Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GPER1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GPER1_HUMAN
GO:0017076 purine nucleotide binding 50.0000 4 no
GO:0019900 kinase binding 50.0000 4 no
GO:0019901 protein kinase binding 50.0000 5 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0001664 G protein-coupled receptor binding 37.5000 4 no
GO:0004930 G protein-coupled receptor activity 25.0000 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.0000 4 no
GO:0004713 protein tyrosine kinase activity 25.0000 4 no
GO:0004715 non-membrane spanning protein tyrosine kinase activity 25.0000 5 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0019902 phosphatase binding 25.0000 4 no
GO:0019903 protein phosphatase binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0042169 SH2 domain binding 25.0000 4 no
GO:0030165 PDZ domain binding 25.0000 4 no
GO:0031690 adrenergic receptor binding 25.0000 5 no
GO:0031698 beta-2 adrenergic receptor binding 25.0000 6 no
GO:0031748 D1 dopamine receptor binding 25.0000 6 no
GO:0035254 glutamate receptor binding 25.0000 4 no
GO:0035255 ionotropic glutamate receptor binding 25.0000 5 no
GO:0050780 dopamine receptor binding 25.0000 5 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019001 guanyl nucleotide binding 25.0000 5 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0046872 metal ion binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in GPER1_HUMAN
GO:0009966 regulation of signal transduction 87.5000 4 yes
GO:0010646 regulation of cell communication 87.5000 4 yes
GO:0031323 regulation of cellular metabolic process 75.0000 4 yes
GO:0031399 regulation of protein modification process 75.0000 6 yes
GO:0042325 regulation of phosphorylation 75.0000 7 yes
GO:0043085 positive regulation of catalytic activity 75.0000 4 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0048584 positive regulation of response to stimulus 75.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 75.0000 4 yes
GO:0051174 regulation of phosphorus metabolic process 75.0000 5 yes
GO:0051246 regulation of protein metabolic process 75.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0080090 regulation of primary metabolic process 75.0000 4 yes
GO:0001932 regulation of protein phosphorylation 75.0000 7 yes
GO:0009893 positive regulation of metabolic process 75.0000 4 yes
GO:0009967 positive regulation of signal transduction 75.0000 5 yes
GO:0010647 positive regulation of cell communication 75.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 75.0000 6 yes
GO:0023056 positive regulation of signaling 75.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 yes
GO:0031401 positive regulation of protein modification process 62.5000 7 yes
GO:0043549 regulation of kinase activity 62.5000 5 no
GO:0045859 regulation of protein kinase activity 62.5000 6 no
GO:0051338 regulation of transferase activity 62.5000 4 no
GO:0044057 regulation of system process 62.5000 4 yes
GO:0050804 modulation of chemical synaptic transmission 62.5000 5 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 62.5000 5 yes
GO:0051247 positive regulation of protein metabolic process 62.5000 6 yes
GO:0099177 regulation of trans-synaptic signaling 62.5000 4 yes
GO:1902531 regulation of intracellular signal transduction 62.5000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 62.5000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0032101 regulation of response to external stimulus 50.0000 4 yes
GO:0051347 positive regulation of transferase activity 50.0000 5 no
GO:0042327 positive regulation of phosphorylation 50.0000 8 yes
GO:0042981 regulation of apoptotic process 50.0000 6 yes
GO:0043067 regulation of programmed cell death 50.0000 5 yes
GO:0043408 regulation of MAPK cascade 50.0000 6 yes
GO:0043410 positive regulation of MAPK cascade 50.0000 7 yes
GO:0031644 regulation of nervous system process 50.0000 5 no
GO:0045862 positive regulation of proteolysis 50.0000 7 yes
GO:0045937 positive regulation of phosphate metabolic process 50.0000 7 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0051336 regulation of hydrolase activity 50.0000 4 yes
GO:0051896 regulation of protein kinase B signaling 50.0000 6 yes
GO:0080134 regulation of response to stress 50.0000 4 yes
GO:0001934 positive regulation of protein phosphorylation 50.0000 8 yes
GO:0006996 organelle organization 50.0000 4 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 50.0000 6 yes
GO:2000145 regulation of cell motility 50.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010941 regulation of cell death 50.0000 4 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 50.0000 6 yes
GO:0030162 regulation of proteolysis 50.0000 6 yes
GO:0030334 regulation of cell migration 50.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0022604 regulation of cell morphogenesis 37.5000 5 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 yes
GO:0030155 regulation of cell adhesion 37.5000 4 no
