GO:0060997 | dendritic spine morphogenesis | 25.0000 | 6 | no |
GO:0061097 | regulation of protein tyrosine kinase activity | 25.0000 | 7 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | yes |
GO:0061098 | positive regulation of protein tyrosine kinase activity | 25.0000 | 8 | no |
GO:0097061 | dendritic spine organization | 25.0000 | 5 | no |
GO:0098815 | modulation of excitatory postsynaptic potential | 25.0000 | 4 | no |
GO:0099173 | postsynapse organization | 25.0000 | 4 | no |
GO:0099601 | regulation of neurotransmitter receptor activity | 25.0000 | 4 | no |
GO:0106027 | neuron projection organization | 25.0000 | 6 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 25.0000 | 6 | no |
GO:2000463 | positive regulation of excitatory postsynaptic potential | 25.0000 | 5 | no |
GO:0048545 | response to steroid hormone | 25.0000 | 4 | yes |
GO:0007600 | sensory perception | 25.0000 | 4 | no |
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 25.0000 | 6 | no |
GO:0001933 | negative regulation of protein phosphorylation | 25.0000 | 8 | no |
GO:0048660 | regulation of smooth muscle cell proliferation | 25.0000 | 5 | yes |
GO:0001953 | negative regulation of cell-matrix adhesion | 25.0000 | 7 | no |
GO:0048662 | negative regulation of smooth muscle cell proliferation | 25.0000 | 6 | yes |
GO:0006469 | negative regulation of protein kinase activity | 25.0000 | 7 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
GO:0010812 | negative regulation of cell-substrate adhesion | 25.0000 | 6 | no |
GO:0050727 | regulation of inflammatory response | 25.0000 | 5 | yes |
GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
GO:0050728 | negative regulation of inflammatory response | 25.0000 | 6 | yes |
GO:0033673 | negative regulation of kinase activity | 25.0000 | 6 | no |
GO:0050767 | regulation of neurogenesis | 25.0000 | 6 | yes |
GO:0034329 | cell junction assembly | 25.0000 | 5 | no |
GO:0034330 | cell junction organization | 25.0000 | 4 | no |
GO:0036293 | response to decreased oxygen levels | 25.0000 | 4 | no |
GO:0036294 | cellular response to decreased oxygen levels | 25.0000 | 5 | no |
GO:0042326 | negative regulation of phosphorylation | 25.0000 | 8 | no |
GO:0050865 | regulation of cell activation | 25.0000 | 4 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
GO:0050821 | protein stabilization | 25.0000 | 4 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | yes |
GO:0051895 | negative regulation of focal adhesion assembly | 25.0000 | 7 | no |
GO:0071257 | cellular response to electrical stimulus | 25.0000 | 4 | no |
GO:0051093 | negative regulation of developmental process | 25.0000 | 4 | yes |
GO:0071453 | cellular response to oxygen levels | 25.0000 | 4 | no |
GO:0071456 | cellular response to hypoxia | 25.0000 | 4 | no |
GO:0071900 | regulation of protein serine/threonine kinase activity | 25.0000 | 7 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
GO:0150118 | negative regulation of cell-substrate junction organization | 25.0000 | 6 | no |
GO:1901889 | negative regulation of cell junction assembly | 25.0000 | 6 | no |
GO:1904029 | regulation of cyclin-dependent protein kinase activity | 25.0000 | 5 | no |
GO:0007215 | glutamate receptor signaling pathway | 25.0000 | 4 | no |
GO:0030111 | regulation of Wnt signaling pathway | 25.0000 | 5 | no |
GO:0060828 | regulation of canonical Wnt signaling pathway | 25.0000 | 6 | no |
GO:0051222 | positive regulation of protein transport | 25.0000 | 5 | yes |
GO:0051223 | regulation of protein transport | 25.0000 | 5 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | yes |
GO:0051345 | positive regulation of hydrolase activity | 25.0000 | 5 | yes |
GO:0051385 | response to mineralocorticoid | 25.0000 | 6 | yes |
GO:0051898 | negative regulation of protein kinase B signaling | 25.0000 | 7 | yes |
GO:0051960 | regulation of nervous system development | 25.0000 | 5 | yes |
GO:0052547 | regulation of peptidase activity | 25.0000 | 5 | yes |
GO:0052548 | regulation of endopeptidase activity | 25.0000 | 6 | yes |
GO:0060284 | regulation of cell development | 25.0000 | 5 | yes |
GO:0061024 | membrane organization | 25.0000 | 4 | yes |
GO:0062012 | regulation of small molecule metabolic process | 25.0000 | 4 | yes |
GO:0062013 | positive regulation of small molecule metabolic process | 25.0000 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | yes |
GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 25.0000 | 8 | yes |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 25.0000 | 5 | yes |
