Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NETO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NETO1_HUMAN
GO:0005216 ion channel activity 40.0000 4 no
GO:0005230 extracellular ligand-gated ion channel activity 40.0000 6 no
GO:0005261 cation channel activity 40.0000 5 no
GO:0008324 cation transmembrane transporter activity 40.0000 4 no
GO:0015267 channel activity 40.0000 4 no
GO:0015276 ligand-gated ion channel activity 40.0000 5 no
GO:0022824 transmitter-gated ion channel activity 40.0000 5 no
GO:0022834 ligand-gated channel activity 40.0000 6 no
GO:0022835 transmitter-gated channel activity 40.0000 4 no
GO:0022836 gated channel activity 40.0000 5 no
GO:0022890 inorganic cation transmembrane transporter activity 40.0000 4 no
GO:0046872 metal ion binding 40.0000 4 no
GO:0099094 ligand-gated cation channel activity 40.0000 6 no
GO:0001540 amyloid-beta binding 30.0000 4 no
GO:0004970 ionotropic glutamate receptor activity 30.0000 5 no
GO:0004972 NMDA glutamate receptor activity 30.0000 6 no
GO:0005244 voltage-gated ion channel activity 30.0000 4 no
GO:0005262 calcium channel activity 30.0000 6 no
GO:0008066 glutamate receptor activity 30.0000 4 no
GO:0015085 calcium ion transmembrane transporter activity 30.0000 6 no
GO:0022832 voltage-gated channel activity 30.0000 6 no
GO:0022843 voltage-gated cation channel activity 30.0000 5 no
GO:0022849 glutamate-gated calcium ion channel activity 30.0000 6 no
GO:0046873 metal ion transmembrane transporter activity 30.0000 5 no
GO:0099604 ligand-gated calcium channel activity 30.0000 7 no
GO:0019900 kinase binding 30.0000 4 no
GO:0046914 transition metal ion binding 30.0000 5 no
GO:0035254 glutamate receptor binding 20.0000 4 yes
GO:0035255 ionotropic glutamate receptor binding 20.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NETO1_HUMAN
GO:0048522 positive regulation of cellular process 90.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 80.0000 4 no
GO:0080090 regulation of primary metabolic process 80.0000 4 no
GO:0009893 positive regulation of metabolic process 70.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 70.0000 4 no
GO:0010646 regulation of cell communication 70.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 70.0000 5 yes
GO:0050890 cognition 70.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 70.0000 4 yes
GO:0007268 chemical synaptic transmission 60.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0043085 positive regulation of catalytic activity 60.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 60.0000 5 no
GO:0051246 regulation of protein metabolic process 60.0000 5 no
GO:0051247 positive regulation of protein metabolic process 60.0000 6 no
GO:0098916 anterograde trans-synaptic signaling 60.0000 5 no
GO:0099537 trans-synaptic signaling 60.0000 4 no
GO:0007612 learning 60.0000 4 yes
GO:0010647 positive regulation of cell communication 60.0000 5 yes
GO:0023056 positive regulation of signaling 60.0000 4 yes
GO:0051049 regulation of transport 60.0000 4 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0008104 protein localization 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0008306 associative learning 50.0000 5 yes
GO:0008542 visual learning 50.0000 4 yes
GO:0009416 response to light stimulus 50.0000 4 yes
GO:0043269 regulation of ion transport 50.0000 5 yes
GO:1904062 regulation of cation transmembrane transport 40.0000 6 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 40.0000 5 yes
GO:0006811 ion transport 40.0000 4 no
GO:0006812 cation transport 40.0000 5 no
GO:0006816 calcium ion transport 40.0000 7 no
GO:0007215 glutamate receptor signaling pathway 40.0000 4 no
GO:0007420 brain development 40.0000 4 no
GO:0010243 response to organonitrogen compound 40.0000 4 no
GO:0010950 positive regulation of endopeptidase activity 40.0000 7 no
GO:0010952 positive regulation of peptidase activity 40.0000 6 no
GO:0030001 metal ion transport 40.0000 6 no
GO:0030162 regulation of proteolysis 40.0000 6 no
GO:0043933 protein-containing complex organization 40.0000 4 no
GO:0045471 response to ethanol 40.0000 5 no
GO:0045862 positive regulation of proteolysis 40.0000 7 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0051336 regulation of hydrolase activity 40.0000 4 no
GO:0051345 positive regulation of hydrolase activity 40.0000 5 no
GO:0052547 regulation of peptidase activity 40.0000 5 no
GO:0052548 regulation of endopeptidase activity 40.0000 6 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0065003 protein-containing complex assembly 40.0000 5 no
GO:0097305 response to alcohol 40.0000 4 no
GO:2000116 regulation of cysteine-type endopeptidase activity 40.0000 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 40.0000 8 no
GO:0072657 protein localization to membrane 40.0000 4 no