GO:0031175 neuron projection development 37.5000 6 no
GO:0033674 positive regulation of kinase activity 37.5000 6 no
GO:0036211 protein modification process 37.5000 4 no
GO:0032102 negative regulation of response to external stimulus 37.5000 5 yes
GO:0043066 negative regulation of apoptotic process 37.5000 7 no
GO:0032880 regulation of protein localization 37.5000 5 yes
GO:0043069 negative regulation of programmed cell death 37.5000 6 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0043933 protein-containing complex organization 37.5000 4 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0045860 positive regulation of protein kinase activity 37.5000 7 no
GO:0040017 positive regulation of locomotion 37.5000 4 yes
GO:0042127 regulation of cell population proliferation 37.5000 4 yes
GO:0051893 regulation of focal adhesion assembly 37.5000 7 no
GO:0060548 negative regulation of cell death 37.5000 5 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0043065 positive regulation of apoptotic process 37.5000 7 yes
GO:0090109 regulation of cell-substrate junction assembly 37.5000 6 no
GO:0043068 positive regulation of programmed cell death 37.5000 6 yes
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0150116 regulation of cell-substrate junction organization 37.5000 5 no
GO:1901888 regulation of cell junction assembly 37.5000 5 no
GO:0007268 chemical synaptic transmission 37.5000 6 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0045595 regulation of cell differentiation 37.5000 4 yes
GO:0051129 negative regulation of cellular component organization 37.5000 5 no
GO:0098916 anterograde trans-synaptic signaling 37.5000 5 no
GO:0099537 trans-synaptic signaling 37.5000 4 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 yes
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0050806 positive regulation of synaptic transmission 37.5000 5 yes
GO:0043086 negative regulation of catalytic activity 37.5000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051248 negative regulation of protein metabolic process 37.5000 6 no
GO:0051348 negative regulation of transferase activity 37.5000 5 no
GO:0051094 positive regulation of developmental process 37.5000 4 yes
GO:0051130 positive regulation of cellular component organization 37.5000 5 yes
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 yes
GO:0051252 regulation of RNA metabolic process 37.5000 5 yes
GO:0051726 regulation of cell cycle 37.5000 4 yes
GO:0060341 regulation of cellular localization 37.5000 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 37.5000 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 37.5000 8 yes
GO:1902532 negative regulation of intracellular signal transduction 37.5000 6 yes
GO:0006355 regulation of DNA-templated transcription 37.5000 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 37.5000 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 37.5000 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 37.5000 5 yes
GO:1903829 positive regulation of protein localization 37.5000 5 yes
GO:0008284 positive regulation of cell population proliferation 37.5000 5 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 yes
GO:0009968 negative regulation of signal transduction 37.5000 5 yes
GO:0010468 regulation of gene expression 37.5000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 yes
GO:2000147 positive regulation of cell motility 37.5000 5 yes
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 yes
GO:0010648 negative regulation of cell communication 37.5000 5 yes
GO:2001233 regulation of apoptotic signaling pathway 37.5000 5 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 37.5000 6 yes
GO:0001952 regulation of cell-matrix adhesion 37.5000 6 no
GO:0010942 positive regulation of cell death 37.5000 5 yes
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0007162 negative regulation of cell adhesion 37.5000 5 no
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 37.5000 7 yes
GO:0019216 regulation of lipid metabolic process 37.5000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 yes
GO:0023057 negative regulation of signaling 37.5000 4 yes
GO:0010632 regulation of epithelial cell migration 37.5000 4 no
GO:0010810 regulation of cell-substrate adhesion 37.5000 5 no
GO:0030335 positive regulation of cell migration 37.5000 6 yes
GO:0030518 intracellular steroid hormone receptor signaling pathway 25.0000 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 yes
GO:0031347 regulation of defense response 25.0000 5 yes
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0031348 negative regulation of defense response 25.0000 5 yes
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:0032103 positive regulation of response to external stimulus 25.0000 5 no
GO:0031960 response to corticosteroid 25.0000 5 yes
GO:0038093 Fc receptor signaling pathway 25.0000 5 no
GO:0038094 Fc-gamma receptor signaling pathway 25.0000 6 no
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 25.0000 4 no
