GPER1_HUMAN
Evidence for PS localization
Functions
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPER1_HUMAN |
|---|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | 50.0000 | 4 | yes |
| GO:0030165 | PDZ domain binding | 50.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPER1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 100.0000 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 100.0000 | 4 | yes |
| GO:0044057 | regulation of system process | 100.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 100.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 100.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 75.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 75.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 75.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 75.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 75.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 75.0000 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 75.0000 | 4 | yes |
| GO:0051051 | negative regulation of transport | 75.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 75.0000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 75.0000 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 75.0000 | 7 | yes |
| GO:0034762 | regulation of transmembrane transport | 75.0000 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 75.0000 | 7 | yes |
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 75.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 75.0000 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 75.0000 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 75.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 75.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 75.0000 | 6 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 75.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 75.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 75.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 75.0000 | 7 | yes |
| GO:0006996 | organelle organization | 75.0000 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 50.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 50.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 50.0000 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 50.0000 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 50.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 50.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 50.0000 | 6 | yes |
| GO:0010564 | regulation of cell cycle process | 50.0000 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 50.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 50.0000 | 5 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 50.0000 | 5 | no |
| GO:0010948 | negative regulation of cell cycle process | 50.0000 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 50.0000 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 50.0000 | 4 | yes |
| GO:0030162 | regulation of proteolysis | 50.0000 | 6 | yes |
| GO:0030334 | regulation of cell migration | 50.0000 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 50.0000 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 50.0000 | 5 | yes |
| GO:0032870 | cellular response to hormone stimulus | 50.0000 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 50.0000 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 50.0000 | 4 | yes |
| GO:0042327 | positive regulation of phosphorylation | 50.0000 | 8 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 50.0000 | 5 | yes |
| GO:0043434 | response to peptide hormone | 50.0000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 50.0000 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 50.0000 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
| GO:0030030 | cell projection organization | 50.0000 | 4 | no |
| GO:0045786 | negative regulation of cell cycle | 50.0000 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 50.0000 | 7 | yes |
| GO:0031175 | neuron projection development | 50.0000 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 50.0000 | 7 | yes |
| GO:0031644 | regulation of nervous system process | 50.0000 | 5 | no |
| GO:0046883 | regulation of hormone secretion | 50.0000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 50.0000 | 4 | yes |
| GO:0048660 | regulation of smooth muscle cell proliferation | 50.0000 | 5 | yes |
| GO:0048662 | negative regulation of smooth muscle cell proliferation | 50.0000 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 50.0000 | 5 | no |
| GO:0050767 | regulation of neurogenesis | 50.0000 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 50.0000 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 50.0000 | 6 | no |
| GO:0051046 | regulation of secretion | 50.0000 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 50.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 50.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 50.0000 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 50.0000 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 50.0000 | 4 | yes |
| GO:0050890 | cognition | 50.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 50.0000 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 50.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 50.0000 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 50.0000 | 5 | no |
| GO:0051726 | regulation of cell cycle | 50.0000 | 4 | yes |
| GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 50.0000 | 6 | yes |
| GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 50.0000 | 7 | yes |
| GO:0051924 | regulation of calcium ion transport | 50.0000 | 7 | yes |
| GO:0060997 | dendritic spine morphogenesis | 50.0000 | 6 | no |
| GO:0051960 | regulation of nervous system development | 50.0000 | 5 | yes |
| GO:0060284 | regulation of cell development | 50.0000 | 5 | yes |
| GO:0061024 | membrane organization | 50.0000 | 4 | yes |
| GO:0097061 | dendritic spine organization | 50.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 50.0000 | 4 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 50.0000 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 6 | no |
| GO:0099173 | postsynapse organization | 50.0000 | 4 | no |
| GO:0099536 | synaptic signaling | 50.0000 | 4 | no |
| GO:0071375 | cellular response to peptide hormone stimulus | 50.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 5 | no |
| GO:0106027 | neuron projection organization | 50.0000 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 50.0000 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 50.0000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 50.0000 | 4 | yes |
| GO:0080134 | regulation of response to stress | 50.0000 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 50.0000 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 50.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 50.0000 | 5 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 50.0000 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 50.0000 | 8 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 50.0000 | 7 | yes |
| GO:1903530 | regulation of secretion by cell | 50.0000 | 4 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 50.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 50.0000 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 50.0000 | 6 | yes |
| GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 50.0000 | 6 | yes |
| GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation | 50.0000 | 7 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 50.0000 | 4 | yes |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 50.0000 | 5 | yes |
| GO:0007399 | nervous system development | 50.0000 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 50.0000 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 50.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAQR8_HUMAN | [view interactions] | Low throughput | no | no |
| CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 5HT1A_HUMAN | [view interactions] | Low throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTTG1_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |