Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRFN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004287 TRG_DiLeu_BaLyEn_6 TRG 694 699 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRFN2_HUMAN
GO:0001540 amyloid-beta binding 33.3333 4 no
GO:0004970 ionotropic glutamate receptor activity 33.3333 5 no
GO:0004972 NMDA glutamate receptor activity 33.3333 6 no
GO:0005216 ion channel activity 33.3333 4 no
GO:0005230 extracellular ligand-gated ion channel activity 33.3333 6 no
GO:0005244 voltage-gated ion channel activity 33.3333 4 no
GO:0005261 cation channel activity 33.3333 5 no
GO:0005262 calcium channel activity 33.3333 6 no
GO:0008066 glutamate receptor activity 33.3333 4 no
GO:0008324 cation transmembrane transporter activity 33.3333 4 no
GO:0015085 calcium ion transmembrane transporter activity 33.3333 6 no
GO:0015267 channel activity 33.3333 4 no
GO:0015276 ligand-gated ion channel activity 33.3333 5 no
GO:0022824 transmitter-gated ion channel activity 33.3333 5 no
GO:0022832 voltage-gated channel activity 33.3333 6 no
GO:0022834 ligand-gated channel activity 33.3333 6 no
GO:0022835 transmitter-gated channel activity 33.3333 4 no
GO:0022836 gated channel activity 33.3333 5 no
GO:0022843 voltage-gated cation channel activity 33.3333 5 no
GO:0022849 glutamate-gated calcium ion channel activity 33.3333 6 no
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 no
GO:0046872 metal ion binding 33.3333 4 no
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 no
GO:0099094 ligand-gated cation channel activity 33.3333 6 no
GO:0099604 ligand-gated calcium channel activity 33.3333 7 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019902 phosphatase binding 33.3333 4 no
GO:0016594 glycine binding 22.2222 4 no
GO:0016595 glutamate binding 22.2222 5 no
GO:0016597 amino acid binding 22.2222 4 no
GO:0031406 carboxylic acid binding 22.2222 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0098879 structural constituent of postsynaptic specialization 22.2222 4 no
GO:0098919 structural constituent of postsynaptic density 22.2222 5 no
GO:0008270 zinc ion binding 22.2222 6 no
GO:0046914 transition metal ion binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in LRFN2_HUMAN
GO:0009893 positive regulation of metabolic process 77.7778 4 no
GO:0010604 positive regulation of macromolecule metabolic process 77.7778 5 no
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0051171 regulation of nitrogen compound metabolic process 77.7778 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 77.7778 5 no
GO:0051246 regulation of protein metabolic process 77.7778 5 no
GO:0051247 positive regulation of protein metabolic process 77.7778 6 no
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 no
GO:0080090 regulation of primary metabolic process 77.7778 4 no
GO:0010646 regulation of cell communication 77.7778 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0043085 positive regulation of catalytic activity 66.6667 4 no
GO:0050804 modulation of chemical synaptic transmission 55.5556 5 yes
GO:0099177 regulation of trans-synaptic signaling 55.5556 4 yes
GO:0007268 chemical synaptic transmission 55.5556 6 no
GO:0022607 cellular component assembly 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0098916 anterograde trans-synaptic signaling 55.5556 5 no
GO:0099537 trans-synaptic signaling 55.5556 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0043933 protein-containing complex organization 44.4444 4 no
GO:0050890 cognition 44.4444 4 no
GO:0065003 protein-containing complex assembly 44.4444 5 no
GO:0008104 protein localization 44.4444 4 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0031401 positive regulation of protein modification process 44.4444 7 no
GO:0072657 protein localization to membrane 44.4444 4 no
GO:0050807 regulation of synapse organization 33.3333 5 yes
GO:0099175 regulation of postsynapse organization 33.3333 6 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 7 no
GO:0006811 ion transport 33.3333 4 no
GO:0006812 cation transport 33.3333 5 no
GO:0006816 calcium ion transport 33.3333 7 no
GO:0007215 glutamate receptor signaling pathway 33.3333 4 no
GO:0007420 brain development 33.3333 4 no
GO:0007612 learning 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010950 positive regulation of endopeptidase activity 33.3333 7 no
GO:0010952 positive regulation of peptidase activity 33.3333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0030001 metal ion transport 33.3333 6 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0034765 regulation of ion transmembrane transport 33.3333 5 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0045471 response to ethanol 33.3333 5 no