GO:0038127 ERBB signaling pathway 25.0000 6 no
GO:0032870 cellular response to hormone stimulus 25.0000 4 yes
GO:0043550 regulation of lipid kinase activity 25.0000 6 no
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 25.0000 7 no
GO:0033993 response to lipid 25.0000 4 yes
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 25.0000 7 no
GO:0034097 response to cytokine 25.0000 4 yes
GO:0045834 positive regulation of lipid metabolic process 25.0000 5 no
GO:0034762 regulation of transmembrane transport 25.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 25.0000 5 yes
GO:0046777 protein autophosphorylation 25.0000 6 no
GO:0048010 vascular endothelial growth factor receptor signaling pathway 25.0000 6 no
GO:0048013 ephrin receptor signaling pathway 25.0000 6 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050778 positive regulation of immune response 25.0000 5 no
GO:0051897 positive regulation of protein kinase B signaling 25.0000 7 no
GO:0061041 regulation of wound healing 25.0000 6 no
GO:0090218 positive regulation of lipid kinase activity 25.0000 6 no
GO:0043269 regulation of ion transport 25.0000 5 yes
GO:1903034 regulation of response to wounding 25.0000 5 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 25.0000 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 25.0000 8 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 25.0000 8 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 25.0000 6 no
GO:0043401 steroid hormone mediated signaling pathway 25.0000 4 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:2000209 regulation of anoikis 25.0000 7 no
GO:0043409 negative regulation of MAPK cascade 25.0000 7 yes
GO:2000811 negative regulation of anoikis 25.0000 8 no
GO:0043434 response to peptide hormone 25.0000 4 yes
GO:0030100 regulation of endocytosis 25.0000 5 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0045596 negative regulation of cell differentiation 25.0000 5 yes
GO:0032990 cell part morphogenesis 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0048858 cell projection morphogenesis 25.0000 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 25.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 no
GO:0045786 negative regulation of cell cycle 25.0000 5 yes
GO:0050890 cognition 25.0000 4 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 7 yes
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0045913 positive regulation of carbohydrate metabolic process 25.0000 5 yes
GO:0060997 dendritic spine morphogenesis 25.0000 6 no
GO:0061097 regulation of protein tyrosine kinase activity 25.0000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 no
GO:0097061 dendritic spine organization 25.0000 5 no
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 no
GO:0099173 postsynapse organization 25.0000 4 no
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 no
GO:2000463 positive regulation of excitatory postsynaptic potential 25.0000 5 no
GO:0048545 response to steroid hormone 25.0000 4 yes
GO:0007600 sensory perception 25.0000 4 no
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 25.0000 6 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0048660 regulation of smooth muscle cell proliferation 25.0000 5 yes
GO:0001953 negative regulation of cell-matrix adhesion 25.0000 7 no
GO:0048662 negative regulation of smooth muscle cell proliferation 25.0000 6 yes
GO:0006469 negative regulation of protein kinase activity 25.0000 7 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010812 negative regulation of cell-substrate adhesion 25.0000 6 no
GO:0050727 regulation of inflammatory response 25.0000 5 yes
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0050728 negative regulation of inflammatory response 25.0000 6 yes
GO:0033673 negative regulation of kinase activity 25.0000 6 no
GO:0050767 regulation of neurogenesis 25.0000 6 yes
GO:0034329 cell junction assembly 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0036293 response to decreased oxygen levels 25.0000 4 no
GO:0036294 cellular response to decreased oxygen levels 25.0000 5 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0050865 regulation of cell activation 25.0000 4 yes
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0050821 protein stabilization 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0051895 negative regulation of focal adhesion assembly 25.0000 7 no
GO:0071257 cellular response to electrical stimulus 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 yes
GO:0071453 cellular response to oxygen levels 25.0000 4 no
GO:0071456 cellular response to hypoxia 25.0000 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 25.0000 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0150118 negative regulation of cell-substrate junction organization 25.0000 6 no
GO:1901889 negative regulation of cell junction assembly 25.0000 6 no
GO:1904029 regulation of cyclin-dependent protein kinase activity 25.0000 5 no