GO:0071383 | cellular response to steroid hormone stimulus | 25.0000 | 5 | yes |
GO:0071396 | cellular response to lipid | 25.0000 | 5 | yes |
GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | yes |
GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | yes |
GO:0001508 | action potential | 25.0000 | 4 | yes |
GO:0002683 | negative regulation of immune system process | 25.0000 | 4 | yes |
GO:0002694 | regulation of leukocyte activation | 25.0000 | 4 | yes |
GO:1901652 | response to peptide | 25.0000 | 4 | yes |
GO:1901653 | cellular response to peptide | 25.0000 | 5 | yes |
GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | yes |
GO:0003018 | vascular process in circulatory system | 25.0000 | 4 | yes |
GO:0006109 | regulation of carbohydrate metabolic process | 25.0000 | 5 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 25.0000 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 25.0000 | 8 | yes |
GO:0008285 | negative regulation of cell population proliferation | 25.0000 | 5 | yes |
GO:1904062 | regulation of cation transmembrane transport | 25.0000 | 6 | yes |
GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | yes |
GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 25.0000 | 6 | yes |
GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation | 25.0000 | 7 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 25.0000 | 6 | yes |
GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | yes |
GO:1905475 | regulation of protein localization to membrane | 25.0000 | 6 | yes |
GO:1905477 | positive regulation of protein localization to membrane | 25.0000 | 6 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | yes |
GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | yes |
GO:2000116 | regulation of cysteine-type endopeptidase activity | 25.0000 | 7 | yes |
GO:0010564 | regulation of cell cycle process | 25.0000 | 5 | yes |
GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | yes |
GO:0010638 | positive regulation of organelle organization | 25.0000 | 6 | yes |
GO:0010675 | regulation of cellular carbohydrate metabolic process | 25.0000 | 5 | yes |
GO:2001235 | positive regulation of apoptotic signaling pathway | 25.0000 | 6 | yes |
GO:0010676 | positive regulation of cellular carbohydrate metabolic process | 25.0000 | 6 | yes |
GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 25.0000 | 7 | yes |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 25.0000 | 4 | no |
GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 25.0000 | 5 | no |
GO:0002684 | positive regulation of immune system process | 25.0000 | 4 | no |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 25.0000 | 4 | no |
GO:0010948 | negative regulation of cell cycle process | 25.0000 | 6 | yes |
GO:0006468 | protein phosphorylation | 25.0000 | 5 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.0000 | 5 | no |
GO:0007172 | signal complex assembly | 25.0000 | 5 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | yes |
GO:0007173 | epidermal growth factor receptor signaling pathway | 25.0000 | 7 | no |
GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 25.0000 | 5 | no |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 25.0000 | 6 | no |
GO:0007229 | integrin-mediated signaling pathway | 25.0000 | 4 | no |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0009896 | positive regulation of catabolic process | 25.0000 | 5 | no |
GO:0016310 | phosphorylation | 25.0000 | 5 | no |
GO:0018108 | peptidyl-tyrosine phosphorylation | 25.0000 | 6 | no |
GO:0018193 | peptidyl-amino acid modification | 25.0000 | 5 | no |
GO:0018212 | peptidyl-tyrosine modification | 25.0000 | 6 | no |
GO:0022407 | regulation of cell-cell adhesion | 25.0000 | 5 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ESR1_HUMAN | [view interactions] | Low throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PAQR8_HUMAN | [view interactions] | Low throughput | no | no |
CRFR1_HUMAN | [view interactions] | Low throughput | no | yes |
5HT1A_HUMAN | [view interactions] | Low throughput | no | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTTG1_HUMAN | [view interactions] | High throughput | no | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
GPR61_HUMAN | [view interactions] | Computational | no | yes |
GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ESR2_HUMAN | [view interactions] | Computational | no | no |
GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EGFR_HUMAN | [view interactions] | Computational | no | no |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GPR62_HUMAN | [view interactions] | Computational | no | no |