GO:0031344 regulation of cell projection organization 40.0000 5 no
GO:0050806 positive regulation of synaptic transmission 40.0000 5 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0010941 regulation of cell death 40.0000 4 no
GO:0007613 memory 40.0000 4 yes
GO:0009966 regulation of signal transduction 40.0000 4 yes
GO:0009967 positive regulation of signal transduction 40.0000 5 yes
GO:0031644 regulation of nervous system process 40.0000 5 yes
GO:0034762 regulation of transmembrane transport 40.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 40.0000 5 yes
GO:0044057 regulation of system process 40.0000 4 yes
GO:0048584 positive regulation of response to stimulus 40.0000 4 yes
GO:0098815 modulation of excitatory postsynaptic potential 40.0000 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 30.0000 4 yes
GO:2001257 regulation of cation channel activity 30.0000 6 yes
GO:0006355 regulation of DNA-templated transcription 30.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 30.0000 7 no
GO:0009889 regulation of biosynthetic process 30.0000 4 no
GO:0010468 regulation of gene expression 30.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no
GO:0051259 protein complex oligomerization 30.0000 6 no
GO:0051262 protein tetramerization 30.0000 7 no
GO:0060078 regulation of postsynaptic membrane potential 30.0000 4 no
GO:0060079 excitatory postsynaptic potential 30.0000 5 no
GO:0070588 calcium ion transmembrane transport 30.0000 6 no
GO:0097553 calcium ion transmembrane import into cytosol 30.0000 7 no
GO:0098655 cation transmembrane transport 30.0000 4 no
GO:0098660 inorganic ion transmembrane transport 30.0000 4 no
GO:0098662 inorganic cation transmembrane transport 30.0000 5 no
GO:0098976 excitatory chemical synaptic transmission 30.0000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 30.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 30.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:0031401 positive regulation of protein modification process 30.0000 7 no
GO:0033674 positive regulation of kinase activity 30.0000 6 no
GO:0042127 regulation of cell population proliferation 30.0000 4 no
GO:0042325 regulation of phosphorylation 30.0000 7 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0043113 receptor clustering 30.0000 5 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0045859 regulation of protein kinase activity 30.0000 6 no
GO:0045860 positive regulation of protein kinase activity 30.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 30.0000 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 30.0000 9 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0051347 positive regulation of transferase activity 30.0000 5 no
GO:0061097 regulation of protein tyrosine kinase activity 30.0000 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 30.0000 8 no
GO:0010038 response to metal ion 30.0000 4 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0032880 regulation of protein localization 30.0000 5 no
GO:0032990 cell part morphogenesis 30.0000 4 no
GO:0035418 protein localization to synapse 30.0000 6 no
GO:0048812 neuron projection morphogenesis 30.0000 7 no
GO:0048858 cell projection morphogenesis 30.0000 5 no
GO:0050905 neuromuscular process 30.0000 4 no
GO:0051129 negative regulation of cellular component organization 30.0000 5 no
GO:0071241 cellular response to inorganic substance 30.0000 4 no
GO:0071248 cellular response to metal ion 30.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 30.0000 6 no
GO:1902414 protein localization to cell junction 30.0000 5 no
GO:1903829 positive regulation of protein localization 30.0000 5 no
GO:0009892 negative regulation of metabolic process 30.0000 4 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0010942 positive regulation of cell death 30.0000 5 no
GO:0010970 transport along microtubule 30.0000 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 30.0000 4 no
GO:0042981 regulation of apoptotic process 30.0000 6 no
GO:0043067 regulation of programmed cell death 30.0000 5 no
GO:0050807 regulation of synapse organization 30.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0099111 microtubule-based transport 30.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.0000 6 no
GO:0022898 regulation of transmembrane transporter activity 30.0000 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 30.0000 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 30.0000 4 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 30.0000 5 yes
GO:0010959 regulation of metal ion transport 20.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HNRPL_HUMAN [view interactions] High throughput no yes
ACHB2_HUMAN [view entry] [view interactions] High throughput yes no
SYK_HUMAN [view interactions] Computational no yes