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0060828 regulation of canonical Wnt signaling pathway 25.0000 6 no
GO:0051222 positive regulation of protein transport 25.0000 5 yes
GO:0051223 regulation of protein transport 25.0000 5 yes
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 yes
GO:0051345 positive regulation of hydrolase activity 25.0000 5 yes
GO:0051385 response to mineralocorticoid 25.0000 6 yes
GO:0051898 negative regulation of protein kinase B signaling 25.0000 7 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0052547 regulation of peptidase activity 25.0000 5 yes
GO:0052548 regulation of endopeptidase activity 25.0000 6 yes
GO:0060284 regulation of cell development 25.0000 5 yes
GO:0061024 membrane organization 25.0000 4 yes
GO:0062012 regulation of small molecule metabolic process 25.0000 4 yes
GO:0062013 positive regulation of small molecule metabolic process 25.0000 5 yes
GO:0070201 regulation of establishment of protein localization 25.0000 6 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 25.0000 8 yes
GO:0071310 cellular response to organic substance 25.0000 4 yes
GO:0071375 cellular response to peptide hormone stimulus 25.0000 5 yes
GO:0071383 cellular response to steroid hormone stimulus 25.0000 5 yes
GO:0071396 cellular response to lipid 25.0000 5 yes
GO:0071407 cellular response to organic cyclic compound 25.0000 5 yes
GO:0071417 cellular response to organonitrogen compound 25.0000 4 yes
GO:0001508 action potential 25.0000 4 yes
GO:0002683 negative regulation of immune system process 25.0000 4 yes
GO:0002694 regulation of leukocyte activation 25.0000 4 yes
GO:1901652 response to peptide 25.0000 4 yes
GO:1901653 cellular response to peptide 25.0000 5 yes
GO:1901699 cellular response to nitrogen compound 25.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 yes
GO:0003018 vascular process in circulatory system 25.0000 4 yes
GO:0006109 regulation of carbohydrate metabolic process 25.0000 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 25.0000 8 yes
GO:0008285 negative regulation of cell population proliferation 25.0000 5 yes
GO:1904062 regulation of cation transmembrane transport 25.0000 6 yes
GO:0009890 negative regulation of biosynthetic process 25.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 25.0000 6 yes
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 25.0000 7 yes
GO:1904951 positive regulation of establishment of protein localization 25.0000 6 yes
GO:0010243 response to organonitrogen compound 25.0000 4 yes
GO:1905475 regulation of protein localization to membrane 25.0000 6 yes
GO:1905477 positive regulation of protein localization to membrane 25.0000 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 yes
GO:2000026 regulation of multicellular organismal development 25.0000 4 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 25.0000 7 yes
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0010628 positive regulation of gene expression 25.0000 6 yes
GO:0010638 positive regulation of organelle organization 25.0000 6 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 25.0000 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 25.0000 6 yes
GO:0010676 positive regulation of cellular carbohydrate metabolic process 25.0000 6 yes
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 25.0000 7 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 25.0000 4 no
GO:0002431 Fc receptor mediated stimulatory signaling pathway 25.0000 5 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 25.0000 4 no
GO:0010948 negative regulation of cell cycle process 25.0000 6 yes
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0007172 signal complex assembly 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0007173 epidermal growth factor receptor signaling pathway 25.0000 7 no
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 25.0000 5 no
GO:0007179 transforming growth factor beta receptor signaling pathway 25.0000 6 no
GO:0007229 integrin-mediated signaling pathway 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0018108 peptidyl-tyrosine phosphorylation 25.0000 6 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0018212 peptidyl-tyrosine modification 25.0000 6 no
GO:0022407 regulation of cell-cell adhesion 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ESR1_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
PAQR8_HUMAN [view interactions] Low throughput no no
CRFR1_HUMAN [view interactions] Low throughput no yes
5HT1A_HUMAN [view interactions] Low throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
PTTG1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
GPR61_HUMAN [view interactions] Computational no yes
GRM1_HUMAN [view entry] [view interactions] Computational yes yes
ESR2_HUMAN [view interactions] Computational no no
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
EGFR_HUMAN [view interactions] Computational no no
SRC_HUMAN [view entry] [view interactions] Computational yes no
GPR62_HUMAN [view interactions] Computational no no