Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SLIK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed, PubMed). Suppresses neurite outgrowth . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SLIK2_HUMAN
GO:0019900 kinase binding 42.8571 4 no
GO:0019902 phosphatase binding 28.5714 4 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0003924 GTPase activity 28.5714 7 no
GO:0005525 GTP binding 28.5714 5 no
GO:0016462 pyrophosphatase activity 28.5714 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.5714 6 no
GO:0019001 guanyl nucleotide binding 28.5714 6 no
GO:0019003 GDP binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032561 guanyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SLIK2_HUMAN
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0051094 positive regulation of developmental process 57.1429 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0099536 synaptic signaling 57.1429 4 no
GO:0099537 trans-synaptic signaling 57.1429 5 no
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 42.8571 4 no
GO:0042127 regulation of cell population proliferation 42.8571 4 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0042327 positive regulation of phosphorylation 42.8571 8 no
GO:0043113 receptor clustering 42.8571 5 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 42.8571 5 no
GO:0045937 positive regulation of phosphate metabolic process 42.8571 7 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0072657 protein localization to membrane 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0098916 anterograde trans-synaptic signaling 42.8571 6 no
GO:0051128 regulation of cellular component organization 42.8571 4 yes
GO:0051130 positive regulation of cellular component organization 42.8571 5 yes
GO:0051240 positive regulation of multicellular organismal process 42.8571 4 yes
GO:0051960 regulation of nervous system development 42.8571 5 yes
GO:0051962 positive regulation of nervous system development 42.8571 5 yes
GO:2000026 regulation of multicellular organismal development 42.8571 4 yes
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 no
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 no
GO:0001932 regulation of protein phosphorylation 42.8571 7 no
GO:0001934 positive regulation of protein phosphorylation 42.8571 8 no
GO:0007268 chemical synaptic transmission 42.8571 7 no
GO:0008104 protein localization 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010562 positive regulation of phosphorus metabolic process 42.8571 6 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0033674 positive regulation of kinase activity 28.5714 6 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045860 positive regulation of protein kinase activity 28.5714 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 28.5714 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 28.5714 9 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0061097 regulation of protein tyrosine kinase activity 28.5714 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 28.5714 8 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007612 learning 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0035418 protein localization to synapse 28.5714 6 no
GO:0035864 response to potassium ion 28.5714 5 no
GO:0035865 cellular response to potassium ion 28.5714 6 no
GO:0048168 regulation of neuronal synaptic plasticity 28.5714 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0050890 cognition 28.5714 4 no
GO:0071241 cellular response to inorganic substance 28.5714 4 no
GO:0071248 cellular response to metal ion 28.5714 5 no
GO:1902414 protein localization to cell junction 28.5714 5 no
GO:0000165 MAPK cascade 28.5714 5 no
GO:0007264 small GTPase-mediated signal transduction 28.5714 5 no
GO:0007265 Ras protein signal transduction 28.5714 6 no
GO:0008284 positive regulation of cell population proliferation 28.5714 5 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 yes
GO:0044087 regulation of cellular component biogenesis 28.5714 4 yes
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 yes
GO:0048812 neuron projection morphogenesis 28.5714 5 yes
GO:0050807 regulation of synapse organization 28.5714 5 yes
GO:0051963 regulation of synapse assembly 28.5714 6 yes
GO:0051965 positive regulation of synapse assembly 28.5714 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 28.5714 4 yes
GO:0099560 synaptic membrane adhesion 28.5714 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 yes
GO:1901888 regulation of cell junction assembly 28.5714 5 yes
GO:1901890 positive regulation of cell junction assembly 28.5714 6 yes
GO:0010720 positive regulation of cell development 28.5714 6 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0022604 regulation of cell morphogenesis 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0045597 positive regulation of cell differentiation 28.5714 5 no
GO:0050767 regulation of neurogenesis 28.5714 6 no
GO:0050769 positive regulation of neurogenesis 28.5714 6 no
GO:0060284 regulation of cell development 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
MD12L_HUMAN [view interactions] High throughput no yes
BROMI_HUMAN [view interactions] High throughput no no
RASN_HUMAN [view entry] [view interactions] High throughput yes no