GO:0045862 positive regulation of proteolysis 33.3333 7 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0051345 positive regulation of hydrolase activity 33.3333 5 no
GO:0052547 regulation of peptidase activity 33.3333 5 no
GO:0052548 regulation of endopeptidase activity 33.3333 6 no
GO:0060078 regulation of postsynaptic membrane potential 33.3333 4 no
GO:0060079 excitatory postsynaptic potential 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0070588 calcium ion transmembrane transport 33.3333 6 no
GO:0097305 response to alcohol 33.3333 4 no
GO:0097553 calcium ion transmembrane import into cytosol 33.3333 7 no
GO:0098655 cation transmembrane transport 33.3333 4 no
GO:0098660 inorganic ion transmembrane transport 33.3333 4 no
GO:0098662 inorganic cation transmembrane transport 33.3333 5 no
GO:0098976 excitatory chemical synaptic transmission 33.3333 7 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:1904062 regulation of cation transmembrane transport 33.3333 6 no
GO:2000116 regulation of cysteine-type endopeptidase activity 33.3333 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 33.3333 8 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043113 receptor clustering 33.3333 5 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0006996 organelle organization 33.3333 4 no
GO:0035418 protein localization to synapse 33.3333 6 no
GO:0050806 positive regulation of synaptic transmission 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0062237 protein localization to postsynapse 33.3333 7 no
GO:1902414 protein localization to cell junction 33.3333 5 no
GO:1903539 protein localization to postsynaptic membrane 33.3333 5 no
GO:1990778 protein localization to cell periphery 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0008306 associative learning 22.2222 5 no
GO:0008542 visual learning 22.2222 4 no
GO:0009416 response to light stimulus 22.2222 4 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0031644 regulation of nervous system process 22.2222 5 no
GO:0043270 positive regulation of ion transport 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051259 protein complex oligomerization 22.2222 6 no
GO:0051262 protein tetramerization 22.2222 7 no
GO:0051290 protein heterotetramerization 22.2222 8 no
GO:0051291 protein heterooligomerization 22.2222 7 no
GO:0098815 modulation of excitatory postsynaptic potential 22.2222 4 no
GO:2000463 positive regulation of excitatory postsynaptic potential 22.2222 5 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 22.2222 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 22.2222 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0061097 regulation of protein tyrosine kinase activity 22.2222 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 22.2222 8 no
GO:0016050 vesicle organization 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0032412 regulation of ion transmembrane transporter activity 22.2222 5 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0050905 neuromuscular process 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0099633 protein localization to postsynaptic specialization membrane 22.2222 6 no
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:1905477 positive regulation of protein localization to membrane 22.2222 6 no
GO:2001257 regulation of cation channel activity 22.2222 6 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0010942 positive regulation of cell death 22.2222 5 no
GO:0060291 long-term synaptic potentiation 22.2222 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0006508 proteolysis 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0007015 actin filament organization 22.2222 5 no
GO:0007346 regulation of mitotic cell cycle 22.2222 5 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010564 regulation of cell cycle process 22.2222 5 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:1901987 regulation of cell cycle phase transition 22.2222 6 no
GO:1901990 regulation of mitotic cell cycle phase transition 22.2222 6 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 22.2222 8 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
PNPT1_HUMAN [view interactions] High throughput no yes
ACD11_HUMAN [view interactions] High throughput no yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
VEZA_HUMAN [view interactions] High throughput no yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes